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2025 Journal Article Multiplexing label-free polymeric nanocarriers via antipolymer antibodiesHumphries, James, Hobson-Peters, Jody, Ghosh, Saikat, Howard, Christopher B., Huda, Pie, Bell, Craig A., Fletcher, Nicholas L., Kempe, Kristian and Thurecht, Kristofer J. (2025). Multiplexing label-free polymeric nanocarriers via antipolymer antibodies. ACS Sensors, 10 (2), 1280-1288. doi: 10.1021/acssensors.4c03184 |
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2025 Journal Article Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancerLiu, Feifei, Howard, Christopher B., Huda, Pie, Fletcher, Nicholas L., Bell, Craig A., Blakey, Idriss, Agrez, Michael and Thurecht, Kristofer J. (2025). Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancer. Biomaterials, 317 123089, 123089. doi: 10.1016/j.biomaterials.2025.123089 |
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2024 Journal Article Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastomaLogan, Amy, Howard, Christopher B., Huda, Pie, Kimpton, Kathleen, Ma, Zerong, Thurecht, Kristofer J., McCarroll, Joshua A., Moles, Ernest and Kavallaris, Maria (2024). Targeted delivery of polo-like kinase 1 siRNA nanoparticles using an EGFR-PEG bispecific antibody inhibits proliferation of high-risk neuroblastoma. Journal of Controlled Release, 367, 806-820. doi: 10.1016/j.jconrel.2024.02.007 |
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2023 Journal Article Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporationHuda, Pie, Humphries, James, Fletcher, Nicholas L., Howard, Christopher B., Thurecht, Kristofer J. and Bell, Craig A. (2023). Click‐on antibody fragments for customisable targeted nanomedicines – site‐specific tetrazine and azide functionalisation through non‐canonical amino acid incorporation. Chemistry–Methods, 4 (2) e202300036. doi: 10.1002/cmtd.202300036 |
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2023 Journal Article RAFT polymer–antibody conjugation: squaramide ester chemistry leads to conjugates with a therapeutic anti-EGFR antibody with full retention of activity and increased tumor uptake in vivoArdana, Aditya, Ghosh, Saikat, Huda, Pie, Fletcher, Nicholas L., Thurecht, Kristofer J. and Williams, Charlotte C. (2023). RAFT polymer–antibody conjugation: squaramide ester chemistry leads to conjugates with a therapeutic anti-EGFR antibody with full retention of activity and increased tumor uptake in vivo. Molecular Pharmaceutics, 20 (6), 3073-3087. doi: 10.1021/acs.molpharmaceut.3c00085 |
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2023 Journal Article Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemiaMoles, Ernest, Howard, Christopher B., Huda, Pie, Karsa, Mawar, McCalmont, Hannah, Kimpton, Kathleen, Duly, Alastair, Chen, Yongjuan, Huang, Yizhou, Tursky, Melinda L., Ma, David, Bustamante, Sonia, Pickford, Russell, Connerty, Patrick, Omari, Sofia, Jolly, Christopher J., Joshi, Swapna, Shen, Sylvie, Pimanda, John E., Dolnikov, Alla, Cheung, Laurence C., Kotecha, Rishi S., Norris, Murray D., Haber, Michelle, de Bock, Charles E., Somers, Klaartje, Lock, Richard B., Thurecht, Kristofer J. and Kavallaris, Maria (2023). Delivery of PEGylated liposomal doxorubicin by bispecific antibodies improves treatment in models of high-risk childhood leukemia. Science Translational Medicine, 15 (696) abm1262, 1-17. doi: 10.1126/scitranslmed.abm1262 |
