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2022 Journal Article Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signaturesKulasinghe, Arutha, Tan, Chin Wee, dos Santos Miggiolaro, Anna Flavia Ribeiro, Monkman, James, SadeghiRad, Habib, Bhuva, Dharmesh D., da Silva Motta Junior, Jarbas, Vaz de Paula, Caroline Busatta, Nagashima, Seigo, Baena, Cristina Pellegrino, Souza-Fonseca-Guimaraes, Paulo, de Noronha, Lucia, McCulloch, Timothy, Rodrigues Rossi, Gustavo, Cooper, Caroline, Tang, Benjamin, Short, Kirsty R., Davis, Melissa J., Souza-Fonseca-Guimaraes, Fernando, Belz, Gabrielle T. and O'Byrne, Ken (2022). Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures. European Respiratory Journal, 59 (6) 2101881, 1-19. doi: 10.1183/13993003.01881-2021 |
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2025 Journal Article Spatial interaction mapping of PD-1/PD-L1 in head and neck cancer reveals the role of macrophage-tumour barriers associated with immunotherapy responseNaei, Vahid Yaghoubi, Tubelleza, Rafael, Monkman, James, Sadeghirad, Habib, Donovan, Meg L., Blick, Tony, Wicher, Agata, Bodbin, Sara, Viratham, Amelie, Stad, Robert, Basu, Subham, Cooper, Caroline, Barnett, Catherine, O’Byrne, Ken, Ladwa, Rahul, Warkiani, Majid Ebrahimi, Hughes, Brett G. M. and Kulasinghe, Arutha (2025). Spatial interaction mapping of PD-1/PD-L1 in head and neck cancer reveals the role of macrophage-tumour barriers associated with immunotherapy response. Journal of Translational Medicine, 23 (1) 177. doi: 10.1186/s12967-025-06186-y |
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2025 Book Chapter Spatial-Omics Methods and ApplicationsKulasinghe, Arutha, Berrell, Naomi, Donovan, Meg L. and Nilges, Benedikt S. (2025). Spatial-Omics Methods and Applications. Methods in Molecular Biology. (pp. 101-146) New York, NY: Springer US. doi: 10.1007/978-1-0716-4276-4_5 |
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2024 Journal Article Copper chelation redirects neutrophil function to enhance anti-GD2 antibody therapy in neuroblastomaRouaen, Jourdin R. C., Salerno, Antonietta, Shai-Hee, Tyler, Murray, Jayne E., Castrogiovanni, Giulia, McHenry, Charlotte, Jue, Toni Rose, Pham, Vu, Bell, Jessica Lilian, Poursani, Ensieh, Valli, Emanuele, Cazzoli, Riccardo, Damstra, Naomi, Nelson, Delia J., Stevens, Kofi L. P., Chee, Jonathan, Slapetova, Iveta, Kasherman, Maria, Whan, Renee, Lin, Francis, Cochran, Blake J., Tedla, Nicodemus, Veli, Feyza Colakoglu, Yuksel, Aysen, Mayoh, Chelsea, Saletta, Federica, Mercatelli, Daniele, Chtanova, Tatyana, Kulasinghe, Arutha ... Vittorio, Orazio (2024). Copper chelation redirects neutrophil function to enhance anti-GD2 antibody therapy in neuroblastoma. Nature Communications, 15 (1) 10462, 10462. doi: 10.1038/s41467-024-54689-x |
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2024 Conference Publication Spatial dynamics and cellular architecture mapping in head and neck cancer: insights into immunotherapy responseKulasinghe, Arutha (2024). Spatial dynamics and cellular architecture mapping in head and neck cancer: insights into immunotherapy response. SITC 39th Annual Meeting (SITC 2024), Houston, TX United States, 6-10 November 2024. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2024-sitc2024.0110 |
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2024 Conference Publication Multi-omic spatial data integration resolves immunometabolic heterogeneity associated with Nivolumab response in non-small cell lung cancer (NSCLC) patientsYan, Raymond, Quinn, Shannon, Falkenstein, Brian, Monkman, James, O’Bryne, Kenneth, Chakra Chennubhotla, S, Pullara, Filippo and Kulasinghe, Arutha (2024). Multi-omic spatial data integration resolves immunometabolic heterogeneity associated with Nivolumab response in non-small cell lung cancer (NSCLC) patients. SITC 39th Annual Meeting (SITC 2024), Houston, TX United States, 6-10 November 2024. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2024-sitc2024.0212 |
