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2021

Journal Article

Metaproteomic sample preparation methods bias the recovery of host and microbial proteins according to taxa and cellular compartment

Gavin, Patrick G., Wong, Justin, Loo, Dorothy, Zipris, Danny, Hill, Michelle M. and Hamilton-Williams, Emma E. (2021). Metaproteomic sample preparation methods bias the recovery of host and microbial proteins according to taxa and cellular compartment. Journal of Proteomics, 240 104219, 104219. doi: 10.1016/j.jprot.2021.104219

Metaproteomic sample preparation methods bias the recovery of host and microbial proteins according to taxa and cellular compartment

2021

Journal Article

A triple threat? The role of diet, nutrition, and the microbiota in T1D pathogenesis

Hamilton-Williams, Emma E., Lorca, Graciela L., Norris, Jill M. and Dunne, Jessica L. (2021). A triple threat? The role of diet, nutrition, and the microbiota in T1D pathogenesis. Frontiers in Nutrition, 8 600756, 600756. doi: 10.3389/fnut.2021.600756

A triple threat? The role of diet, nutrition, and the microbiota in T1D pathogenesis

2021

Journal Article

An acetate‐yielding diet imprints an immune and anti‐microbial programme against enteric infection

Yap, Yu Anne, McLeod, Keiran H., McKenzie, Craig I., Gavin, Patrick G., Davalos‐Salas, Mercedes, Richards, James L., Moore, Robert J., Lockett, Trevor J., Clarke, Julie M., Eng, Vik Ven, Pearson, Jaclyn S., Hamilton‐Williams, Emma E., Mackay, Charles R. and Mariño, Eliana (2021). An acetate‐yielding diet imprints an immune and anti‐microbial programme against enteric infection. Clinical and Translational Immunology, 10 (1) e1233, e1233. doi: 10.1002/cti2.1233

An acetate‐yielding diet imprints an immune and anti‐microbial programme against enteric infection

2021

Journal Article

Proinsulin‐specific T‐cell responses correlate with estimated c‐peptide and predict partial remission duration in type 1 diabetes

Musthaffa, Yassmin, Hamilton‐Williams, Emma E, Nel, Hendrik J., Bergot, Anne‐Sophie, Mehdi, Ahmed M., Harris, Mark and Thomas, Ranjeny (2021). Proinsulin‐specific T‐cell responses correlate with estimated c‐peptide and predict partial remission duration in type 1 diabetes. Clinical & Translational Immunology, 10 (7) e1315, e1315. doi: 10.1002/cti2.1315

Proinsulin‐specific T‐cell responses correlate with estimated c‐peptide and predict partial remission duration in type 1 diabetes

2020

Journal Article

Optimization of a method to detect autoantigen-specific t-cell responses in type 1 diabetes

Musthaffa, Yassmin, Nel, Hendrik J., Ramnoruth, Nishta, Patel, Swati, Hamilton-Williams, Emma E., Harris, Mark and Thomas, Ranjeny (2020). Optimization of a method to detect autoantigen-specific t-cell responses in type 1 diabetes. Frontiers in Immunology, 11 587469, 587469. doi: 10.3389/fimmu.2020.587469

Optimization of a method to detect autoantigen-specific t-cell responses in type 1 diabetes

2020

Journal Article

A Question of Tolerance—Antigen-Specific Immunotherapy for Type 1 Diabetes

Loaiza Naranjo, Jeniffer D., Bergot, Anne-Sophie, Buckle, Irina and Hamilton-Williams, Emma E. (2020). A Question of Tolerance—Antigen-Specific Immunotherapy for Type 1 Diabetes. Current Diabetes Reports, 20 (12) 70, 70. doi: 10.1007/s11892-020-01363-3

A Question of Tolerance—Antigen-Specific Immunotherapy for Type 1 Diabetes

2020

Journal Article

Regulatory T cells induced by single-peptide liposome immunotherapy suppress islet-Specific T cell responses to multiple antigens and protect from autoimmune diabetes

Bergot, Anne-Sophie, Buckle, Irina, Cikaluru, Sumana, Naranjo, Jennifer Loaiza, Wright, Casey Maree, Zheng, Guoliang, Talekar, Meghna, Hamilton-Williams, Emma E. and Thomas, Ranjeny (2020). Regulatory T cells induced by single-peptide liposome immunotherapy suppress islet-Specific T cell responses to multiple antigens and protect from autoimmune diabetes. Journal of Immunology, 204 (7), ji1901128-1797. doi: 10.4049/jimmunol.1901128

Regulatory T cells induced by single-peptide liposome immunotherapy suppress islet-Specific T cell responses to multiple antigens and protect from autoimmune diabetes

2019

Journal Article

Early-life factors contributing to type 1 diabetes

Craig, Maria E., Kim, Ki Wook, Isaacs, Sonia R., Penno, Megan A., Hamilton-Williams, Emma E., Couper, Jennifer J. and Rawlinson, William D. (2019). Early-life factors contributing to type 1 diabetes. Diabetologia, 62 (10), 1823-1834. doi: 10.1007/s00125-019-4942-x

Early-life factors contributing to type 1 diabetes

2019

Journal Article

The gut microbiota in type 1 diabetes: friend or foe?

