|
2026 Journal Article GPCR crosstalk beyond obligate dimerisation: Effector coincidence detection, compartmentation, and pharmacological implicationsDehkhoda, Farhad, Xing, Jingjing, Misganaw, Desye, Mutunduwe, Keith, Han, Myat N. and Furness, Sebastian G.B. (2026). GPCR crosstalk beyond obligate dimerisation: Effector coincidence detection, compartmentation, and pharmacological implications. Pharmacology and Therapeutics, 285 109056, 1-17. doi: 10.1016/j.pharmthera.2026.109056 |
|
2026 Other Outputs Coarse-grained molecular dynamics simulations of GP130 juxtamembrane and transmembrane helix variantsDehkhoda, Farhad, Furness, Sebastian, Brooks, Andrew J. and Whelan, Fiona (2026). Coarse-grained molecular dynamics simulations of GP130 juxtamembrane and transmembrane helix variants. The University of Queensland. (Dataset) doi: 10.48610/cc81689 |
|
2026 Journal Article Transmembrane orientation and extracellular juxtamembrane residues of GP130 are critical for signal transductionDehkhoda, Farhad, Chhabra, Yash, Whelan, Fiona, Nowell, Cameron J., Morris, Matthew J., Furness, Sebastian G.B. and Brooks, Andrew J. (2026). Transmembrane orientation and extracellular juxtamembrane residues of GP130 are critical for signal transduction. Journal of Immunology, 215 (6) vkag118, 1-16. doi: 10.1093/jimmun/vkag118 |
|
2026 Journal Article Microcephaly-associated protein WDR62 supports purine metabolism by interacting with co-chaperone BAG2Morris, Matthew J., Yeap, Yvonne Y., Edwards, Jonathon R., Chen, Chi, Paolino, Annalisa, Furness, Sebastian G. B., Millard, S. Sean, Pagan, Julia K., Fenlon, Laura R. and Ng, Dominic C. H. (2026). Microcephaly-associated protein WDR62 supports purine metabolism by interacting with co-chaperone BAG2. The EMBO Journal, 45 (7), 2157-2181. doi: 10.1038/s44318-026-00724-0 |
|
2025 Journal Article Gut-brain communication: nerve circuits and chemical messengers of colorectal motility control pathwaysHan, Myat Noe, Furness, John B, Ringuet, Mitchell T, Montenegro, Ella, Wu, Hongkang, Hossain, Mohammad Akhter, Diwakarla, Shanti, Dehkhoda, Farhad and Furness, Sebastian Gb (2025). Gut-brain communication: nerve circuits and chemical messengers of colorectal motility control pathways. American journal of physiology: regulatory, integrative and comparative physiology, 329 (6) ajpregu.00212.2025, R931-R945. doi: 10.1152/ajpregu.00212.2025 |
|
2025 Journal Article Constitutive ghrelin receptor activity enables reversal of dopamine D2 receptor signalingDehkhoda, Farhad, Ringuet, Mitchell T., Whitfield, Emily A., Mutunduwe, Keith, Whelan, Fiona, Nowell, Cameron J., Misganaw, Desye, Xu, Zheng, Piper, Noah B. C., Clark, Richard J., Hossain, Mohammed Akhter, Fothergill, Linda J., McDougall, Stuart J., Furness, John B. and Furness, Sebastian G. B. (2025). Constitutive ghrelin receptor activity enables reversal of dopamine D2 receptor signaling. Molecular Cell, 85 (11), 2246-2260.e10. doi: 10.1016/j.molcel.2025.05.005 |
|
2025 Conference Publication The molecular mechanism for reversed dopamine D2 receptor cellular output and defecation control, enabled by constitutive ghrelin receptor activityDhekhoda, Farhad, Furness, John and Furness, Sebastian (2025). The molecular mechanism for reversed dopamine D2 receptor cellular output and defecation control, enabled by constitutive ghrelin receptor activity. American Physiology Summit, Baltimore Md, Apr 24-27, 2025. Rockville: AMER PHYSIOLOGICAL SOC. doi: 10.1152/physiol.2025.40.S1.2010 |
|
2025 Conference Publication The Molecular Mechanism for Reversed Dopamine D2 Receptor Cellular Output and Defecation Control, Enabled by Constitutive Ghrelin Receptor ActivityFurness, Sebastian, Dehkhoda, Farhad, Ringuet, Mitchell, Nowell, Cameron, Misganaw, Desye, Xu, Zheng, McDougall, Stuart and Furness, John (2025). The Molecular Mechanism for Reversed Dopamine D2 Receptor Cellular Output and Defecation Control, Enabled by Constitutive Ghrelin Receptor Activity. 2025 ASBMB Annual Meeting, Brisbane, QLD Australia, 29 September - 1 October 2025. Bethesda, MD United States: American Society for Biochemistry and Molecular Biology. doi: 10.1016/j.jbc.2025.110108 |
|
