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2024 Journal Article CD8<sup>+</sup>tissue-resident memory T cells are expanded in primary Sjögren’s disease and can be therapeutically targeted by CD103 blockadeMauro, Daniele, Lin, Xiang, Pontarini, Elena, Wehr, Pascale, Guggino, Giuliana, Tang, Yuan, Deng, Chong, Gandolfo, Saviana, Xiao, Fan, Rui, Ke, Huang, Enyu, Tian, Jie, Raimondo, Stefania, Rischmueller, Maureen, Boroky, Jane, Downie-Doyle, Sarah, Nel, Hendrik, Baz-Morelli, Adriana, Hsu, Arthur, Maraskovsky, Eugene, Barr, Adele, Hemon, Patrice, Chatzis, Loukas, Boschetti, Ciro Emiliano, Colella, Giuseppe, Alessandro, Riccardo, Rizzo, Aroldo, Pers, Jacques-Olivier, Bombardieri, Michele ... Ciccia, Francesco (2024). CD8+tissue-resident memory T cells are expanded in primary Sjögren’s disease and can be therapeutically targeted by CD103 blockade. Annals of the Rheumatic Diseases, 83 (10), 1-13. doi: 10.1136/ard-2023-225069 |
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2023 Journal Article Genetically encoded Runx3 and CD4+ intestinal epithelial lymphocyte deficiencies link SKG mouse and human predisposition to spondyloarthropathyBhuyan, Zaied Ahmed, Rahman, M. Arifur, Maradana, Muralidhara Rao, Mehdi, Ahmed M., Bergot, Anne-Sophie, Simone, Davide, El-Kurdi, Marya, Garrido-Mesa, Jose, Cai, Cheng Bang Benjamin, Cameron, Amy J., Hanson, Aimee L., Nel, Hendrik J., Kenna, Tony, Leo, Paul, Rehaume, Linda, Brown, Matthew A., Ciccia, Francesco and Thomas, Ranjeny (2023). Genetically encoded Runx3 and CD4+ intestinal epithelial lymphocyte deficiencies link SKG mouse and human predisposition to spondyloarthropathy. Clinical Immunology, 247 109220, 1-14. doi: 10.1016/j.clim.2022.109220 |
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2022 Journal Article Randomized phase I trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritisSonigra, Amee, Nel, Hendrik J., Wehr, Pascale, Ramnoruth, Nishta, Patel, Swati, van Schie, Karin A., Bladen, Maxwell W., Mehdi, Ahmed M., Tesiram, Joanne, Talekar, Meghna, Rossjohn, Jamie, Reid, Hugh H., Stuurman, Frederik E., Roberts, Helen, Vecchio, Phillip, Gourley, Ian, Rigby, Mark, Becart, Stephane, Toes, Rene E.M., Scherer, Hans Ulrich, Lê Cao, Kim-Anh, Campbell, Kim and Thomas, Ranjeny (2022). Randomized phase I trial of antigen-specific tolerizing immunotherapy with peptide/calcitriol liposomes in ACPA+ rheumatoid arthritis. JCI Insight, 7 (20) e160964, 1-18. doi: 10.1172/jci.insight.160964 |
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2022 Journal Article Evaluation of a fit-for-purpose assay to monitor antigen-specific functional CD4+ T-cell subpopulations in rheumatoid arthritis using flow cytometry-based peptide-MHC class-II tetramer stainingPatel, Swati, Ramnoruth, Nishta, Wehr, Pascale, Rossjohn, Jamie, Reid, Hugh H., Campbell, Kim, Nel, Hendrik J. and Thomas, Ranjeny (2022). Evaluation of a fit-for-purpose assay to monitor antigen-specific functional CD4+ T-cell subpopulations in rheumatoid arthritis using flow cytometry-based peptide-MHC class-II tetramer staining. Clinical and Experimental Immunology, 207 (1), 72-83. doi: 10.1093/cei/uxab008 |
