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2025 Journal Article PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease modelsAlbornoz, Eduardo A, Mardon, Karine, Bhalla, Rajiv, Kumar, Vinod, Stimson, Damion H R, Cowin, Gary, Cui, Cedric S, Butler, Mark S, Pelingon, Ruby, Gordon, Richard, Coll, Rebecca C, Schroder, Kate, Halai, Reena, MacLeod, Angus M, Matthews, Kim, Robertson, Avril A B, Cooper, Matthew A and Woodruff, Trent M (2025). PET-MRI biomarkers reveal efficacy of a novel NLRP3 inhibitor in Parkinson’s disease models. Brain awaf372. doi: 10.1093/brain/awaf372 |
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2025 Journal Article Complement C9-mediated RBC hemolysis drives microvascular obstruction via endothelial necroptosis and hemolyzed RBC aggregation in COVID-19Lun (Mike) Wu, Chia, Ju, Lining Arnold, Italiano, Ethan, Jarvis-Child, Rocko, Alwis, Imala, Smythe, Rhyll, Albornoz, Eduardo A., Noonan, Jonathan, Portelli, Marie, Baptista, Marrisa, Maclean, Jessica, Norri, Pashtana, Yang, Jinglu, Lee, John, McFadyen, James D., Sharland, Alexandra, Woodruff, Trent M., Samson, Andre, Rapkiewicz, Amy, Barrett, Tessa, Pham, Alan, Schoenwaelder, Simone, Yuan, Yuping and Jackson, Shaun P. (2025). Complement C9-mediated RBC hemolysis drives microvascular obstruction via endothelial necroptosis and hemolyzed RBC aggregation in COVID-19. Immunobiology, 230 (4) 153045, 53-53. doi: 10.1016/j.imbio.2025.153045 |
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2025 Conference Publication Motor neuron disease C9orf72 dipeptides mediate neurotoxicity in human brain organoids through activation of C5aR1Cao, Yuzhihan, Pietrogrande, Giovanni, Pars, Selin, Clark, Richard, Wolvetang, Ernst, Woodruff, Trent and Albornoz, Eduardo (2025). Motor neuron disease C9orf72 dipeptides mediate neurotoxicity in human brain organoids through activation of C5aR1. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.153008 |
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2025 Conference Publication Live-cell single-molecule imaging of a new fluorescent C5a receptor antagonist reveals the heterogeneous spatiotemporal dynamics of C5aR1 at the plasma membraneSun, Jinda, Parker, Sandra, Lee, Jonathan, Gorman, Declan, Li, Xaria, Albornoz Balmaceda, Eduardo, Bellingham, Mark, Clark, Richard, Woodruff, Trent and Padmanabhan, Pranesh (2025). Live-cell single-molecule imaging of a new fluorescent C5a receptor antagonist reveals the heterogeneous spatiotemporal dynamics of C5aR1 at the plasma membrane. 30th International Complement Workshop 2025, Brisbane, QLD, Australia, 14-19 September 2025. Munich, Germany: Elsevier. doi: 10.1016/j.imbio.2025.152969 |
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2025 Conference Publication Microglial Complement C5aR1 signalling drives inflammasome mediated neuropathology in Parkinson’s diseaseAlbornoz, Eduardo, Gordon, Richard, Javed, Ibrahim, Bodea, Gabriela, Kumar, Vinod, Cui, Cedric, Aguado, Julio, Mardon, Karine, Bhalla, Rajiv, Cowin, Gary and Woodruff, Trent (2025). Microglial Complement C5aR1 signalling drives inflammasome mediated neuropathology in Parkinson’s disease. 30th International Complement Workshop 2025, Brisbane, QLD Australia, 14-19 September 2025. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2025.152955 |
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2025 Journal Article Ischaemic endothelial necroptosis induces haemolysis and COVID-19 angiopathyWu, Mike C. L., Italiano, Ethan, Jarvis-Child, Rocko, Alwis, Imala, Smythe, Rhyll, Albornoz, Eduardo A., Noonan, Jonathan, Portelli, Marie, Baptista, Marissa, Maclean, Jessica, Noori, Pashtana, Yang, Jinglu, Lee, John D., McFadyen, James D., Sharland, Alexandra F., Woodruff, Trent M., Samson, Andre L., Rapkiewicz, Amy, Barrett, Tessa J., Pham, Alan, Schoenwaelder, Simone M., Yuan, Yuping and Jackson, Shaun P. (2025). Ischaemic endothelial necroptosis induces haemolysis and COVID-19 angiopathy. Nature, 643 (8070), 1-10. doi: 10.1038/s41586-025-09076-x |
