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2024 Journal Article Sounding an Alarm over Spatial Biology : Scientists from across the globe highlight spatial biology's triumphs and legal trials while issuing an urgent call for antitrust actionOrr, Miranda E., Kulasinghe, Arutha, Kolar, Grant R., Heyn, Holger, Plummer, Jasmine, Kristensen, Lasse Sommer, Kjems, Jorgen, Mills, Gordon, Garcia-Vallejo, Juan J., Nijman, I.J., West, Nicholas P. and Cox, Amanda (2024). Sounding an Alarm over Spatial Biology : Scientists from across the globe highlight spatial biology's triumphs and legal trials while issuing an urgent call for antitrust action. Genetic Engineering and Biotechnology News, 44 (3), 16-17. doi: 10.1089/gen.44.03.07 |
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2024 Journal Article In situ single-cell profiling sheds light on IFI27 localisation during SARS-CoV-2 infectionTan, Chin Wee, Chen, Jinjin, Liu, Ning, Bhuva, Dharmesh D., Blick, Tony, Monkman, James, Cooper, Caroline, Kharbanda, Malvika, Feher, Kristen, Phipson, Belinda, Killingbeck, Emily E., Pan, Liuliu, Kim, Youngmi, Liang, Yan, Nam, Andy, Leon, Michael, Souza-Fonseca-Guimaraes, Paulo, Nagashima, Seigo, Camargo Martins, Ana Paula, Machado-Souza, Cleber, de Noronha, Lucia, Tang, Benjamin, Short, Kirsty, Fraser, John, Belz, Gabrielle T., Souza-Fonseca-Guimaraes, Fernando, Kulasinghe, Arutha and Davis, Melissa J. (2024). In situ single-cell profiling sheds light on IFI27 localisation during SARS-CoV-2 infection. eBioMedicine, 101 105016, 1-4. doi: 10.1016/j.ebiom.2024.105016 |
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2024 Journal Article Tissue biomarkers of immune checkpoint inhibitor therapyDavoudi, Fatemeh, Moradi, Afshin, Sadeghirad, Habib and Kulasinghe, Arutha (2024). Tissue biomarkers of immune checkpoint inhibitor therapy. Immunology and Cell Biology, 102 (3), 179-193. doi: 10.1111/imcb.12723 |
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2024 Journal Article Poor patient outcome correlates with active engulfment of cytokeratin positive CTCs within cancer-associated monocyte population in lung cancerWiegmans, A. P., Ivanova, E., Naei, V. Y., Monkman, J., Fletcher, J., Mullally, W., Warkiani, M. E., O’Byrne, K. and Kulasinghe, A. (2024). Poor patient outcome correlates with active engulfment of cytokeratin positive CTCs within cancer-associated monocyte population in lung cancer. Clinical and Experimental Metastasis, 41 (2), 219-228. doi: 10.1007/s10585-024-10270-w |
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2024 Journal Article Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signaturesStylianou, Nataly, Sebina, Ismail, Matigian, Nicholas, Monkman, James, Doehler, Hadeel, Röhl, Joan, Allenby, Mark, Nam, Andy, Pan, Liuliu, Rockstroh, Anja, Sadeghirad, Habib, Chung, Kimberly, Sobanski, Thais, O'Byrne, Ken, Almeida, Ana Clara Simoes Florido, Rebutini, Patricia Zadorosnei, Machado‐Souza, Cleber, Stonoga, Emanuele Therezinha Schueda, Warkiani, Majid E., Salomon, Carlos, Short, Kirsty, McClements, Lana, de Noronha, Lucia, Huang, Ruby, Belz, Gabrielle T., Souza‐Fonseca‐Guimaraes, Fernando, Clifton, Vicki and Kulasinghe, Arutha (2024). Whole transcriptome profiling of placental pathobiology in SARS‐CoV‐2 pregnancies identifies placental dysfunction signatures. Clinical and Translational Immunology, 13 (2) e1488, 1-11. doi: 10.1002/cti2.1488 |
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2024 Journal Article The in situ transcriptomic landscape of breast tumour-associated and normal adjacent endothelial cellsRavichandran, Akhilandeshwari, Monkman, James, Mehdi, Ahmed M., Blick, Tony, Snell, Cameron, Kulasinghe, Arutha and Bray, Laura J. (2024). The in situ transcriptomic landscape of breast tumour-associated and normal adjacent endothelial cells. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1870 (2) 166985, 166985. doi: 10.1016/j.bbadis.2023.166985 |
