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2025 Journal Article Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancerAung, Thazin N., Monkman, James, Warrell, Jonathan, Vathiotis, Ioannis, Bates, Katherine M., Gavrielatou, Niki, Trontzas, Ioannis P., Tan, Chin Wee, Fernandez, Aileen I., Moutafi, Myrto, O’ Byrne, Ken, Schalper, Kurt A., Syrigos, Konstantinos, Herbst, Roy S., Kulasinghe, Arutha and Rimm, David L. (2025). Spatial signatures for predicting immunotherapy outcomes using multi-omics in non-small cell lung cancer. Nature Genetics, 57 (10), 2482-2493. doi: 10.1038/s41588-025-02351-7 |
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2022 Journal Article Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signaturesKulasinghe, Arutha, Tan, Chin Wee, dos Santos Miggiolaro, Anna Flavia Ribeiro, Monkman, James, SadeghiRad, Habib, Bhuva, Dharmesh D., da Silva Motta Junior, Jarbas, Vaz de Paula, Caroline Busatta, Nagashima, Seigo, Baena, Cristina Pellegrino, Souza-Fonseca-Guimaraes, Paulo, de Noronha, Lucia, McCulloch, Timothy, Rodrigues Rossi, Gustavo, Cooper, Caroline, Tang, Benjamin, Short, Kirsty R., Davis, Melissa J., Souza-Fonseca-Guimaraes, Fernando, Belz, Gabrielle T. and O'Byrne, Ken (2022). Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures. European Respiratory Journal, 59 (6) 2101881, 1-19. doi: 10.1183/13993003.01881-2021 |
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2026 Journal Article Tumour microenvironment diversity of HNSCC and the molecular landscape of recurrent diseaseSteele, Katelyn, Barnett, Catherine, Ladwa, Rahul, Donovan, Meg L, Lawler, Clara and Kulasinghe, Arutha (2026). Tumour microenvironment diversity of HNSCC and the molecular landscape of recurrent disease. Oral Oncology, 174 107864, 107864-174. doi: 10.1016/j.oraloncology.2026.107864 |
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2026 Journal Article Metabolic characterization of tumor-immune interactions by multiplexed immunofluorescence reveals spatial mechanisms of immunotherapy response in non-small cell lung carcinoma (NSCLC)Monkman, James, Kilgallon, Aaron, Lawler, Clara, Tubelleza, Rafael, Aung, Thazin Nwe, Warrell, Jonathan H., Vathiotis, Ioannis, Trontzas, Ioannis P., Gavrielatou, Niki, Nyein Chan, Nay Nwe, Czertok, Rotem, Bookstein, Shai, O’Byrne, Ken, Markovits, Ettai, Rimm, David L. and Kulasinghe, Arutha (2026). Metabolic characterization of tumor-immune interactions by multiplexed immunofluorescence reveals spatial mechanisms of immunotherapy response in non-small cell lung carcinoma (NSCLC). Nature Communications, 17 (1) 837, 837. doi: 10.1038/s41467-026-68633-8 |
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2026 Journal Article Large-scale spatial profiling of the tumor microenvironmentKilgallon, Aaron, Tubelleza, Rafael and Kulasinghe, Arutha (2026). Large-scale spatial profiling of the tumor microenvironment. Cell, 189 (2) PMID 413066, 343-344. doi: 10.1016/j.cell.2025.12.028 |
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2026 Journal Article SM3DD with segmented PCA: a comprehensive method for interpreting 3D spatial transcriptomicsBlick, Tony, Kilgallon, Aaron, Monkman, James, Cooper, Caroline, Tan, Chin Wee, Killingbeck, Emily E., Pan, Liuliu, Kim, Youngmi, Liang, Yan, Nam, Andy, Leon, Michael, Guimaraes, Paulo S. F., Nagashima, Seigo, Martins, Ana P. C., Machado-Souza, Cleber, de Noronha, Lucia, Fraser, John F., Belz, Gabrielle T., Souza-Fonseca-Guimaraes, Fernando and Kulasinghe, Arutha (2026). SM3DD with segmented PCA: a comprehensive method for interpreting 3D spatial transcriptomics. NAR Genomics and Bioinformatics, 8 (1) lqag007, 1-10. doi: 10.1093/nargab/lqag007 |
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2026 Journal Article Integrating mass spectrometry‐based multi‐omic signatures of extracellular vesicles: from discovery to clinical translationWijerathna‐Yapa, Akila, Aubert, Dimitri and Kulasinghe, Arutha (2026). Integrating mass spectrometry‐based multi‐omic signatures of extracellular vesicles: from discovery to clinical translation. Clinical & Translational Immunology, 15 (1) e70078, e70078-1. doi: 10.1002/cti2.70078 |
