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2024

Conference Publication

Spatial-specific gene signatures to predict immunotherapy outcomes in lung cancer

Aung, Thazin N., Moutafi, Myrto, Trontzas, Ioannis, Kulasinghe, Arutha, Monkman, James, Gavrielatou, Niki, Vathiotis, Ioannis, Warrell, Jonathan H. and Rimm, David L. (2024). Spatial-specific gene signatures to predict immunotherapy outcomes in lung cancer. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-1141

Spatial-specific gene signatures to predict immunotherapy outcomes in lung cancer

2024

Conference Publication

Spatially resolved cell profiling unveils tumor metabolic states associated with immunotherapy response in NSCLC

Monkman, James, Czertok, Rotem, Bookstein, Shai, Arbiv, Becky, Shachaf, Yuval, Elran, Ron, Bloom, Kenneth, Puig, Oscar, O'Byrne, Ken, Markovits, Ettai and Kulasinghe, Arutha (2024). Spatially resolved cell profiling unveils tumor metabolic states associated with immunotherapy response in NSCLC. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-1158

Spatially resolved cell profiling unveils tumor metabolic states associated with immunotherapy response in NSCLC

2024

Conference Publication

Integration of high-plex tumor-Immune phenotyping and checkpoint interactions for deeper spatial characterization of human cancer tissues

Bodbin, Sara, Ma, Ning, Pratapa, Aditya, Nikulina, Nadya, Monkman, James, Jhaveri, Niyati, Elofsson, Hampus, Basu, Subham, Zieba-Wicher, Agata and Kulasinghe, Arutha (2024). Integration of high-plex tumor-Immune phenotyping and checkpoint interactions for deeper spatial characterization of human cancer tissues. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-1525

Integration of high-plex tumor-Immune phenotyping and checkpoint interactions for deeper spatial characterization of human cancer tissues

2024

Conference Publication

Spatial profiling of the tumor microenvironment in head and neck squamous cell carcinoma revealed immune cell type infiltration into the TME as a predictor of immunotherapy response

Sadeghirad, Habib, Tan, Chin Wee, Liu, Ning, Monkman, James, Cooper, Caroline, O’Byrne, Ken, Davis, Melissa, Hughes, Brett and Kulasinghe, Arutha (2024). Spatial profiling of the tumor microenvironment in head and neck squamous cell carcinoma revealed immune cell type infiltration into the TME as a predictor of immunotherapy response. American Association for Cancer Research Annual Meeting 2024, San Diego, CA United States, 5-10 April 2024. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2024-1154

Spatial profiling of the tumor microenvironment in head and neck squamous cell carcinoma revealed immune cell type infiltration into the TME as a predictor of immunotherapy response

2023

Conference Publication

Identifying a role for macrophages in predicting immunotherapy responses of non-small cell lung cancer (NSCLC)

Ma, Ning, Pratapa, Aditya, Monkman, James, O’Byrne, Ken and Kulasinghe, Arutha (2023). Identifying a role for macrophages in predicting immunotherapy responses of non-small cell lung cancer (NSCLC). Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting, San Diego, CA United States, 1-5 November 2023. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2023-sitc2023.0105

Identifying a role for macrophages in predicting immunotherapy responses of non-small cell lung cancer (NSCLC)

2023

Conference Publication

Spatio-temporal monitoring of the tumor microenvironment in cutaneous squamous cell carcinoma

Jhaveri, Niyati, Klymyshyn, Dmytro, Pratapa, Aditya, Cheikh, Bassem Ben, Monkman, James, Prater, Michael, Nelson, Nadine, Mammadova, Najiba and Kulasinghe, Arutha (2023). Spatio-temporal monitoring of the tumor microenvironment in cutaneous squamous cell carcinoma. Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting, San Diego, CA United States, 1-5 November 2023. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2023-sitc2023.0090

Spatio-temporal monitoring of the tumor microenvironment in cutaneous squamous cell carcinoma

2023

Conference Publication

Extracellular Small Vesicle Phosphorylated PD-L1 Liquid Biopsy Levels Correlate with Tumour Proportion Score (TPS) in NSCLC

O'Byrne, K., Shanmugasundaram, K.B., Ahmed, E., Kulasinghe, A., Monkman, J., Fletcher, J.A., Mainwaring, P.N., Masud, M.K., Park, H., Hossain, M.S.A., Yamauchi, Y., Sina, A.A.I., Wuethrich, A. and Trau, M. (2023). Extracellular Small Vesicle Phosphorylated PD-L1 Liquid Biopsy Levels Correlate with Tumour Proportion Score (TPS) in NSCLC. 2023 World Conference on Lung Cancer, Singapore, 9-12 September 2023. New York, NY United States: Elsevier. doi: 10.1016/j.jtho.2023.09.432