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2024 Journal Article Host transcriptomics and machine learning for secondary bacterial infections in patients with COVID-19: a prospective, observational cohort studyCarney, Meagan, Pelaia, Tiana Maria, Chew, Tracy, Teoh, Sally, Phu, Amy, Kim, Karan, Wang, Ya, Iredell, Jonathan, Zerbib, Yoann, McLean, Anthony, Schughart, Klaus, Tang, Benjamin, Shojaei, Maryam, Short, Kirsty R, PREDICT-19 consortium and Kulasinghe, Arutha (PREDICT-19 consortium member) (2024). Host transcriptomics and machine learning for secondary bacterial infections in patients with COVID-19: a prospective, observational cohort study. The Lancet Microbe, 5 (3), e272-e281. doi: 10.1016/S2666-5247(23)00363-4 |
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2024 Journal Article standR: spatial transcriptomic analysis for GeoMx DSP dataLiu, Ning, Bhuva, Dharmesh D, Mohamed, Ahmed, Bokelund, Micah, Kulasinghe, Arutha, Tan, Chin Wee and Davis, Melissa J (2024). standR: spatial transcriptomic analysis for GeoMx DSP data. Nucleic Acids Research, 52 (1) e2, 1-11. doi: 10.1093/nar/gkad1026 |
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2024 Journal Article Leveraging spatial omics for the development of precision sarcoma treatmentsTu, Cui, Kulasinghe, Arutha, Barbour, Andrew and Souza-Fonseca-Guimaraes, Fernando (2024). Leveraging spatial omics for the development of precision sarcoma treatments. Trends in Pharmacological Sciences, 45 (2), 134-144. doi: 10.1016/j.tips.2023.12.006 |
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2024 Journal Article Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cellsShah, Esha T., Molloy, Christopher, Gough, Madeline, Kryza, Thomas, Samuel, Selwin G., Tucker, Amos, Bhatia, Maneet, Ferguson, Genevieve, Heyman, Rebecca, Vora, Shivam, Monkman, James, Bolderson, Emma, Kulasinghe, Arutha, He, Yaowu, Gabrielli, Brian, Hooper, John D., Richard, Derek J., O’Byrne, Kenneth J. and Adams, Mark N. (2024). Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells. British Journal of Cancer, 130 (7), 1196-1205. doi: 10.1038/s41416-024-02584-z |
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2023 Journal Article Metabolomics at the tumor microenvironment interface: decoding cellular conversationsBerrell, Naomi, Sadeghirad, Habib, Blick, Tony, Bidgood, Charles, Leggatt, Graham R., O'Byrne, Ken and Kulasinghe, Arutha (2023). Metabolomics at the tumor microenvironment interface: decoding cellular conversations. Medicinal Research Reviews, 44 (3), 1121-1146. doi: 10.1002/med.22010 |
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2023 Conference Publication Identifying a role for macrophages in predicting immunotherapy responses of non-small cell lung cancer (NSCLC)Ma, Ning, Pratapa, Aditya, Monkman, James, O’Byrne, Ken and Kulasinghe, Arutha (2023). Identifying a role for macrophages in predicting immunotherapy responses of non-small cell lung cancer (NSCLC). Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting, San Diego, CA United States, 1-5 November 2023. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2023-sitc2023.0105 |
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2023 Conference Publication Spatio-temporal monitoring of the tumor microenvironment in cutaneous squamous cell carcinomaJhaveri, Niyati, Klymyshyn, Dmytro, Pratapa, Aditya, Cheikh, Bassem Ben, Monkman, James, Prater, Michael, Nelson, Nadine, Mammadova, Najiba and Kulasinghe, Arutha (2023). Spatio-temporal monitoring of the tumor microenvironment in cutaneous squamous cell carcinoma. Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting, San Diego, CA United States, 1-5 November 2023. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2023-sitc2023.0090 |