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2023 Journal Article Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathologyAguado, Julio, Amarilla, Alberto A., Taherian Fard, Atefeh, Albornoz, Eduardo A., Tyshkovskiy, Alexander, Schwabenland, Marius, Chaggar, Harman K., Modhiran, Naphak, Gómez-Inclán, Cecilia, Javed, Ibrahim, Baradar, Alireza A., Liang, Benjamin, Peng, Lianli, Dharmaratne, Malindrie, Pietrogrande, Giovanni, Padmanabhan, Pranesh, Freney, Morgan E., Parry, Rhys, Sng, Julian D. J., Isaacs, Ariel, Khromykh, Alexander A., Valenzuela Nieto, Guillermo, Rojas-Fernandez, Alejandro, Davis, Thomas P., Prinz, Marco, Bengsch, Bertram, Gladyshev, Vadim N., Woodruff, Trent M., Mar, Jessica C. ... Wolvetang, Ernst J. (2023). Senolytic therapy alleviates physiological human brain aging and COVID-19 neuropathology. Nature Aging, 3 (12), 1561-1575. doi: 10.1038/s43587-023-00519-6 |
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2023 Journal Article 200 Complement drives Parkinson’s disease neuropathology through activation of microglial C5a receptorsAlbornoz, Eduardo and Woodruff, Trent (2023). 200 Complement drives Parkinson’s disease neuropathology through activation of microglial C5a receptors. Immunobiology, 228 (5) 152650, 1-1. doi: 10.1016/j.imbio.2023.152650 |
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2023 Journal Article Response to comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”Albornoz, Eduardo A., Gordon, Richard, Kumar, Vinod, Robertson, Avril A. B., Schroder, Kate and Woodruff, Trent M. (2023). Response to comment on “Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice”. Science Translational Medicine, 15 (696) adh0604, 1-4. doi: 10.1126/scitranslmed.adh0604 |
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2023 Journal Article SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike proteinAlbornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0 |
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2022 Journal Article SARS-CoV-2 triggers complement activation through interactions with heparan sulfateLo, Martin W., Amarilla, Alberto A., Lee, John D., Albornoz, Eduardo A., Modhiran, Naphak, Clark, Richard J., Ferro, Vito, Chhabra, Mohit, Khromykh, Alexander A., Watterson, Daniel and Woodruff, Trent M. (2022). SARS-CoV-2 triggers complement activation through interactions with heparan sulfate. Clinical and Translational Immunology, 11 (8) e1413, e1413. doi: 10.1002/cti2.1413 |
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2022 Journal Article Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variantsIsaacs, Ariel, Amarilla, Alberto A., Aguado, Julio, Modhiran, Naphak, Albornoz, Eduardo A., Baradar, Alireza A., McMillan, Christopher L. D., Choo, Jovin J. Y., Idris, Adi, Supramaniam, Aroon, McMillan, Nigel A. J., Muller, David A., Young, Paul R., Woodruff, Trent M., Wolvetang, Ernst J., Chappell, Keith J. and Watterson, Daniel (2022). Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variants. Frontiers in Immunology, 13 926262, 926262. doi: 10.3389/fimmu.2022.926262 |
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2020 Journal Article The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteinsDeora, Vandana, Lee, John D., Albornoz, Eduardo A., McAlary, Luke, Jagaraj, Cyril J., Robertson, Avril A. B., Atkin, Julie D, Cooper, Matthew A., Schroder, Kate, Yerbury, Justin J., Gordon, Richard and Woodruff, Trent M. (2020). The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins. Glia, 68 (2) glia.23728, 407-421. doi: 10.1002/glia.23728 |