Extracellular Small Vesicle Phosphorylated PD-L1 Liquid Biopsy Levels Correlate with Tumour Proportion Score (TPS) in NSCLC

2023

Conference Publication

High-dimensional profiling of the tumour microenvironment of non-small cell lung cancer

Kulasinghe, A., Monkman, J., Moradi, A., Yunis, J., Ivison, G., Mayer, A. and O'Byrne, K. (2023). High-dimensional profiling of the tumour microenvironment of non-small cell lung cancer. 2023 World Conference on Lung Cancer, Singapore, Singapore, 9 - 12 September 2023. New York, NY, United States: Elsevier.

High-dimensional profiling of the tumour microenvironment of non-small cell lung cancer

2023

Conference Publication

From pixels to clinical Insights: deciphering spatial tumour-immune microenvironment features of immunotherapy response and resistance in lung cancer

Kulasinghe, Arutha (2023). From pixels to clinical Insights: deciphering spatial tumour-immune microenvironment features of immunotherapy response and resistance in lung cancer. Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting, San Diego, CA United States, 1-5 November 2023. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2023-sitc2023.0099

From pixels to clinical Insights: deciphering spatial tumour-immune microenvironment features of immunotherapy response and resistance in lung cancer

2023

Conference Publication

High-plex spatial profiling of cutaneous squamous cell carcinoma to identify biomarkers associated with clinical outcomes: The cMIC study

Ladwa, R., Monkman, J., Sadeghirad, H., Cooper, C., Belz, G., Bowman, J., Schaider, H., Liu, H., Kulasinghe, A. and Porceddu, S. (2023). High-plex spatial profiling of cutaneous squamous cell carcinoma to identify biomarkers associated with clinical outcomes: The cMIC study. ESMO Congress 2023, Madrid, Spain, 20-24 October 2023. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2023.09.2278

High-plex spatial profiling of cutaneous squamous cell carcinoma to identify biomarkers associated with clinical outcomes: The cMIC study

2023

Conference Publication

Multi-omic spatial phenotyping of the NSCLC tumour microenvironment for the development of a spatial score associated with immunotherapy resistance

Kulasinghe, A., Ma, N., Pratapa, A., Monkman, J., Braubach, O. and O'Byrne, K. J. (2023). Multi-omic spatial phenotyping of the NSCLC tumour microenvironment for the development of a spatial score associated with immunotherapy resistance. ESMO Congress 2023, Madrid, Spain, 20-24 October 2023. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2023.09.1352

Multi-omic spatial phenotyping of the NSCLC tumour microenvironment for the development of a spatial score associated with immunotherapy resistance

2023

Conference Publication

Spatial phenotyping of cytokine signatures reflecting the immunotherapy responses in head and neck cancer

Ji, HaYeun, Jhaveri, Niyati, Pratapa, Aditya, Ma, Ning, Ben Cheikh, Bassem, Monkman, James, O’Byrne, Ken, Hughes, Brett, Kulasinghe, Arutha and Braubach, Oliver (2023). Spatial phenotyping of cytokine signatures reflecting the immunotherapy responses in head and neck cancer. Immunology 2023™ Meeting, Washington, DC United States, 11-15 May 2023. Rockville, MD United States: American Association of Immunologists. doi: 10.4049/jimmunol.210.supp.171.09

Spatial phenotyping of cytokine signatures reflecting the immunotherapy responses in head and neck cancer

2023

Conference Publication

Spatial phenotyping of cytokine signatures reflecting the immunotherapy responses in head and neck cancer

Ji, HaYeun, Jhaveri, Niyati, Pratapa, Aditya, Ma, Ning, Ben Cheikh, Bassem, Monkman, James, O'Byrne, Ken, Hughes, Brett, Kulasinghe, Arutha and Braubach, Oliver (2023). Spatial phenotyping of cytokine signatures reflecting the immunotherapy responses in head and neck cancer. Annual Meeting of the American-Association-of-Immunologists (AAI), Washington Dc, May 11-15, 2023. BETHESDA: AMER ASSOC IMMUNOLOGISTS.

