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2013 Journal Article Downsizing a human inflammatory protein to a small molecule with equal potency and functionalityReid, Robert C., Yau, Mei-Kwan, Singh, Ranee, Hamidon, Johan K., Reed, Anthony N., Chu, Peifei, Suen, Jacky Y., Stoermer, Martin J., Blakeney, Jade S., Lim, Junxian, Faber, Jonathan M. and David P. Fairlie, (2013). Downsizing a human inflammatory protein to a small molecule with equal potency and functionality. Nature Communications, 4 (2802) 2802, 1-9. doi: 10.1038/ncomms3802 |
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2025 Journal Article Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieuBoulouis, Caroline, Mouchtaridi, Elli, Müller, Thomas R., Mak, Jeffrey Y. W., Fairlie, David P., Bergman, Peter, Michaëlsson, Jakob, Halfvarson, Jonas, Mjösberg, Jenny, Buggert, Marcus and Sandberg, Johan K (2025). Human MAIT cell response profiles biased toward IL-17 or IL-10 are distinct effector states directed by the cytokine milieu. Proceedings of the National Academy of Sciences of the United States of America, 122 (6) e2414230122, 1-11. doi: 10.1073/pnas.2414230122 |
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2025 Journal Article Cigarette smoke components modulate the MR1–MAIT axisAwad, Wael, Mayall, Jemma R., Xu, Weijun, Johansen, Matt D., Patton, Timothy, Lim, Xin Yi, Galvao, Izabela, Howson, Lauren J., Brown, Alexandra C., Haw, Tatt Jhong, Donovan, Chantal, Das, Shatarupa, Albers, Gesa J., Pai, Tsung-Yu, Hortle, Elinor, Gillis, Caitlin M., Hansbro, Nicole G., Horvat, Jay C., Liu, Ligong, Mak, Jeffrey Y.W., McCluskey, James, Fairlie, David P., Corbett, Alexandra J., Hansbro, Philip M. and Rossjohn, Jamie (2025). Cigarette smoke components modulate the MR1–MAIT axis. Journal of Experimental Medicine, 222 (2) e20240896, 1-19+. doi: 10.1084/jem.20240896 |
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2025 Journal Article Protease-activated receptor 2: a promising therapeutic target for women's cancersShah, Himani, Fairlie, David P. and Lim, Junxian (2025). Protease-activated receptor 2: a promising therapeutic target for women's cancers. Journal of Pharmacology and Experimental Therapeutics, 392 (1) 100016, 100016. doi: 10.1124/jpet.124.002176 |
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2024 Journal Article MAIT cell plasticity enables functional adaptation that drives antibacterial immune protectionWang, Huimeng, Souter, Michael N. T., de Lima Moreira, Marcela, Li, Shihan, Zhou, Yuchen, Nelson, Adam G., Yu, Jinhan, Meehan, Lucy J., Meehan, Bronwyn S., Eckle, Sidonia B. G., Lee, Hyun Jae, Schröder, Jan, Haque, Ashraful, Mak, Jeffrey Y. W., Fairlie, David P., McCluskey, James, Wang, Zhongfang, Chen, Zhenjun and Corbett, Alexandra J. (2024). MAIT cell plasticity enables functional adaptation that drives antibacterial immune protection. Science Immunology, 9 (102) eadp9841. doi: 10.1126/sciimmunol.adp9841 |
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2024 Journal Article MR1 presents vitamin B6–related compounds for recognition by MR1-reactive T cellsMcInerney, Mitchell P., Awad, Wael, Souter, Michael N. T., Kang, Yang, Wang, Carl J. H., Chan Yew Poa, Kean, Abdelaal, Mohamed R., Le, Ngoc H., Shepherd, Chloe M., McNeice, Conor, Meehan, Lucy J., Nelson, Adam G., Raynes, Jeremy M., Mak, Jeffrey Y. W., McCluskey, James, Chen, Zhenjun, Ang, Ching-Seng, Fairlie, David P., Le Nours, Jérôme, Illing, Patricia T., Rossjohn, Jamie and Purcell, Anthony W. (2024). MR1 presents vitamin B6–related compounds for recognition by MR1-reactive T cells. Proceedings of the National Academy of Sciences, 121 (49) e2414792121. doi: 10.1073/pnas.2414792121 |
