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2024 Journal Article The role and treatment potential of the complement pathway in chronic painVygonskaya, Marina, Wu, Youzhi, Price, Theodore J., Chen, Zhuo, Smith, Maree T., Klyne, David M. and Han, Felicity Y. (2024). The role and treatment potential of the complement pathway in chronic pain. The Journal of Pain 104689, 104689. doi: 10.1016/j.jpain.2024.104689 |
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2024 Journal Article J-2156, a small molecule somatostatin type 4 receptor agonist, alleviated hindpaw hypersensitivity in the streptozotocin-induced rat model of painful diabetic neuropathy but with a 2-fold decrease in potency at an advanced stage in the model, mimicking morphineKuo, A., Imam, M. Z., Li, R., Lin, L., Raboczyj, A., Bohmer, A. E., Nicholson, J. R., Corradini, L. and Smith, M. T. (2024). J-2156, a small molecule somatostatin type 4 receptor agonist, alleviated hindpaw hypersensitivity in the streptozotocin-induced rat model of painful diabetic neuropathy but with a 2-fold decrease in potency at an advanced stage in the model, mimicking morphine. Frontiers in Pharmacology, 15 1346801. doi: 10.3389/fphar.2024.1346801 |
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2024 Book Chapter Side Effects of Central Analgesic DrugsImam, M. Z., Kuo, A. and Smith, M. T. (2024). Side Effects of Central Analgesic Drugs. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. (pp. 735-758) Cham: Springer International Publishing. doi: 10.1007/978-3-031-35529-5_70 |
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2024 Book Chapter Pain pharmacology and the pharmacological management of painSmith, Maree T. and Muralidharan, Arjun (2024). Pain pharmacology and the pharmacological management of pain. Pain: a textbook for health professionals. (pp. 225-248) edited by Hubert van Griensven and Jenny Strong. London, United Kingdom: Elsevier. |
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2023 Journal Article seco-1-Azacubane-2-carboxylic acid: derivative scope and comparative biological evaluationKong, Dehui, Fahrenhorst-Jones, Tyler, Kuo, Andy, Simmons, Jacinta L., Tan, Lendl, Burns, Jed M., Pierens, Gregory K., Li, Rui, West, Nicholas P., Boyle, Glen M., Smith, Maree T., Savage, G. Paul and Williams, Craig M. (2023). seco-1-Azacubane-2-carboxylic acid: derivative scope and comparative biological evaluation. The Journal of Organic Chemistry, 89 (1), 798-803. doi: 10.1021/acs.joc.3c02333 |
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2023 Journal Article Angiotensin II type 2 receptor signalling as a pain target: bench, bedside and back-translationShepherd, Andrew J., Rice, Andrew SC. and Smith, Maree T. (2023). Angiotensin II type 2 receptor signalling as a pain target: bench, bedside and back-translation. Current Opinion in Pharmacology, 73 102415, 1-8. doi: 10.1016/j.coph.2023.102415 |
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2023 Journal Article In Vitro Assessment of the Metabolic Stability of Two Novel Endomorphin-2 Analogs, CYX-5 and CYX-6, in Rat Liver MicrosomesImam, Mohammad Zafar, Ghassabian, Sussan, Kuo, Andy, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2023). In Vitro Assessment of the Metabolic Stability of Two Novel Endomorphin-2 Analogs, CYX-5 and CYX-6, in Rat Liver Microsomes. European Journal of Drug Metabolism and Pharmacokinetics, 48 (4), 463-466. doi: 10.1007/s13318-023-00828-6 |
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2023 Journal Article The NLRP3 inflammasome: role in the pathobiology of chronic painChen, Chen and Smith, Maree T. (2023). The NLRP3 inflammasome: role in the pathobiology of chronic pain. Inflammopharmacology, 31 (4), 1589-1603. doi: 10.1007/s10787-023-01235-8 |
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2023 Journal Article Multitargeted opioid ligand discovery as a strategy to retain analgesia and reduce opioid-related adverse effectsSmith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2023). Multitargeted opioid ligand discovery as a strategy to retain analgesia and reduce opioid-related adverse effects. Journal of Medicinal Chemistry, 66 (6), 3746-3784. doi: 10.1021/acs.jmedchem.2c01695 |
