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2026 Conference Publication Cellular decomposition and metabolic profiling of the tumor microenvironment tumor-stroma interface using high-dimensional spatial proteomics and image analyticsKulasinghe, Arutha, Roland, Felicia, Poulin, Michelle, Mihani, Ritu, Hales, Katherine and Winkowski, Daniel (2026). Cellular decomposition and metabolic profiling of the tumor microenvironment tumor-stroma interface using high-dimensional spatial proteomics and image analytics. AACR Annual Meeting, San Diego Ca, Apr 17-22, 2026. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1538-7445.AM2026-790 |
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2026 Conference Publication Plasma proteomic profiling of lung cancer blood samples reveals immune-related inflammatory signatures as prognostic biomarkersWijerathna-Yapa, Akila, Kilgallon, Aaron, Lawler, Clara, Monkman, James, Robichaud, Nathaniel, Rosebloom, Alyssa, Mullaly, William, O'Byrne, Ken and Kulasinghe, Arutha (2026). Plasma proteomic profiling of lung cancer blood samples reveals immune-related inflammatory signatures as prognostic biomarkers. AACR Annual Meeting, San Diego Ca, Apr 17-22, 2026. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1538-7445.AM2026-1186 |
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2025 Conference Publication Markers of Wnt/B-catenin signaling and glutamine utilization within the stromal microenvironment in head & neck squamous cell carcinoma (HNSCC) predict cancer recurrenceYan, Raymond, Falkenstein, Brian, Burak Tosun, A, Monkman, James, Pullara, Filippo, Kulasinghe, Arutha and Chakra Chennubhotla, S (2025). Markers of Wnt/B-catenin signaling and glutamine utilization within the stromal microenvironment in head & neck squamous cell carcinoma (HNSCC) predict cancer recurrence. SITC 40th Annual Meeting, 5-9 November 2025, National Harbor, MA United States. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2025-sitc2025.0069 |
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2025 Conference Publication Metabolic reprogramming of glycolysis, fatty acid oxidation, and anti-oxidative stress in macrophages is predictive of immunotherapy response in patients with non-small cell lung cancer (NSCLC)Yan, Raymond, Falkenstein, Brian, Burak Tosun, A, Monkman, James, Pullara, Filippo, Kulasinghe, Arutha and Chakra Chennubhotla, S (2025). Metabolic reprogramming of glycolysis, fatty acid oxidation, and anti-oxidative stress in macrophages is predictive of immunotherapy response in patients with non-small cell lung cancer (NSCLC). SITC 40th Annual Meeting, 5-9 November 2025, National Harbor, MA United States. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2025-sitc2025.0095 |
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2025 Conference Publication Metabolic mapping of non-small cell lung cancer reveals spatial features associated with immunotherapy resistance and response in the first-line settingKulasinghe, Arutha (2025). Metabolic mapping of non-small cell lung cancer reveals spatial features associated with immunotherapy resistance and response in the first-line setting. SITC 40th Annual Meeting, 5-9 November 2025, National Harbor, MA United States. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2025-sitc2025.1256 |
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2025 Conference Publication Tumor microenvironment profiling of multiplexed images in head and neck cancer reveals spatial features associated with immunotherapy responseMarkovits, Ettai, Monkman, James, Kilgallon, Aaron, Aung, Thazin Nwe, Rimm, David and Kulasinghe, Arutha (2025). Tumor microenvironment profiling of multiplexed images in head and neck cancer reveals spatial features associated with immunotherapy response. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-156 |
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2025 Conference Publication A Bayesian framework for unraveling disease biology from spatially resolved single-cell omics datasets by combining unbiased approaches with biological priors for cell-based microdomain discoveryFalkenstein, Brian, Yan, Raymond, Quinn, Shannon, Tosun, Akif Burak, Chennubhotla, S. Chakra, Kulasinghe, Arutha and Pullara, Filippo (2025). A Bayesian framework for unraveling disease biology from spatially resolved single-cell omics datasets by combining unbiased approaches with biological priors for cell-based microdomain discovery. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-2485 |