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2024 Journal Article Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signalingXu, Calvin, Obers, Andreas, Qin, Minyi, Brandli, Alice, Wong, Joelyn, Huang, Xin, Clatch, Allison, Fayed, Aly, Starkey, Graham, D’Costa, Rohit, Gordon, Claire L., Mak, Jeffrey Y.W., Fairlie, David P., Beattie, Lynette, Mackay, Laura K., Godfrey, Dale I. and Koay, Hui-Fern (2024). Selective regulation of IFN-γ and IL-4 co-producing unconventional T cells by purinergic signaling. Journal of Experimental Medicine, 221 (12) e20240354. doi: 10.1084/jem.20240354 |
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2024 Journal Article Histone deacetylase 7 activates 6-phosphogluconate dehydrogenase via an enzyme-independent mechanism that involves the N-terminal protein-protein interaction domainWang, Yizhuo, Curson, James E.B., Ramnath, Divya, Das Gupta, Kaustav, Reid, Robert C., Karunakaran, Denuja, Fairlie, David P. and Sweet, Matthew J. (2024). Histone deacetylase 7 activates 6-phosphogluconate dehydrogenase via an enzyme-independent mechanism that involves the N-terminal protein-protein interaction domain. Biochemical Journal, 481 (21), 1569-1584. doi: 10.1042/bcj20240380 |
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2024 Journal Article Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responsesPurohit, Shivam K., Stern, Lauren, Corbett, Alexandra J., Mak, Jeffrey Y.W., Fairlie, David P., Slobedman, Barry and Abendroth, Allison (2024). Varicella Zoster Virus disrupts MAIT cell polyfunctional effector responses. PLoS Pathogens, 20 (8 August) e1012372, e1012372. doi: 10.1371/journal.ppat.1012372 |
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2024 Journal Article PAR2 activation on human tubular epithelial cells engages converging signaling pathways to induce an inflammatory and fibrotic milieuVesey, David A., Iyer, Abishek, Owen, Evan, Kamato, Danielle, Johnson, David W., Gobe, Glenda C., Fairlie, David P. and Nikolic-Paterson, David J. (2024). PAR2 activation on human tubular epithelial cells engages converging signaling pathways to induce an inflammatory and fibrotic milieu. Frontiers in Pharmacology, 15 1382094. doi: 10.3389/fphar.2024.1382094 |
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2024 Journal Article Hydrolases & Lipases in GtoPdb v.2024.2Alexander, Stephen P. H., Doherty, Patrick, Fairlie, David, Fowler, Christopher J., Overall, Christopher M., Rawlings, Neil, Southan, Christopher and Turner, Anthony J. (2024). Hydrolases & Lipases in GtoPdb v.2024.2. IUPHAR/BPS Guide to Pharmacology CITE, 2024 (2). doi: 10.2218/gtopdb/f799/2024.2 |
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2024 Journal Article Potent Immunomodulators Developed from an Unstable Bacterial Metabolite of Vitamin B2 BiosynthesisMak, Jeffrey Y. W., Rivero, Ryan J. D., Hoang, Huy N., Lim, Xin Yi, Deng, Jieru, McWilliam, Hamish E. G., Villadangos, Jose A., McCluskey, James, Corbett, Alexandra J. and Fairlie, David P. (2024). Potent Immunomodulators Developed from an Unstable Bacterial Metabolite of Vitamin B2 Biosynthesis. Angewandte Chemie, 136 (31). doi: 10.1002/ange.202400632 |
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2024 Journal Article MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitisZheng, Yichao, Han, Fei, Wu, Zhengyu, Wang, Bingjie, Chen, Xingchi, Boulouis, Caroline, Jiang, Yuebin, Ho, Amanda, He, Dan, Sia, Wan Rong, Mak, Jeffrey Y. W., Fairlie, David P., Wang, Lin-Fa, Sandberg, Johan K., Lobie, Peter E., Ma, Shaohua and Leeansyah, Edwin (2024). MAIT cell activation and recruitment in inflammation and tissue damage in acute appendicitis. Science Advances, 10 (24) eadn6331, eadn6331. doi: 10.1126/sciadv.adn6331 |
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2024 Journal Article MAIT cell-MR1 reactivity is highly conserved across multiple divergent speciesEdmans, Matthew D., Connelley, Timothy K., Morgan, Sophie, Pediongco, Troi J., Jayaraman, Siddharth, Juno, Jennifer A., Meehan, Bronwyn S., Dewar, Phoebe M., Maze, Emmanuel A., Roos, Eduard O., Paudyal, Basu, Mak, Jeffrey YW., Liu, Ligong, Fairlie, David P., Wang, Huimeng, Corbett, Alexandra J., McCluskey, James, Benedictus, Lindert, Tchilian, Elma, Klenerman, Paul and Eckle, Sidonia BG. (2024). MAIT cell-MR1 reactivity is highly conserved across multiple divergent species. Journal of Biological Chemistry, 300 (6) 107338, 1-21. doi: 10.1016/j.jbc.2024.107338 |