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2023 Journal Article Development and validation of a targeted treatment for brain tumors using a multi-drug loaded, relapse-resistant polymeric theranosticChu, Weijing, Houston, Zachary H., Fletcher, Nicholas L., Huda, Pie, Ahamed, Muneer, Lim, Ting Xiang, Day, Bryan W., Pinkham, Mark and Thurecht, Kristofer J. (2023). Development and validation of a targeted treatment for brain tumors using a multi-drug loaded, relapse-resistant polymeric theranostic. Biomacromolecules, 24 (6), 2674-2690. doi: 10.1021/acs.biomac.3c00138 |
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2023 Journal Article Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in GlioblastomaGhosh, Saikat, Fletcher, Nicholas L., Huda, Pie, Houston, Zachary H., Howard, Christopher B., Lund, Maria E., Lu, Yanling, Campbell, Douglas H., Walsh, Bradley J. and Thurecht, Kristofer J. (2023). Pharmacokinetics and Biodistribution of Zr-Miltuximab and Its Antibody Fragments as Glypican-1 Targeting Immuno-PET Agents in Glioblastoma. Molecular pharmaceutics, 20 (3), 1549-1563. doi: 10.1021/acs.molpharmaceut.2c00760 |
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2022 Journal Article Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted deliveryGao, Zhiliang, Li, Xiaoyu, Zhao, Kaijie, Geng, Huimin, Zhang, Peiyu, Ju, Yi, Huda, Pie, Howard, Christopher B, Thurecht, Kristofer J, Ashokkumar, Muthupandian, Hao, Jingcheng and Cui, Jiwei (2022). Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery. Chemical Communications, 58 (56), 7777-7780. doi: 10.1039/d2cc01874h |
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2022 Journal Article Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearanceFletcher, N. L., Prior, A., Choy, O., Humphries, J., Huda, P., Ghosh, S., Houston, Z. H., Bell, C. A. and Thurecht, K. J. (2022). Pre-targeting of polymeric nanomaterials to balance tumour accumulation and clearance. Chemical Communications, 58 (57), 7912-7915. doi: 10.1039/d2cc02443h |
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2022 Journal Article Development of targeted micelles and polymersomes prepared from degradable RAFT-based diblock copolymers and their potential role as nanocarriers for chemotherapeuticsAhmed, Salma E., Fletcher, Nicholas L., Prior, Amber R., Huda, Pie, Bell, Craig A. and Thurecht, Kristofer J. (2022). Development of targeted micelles and polymersomes prepared from degradable RAFT-based diblock copolymers and their potential role as nanocarriers for chemotherapeutics. Polymer Chemistry, 13 (27), 4004-4017. doi: 10.1039/d2py00257d |
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2022 Journal Article Antibody-based formats to target glioblastoma: overcoming barriers to protein drug deliveryGhosh, Saikat, Huda, Pie, Fletcher, Nicholas L., Howard, Christopher B., Walsh, Bradley, Campbell, Douglas, Pinkham, Mark B. and Thurecht, Kristofer J. (2022). Antibody-based formats to target glioblastoma: overcoming barriers to protein drug delivery. Molecular Pharmaceutics, 19 (5), 1233-1247. doi: 10.1021/acs.molpharmaceut.1c00996 |
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2022 Journal Article Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruptionJanowicz, Phillip W., Houston, Zachary H., Bunt, Jens, Fletcher, Nicholas L., Bell, Craig A., Cowin, Gary, Howard, Christopher B., Taslima, Dewan, Westra van Holthe, Nicholas, Prior, Amber, Soh, Vanessa, Ghosh, Saikat, Humphries, James, Huda, Pie, Mahler, Stephen M., Richards, Linda J. and Thurecht, Kristofer J. (2022). Understanding nanomedicine treatment in an aggressive spontaneous brain cancer model at the stage of early blood brain barrier disruption. Biomaterials, 283 121416, 121416. doi: 10.1016/j.biomaterials.2022.121416 |