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2025 Conference Publication Unravelling melanoma brain metastasis tumor microenvironment characteristics using spatial transcriptomicsBelle, Clemence J., Brosda, Sandra, Bonazzi, Vanessa F., Bulteau, Victor, Stuart, Thomas, Xiong, Zherui, Lambie, Duncan, Johansson, Peter A., Aoude, Lauren G., Patel, Kalpana, Stehbens, Samantha J., Stark, Mitchell S., Haass, Nikolas K., Xu, Wen, Pinkham, Mark B., Foote, Matthew C., Olson, Sarah, Atkinson, Victoria, Kulasinghe, Arutha, Nguyen, Quan H. and Barbour, Andrew (2025). Unravelling melanoma brain metastasis tumor microenvironment characteristics using spatial transcriptomics. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-5076 |
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2025 Conference Publication Exploring PD1/PDL1 interactions and macrophage-tumor barriers in head and neck cancer: A spatial approach to immunotherapy responseNaei, Vahid Yaghoubi, Tubelleza, Rafael, Monkman, James, Sadeghirad, Habib, Donovan, Meg L., Blick, Tony, Wicher, Agata, Bodbin, Sara, Basu, Subham, Stad, Robert, Barnett, Catherine, O’Byrne, Ken, Ladwa, Rahul, Cooper, Caroline, Warkiani, Majid Ebrahimi, Hughes, Brett G.M. and Kulasinghe, Arutha (2025). Exploring PD1/PDL1 interactions and macrophage-tumor barriers in head and neck cancer: A spatial approach to immunotherapy response. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-750 |
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2025 Conference Publication Spatial deconvolution of non-small-cell lung cancer tissues prior to immune checkpoint inhibitor therapyMonkman, James, Tan, Chin Wee, Tubelleza, Rafael, OByrne, Ken and Kulasinghe, Arutha (2025). Spatial deconvolution of non-small-cell lung cancer tissues prior to immune checkpoint inhibitor therapy. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-2082 |
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2025 Conference Publication 2D and 3D spatial characterisation of tertiary lymphoid structures in head and neck cancer patients receiving immune checkpoint blockade therapyDonovan, Meg L., Sadeghirad, Habib, Berrell, Naomi, Monkman, James, Naei, Vahid Yaghoubi, Tan, Chin Wee, Yunis, Joseph, West, Zoe, Warkiani, Majid E., Ladwa, Rahul, Hughes, Brett G., Da Gama Duarte, Jessica and Kulasinghe, Arutha (2025). 2D and 3D spatial characterisation of tertiary lymphoid structures in head and neck cancer patients receiving immune checkpoint blockade therapy. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-5252 |
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2025 Conference Publication Characterising head and neck tumour microenvironment using high plex spatial omics technologies and analysesTan, Chin Wee, Berrell, Naomi, Donovan, Meg L., Monkman, James, Sadeghirad, Habib, Naei, Vahid Yaghoubi, Chen, Jinjin, Rossenbloom, Alyssa, Bonnett, Shilah, Conner, Mark, Filanoski, Brian, Kang, Christine, Beechem, Joseph M., Fraser, John F., Barnett, Catherine, Ladwa, Rahul, Hughes, Brett G. and Kulasinghe, Arutha (2025). Characterising head and neck tumour microenvironment using high plex spatial omics technologies and analyses. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-175 |
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2025 Conference Publication Spatial profiling of tumor microenvironment uncovers potential novel therapeutic approach in pediatric neuroblastomaTu, Cui, Tan, Chin Wee, Monkman, James, Almeida, Ana Clara, Antonio-Carreon, Gabrielle, Omer, Natacha, Hull, Giaan, Chung, Kimberly, Mehdi, Ahmed, Salerno, Antonietta, Vittorio, Orazio, Mayer, Aaron, Machado de Souza, Cleber, de Almeida Brehm Pinhati, Fernanda, Elifio-Esposito, Selene, Nicholls, Wayne, de Noronha, Lucia, Kulasinghe, Arutha and Souza-Fonseca-Guimaraes, Fernando (2025). Spatial profiling of tumor microenvironment uncovers potential novel therapeutic approach in pediatric neuroblastoma. AACR Annual Meeting 2025, Chicago, IL United States, 25-30 April 2025. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1538-7445.am2025-2705 |