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2021 Journal Article IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetesGreenbaum, Carla J., Serti, Elisavet, Lambert, Katharina, Weiner, Lia J., Kanaparthi, Sai, Lord, Sandra, Gitelman, Stephen E., Wilson, Darrell M., Gaglia, Jason L., Griffin, Kurt J., Russell, William E., Raskin, Philip, Moran, Antoinette, Willi, Steven M., Tsalikian, Eva, DiMeglio, Linda A., Herold, Kevan C., Moore, Wayne V., Goland, Robin, Harris, Mark, Craig, Maria E., Schatz, Desmond A., Baidal, David A., Rodriguez, Henry, Utzschneider, Kristina M., Nel, Hendrik J., Soppe, Carol L., Boyle, Karen D., Cerosaletti, Karen ... Sanda, Srinath (2021). IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes. JCI Insight, 6 (21) e150074. doi: 10.1172/jci.insight.150074 |
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2021 Journal Article Streptococcus species enriched in the oral cavity of patients with RA are a source of peptidoglycan-polysaccharide polymers that can induce arthritis in miceMoentadj, Rabia, Wang, Yiwen, Bowerman, Kate, Rehaume, Linda, Nel, Hendrik, O Cuiv, Paraic, Stephens, Juliette, Baharom, Amalina, Maradana, Muralidhara, Lakis, Vanessa, Morrison, Mark, Wells, Timothy, Hugenholtz, Philip, Benham, Helen, Le Cao, Kim-Anh and Thomas, Ranjeny (2021). Streptococcus species enriched in the oral cavity of patients with RA are a source of peptidoglycan-polysaccharide polymers that can induce arthritis in mice. Annals of the Rheumatic Diseases, 80 (5) annrheumdis-2020-219009, annrheumdis-2020. doi: 10.1136/annrheumdis-2020-219009 |
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2021 Journal Article Proinsulin‐specific T‐cell responses correlate with estimated c‐peptide and predict partial remission duration in type 1 diabetesMusthaffa, Yassmin, Hamilton‐Williams, Emma E, Nel, Hendrik J., Bergot, Anne‐Sophie, Mehdi, Ahmed M., Harris, Mark and Thomas, Ranjeny (2021). Proinsulin‐specific T‐cell responses correlate with estimated c‐peptide and predict partial remission duration in type 1 diabetes. Clinical & Translational Immunology, 10 (7) e1315, e1315. doi: 10.1002/cti2.1315 |
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2020 Journal Article Optimization of a method to detect autoantigen-specific t-cell responses in type 1 diabetesMusthaffa, Yassmin, Nel, Hendrik J., Ramnoruth, Nishta, Patel, Swati, Hamilton-Williams, Emma E., Harris, Mark and Thomas, Ranjeny (2020). Optimization of a method to detect autoantigen-specific t-cell responses in type 1 diabetes. Frontiers in Immunology, 11 587469, 587469. doi: 10.3389/fimmu.2020.587469 |
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2020 Journal Article Autoantigens in rheumatoid arthritis and the potential for antigen-specific tolerising immunotherapyNel, Hendrik J., Malmström, Vivianne, Wraith, David C. and Thomas, Ranjeny (2020). Autoantigens in rheumatoid arthritis and the potential for antigen-specific tolerising immunotherapy. The Lancet Rheumatology, 2 (11), e712-e723. doi: 10.1016/S2665-9913(20)30344-1 |
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2020 Journal Article T‐cell receptor immunosequencing reveals altered repertoire diversity and disease‐associated clonal expansions in ankylosing spondylitis patientsHanson, Aimee L., Nel, Hendrik J., Bradbury, Linda, Phipps, Julie, Thomas, Ranjeny, Lê Cao, Kim‐Anh, Kenna, Tony J. and Brown, Matthew A. (2020). T‐cell receptor immunosequencing reveals altered repertoire diversity and disease‐associated clonal expansions in ankylosing spondylitis patients. Arthritis and Rheumatology, 72 (8) art.41252, 1289-1302. doi: 10.1002/art.41252 |