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2024 Conference Publication An integrated approach to high dimensional spatial proteomics and interaction mapping in head and neck cancer tissues prior to immune checkpoint inhibitor therapyNaei, Vahid Yaghoubi, Monkman, James, Hughes, Brett and Kulasinghe, Arutha (2024). An integrated approach to high dimensional spatial proteomics and interaction mapping in head and neck cancer tissues prior to immune checkpoint inhibitor therapy. SITC 39th Annual Meeting (SITC 2024), Houston, TX United States, 6-10 November 2024. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2024-sitc2024.0558 |
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2024 Conference Publication Development of a novel immuno-metabolic spatial signature to predict response and resistance to immunotherapy in NSCLC patientsMarkovits, Ettai, Monkman, James, Aung, Thazin, Reeves, Jason, O’Byrne, Ken, Czertock, Rotem, Puig, Oscar, Rimm, David and Kulasinghe, Arutha (2024). Development of a novel immuno-metabolic spatial signature to predict response and resistance to immunotherapy in NSCLC patients. SITC 39th Annual Meeting (SITC 2024), Houston, TX United States, 6-10 November 2024. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2024-sitc2024.0109 |
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2024 Journal Article Spatial resolution of the head and neck cancer tumor microenvironment to identify tumor and stromal features associated with therapy responseBerrell, Naomi, Monkman, James, Donovan, Meg, Blick, Tony, O'Byrne, Ken, Ladwa, Rahul, Tan, Chin Wee and Kulasinghe, Arutha (2024). Spatial resolution of the head and neck cancer tumor microenvironment to identify tumor and stromal features associated with therapy response. Immunology and Cell Biology, 102 (9), 830-846. doi: 10.1111/imcb.12811 |
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2024 Conference Publication Deciphering Single-Cell Resolved Tumour Microenvironment Profiles Using Spatial Metabolic MappingKulasinghe, A., Monkman, J., Markovits, E. and O'Byrne, K. (2024). Deciphering Single-Cell Resolved Tumour Microenvironment Profiles Using Spatial Metabolic Mapping. 2024 World Conference on Lung Cancer, San Diego, CA United States, 7-10 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jtho.2024.09.032 |
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2024 Conference Publication Characterization of Circulating Tumor-Associated and Immune Cells in Advanced-Stage NSCLCYaghoubi Naei, V., Mullally, W., Warkiani, M., O'Byrne, K. and Kulasinghe, A. (2024). Characterization of Circulating Tumor-Associated and Immune Cells in Advanced-Stage NSCLC. 2024 World Conference on Lung Cancer, San Diego, CA United States, 7-10 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jtho.2024.09.473 |
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2024 Journal Article Protocol for high-plex, whole-slide imaging of human formalin-fixed paraffin-embedded tissue using PhenoCycler-FusionDonovan, Meg L., Jhaveri, Niyati, Ma, Ning, Cheikh, Bassem Ben, DeRosa, James, Mihani, Ritu, Berrell, Naomi, Suen, Jacky Y., Monkman, James, Fraser, John F. and Kulasinghe, Arutha (2024). Protocol for high-plex, whole-slide imaging of human formalin-fixed paraffin-embedded tissue using PhenoCycler-Fusion. STAR Protocols, 5 (3) 103226, 1-18. doi: 10.1016/j.xpro.2024.103226 |
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2024 Journal Article Glycan profiling in small extracellular vesicles with a SERS microfluidic biosensor identifies early malignant development in lung cancerZhou, Quan, Niu, Xueming, Zhang, Zhen, O'Byrne, Kenneth, Kulasinghe, Arutha, Fielding, David, Möller, Andreas, Wuethrich, Alain, Lobb, Richard J. and Trau, Matt (2024). Glycan profiling in small extracellular vesicles with a SERS microfluidic biosensor identifies early malignant development in lung cancer. Advanced Science, 11 (33) 2401818, 1-12. doi: 10.1002/advs.202401818 |
