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2014 Journal Article Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand biasAndreassen, Kim Vietz, Hjuler, Sara Toftegaard, Furness, Sebastian G., Sexton, Patrick M., Christopoulos, Arthur, Nosjean, Olivier, Karsdal, Morten Asser and Henriksen, Kim (2014). Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias. PLoS One, 9 (3) e92042, e92042. doi: 10.1371/journal.pone.0092042 |
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2014 Journal Article Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activationPabreja, K., Mohd, M. A., Koole, C., Wootten, D. and Furness, S. G.B. (2014). Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation. British Journal of Pharmacology, 171 (5), 1114-1128. doi: 10.1111/bph.12313 |
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2013 Journal Article A simple method to generate stable cell lines for the analysis of transient protein-protein interactionsSavage, Emilia Elizabeth, Wootten, Denise, Christopoulos, Arthur, Sexton, Patrick Michael and Furness, Sebastian George Barton (2013). A simple method to generate stable cell lines for the analysis of transient protein-protein interactions. BioTechniques, 54 (4), 217-221. doi: 10.2144/000114013 |
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2012 Journal Article Small molecule allosteric modulation of the glucagon-like peptide-1 receptor enhances the insulinotropic effect of oxyntomodulinWillard, Francis S., Wootten, Denise, Showalter, Aaron D., Savage, Emilia E., Ficorilli, James, Farb, Thomas B., Bokvist, Krister, Alsina-Fernandez, Jorge, Furness, Sebastian G. B., Christopoulos, Arthur, Sexton, Patrick M. and Sloop, Kyle W. (2012). Small molecule allosteric modulation of the glucagon-like peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin. Molecular Pharmacology, 82 (6), 1066-1073. doi: 10.1124/mol.112.080432 |
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2012 Journal Article Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signalingHao, Nan, Lee, Kian Leong, Furness, Sebastian G. B., Bosdotter, Cecilia, Poellinger, Lorenz and Whitelaw, Murray L. (2012). Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling. Molecular Pharmacology, 82 (6), 1082-1093. doi: 10.1124/mol.112.078873 |
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2012 Journal Article Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allosteryHarikumar, Kaleeckal G., Wootten, Denise, Pinon, Delia I., Koole, Cassandra, Ball, Alicja M., Furness, Sebastian G. B., Graham, Bim, Dong, Maoqing, Christopoulos, Arthur, Miller, Laurence J. and Sexton, Patrick M. (2012). Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery. Proceedings of the National Academy of Sciences of the United States of America, 109 (45), 18607-18612. doi: 10.1073/pnas.1205227109 |
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2012 Journal Article Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptorSato, Masaaki, Hutchinson, Dana S., Halls, Michelle L., Furness, Sebastian G. B., Bengtsson, Tore, Evans, Bronwyn A. and Summers, Roger J. (2012). Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor. Journal of Biological Chemistry, 287 (24), 20674-20688. doi: 10.1074/jbc.M111.280651 |
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2012 Journal Article Consequences of splice variation on Secretin family G protein-coupled receptor functionFurness, Sebastian G.B., Wootten, Denise, Christopoulos, Arthur and Sexton, Patrick M. (2012). Consequences of splice variation on Secretin family G protein-coupled receptor function. British Journal of Pharmacology, 166 (1), 98-109. doi: 10.1111/j.1476-5381.2011.01571.x |
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2012 Journal Article The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172Wookey, Peter J., Mclean, Catriona A., Hwang, Peter, Furness, Sebastian G.B., Nguyen, Sandy, Kourakis, Angela, Hare, David L. and Rosenfeld, Jeffrey V. (2012). The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172. Histopathology, 60 (6), 895-910. doi: 10.1111/j.1365-2559.2011.04146.x |
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2010 Journal Article Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activatorWhelan, Fiona, Hao, Nan, Furness, Sebastian G. B., Whitelaw, Murray L. and Chapman-Smith, Anne (2010). Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator. Molecular Pharmacology, 77 (6), 1037-1046. doi: 10.1124/mol.109.062927 |
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2009 Journal Article The pleiotropy of dioxin toxicity - Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological rolesFurness, Sebastian G.B. and Whelan, Fiona (2009). The pleiotropy of dioxin toxicity - Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles. Pharmacology and Therapeutics, 124 (3), 336-353. doi: 10.1016/j.pharmthera.2009.09.004 |
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2009 Journal Article Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modificationsDave, Keyur A., Whelan, Fiona, Bindloss, Colleen, Furness, Sebastian G. B., Chapman-Smith, Anne, Whitelaw, Murray L. and Gorman, Jeffrey J. (2009). Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications. Molecular & Cellular Proteomics, 8 (4), 706-719. doi: 10.1074/mcp.M800459-MCP200 |
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2008 Journal Article Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptorsMorfis, Maria, Tilakaratne, Nanda, Furness, Sebastian G. B., Christopoulos, George, Werry, Tim D., Christopoulos, Arthur and Sexton, Patrick M. (2008). Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors. Endocrinology, 149 (11), 5423-5431. doi: 10.1210/en.2007-1735 |
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2007 Journal Article The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factorsFurness, Sebastian G.B., Lees, Michael J. and Whitelaw, Murray L. (2007). The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors. FEBS Letters, 581 (19), 3616-3625. doi: 10.1016/j.febslet.2007.04.011 |
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2007 Journal Article Identification of N,N epsilon-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MSDave, KA, Hamilton, BR, Wallis, TP, Furness, SGB, Whitelaw, ML and Gorman, JJ (2007). Identification of N,N epsilon-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS. International Journal of Mass Spectrometry, 268 (2-3), 168-180. doi: 10.1016/j.ijms.2007.06.001 |
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2006 Journal Article Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteinsTan, Poh C., Furness, Sebastian G.B., Merkens, Helen, Lin, Shujun, McCoy, Marcia L., Roskelley, Calvin D., Kast, Jürgen and McNagny, Kelly M. (2006). Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins. Stem Cells, 24 (5), 1150-1161. doi: 10.1634/stemcells.2005-0426 |
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2006 Journal Article Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesisFurness, Sebastian George Barton and McNagny, Kelly (2006). Beyond mere markers: functions for CD34 family of sialomucins in hematopoiesis. Immunologic Research, 34 (1), 13-32. doi: 10.1385/ir:34:1:13 |