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2020 Journal Article RelB suppresses type I Interferon signaling in dendritic cellsSaha, Irene, Jaiswal, Hemant, Mishra, Richa, Nel, Hendrik J., Schreuder, Jaring, Kaushik, Monika, Singh Chauhan, Kuldeep, Singh Rawat, Bhupendra, Thomas, Ranjeny, Naik, Shalin, Kumar, Himanshu and Tailor, Prafullakumar (2020). RelB suppresses type I Interferon signaling in dendritic cells. Cellular Immunology, 349 104043, 104043. doi: 10.1016/j.cellimm.2020.104043 |
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2019 Journal Article PD-L1 and calcitriol dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune diseaseGalea, Ryan, Nel, Hendrik, Talekar, Meghna, Liu, Xiao, Ooi, Joshua D., Huynh, Megan, Hadjigol, Sara, Robson, Kate J., Ting, Yi Tian, Cole, Suzanne, Cochlin, Karyn, Hitchcock, Shannon, Zeng, Bijun, Yekollu, Suman, Boks, Martine, Goh, Natalie, Roberts, Helen, Rossjohn, Jamie, Reid, Hugh H., Boyd, Ben J., Malaviya, Ravi, Shealy, David J., Baker, Daniel G., Madakamutil, Loui, Kitching, A. Richard, O’Sullivan, Brendan J. and Thomas, Ranjeny (2019). PD-L1 and calcitriol dependent liposomal antigen-specific regulation of systemic inflammatory autoimmune disease. JCI Insight, 4 (18) e126025. doi: 10.1172/jci.insight.126025 |
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2019 Journal Article Regulation of tolerogenic features on dexamethasone-modulated MPLA-activated dendritic cells by MYCGarcia-Gonzalez, Paulina A., Maggi, Jaxaira, Schinnerling, Katina, Sepulveda-Gutierrez, Alejandro, Soto, Lilian, Neire, Oscar, Mehdi, Ahmed M., Nel, Hendrik J., Pesce, Barbara, Aravena, Octavio, Carmen Molina, Maria, Catalan, Diego, Thomas, Ranjeny, Verdugo, Ricardo A. and Carlos Aguillon, Juan (2019). Regulation of tolerogenic features on dexamethasone-modulated MPLA-activated dendritic cells by MYC. Frontiers in Immunology, 10 (MAY) 1171, 1171. doi: 10.3389/fimmu.2019.01171 |
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2019 Journal Article A microfluidic-SERSplatform for isolation and immuno-phenotyping of antigen specific T-cellsDey, Shuvashis, Vaidyanathan, Ramanathan, Reza, K. Kamil, Wang, Jing, Wang, Yuling, Nel, Hendrik J., Law, Soi-Cheng, Tyler, Jennifer, Rossjohn, Jamie, Reid, Hugh H., Ibn Sina, Abu Ali, Thomas, Ranjeny and Trau, Matt (2019). A microfluidic-SERSplatform for isolation and immuno-phenotyping of antigen specific T-cells. Sensors and Actuators B: Chemical, 284, 281-288. doi: 10.1016/j.snb.2018.12.099 |
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2018 Journal Article Airway cells from protracted bacterial bronchitis and bronchiectasis share similar gene expression profilesChen, Alice C. -H., Pena, Olga M., Nel, Hendrik J., Yerkovich, Stephanie T., Chang, Anne B., Baines, Katherine J., Gibson, Peter G., Petsky, Helen L., Pizzutto, Susan J., Hodge, Sandra, Masters, Ian B., Buntain, Helen L. and Upham, John W. (2018). Airway cells from protracted bacterial bronchitis and bronchiectasis share similar gene expression profiles. Pediatric Pulmonology, 53 (5), 575-582. doi: 10.1002/ppul.23984 |