Gavin, Patrick G. and Hamilton-Williams, Emma E. (2019). The gut microbiota in type 1 diabetes: friend or foe?. Current Opinion in Endocrinology, Diabetes and Obesity, 26 (4), 207-212. doi: 10.1097/MED.0000000000000483

The gut microbiota in type 1 diabetes: friend or foe?

2018

Journal Article

Early-life exposure to gut microbiota from disease protected mice does not impact disease outcome in type 1 diabetes susceptible NOD mice

Mullaney, Jane A., Stephens, Juliette E., Geeling, Brooke E. and Hamilton-Williams, Emma E. (2018). Early-life exposure to gut microbiota from disease protected mice does not impact disease outcome in type 1 diabetes susceptible NOD mice. Immunology and Cell Biology, 97 (1), 97-103. doi: 10.1111/imcb.12201

Early-life exposure to gut microbiota from disease protected mice does not impact disease outcome in type 1 diabetes susceptible NOD mice

2018

Journal Article

Correction to: Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota

Mullaney, Jane A., Stephens, Juliette E., Costello, Mary-Ellen, Fong, Cai, Geeling, Brooke E., Gavin, Patrick G., Wright, Casey M., Spector, Timothy D., Brown, Matthew A. and Hamilton-Williams, Emma E. (2018). Correction to: Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota. Microbiome, 6 (1), 51. doi: 10.1186/s40168-018-0438-z

Correction to: Type 1 diabetes susceptibility alleles are associated with distinct alterations in the gut microbiota

Featured

2018

Journal Article

A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes

Mehdi, Ahmed M., Hamilton-Williams, Emma E., Cristino, Alexandre, Ziegler, Anette, Bonifacio, Ezio, Le Cao, Kim-Anh, Harris, Mark and Thomas, Ranjeny (2018). A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes. JCI Insight, 3 (5) e98212. doi: 10.1172/jci.insight.98212

A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes

2017

Journal Article

CD11a/ICAM-1 blockade combined with IL-2 targeting therapy causes a paradoxical acceleration of type 1 diabetes

Brenu, Ekua W., Bartley, Timothy J., Wright, Casey M. and Hamilton-Williams, Emma E. (2017). CD11a/ICAM-1 blockade combined with IL-2 targeting therapy causes a paradoxical acceleration of type 1 diabetes. Immunology and Cell Biology, 95 (9), 803-813. doi: 10.1038/icb.2017.49

CD11a/ICAM-1 blockade combined with IL-2 targeting therapy causes a paradoxical acceleration of type 1 diabetes

2017

Journal Article

Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice

Reeves, Peta L. S., Rudraraju, Rajeev, Wong, F. Susan, Hamilton-Williams, Emma E. and Steptoe, Raymond J. (2017). Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice. European Journal of Immunology, 47 (9), 1550-1561. doi: 10.1002/eji.201747089

Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice

2017

Journal Article

APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice

Reeves, Peta L. S., Rudraraju, Rajeev, Liu, Xiao, Wong, F. Susan, Hamilton-Williams, Emma E. and Steptoe, Raymond J. (2017). APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice. Immunology and Cell Biology, 95 (9), 765-774. doi: 10.1038/icb.2017.48

APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice

2016

Journal Article

Maintenance of peripheral tolerance to islet antigens

Hamilton-Williams, Emma E., Bergot, Anne-Sophie, Reeves, Peta L. S and Steptoe, Raymond J. (2016). Maintenance of peripheral tolerance to islet antigens. Journal of Autoimmunity, 72, 118-125. doi: 10.1016/j.jaut.2016.05.009

Maintenance of peripheral tolerance to islet antigens

2016

Journal Article

Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice

James, Cini R., Buckle, Irina, Muscate, Franziska, Otsuka, Masayuki, Nakao, Mari, Oon, Jack S. H., Steptoe, Raymond J., Thomas, Ranjeny and Hamilton-Williams, Emma E. (2016). Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice. Immunology and Cell Biology, 94 (5), 509-519. doi: 10.1038/icb.2016.7

Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice

2015

Journal Article

Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes

Pang, Dimeng, Irvine, Katharine M., Mehdi, Ahmed M., Thomas, Helen E., Harris, Mark, Hamilton-Williams, Emma E. and Thomas, Ranjeny (2015). Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes. Clinical and Translational Immunology, 4 (8) e41, e41.1-e41.9. doi: 10.1038/cti.2015.17

Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes

2013

Journal Article

Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity

Hamilton-Williams, Emma E., Rainbow, Daniel B., Cheung, Jocelyn, Christensen, Mikkel, Lyons, Paul A., Peterson, Laurence B., Steward, Charles A., Sherman, Linda A. and Wicker, Linda S. (2013). Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity. Mammalian Genome, 24 (9-10), 358-375. doi: 10.1007/s00335-013-9466-y

Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity

2013

Journal Article

Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes

Lin, Xiaotian, Hamilton-Williams, Emma E., Rainbow, Daniel B., Hunter, Kara M., Dai, Yang D., Cheung, Jocelyn, Peterson, Laurence B., Wicker, Linda S. and Sherman, Linda A. (2013). Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes. Journal of Immunology, 190 (7), 3109-3120. doi: 10.4049/jimmunol.1203422

Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes