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2013

Journal Article

Lynch syndrome-associated breast cancers do not overexpress chromosome 11-encoded mucins

Walsh, Michael D., Cummings, Margaret C., Pearson, Sally-Ann, Clendenning, Mark, Walters, Rhiannon J., Nagler, Belinda, Hopper, John L., Jenkins, Mark A., Suthers, Graeme K., Goldblatt, Jack, Tucker, Kathy, Gattas, Michael R., Arnold, Julie L., Parry, Susan, Macrae, Finlay A., McGuckin, Michael A., Young, Joanne P. and Buchanan, Daniel D. (2013). Lynch syndrome-associated breast cancers do not overexpress chromosome 11-encoded mucins. Modern Pathology, 26 (7), 944-954. doi: 10.1038/modpathol.2012.232

Lynch syndrome-associated breast cancers do not overexpress chromosome 11-encoded mucins

2013

Journal Article

Gastrointestinal cell lines form polarized epithelia with an adherent mucus layer when cultured in semi-wet interfaces with mechanical stimulation

Navabi, Nazanin, McGuckin, Michael A. and Linden, Sara K. (2013). Gastrointestinal cell lines form polarized epithelia with an adherent mucus layer when cultured in semi-wet interfaces with mechanical stimulation. PLoS One, 8 (7) e68761, e68761.1-e68761.15. doi: 10.1371/journal.pone.0068761

Gastrointestinal cell lines form polarized epithelia with an adherent mucus layer when cultured in semi-wet interfaces with mechanical stimulation

2013

Journal Article

Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins

Das, Indrajit, Png, Chin Wen, Oancea, Iulia, Hasnain, Sumaira Z., Lourie, Rohan, Proctor, Martina, Eri, Rajaraman D., Sheng, Yong, Crane, Denis I., Florin, Timothy H. and McGuckin, Michael A. (2013). Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins. Journal of Experimental Medicine, 210 (6), 1201-1216. doi: 10.1084/jem.20121268

Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins

2013

Journal Article

MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli

Sheng, Y. H., Triyana, S., Wang, R., Das, I., Gerloff, K., Florin, T. H., Sutton, P. and McGuckin, M. A. (2013). MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli. Mucosal Immunology, 6 (3), 557-568. doi: 10.1038/mi.2012.98

MUC1 and MUC13 differentially regulate epithelial inflammation in response to inflammatory and infectious stimuli

2013

Journal Article

A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity

Oancea, Iulia, Png, Chin Wen, Das, Indrajit, Lourie, Rohan, Winkler, Ingrid G., Eri, Rajaraman, Subramaniam, Nathan, Jinnah, H. A., McWhinney, Brett C., Levesque, Jean-Pierre, McGuckin, Michael A., Duley, John A. and Florin, Timothy H. J. (2013). A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity. Gut, 62 (4), 594-605. doi: 10.1136/gutjnl-2012-302274

A novel mouse model of veno-occlusive disease provides strategies to prevent thioguanine-induced hepatic toxicity

2013

Journal Article

A novel NOD1- and CagA-independent pathway of interleukin-8 induction mediated by the Helicobacter pylori type IV secretion system

Gorrell, Rebecca J., Guan, Jyeswei, Xin, Yue, Tafreshi, Mona Anoushiravani, Hutton, Melanie L., McGuckin, Michael A., Ferrero, Richard L. and Kwok, Terry (2013). A novel NOD1- and CagA-independent pathway of interleukin-8 induction mediated by the Helicobacter pylori type IV secretion system. Cellular Microbiology, 15 (4), 554-570. doi: 10.1111/cmi.12055

A novel NOD1- and CagA-independent pathway of interleukin-8 induction mediated by the Helicobacter pylori type IV secretion system

2013

Journal Article

Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice

Sina, Christian, Lipinski, Simone, Gavrilova, Olga, Aden, Konrad, Rehman, Ateequr, Till, Andreas, Rittger, Andrea, Podschun, Rainer, Meyer-Hoffert, Ulf, Haesler, Robert, Midtling, Emilie, Puetsep, Katrin, McGuckin, Michael A., Schreiber, Stefan, Saftig, Paul and Rosenstiel, Philip (2013). Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice. Gut, 62 (4), 520-530. doi: 10.1136/gutjnl-2011-300076

Extracellular cathepsin K exerts antimicrobial activity and is protective against chronic intestinal inflammation in mice

2013

Journal Article

Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial

Serisier, David J., Martin, Megan L., McGuckin, Michael A., Lourie, Rohan, Chen, Alice C., Brain, Barbara, Biga, Sally, Schlebusch, Sanmarié, Dash, Peter and Bowler, Simon D. (2013). Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial. JAMA: The Journal of the American Medical Association, 309 (12), 1260-1267. doi: 10.1001/jama.2013.2290

Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial

2013

Journal Article

Carbohydrate binding and gene expression by in vitro and in vivo propagated Campylobacter jejuni after Immunomagnetic Separation

King, Rebecca M., Day, Christopher J., Hartley-Tassell, Lauren E., Connerton, Ian F., Tiralongo, Joe, McGuckin, Michael A. and Korolik, Victoria (2013). Carbohydrate binding and gene expression by in vitro and in vivo propagated Campylobacter jejuni after Immunomagnetic Separation. Journal of Basic Microbiology, 53 (3), 240-250. doi: 10.1002/jobm.201100466

Carbohydrate binding and gene expression by in vitro and in vivo propagated Campylobacter jejuni after Immunomagnetic Separation

2013

Journal Article

Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment

Dong, Ying, Stephens, Carson, Walpole, Carina, Swedberg, Joakim E., Boyle, Glen M., Parsons, Peter G., McGuckin, Michael A., Harris, Jonathan M. and Clements, Judith A. (2013). Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment. PLoS One, 8 (2) e57056, e57056.1-e57056.12. doi: 10.1371/journal.pone.0057056

Paclitaxel resistance and multicellular spheroid formation are induced by kallikrein-related peptidase 4 in serous ovarian cancer cells in an ascites mimicking microenvironment

2013

Journal Article

There is a 'uc' in mucus, but is there mucus in UC?