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2018 Journal Article Flow Cytometric Clinical Immunomonitoring Using Peptide-MHC Class II Tetramers: Optimization of Methods and Protocol DevelopmentJansen, Diahann T. S. L., Ramnoruth, Nishta, Loh, Khai L., Rossjohn, Jamie, Reid, Hugh H., Nel, Hendrik J. and Thomas, Ranjeny (2018). Flow Cytometric Clinical Immunomonitoring Using Peptide-MHC Class II Tetramers: Optimization of Methods and Protocol Development. Frontiers in Immunology, 9 (JAN) 8, 1-10. doi: 10.3389/fimmu.2018.00008 |
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2017 Journal Article Dexamethasone and monophosphoryl lipid a induce a distinctive profile on monocyte-derived dendritic cells through transcriptional modulation of genes associated with essential processes of the immune responseGarcia-Gonzalez, Paulina A., Schinnerling, Katina, Sepulveda-Gutierrez, Alejandro, Maggi, Jaxaira, Mehdi, Ahmed M., Nel, Hendrik J., Pesce, Barbara, Larrondo, Milton L., Aravena, Octavio, Molina, Mar-A C., Catalan, Diego, Thomas, Ranjeny, Verdugo, Ricardo A. and Aguillon, Juan C. (2017). Dexamethasone and monophosphoryl lipid a induce a distinctive profile on monocyte-derived dendritic cells through transcriptional modulation of genes associated with essential processes of the immune response. Frontiers in Immunology, 8 (OCT) 1350, 1350. doi: 10.3389/fimmu.2017.01350 |
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2017 Journal Article CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skinOvergaard, Nana H., Cruz, Jazmina L., Bridge, Jennifer A., Nel, Hendrik J., Frazer, Ian H., La Gruta, Nicole K., Blumenthal, Antje, Steptoe, Raymond J. and Wells, James W. (2017). CD4+CD8β+ double-positive T cells in skin-draining lymph nodes respond to inflammatory signals from the skin. Journal of Leukocyte Biology, 102 (3), 837-844. doi: 10.1189/jlb.1AB0217-065R |
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2016 Journal Article Treatment with dexamethasone and monophosphoryl lipid a removes disease-associated transcriptional signatures in monocyte-derived dendritic cells from rheumatoid arthritis patients and confers tolerogenic featuresGarcia-Gonzalez, Paulina A., Schinnerling, Katina, Sepulveda-Gutierrez, Alejandro, Maggi, Jaxaira, Hoyos, Lorena, Morales, Rodrigo A., Mehdi, Ahmed M., Nel, Hendrik J., Soto, Lilian, Pesce, Barbara, Carmen Molina, Maria, Cuchacovich, Miguel, Larrondo, Milton L., Neira, Oscar, Francisco Catalan, Diego, Hilkens, Catharien M., Thomas, Ranjeny, Verdugo, Ricardo A. and Aguillon, Juan C. (2016). Treatment with dexamethasone and monophosphoryl lipid a removes disease-associated transcriptional signatures in monocyte-derived dendritic cells from rheumatoid arthritis patients and confers tolerogenic features. Frontiers in Immunology, 7 (OCT) 458, 458. doi: 10.3389/fimmu.2016.00458 |
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Featured 2015 Journal Article Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patientsBenham, Helen, Nel, Hendrik J., Law, Soi Cheng, Mehdi, Ahmed M., Street, Shayna, Ramnoruth, Nishta, Pahau, Helen, Lee, Bernett T., Ng, Jennifer, Brunck, Marion E. G., Hyde, Claire, Trouw, Leendert A., Dudek, Nadine L., Purcell, Anthony W., O'Sullivan, Brendan J., Connolly, John E., Paul, Sanjoy K., Le Cao, Kim-Anh and Thomas, Ranjeny (2015). Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients. Science Translational Medicine, 7 (290) 290ra87, 290ra87.1-290ra87.11. doi: 10.1126/scitranslmed.aaa9301 |