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2025 Journal Article A digital single‐molecule nanocavity assay to monitor phosphoprotein circuits in single‐cellMiao, Xinzhe, Shanmugasundaram, Karthik, Vedelago, Courtney, Naei, Vahid Yaghoubi, Kulasinghe, Arutha, Lobb, Richard, Trau, Matt and Wuethrich, Alain (2025). A digital single‐molecule nanocavity assay to monitor phosphoprotein circuits in single‐cell. Advanced Materials Technologies e02611. doi: 10.1002/admt.202502611 |
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2025 Journal Article Society for Immunotherapy of Cancer: Standards for Reporting of Multiplex Immunohistochemistry/Immunofluorescence Assays (STORMI)Sater, Sam, Bifulco, Carlo B., Rodriguez-Canales, Jaime, Yeong, Joe, Akturk, Guray, Angelo, Michael, Ballesteros-Merino, Carmen, Bankhead, Peter, Basu, Subham, Blando, Jorge M., Brajkovic, Saska, Cassano, Marco, Chen, Benjamin J., Coskun, Ahmet F., Cottrell, Tricia R., De Andrea, Carlos E., Edwards, Robin H., Egelston, Colt, Engle, Logan L., Ernstoff, Marc S., Fan, Rong, Feldman, Michael, Fox, Bernard A., Galon, Jerome, Gartrell, Robyn, Gnjatic, Sacha, Green, Benjamin F., Gulley, James L., Hellebust, Anne ... Taube, Janis M. (2025). Society for Immunotherapy of Cancer: Standards for Reporting of Multiplex Immunohistochemistry/Immunofluorescence Assays (STORMI). Journal for ImmunoTherapy of Cancer, 13 (12) e012280, 1-16. doi: 10.1136/jitc-2025-012280 |
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2025 Journal Article Carbonic anhydrase 3 overexpression modulates signalling pathways associated with cellular stress resilience and proteostasisYu, Yezhou, Anugraham, Merrina, Blick, Tony, Kulasinghe, Arutha, Sternicki, Louise M., Di Trapani, Giovanna, Poulsen, Sally-Ann, Kolarich, Daniel and Tonissen, Kathryn F. (2025). Carbonic anhydrase 3 overexpression modulates signalling pathways associated with cellular stress resilience and proteostasis. International Journal of Molecular Sciences, 26 (24) 12064, 12064. doi: 10.3390/ijms262412064 |
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2025 Conference Publication 1256 Metabolic mapping of non-small cell lung cancer reveals spatial features associated with immunotherapy resistance and response in the first-line settingKulasinghe, Arutha (2025). 1256 Metabolic mapping of non-small cell lung cancer reveals spatial features associated with immunotherapy resistance and response in the first-line setting. BMJ Publishing Group Ltd. doi: 10.1136/jitc-2025-sitc2025.1256 |
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2025 Conference Publication 69 Markers of Wnt/B-catenin signaling and glutamine utilization within the stromal microenvironment in head & neck squamous cell carcinoma (HNSCC) predict cancer recurrenceYan, Raymond, Falkenstein, Brian, Burak Tosun, A, Monkman, James, Pullara, Filippo, Kulasinghe, Arutha and Chakra Chennubhotla, S (2025). 69 Markers of Wnt/B-catenin signaling and glutamine utilization within the stromal microenvironment in head & neck squamous cell carcinoma (HNSCC) predict cancer recurrence. BMJ Publishing Group Ltd. doi: 10.1136/jitc-2025-sitc2025.0069 |
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2025 Conference Publication 95 Metabolic reprogramming of glycolysis, fatty acid oxidation, and anti-oxidative stress in macrophages is predictive of immunotherapy response in patients with non-small cell lung cancer (NSCLC)Yan, Raymond, Falkenstein, Brian, Burak Tosun, A, Monkman, James, Pullara, Filippo, Kulasinghe, Arutha and Chakra Chennubhotla, S (2025). 95 Metabolic reprogramming of glycolysis, fatty acid oxidation, and anti-oxidative stress in macrophages is predictive of immunotherapy response in patients with non-small cell lung cancer (NSCLC). BMJ Publishing Group Ltd. doi: 10.1136/jitc-2025-sitc2025.0095 |
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2025 Journal Article Editorial: Response/resistance to PD-1 axis inhibitors: focus on the tumor microenvironmentFazeli, Parmees, Yaghoubi, Diba, Vathiotis, Ioannis, Kulasinghe, Arutha and Aung, Thazin N. (2025). Editorial: Response/resistance to PD-1 axis inhibitors: focus on the tumor microenvironment. Frontiers in Immunology, 16 1720955, 1720955. doi: 10.3389/fimmu.2025.1720955 |