McGuckin, Michael A. and Hasnain, Sumaira Z. (2013). There is a 'uc' in mucus, but is there mucus in UC?. Gut, 63 (2), 216-217. doi: 10.1136/gutjnl-2013-304602

There is a 'uc' in mucus, but is there mucus in UC?

2013

Journal Article

IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells

Hasnain, Sumaira Z., Tauro, Sharyn, Das, Indrajit, Tong, Hui, Chen, Alice C. -H., Jeffery, Penny L., McDonald, Victoria, Florin, Timothy H. and McGuckin, Michael A. (2013). IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells. Gastroenterology, 144 (2), 357-368. doi: 10.1053/j.gastro.2012.10.043

IL-10 promotes production of intestinal mucus by suppressing protein misfolding and endoplasmic reticulum stress in goblet cells

2013

Journal Article

Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype

Walsh, Michael D., Clendenning, Mark, Williamson, Elizabeth, Pearson, Sally-Ann, Walters, Rhiannon J., Nagler, Belinda, Packenas, David, Win, Aung K., Hopper, John L., Jenkins, Mark A., Haydon, Andrew M., Rosty, Christophe, English, Dallas R., Giles, Graham G., McGuckin, Michael A., Young, Joanne P. and Buchanan, Daniel D. (2013). Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype. Modern Pathology, 26 (12), 1642-1656. doi: 10.1038/modpathol.2013.101

Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype

2012

Journal Article

Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier

Hasnain, Sumaira Z., McGuckin, Michael A., Grencis, Richard K. and Thornton, David J. (2012). Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier. PLoS Neglected Tropical Diseases, 6 (10) e1856, e1856.1-e1856.13. doi: 10.1371/journal.pntd.0001856

Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier

2012

Journal Article

β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice

Ruutu, Merja, Thomas, Gethin, Steck, Roland, Degli-Esposti, Mariapia A., Zinkernagel, Martin S., Alexander, Kylie, Velasco, Jared, Strutton, Geoffrey, Tran, Ai, Benham, Helen, Rehaume, Linda, Wilson, Robert J., Kikly, Kristine, Davies, Julian, Pettit, Allison R., Brown, Matthew A., McGuckin, Michael A. and Thomas, Ranjeny (2012). β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice. Arthritis and Rheumatism, 64 (7), 2211-2222. doi: 10.1002/art.34423

β-glucan triggers spondylarthritis and Crohn's disease–like ileitis in SKG mice

2012

Journal Article

O-Linked glycome and proteome of high-molecular-mass proteins in human ovarian cancer ascites: Identification of sulfation, disialic acid and O-linked fucose

Karlsson, Niclas G. and McGuckin, Michael A. (2012). O-Linked glycome and proteome of high-molecular-mass proteins in human ovarian cancer ascites: Identification of sulfation, disialic acid and O-linked fucose. Glycobiology, 22 (7), 918-929. doi: 10.1093/glycob/cws060

O-Linked glycome and proteome of high-molecular-mass proteins in human ovarian cancer ascites: Identification of sulfation, disialic acid and O-linked fucose

2012

Journal Article

The interplay between endoplasmic reticulum stress and inflammation

Hasnain, Sumaira Z ., Lourie, Rohan, Das, Indrajit, Chen, Alice C-H. and McGuckin, Michael A. (2012). The interplay between endoplasmic reticulum stress and inflammation. Immunology and Cell Biology, 90 (3), 260-270. doi: 10.1038/icb.2011.112

The interplay between endoplasmic reticulum stress and inflammation

2012

Journal Article

Preface: introduction to mucin biology and technical challenges of mucin research

McGuckin, Michael A. and Thornton, David J. (2012). Preface: introduction to mucin biology and technical challenges of mucin research. Mucins: Methods and Protocols, 842.

Preface: introduction to mucin biology and technical challenges of mucin research

2012

Journal Article

Mucins in inflammatory bowel diseases and colorectal cancer

Sheng, Yong H., Hasnain, Sumaira Z., Florin, Timothy H. J. and McGuckin, Michael A. (2012). Mucins in inflammatory bowel diseases and colorectal cancer. Journal of Gastroenterology and Hepatology, 27 (1), 28-38. doi: 10.1111/j.1440-1746.2011.06909.x

Mucins in inflammatory bowel diseases and colorectal cancer

2011

Journal Article

The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis

Sheng, Yong H., Lourie, Rohan, Linden, Sara K., Jeffery, Penny L., Roche, Deborah, Tran, Thu V., Png, Chin W., Waterhouse, Nigel, Sutton, Philip, Florin, Timothy H. J. and McGuckin, Michael A. (2011). The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis. Gut, 60 (12), 1661-1670. doi: 10.1136/gut.2011.239194

The MUC13 cell-surface mucin protects against intestinal inflammation by inhibiting epithelial cell apoptosis