Spatial phenotyping of cytokine signatures reflecting the immunotherapy responses in head and neck cancer

2023

Conference Publication

Abstract 4626: Spatial profiling of the tumor microenvironment in head and neck cancer identifies immune checkpoints and proteins involved in cell death signaling biomarkers of immunotherapy response

Sadeghirad, Habib, Liu, Ning, Monkman, James, Tan, Chin Wee, Cooper, Caroline, Caldera, Jeni, Church, Sarah, Schneider, Fabian, Mansfield, James Robert, O'Byrne, Ken, Davis, Melissa, Hughes, Brett and Kulasinghe, Arutha (2023). Abstract 4626: Spatial profiling of the tumor microenvironment in head and neck cancer identifies immune checkpoints and proteins involved in cell death signaling biomarkers of immunotherapy response. AACR Annual Meeting 2023, Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-4626

Abstract 4626: Spatial profiling of the tumor microenvironment in head and neck cancer identifies immune checkpoints and proteins involved in cell death signaling biomarkers of immunotherapy response

2023

Conference Publication

Abstract 6768: The potential predictive role of spatial phenotyping in non-small cell lung cancer

Ma, Ning, Pratapa, Aditya, Monkman, James, O’Byrne, Ken, Braubach, Oliver and Kulasinghe, Arutha (2023). Abstract 6768: The potential predictive role of spatial phenotyping in non-small cell lung cancer. AACR Annual Meeting 2023, Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-6768

Abstract 6768: The potential predictive role of spatial phenotyping in non-small cell lung cancer

2023

Conference Publication

Abstract 6774: The development of a spatial metabolic map of immunotherapy sensitive and resistant cutaneous skin carcinoma

Jhaveri, Niyati, Klymyshyn, Dmytro, Cheikh, Bassem B., Monkman, James, Winkowski, Dan, Mansfield, James, Basu, Subham, Prater, Michael, Nelson, Nadine, Belz, Gabrielle, Braubach, Oliver and Kulasinghe, Arutha (2023). Abstract 6774: The development of a spatial metabolic map of immunotherapy sensitive and resistant cutaneous skin carcinoma. AACR Annual Meeting 2023, Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-6774

Abstract 6774: The development of a spatial metabolic map of immunotherapy sensitive and resistant cutaneous skin carcinoma

2023

Conference Publication

Immune profiling of immunotherapy and adjuvant chemotherapy pretreatment NSCLC tissues by CODEX

Monkman, James, Moradi, Afshin, O'Leary, Connor, Wu, Zhenqin, Hamel, Steven, Mason, David, Schneider, Fabian, Mansfield, James Robert, Meyer, Aaron, O'Byrne, Ken and Kulasinghe, Arutha (2023). Immune profiling of immunotherapy and adjuvant chemotherapy pretreatment NSCLC tissues by CODEX. AACR Annual Meeting 2023, Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-4627

Immune profiling of immunotherapy and adjuvant chemotherapy pretreatment NSCLC tissues by CODEX

2023

Conference Publication

Abstract 5647: Single cell, multiomic spatial phenotyping of immunotherapy responses in head and neck cancer

Ji, HaYeun, Jhaveri, Niyati, Ma, Ning, Cheikh, Bassem B., Pratapa, Aditya, Monkman, James, O’Byrne, Ken, Hughes, Brett, Kulasinghe, Arutha and Braubach, Oliver (2023). Abstract 5647: Single cell, multiomic spatial phenotyping of immunotherapy responses in head and neck cancer. AACR Annual Meeting 2023, Orlando, FL United States, 14-19 April 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2023-5647

Abstract 5647: Single cell, multiomic spatial phenotyping of immunotherapy responses in head and neck cancer

2023

Conference Publication

Polo-like kinase-1 is a novel biomarker in resected non-small cell lung cancer treated with adjuvant platinum-based chemotherapy

O'Leary, Connor, Monkman, James, Richard, Derek, O'Byrne, Kenneth, Kulasinghe, Arutha and Adams, Mark (2023). Polo-like kinase-1 is a novel biomarker in resected non-small cell lung cancer treated with adjuvant platinum-based chemotherapy. Australian Lung Cancer Conference 2023, Gold Coast, QLD Australia, 15-17 February 2023. Richmond, VIC Australia: John Wiley & Sons.

Polo-like kinase-1 is a novel biomarker in resected non-small cell lung cancer treated with adjuvant platinum-based chemotherapy

2023

Conference Publication

Multiomic dissection of immunotherapy response groups in lung cancer

Kulasinghe, Arutha (2023). Multiomic dissection of immunotherapy response groups in lung cancer. HOBOKEN: WILEY.

Multiomic dissection of immunotherapy response groups in lung cancer