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2022 Journal Article Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulationJohansen, Nicolai Tidemand, Bonaccorsi, Marta, Bengtsen, Tone, Larsen, Andreas Haahr, Tidemand, Frederik Grønbæk, Pedersen, Martin Cramer, Huda, Pie, Berndtsson, Jens, Darwish, Tamim, Yepuri, Nageshewar Rao, Martel, Anne, Pomorski, Thomas Günther, Bertarello, Andrea, Sansom, Mark, Rapp, Mikaela, Crehuet, Ramon, Schubeis, Tobias, Lindorff-Larsen, Kresten, Pintacuda, Guido and Arleth, Lise (2022). Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation. eLife, 11 e71887. doi: 10.7554/elife.71887 |
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2022 Journal Article Clinical development of an anti-GPC-1 antibody for the treatment of cancerGhosh, Saikat, Huda, Pie, Fletcher, Nicholas, Campbell, Douglas, Thurecht, Kristofer J. and Walsh, Bradley (2022). Clinical development of an anti-GPC-1 antibody for the treatment of cancer. Expert Opinion on Biological Therapy, 22 (5), 603-613. doi: 10.1080/14712598.2022.2033204 |
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2021 Journal Article Oligomerization of pharmaceutically relevant insulin analogues for varying concentration and salinity revealed by small-angle X-ray scatteringJensen, Grethe V., Rosenmejer, Katrine R., Huda, Pie and Arleth, Lise (2021). Oligomerization of pharmaceutically relevant insulin analogues for varying concentration and salinity revealed by small-angle X-ray scattering. Molecular Pharmaceutics, 18 (9), 3272-3280. doi: 10.1021/acs.molpharmaceut.1c00164 |
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2020 Journal Article Nanobody-displaying porous silicon nanoparticles for the co-delivery of siRNA and doxorubicinTieu, Terence, Wojnilowicz, Marcin, Huda, Pie, Thurecht, Kristofer J., Thissen, Helmut, Voelcker, Nicolas H. and Cifuentes-Rius, Anna (2020). Nanobody-displaying porous silicon nanoparticles for the co-delivery of siRNA and doxorubicin. Biomaterials Science, 9 (1), 133-147. doi: 10.1039/d0bm01335h |
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2020 Journal Article Targeting the undruggable: emerging technologies in antibody delivery against intracellular targetsNiamsuphap, Suchada, Fercher, Christian, Kumble, Sumukh, Huda, Pie, Mahler, Stephen M. and Howard, Christopher B. (2020). Targeting the undruggable: emerging technologies in antibody delivery against intracellular targets. Expert Opinion on Drug Delivery, 17 (9), 1189-1211. doi: 10.1080/17425247.2020.1781088 |
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2018 Journal Article Invisible detergents for structure determination of membrane proteins by small-angle neutron scatteringMidtgaard, Søren Roi, Darwish, Tamim A., Pedersen, Martin Cramer, Huda, Pie, Larsen, Andreas Haahr, Jensen, Grethe Vestergaard, Kynde, Søren Andreas Røssell, Skar-Gislinge, Nicholas, Nielsen, Agnieszka Janina Zygadlo, Olesen, Claus, Blaise, Mickael, Dorosz, Jerzy Józef, Thorsen, Thor Seneca, Venskutonytė, Raminta, Krintel, Christian, Møller, Jesper V., Frielinghaus, Henrich, Gilbert, Elliot Paul, Martel, Anne, Kastrup, Jette Sandholm, Jensen, Poul Erik, Nissen, Poul and Arleth, Lise (2018). Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering. FEBS Journal, 285 (2), 357-371. doi: 10.1111/febs.14345 |
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2015 Journal Article PET/CT Based In Vivo Evaluation of Cu-64 Labelled Nanodiscs in Tumor Bearing MiceHuda, Pie, Binderup, Tina, Pedersen, Martin Cramer, Midtgaard, Soren Roi, Elema, Dennis Ringkjobing, Kjaer, Andreas, Jensen, Mikael and Arleth, Lise (2015). PET/CT Based In Vivo Evaluation of Cu-64 Labelled Nanodiscs in Tumor Bearing Mice. PLoS One, 10 (7) e0129310. doi: 10.1371/journal.pone.0129310 |