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2024 Conference Publication Spatial dynamics and cellular architecture mapping in head and neck cancer: insights into immunotherapy responseKulasinghe, Arutha (2024). Spatial dynamics and cellular architecture mapping in head and neck cancer: insights into immunotherapy response. SITC 39th Annual Meeting (SITC 2024), Houston, TX United States, 6-10 November 2024. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2024-sitc2024.0110 |
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2024 Conference Publication Multi-omic spatial data integration resolves immunometabolic heterogeneity associated with Nivolumab response in non-small cell lung cancer (NSCLC) patientsYan, Raymond, Quinn, Shannon, Falkenstein, Brian, Monkman, James, O’Bryne, Kenneth, Chakra Chennubhotla, S, Pullara, Filippo and Kulasinghe, Arutha (2024). Multi-omic spatial data integration resolves immunometabolic heterogeneity associated with Nivolumab response in non-small cell lung cancer (NSCLC) patients. SITC 39th Annual Meeting (SITC 2024), Houston, TX United States, 6-10 November 2024. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2024-sitc2024.0212 |
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2024 Conference Publication An integrated approach to high dimensional spatial proteomics and interaction mapping in head and neck cancer tissues prior to immune checkpoint inhibitor therapyNaei, Vahid Yaghoubi, Monkman, James, Hughes, Brett and Kulasinghe, Arutha (2024). An integrated approach to high dimensional spatial proteomics and interaction mapping in head and neck cancer tissues prior to immune checkpoint inhibitor therapy. SITC 39th Annual Meeting (SITC 2024), Houston, TX United States, 6-10 November 2024. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2024-sitc2024.0558 |
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2024 Conference Publication Development of a novel immuno-metabolic spatial signature to predict response and resistance to immunotherapy in NSCLC patientsMarkovits, Ettai, Monkman, James, Aung, Thazin, Reeves, Jason, O’Byrne, Ken, Czertock, Rotem, Puig, Oscar, Rimm, David and Kulasinghe, Arutha (2024). Development of a novel immuno-metabolic spatial signature to predict response and resistance to immunotherapy in NSCLC patients. SITC 39th Annual Meeting (SITC 2024), Houston, TX United States, 6-10 November 2024. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2024-sitc2024.0109 |
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2024 Conference Publication Characterization of Circulating Tumor-Associated and Immune Cells in Advanced-Stage NSCLCYaghoubi Naei, V., Mullally, W., Warkiani, M., O'Byrne, K. and Kulasinghe, A. (2024). Characterization of Circulating Tumor-Associated and Immune Cells in Advanced-Stage NSCLC. 2024 World Conference on Lung Cancer, San Diego, CA United States, 7-10 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jtho.2024.09.473 |
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2024 Conference Publication Deciphering Single-Cell Resolved Tumour Microenvironment Profiles Using Spatial Metabolic MappingKulasinghe, A., Monkman, J., Markovits, E. and O'Byrne, K. (2024). Deciphering Single-Cell Resolved Tumour Microenvironment Profiles Using Spatial Metabolic Mapping. 2024 World Conference on Lung Cancer, San Diego, CA United States, 7-10 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.jtho.2024.09.032 |
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2024 Conference Publication Unraveling functionally distinct metabolic programs to predict immunotherapy response in non-small cell lung cancer (NSCLC)Kulasinghe, A., Yan, R., Quinn, S., Falkenstein, B., Monkman, J., O'Byrne, K.J., Chennubhotla, S.C. and Pullara, F. (2024). Unraveling functionally distinct metabolic programs to predict immunotherapy response in non-small cell lung cancer (NSCLC). ESMO Congress 2024, Barcelona, Spain, 13-17 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.annonc.2024.08.142 |