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2025 Journal Article Proximity and metabolic activity proxies in the Tumour Microenvironment as predictors of survival in High Grade Serous Ovarian Cancer (HGSOC)Berrell, Naomi, Kilgallon, Aaron, Donovan, Meg L., Lawler, Clara, Tan, Chin Wee, Embaye, Kidane S., Tubelleza, Rafael, Monkman, James, Fraser, John F., O’Byrne, Ken, Huang, Ruby and Kulasinghe, Arutha (2025). Proximity and metabolic activity proxies in the Tumour Microenvironment as predictors of survival in High Grade Serous Ovarian Cancer (HGSOC). iScience, 28 (10) 113572, 1-13+. doi: 10.1016/j.isci.2025.113572 |
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2025 Journal Article Cell-cell interactions as predictive and prognostic markers for drug responses in cancerLu, Xuehan, Tan, Xiao, Kim, Eun Ju, Jin, Xinnan, Donovan, Meg L, Gonzalez Cruz, Jazmina L., Xiong, Zherui, de Los Reyes Becerra Perez, Maria Reyes Becerra, Gong, Jialei, Monkman, James, Agrawal, Divya, Kulasinghe, Arutha, U. Q. CellOmics Innovation Forum, Nguyen, Quan and Tuong, Zewen Kelvin (2025). Cell-cell interactions as predictive and prognostic markers for drug responses in cancer. Genome Medicine, 17 (1) 117, 1-20. doi: 10.1186/s13073-025-01518-5 |
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2025 Journal Article Response-adapted surgical and radiotherapy de-escalation in resectable cutaneous squamous cell cancer using pembrolizumab: the De-Squamate studyLadwa, Rahul, Lee, Jenny H., McGrath, Margaret, Cooper, Caroline, Liu, Howard, Bowman, James, Gupta, Ruta, Cuscaden, Claire, Nottage, Michelle, Clark, Jonathan R., Le, Dieu, Pauley, Marketa, Kulasinghe, Arutha, Gonzalez-Cruz, Jazmina, Porceddu, Sandro V., Hughes, Brett G.M. and Panizza, Benedict (2025). Response-adapted surgical and radiotherapy de-escalation in resectable cutaneous squamous cell cancer using pembrolizumab: the De-Squamate study. Journal of Clinical Oncology, 43 (26) JCO-25-00387, 2888-2896. doi: 10.1200/jco-25-00387 |
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2025 Other Outputs Integrating 12 Spatial and Single Cell Technologies to Characterise Tumour Neighbourhoods and Cellular Interactions in three Skin Cancer TypesPrakrithi, P., Grice, Laura F., Zhang, Feng, Hockey, Levi, Tan, Samuel X., Tan, Xiao, Xiong, Zherui, Mulay, Onkar, Causer, Andrew, Newman, Andrew, Pham, Duy, Ni, Guiyan, Tuong, Kelvin, Jin, Xinnan, Kim, Eunju, Tran, Minh, Vu, Hani, Muller, Nicholas M., Killingbeck, Emily E., Gregory, Mark T., Teoh, Siok Min, Vo, Tuan, Zhang, Min, Landi, Maria Teresa, Brown, Kevin M., Iles, Mark M., Reitz, Zachary, Devitt, Katharina, Pan, Liuliu ... Nguyen, Quan (2025). Integrating 12 Spatial and Single Cell Technologies to Characterise Tumour Neighbourhoods and Cellular Interactions in three Skin Cancer Types. doi: 10.1101/2025.07.25.666708 |
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2025 Journal Article PRISM: a Python package for interactive and integrated analysis of multiplexed tissue microarraysTubelleza, Rafael, Kilgallon, Aaron, Tan, Chin Wee, Monkman, James, Fraser, John F and Kulasinghe, Arutha (2025). PRISM: a Python package for interactive and integrated analysis of multiplexed tissue microarrays. NAR Genomics and Bioinformatics, 7 (3) lqaf114, lqaf114-3. doi: 10.1093/nargab/lqaf114 |
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2025 Journal Article The development of a high-plex spatial proteomic methodology for the characterisation of the head and neck tumour microenvironmentTan, Chin Wee, Berrell, Naomi, Donovan, Meg L., Monkman, James, Lawler, Clara, Sadeghirad, Habib, Naei, Vahid Yaghoubi, Chen, Jinjin, Rossenbloom, Alyssa, Bonnett, Shilah, Conner, Mark, Filanoski, Brian, Kang, Christine, Beechem, Joseph M., Fraser, John F., Barnett, Catherine, Ladwa, Rahul, Hughes, Brett G. M. and Kulasinghe, Arutha (2025). The development of a high-plex spatial proteomic methodology for the characterisation of the head and neck tumour microenvironment. NPJ Precision Oncology, 9 (1) 191. doi: 10.1038/s41698-025-00963-0 |