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2024 Journal Article Mouse mucosal-associated invariant T cell receptor recognition of MR1 presenting the vitamin B metabolite, 5-(2-oxopropylideneamino)-6-D-ribitylaminouracilCiacchi, Lisa, Mak, Jeffrey Y.W., Le, Jeremy P., Fairlie, David P., McCluskey, James, Corbett, Alexandra J., Rossjohn, Jamie and Awad, Wael (2024). Mouse mucosal-associated invariant T cell receptor recognition of MR1 presenting the vitamin B metabolite, 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil. Journal of Biological Chemistry, 300 (5) 107229, 1-12. doi: 10.1016/j.jbc.2024.107229 |
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2024 Journal Article Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesodermWu, Zhixuan, Shen, Sophie, Mizikovsky, Dalia, Cao, Yuanzhao, Naval-Sanchez, Marina, Tan, Siew Zhuan, Alvarez, Yanina D., Sun, Yuliangzi, Chen, Xiaoli, Zhao, Qiongyi, Kim, Daniel, Yang, Pengyi, Hill, Timothy A., Jones, Alun, Fairlie, David P., Pébay, Alice, Hewitt, Alex W., Tam, Patrick P.L., White, Melanie D., Nefzger, Christian M. and Palpant, Nathan J. (2024). Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm. Developmental Cell, 59 (6), 705-722.e8. doi: 10.1016/j.devcel.2024.01.019 |
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2024 Journal Article Dynamic MAIT cell recovery after severe COVID-19 is transient with signs of heterogeneous functional anomaliesKammann, Tobias, Gorin, Jean-Baptiste, Parrot, Tiphaine, Gao, Yu, Ponzetta, Andrea, Emgård, Johanna, Maleki, Kimia T., Sekine, Takuya, Rivera-Ballesteros, Olga, Gredmark-Russ, Sara, Rooyackers, Olav, Skagerberg, Magdalena, Eriksson, Lars I., Norrby-Teglund, Anna, Mak, Jeffrey Y. W., Fairlie, David P., Björkström, Niklas K., Klingström, Jonas, Ljunggren, Hans-Gustaf, Aleman, Soo, Buggert, Marcus, Strålin, Kristoffer, Sandberg, Johan K. and Karolinska COVID-19 Study Group (2024). Dynamic MAIT cell recovery after severe COVID-19 is transient with signs of heterogeneous functional anomalies. The Journal of Immunology, 212 (3), 389-396. doi: 10.4049/jimmunol.2300639 |
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2024 Journal Article Sulfated bile acid is a host-derived ligand for MAIT cellsIto, Emi, Inuki, Shinsuke, Izumi, Yoshihiro, Takahashi, Masatomo, Dambayashi, Yuki, Ciacchi, Lisa, Awad, Wael, Takeyama, Ami, Shibata, Kensuke, Mori, Shotaro, Mak, Jeffrey Y. W., Fairlie, David P., Bamba, Takeshi, Ishikawa, Eri, Nagae, Masamichi, Rossjohn, Jamie and Yamasaki, Sho (2024). Sulfated bile acid is a host-derived ligand for MAIT cells. Science Immunology, 9 (91) eade6924, eade6924. doi: 10.1126/sciimmunol.ade6924 |
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2023 Journal Article Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cellsShah, Himani, Hill, Timothy A., Lim, Junxian and Fairlie, David P. (2023). Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells. Journal of Cell Communication and Signaling, 17 (4), 1-15. doi: 10.1007/s12079-023-00791-6 |
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2023 Journal Article N-(2-Aminophenyl)-benzamide Inhibitors of Class I HDAC Enzymes with Antiproliferative and Antifibrotic ActivityGerokonstantis, Dimitrios Triantafyllos, Mantzourani, Christiana, Gkikas, Dimitrios, Wu, Kai-Chen, Hoang, Huy N., Triandafillidi, Ierasia, Barbayianni, Ilianna, Kanellopoulou, Paraskevi, Kokotos, Alexandros C., Moutevelis-Minakakis, Panagiota, Aidinis, Vassilis, Politis, Panagiotis K., Fairlie, David P. and Kokotos, George (2023). N-(2-Aminophenyl)-benzamide Inhibitors of Class I HDAC Enzymes with Antiproliferative and Antifibrotic Activity. Journal of Medicinal Chemistry, 66 (20), 1-20. doi: 10.1021/acs.jmedchem.3c01422 |