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2023 Conference Publication High-dimensional profiling of the tumour microenvironment of non-small cell lung cancerKulasinghe, A., Monkman, J., Moradi, A., Yunis, J., Ivison, G., Mayer, A. and O'Byrne, K. (2023). High-dimensional profiling of the tumour microenvironment of non-small cell lung cancer. 2023 World Conference on Lung Cancer, Singapore, Singapore, 9 - 12 September 2023. New York, NY, United States: Elsevier. |
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2023 Conference Publication Extracellular Small Vesicle Phosphorylated PD-L1 Liquid Biopsy Levels Correlate with Tumour Proportion Score (TPS) in NSCLCO'Byrne, K., Shanmugasundaram, K.B., Ahmed, E., Kulasinghe, A., Monkman, J., Fletcher, J.A., Mainwaring, P.N., Masud, M.K., Park, H., Hossain, M.S.A., Yamauchi, Y., Sina, A.A.I., Wuethrich, A. and Trau, M. (2023). Extracellular Small Vesicle Phosphorylated PD-L1 Liquid Biopsy Levels Correlate with Tumour Proportion Score (TPS) in NSCLC. 2023 World Conference on Lung Cancer, Singapore, 9-12 September 2023. New York, NY United States: Elsevier. doi: 10.1016/j.jtho.2023.09.432 |
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2023 Journal Article MA09.03 High-dimensional profiling of the tumour microenvironment of non-small cell lung cancerKulasinghe, A., Monkman, J., Moradi, A., Yunis, J., Ivison, G., Mayer, A. and O'Byrne, K. (2023). MA09.03 High-dimensional profiling of the tumour microenvironment of non-small cell lung cancer. Journal of Thoracic Oncology, 18 (11), S129-s129. doi: 10.1016/j.jtho.2023.09.173 |
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2023 Conference Publication From pixels to clinical Insights: deciphering spatial tumour-immune microenvironment features of immunotherapy response and resistance in lung cancerKulasinghe, Arutha (2023). From pixels to clinical Insights: deciphering spatial tumour-immune microenvironment features of immunotherapy response and resistance in lung cancer. Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting, San Diego, CA United States, 1-5 November 2023. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2023-sitc2023.0099 |
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2023 Journal Article Genomic communication via circulating extracellular vesicles and long-term health consequences of COVID-19Nair, Soumyalekshmi, Nova-Lamperti, Estefania, Labarca, Gonzalo, Kulasinghe, Arutha, Short, Kirsty R., Carrión, Flavio and Salomon, Carlos (2023). Genomic communication via circulating extracellular vesicles and long-term health consequences of COVID-19. Journal of Translational Medicine, 21 (1) 709, 1-19. doi: 10.1186/s12967-023-04552-2 |
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2023 Journal Article The seductive allure of spatial biology: accelerating new discoveries in the life sciencesKulasinghe, Arutha, Wood, Fiona and Belz, Gabrielle (2023). The seductive allure of spatial biology: accelerating new discoveries in the life sciences. Immunology and Cell Biology, 101 (9), 798-804. doi: 10.1111/imcb.12669 |
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2023 Conference Publication High-plex spatial profiling of cutaneous squamous cell carcinoma to identify biomarkers associated with clinical outcomes: The cMIC studyLadwa, R., Monkman, J., Sadeghirad, H., Cooper, C., Belz, G., Bowman, J., Schaider, H., Liu, H., Kulasinghe, A. and Porceddu, S. (2023). High-plex spatial profiling of cutaneous squamous cell carcinoma to identify biomarkers associated with clinical outcomes: The cMIC study. ESMO Congress 2023, Madrid, Spain, 20-24 October 2023. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2023.09.2278 |