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2024 Conference Publication Multiomic spatial profiling of whole-slide NSCLC tissues from patients receiving anti PD-1 therapy identifies metabolic phenotypes associated with therapy resistanceKulasinghe, A., Monkman, J. and O'Byrne, K.J. (2024). Multiomic spatial profiling of whole-slide NSCLC tissues from patients receiving anti PD-1 therapy identifies metabolic phenotypes associated with therapy resistance. ESMO Congress 2024, Barcelona, Spain, 13-17 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2024.08.2037 |
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2024 Journal Article Mapping the spatial dynamics of the CD4+ T cell spectrum in classical Hodgkin lymphomaMenéndez, Victoria, Solórzano, José L., García-Cosío, Mónica, Cereceda, Laura, Díaz, Eva, Estévez, Mónica, Roncador, Giovanna, Vega, Zaira, Montalbán, Carlos, Kulasinghe, Arutha and García, Juan F. (2024). Mapping the spatial dynamics of the CD4+ T cell spectrum in classical Hodgkin lymphoma. Modern Pathology, 37 (9) 100551, 100551. doi: 10.1016/j.modpat.2024.100551 |
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2024 Conference Publication Unraveling functionally distinct metabolic programs to predict immunotherapy response in non-small cell lung cancer (NSCLC)Kulasinghe, A., Yan, R., Quinn, S., Falkenstein, B., Monkman, J., O'Byrne, K.J., Chennubhotla, S.C. and Pullara, F. (2024). Unraveling functionally distinct metabolic programs to predict immunotherapy response in non-small cell lung cancer (NSCLC). ESMO Congress 2024, Barcelona, Spain, 13-17 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2024.08.142 |
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2024 Journal Article Spatial dynamics of tertiary lymphoid aggregates in head and neck cancer: insights into immunotherapy responseSadeghirad, Habib, Monkman, James, Tan, Chin Wee, Liu, Ning, Yunis, Joseph, Donovan, Meg L., Moradi, Afshin, Jhaveri, Niyati, Perry, Chris, Adams, Mark N., O’Byrne, Ken, Warkiani, Majid E., Ladwa, Rahul, Hughes, Brett G.M. and Kulasinghe, Arutha (2024). Spatial dynamics of tertiary lymphoid aggregates in head and neck cancer: insights into immunotherapy response. Journal of Translational Medicine, 22 (1) 677. doi: 10.1186/s12967-024-05409-y |
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2024 Journal Article Spatial proteomic profiling of tumor and stromal compartments in non‐small‐cell lung cancer identifies signatures associated with overall survivalYaghoubi Naei, Vahid, Monkman, James, Sadeghirad, Habib, Mehdi, Ahmed, Blick, Tony, Mullally, William, O'Byrne, Ken, Warkiani, Majid Ebrahimi and Kulasinghe, Arutha (2024). Spatial proteomic profiling of tumor and stromal compartments in non‐small‐cell lung cancer identifies signatures associated with overall survival. Clinical & Translational Immunology, 13 (7) e1522, e1522. doi: 10.1002/cti2.1522 |
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2024 Journal Article A mesoporous gold sensor unveils phospho PD-L1 in extracellular vesicles as a proxy for PD-L1 expression in lung cancer tissueShanmugasundaram, Karthik B., Ahmed, Emtiaz, Miao, Xinzhe, Kulasinghe, Arutha, Fletcher, James A., Monkman, James, Mainwaring, Paul, Masud, Mostafa Kamal, Park, Hyeongyu, Hossain, Md Shahriar A., Yamauchi, Yusuke, Sina, Abu A. I., O’Byrne, Kenneth, Wuethrich, Alain and Trau, Matt (2024). A mesoporous gold sensor unveils phospho PD-L1 in extracellular vesicles as a proxy for PD-L1 expression in lung cancer tissue. ACS Sensors, 9 (6), 3009-3016. doi: 10.1021/acssensors.4c00192 |
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2024 Journal Article Characterisation of circulating tumor‐associated and immune cells in patients with advanced‐stage non‐small cell lung cancerYaghoubi Naei, Vahid, Ivanova, Ekaterina, Mullally, William, O'Leary, Connor G, Ladwa, Rahul, O'Byrne, Ken, Warkiani, Majid E and Kulasinghe, Arutha (2024). Characterisation of circulating tumor‐associated and immune cells in patients with advanced‐stage non‐small cell lung cancer. Clinical and Translational Immunology, 13 (6) e1516, e1516. doi: 10.1002/cti2.1516 |