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2019 Other Outputs Pharmacological targeting of the inflammasome: towards novel therapeutics for Parkinson’s diseaseAlbornoz Balmaceda, Eduardo (2019). Pharmacological targeting of the inflammasome: towards novel therapeutics for Parkinson’s disease. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/uql.2019.702 |
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2018 Journal Article Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in miceGordon, Richard, Albornoz, Eduardo A., Christie, Daniel C., Langley, Monica R., Kumar, Vinod, Mantovani, Susanna, Robertson, Avril A. B., Butler, Mark S., Rowe, Dominic B., O'Neill, Luke A., Kanthasamy, Anumantha G., Schroder, Kate, Cooper, Matthew A. and Woodruff, Trent M. (2018). Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice. Science Translational Medicine, 10 (465) aah4066, eaah4066. doi: 10.1126/scitranslmed.aah4066 |
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2018 Journal Article Gestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitisHaensgen, Henny, Albornoz, Eduardo, Opazo, María C., Bugueño, Katherinne, Jara Fernández, Evelyn Liliana, Binzberger, Rebecca, Rivero-Castillo, Tomás, Venegas Salas, Luis F., Simon, Felipe, Cabello-Verrugio, Claudio, Elorza, Alvaro A., Kalergis, Alexis M., Bueno, Susan M. and Riedel, Claudia A. (2018). Gestational hypothyroxinemia affects its offspring with a reduced suppressive capacity impairing the outcome of the experimental autoimmune encephalomyelitis. Frontiers in Immunology, 9 (JUN) 1257. doi: 10.3389/fimmu.2018.01257 |
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2018 Journal Article Gestational hypothyroxinemia imprints a switch in the capacity of astrocytes and microglial cells of the offspring to react in inflammationOpazo, María C., González, Pablo A., Flores, Betsi D., Venegas, Luis F., Albornoz, Eduardo A., Cisternas, Pablo, Bohmwald, Karen, Nieto, Pamela A., Bueno, Susan M., Kalergis, Alexis M. and Riedel, Claudia A. (2018). Gestational hypothyroxinemia imprints a switch in the capacity of astrocytes and microglial cells of the offspring to react in inflammation. Molecular Neurobiology, 55 (5), 4373-4387. doi: 10.1007/s12035-017-0627-y |
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2018 Journal Article Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviourGiacomin, Paul R., Kraeuter, Ann Katrin, Albornoz, Eduardo A., Jin, Shuting, Bengtsson, Mia, Gordon, Richard, Woodruff, Trent M., Urich, Tim, Sarnyai, Zoltán and Soares Magalhães, Ricardo J. (2018). Chronic helminth infection perturbs the gut-brain axis, promotes neuropathology and alters behaviour. The Journal of Infectious Diseases, 218 (9), 1511-1516. doi: 10.1093/infdis/jiy092 |
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2018 Conference Publication C5aR1 is required for a-synuclein mediated NLRP3 inflammasome activationGordon, Richard, Albornoz, Eduardo, Kanthasamy, Anumantha and Woodruff, Trent (2018). C5aR1 is required for a-synuclein mediated NLRP3 inflammasome activation. 27th International Complement Workshop (ICW), Santa Fe, NM, United States, Sep 16-20, 2018. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2018.06.247 |
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2018 Book Chapter Inflammasomes in CNS diseasesAlbornoz, Eduardo A., Woodruff, Trent M. and Gordon, Richard (2018). Inflammasomes in CNS diseases. Inflammasomes: clinical and therapeutic implications. (pp. 41-60) edited by Mario D. Cordero and Elisabet Alcocer-Gómez. Cham, Switzerland: Springer International. doi: 10.1007/978-3-319-89390-7_3 |