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2023 Journal Article CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in ratsImam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan, Cai, Yunxin, Qin, Yajuan, Li, Tingyou and Smith, Maree T. (2023). CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats. Pharmacological Reports, 75 (3), 634-646. doi: 10.1007/s43440-023-00446-8 |
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2022 Journal Article Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy (Adv. Therap. 12/2022)Xu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y. (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy (Adv. Therap. 12/2022). Advanced Therapeutics, 5 (12) 2270030, 1-1. doi: 10.1002/adtp.202270030 |
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2022 Journal Article Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trialsSmith, A. E., Muralidharan, A. and Smith, M. T. (2022). Prostate cancer induced bone pain: pathobiology, current treatments and pain responses from recent clinical trials. Discover Oncology, 13 (1) 108, 1-23. doi: 10.1007/s12672-022-00569-z |
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2022 Journal Article Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacyXu, Weizhi, Kumar, Vinod, Cui, Cedric S., Li, Xaria X., Whittaker, Andrew K., Xu, Zhi Ping, Smith, Maree T., Woodruff, Trent M. and Han, Felicity Y (2022). Success in navigating hurdles to oral delivery of a bioactive peptide complement antagonist through use of nanoparticles to increase bioavailability and in vivo efficacy. Advanced Therapeutics, 5 (12) 2200109, 2200109. doi: 10.1002/adtp.202200109 |
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2022 Journal Article Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic painKong, Dehui, Saqer, Alaa A., Carpinelli de Jesus, Matheus, Khan, Nemat, Jones, Alun, Blanchfield, Joanne T., Smith, Maree T. and Williams, Craig M. (2022). Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain. Bioorganic and Medicinal Chemistry, 69 116889, 1-10. doi: 10.1016/j.bmc.2022.116889 |
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2022 Journal Article Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trialSmith, Maree T. (2022). Nonopioid analgesics discovery and the Valley of Death: EMA401 from concept to clinical trial. Pain, Publish Ahead of Print (S1), S15-S28. doi: 10.1097/j.pain.0000000000002675 |
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2022 Journal Article Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the ratHan, Felicity Y., Brockman, David A., Nicholson, Janet R., Corradini, Laura and Smith, Maree Therese (2022). Gait analysis as a robust pain behavioural endpoint in the chronic phase of the monoiodoacetate-induced knee joint pain in the rat. Behavioural Pharmacology, 33 (1), 23-31. doi: 10.1097/fbp.0000000000000663 |
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2022 Journal Article Journey to the market: The evolution of biodegradable drug delivery systemsZhu, Minze, Whittaker, Andrew K., Han, Felicity Y. and Smith, Maree T. (2022). Journey to the market: The evolution of biodegradable drug delivery systems. Applied Sciences, 12 (2) 935, 935. doi: 10.3390/app12020935 |
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2022 Journal Article Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sourcesSmith, Maree T., Kong, Dehui, Kuo, Andy, Imam, Mohammad Z. and Williams, Craig M. (2022). Analgesic opioid ligand discovery based on nonmorphinan scaffolds derived from natural sources. Journal of Medicinal Chemistry, 65 (3) acs.jmedchem.0c01915, 1612-1661. doi: 10.1021/acs.jmedchem.0c01915 |
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2022 Book Chapter Side effects of central analgesic drugsImam, M. Z., Kuo, A. and Smith, M. T. (2022). Side effects of central analgesic drugs. Drug discovery and evaluation: safety and pharmacokinetic assays. (pp. 1-24) Cham, Switzerland: Springer International Publishing. doi: 10.1007/978-3-030-73317-9_70-1 |
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2021 Journal Article Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in miceXu, Weizhi, Maqbool, Faheem, Kumar, Vinod, Falconer, James R., Cui, Cedric S., Woodruff, Trent M., Borges, Karin, Whittaker, Andrew K., Smith, Maree T. and Han, Felicity Y. (2021). Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice. Drug Delivery and Translational Research, 12 (10), 2518-2526. doi: 10.1007/s13346-021-01093-3 |