2025 Conference Publication CCK-58 and CCK-8 are non-equivalent in signal transduction at human cholecystokinin 1 receptor (CCK1R) in transfected cell linesXing, Jingjing, Dehkhoda, Farhad and Furness, Sebastian (2025). CCK-58 and CCK-8 are non-equivalent in signal transduction at human cholecystokinin 1 receptor (CCK1R) in transfected cell lines. ASPET 2025, Portland, OR, United States, 3-6 April 2025. Rockville, MD, United States: American Society for Pharmacology and Experimental Therapeutics. doi: 10.1016/j.jpet.2025.103430 |
|
2025 Other Outputs Molecular Cell Dataset "Determination of the mechanism for reversed dopamine D2 receptor cellular output enabled by constitutive ghrelin receptor activity."Furness, Sebastian, Ambaw, Desye Misganaw, Mutunduwe, Keith, Dehkhoda, Farhad and Piper, Noah (2025). Molecular Cell Dataset "Determination of the mechanism for reversed dopamine D2 receptor cellular output enabled by constitutive ghrelin receptor activity.". The University of Queensland. (Dataset) doi: 10.48610/005d1e7 |
|
2024 Journal Article Fluorescence modulation of pyridinium betaines: a mechanofluorochromic investigationMcDonald, Peter W., Xu, Jingjing, Lonsdale, Dale R., Jones, Isabelle, Poggi, Benjamin, Cox, Rosalind P., Aloise, Stéphane, Scully, Andrew D., Allain, Clémence, Bodelot, Laurence, Moggach, Stephen A., Bell, Toby D. M., Métivier, Rémi, Furness, Sebastian G. B., Goerigk, Lars and Ritchie, Chris (2024). Fluorescence modulation of pyridinium betaines: a mechanofluorochromic investigation. Journal of Materials Chemistry C, 12 (48), 19371-19385. doi: 10.1039/d4tc04290e |
|
2024 Journal Article Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein couplingHarikumar, Kaleeckal G., Zhao, Peishen, Cary, Brian P., Xu, Xiaomeng, Desai, Aditya J., Dong, Maoqing, Mobbs, Jesse I., Toufaily, Chirine, Furness, Sebastian G. B., Christopoulos, Arthur, Belousoff, Matthew J., Wootten, Denise, Sexton, Patrick M. and Miller, Laurence J. (2024). Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling. PLoS Biology, 22 (7) e3002673. doi: 10.1371/journal.pbio.3002673 |
|
2024 Journal Article Role of G protein‐coupled receptor kinases (GRKs) in β<sub>2</sub>‐adrenoceptor‐mediated glucose uptakeHam, Seungmin, Mukaida, Saori, Sato, Masaaki, Keov, Peter, Bengtsson, Tore, Furness, Sebastian, Holliday, Nicholas D., Evans, Bronwyn A., Summers, Roger J. and Hutchinson, Dana S. (2024). Role of G protein‐coupled receptor kinases (GRKs) in β2‐adrenoceptor‐mediated glucose uptake. Pharmacology Research and Perspectives, 12 (1) e1176, e1176. doi: 10.1002/prp2.1176 |
|
2024 Journal Article Cardiac human bitter taste receptors contain naturally occurring variants that alter functionBloxham, Conor J., Hulme, Katina D., Fierro, Fabrizio, Fercher, Christian, Pegg, Cassandra L., O'Brien, Shannon L., Foster, Simon R., Short, Kirsty R., Furness, Sebastian G. B., Reichelt, Melissa E., Niv, Masha Y. and Thomas, Walter G. (2024). Cardiac human bitter taste receptors contain naturally occurring variants that alter function. Biochemical Pharmacology, 219 115932, 115932. doi: 10.1016/j.bcp.2023.115932 |
|
2023 Journal Article Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin receptors in the rodent lumbosacral defecation centreRinguet, Mitchell T., Koo, Ada, Furness, Sebastian G. B., McDougall, Stuart J. and Furness, John B. (2023). Sites and mechanisms of action of colokinetics at dopamine, ghrelin and serotonin receptors in the rodent lumbosacral defecation centre. The Journal of Physiology, 601 (23), 5195-5211. doi: 10.1113/jp285217 |
|
2023 Conference Publication Modulation of dopamine's effect at dopamine 2 receptors (D2R) mediated by association with the ghrelin receptor, GHSRFurness, John, Dehkhoda, Farhad, Whitfield, Emily, Fothergill, Linda, Misgenaw, Desye, Ringuet, Mitchell and Furness, Sebastian (2023). Modulation of dopamine's effect at dopamine 2 receptors (D2R) mediated by association with the ghrelin receptor, GHSR. American Physiology Summit 2023, Long Beach, CA, United States, 20-23 April 2023. Rockville, MD, United States: American Physiological Society. doi: 10.1152/physiol.2023.38.s1.5731818 |
|
2022 Journal Article G protein‐coupled receptor interactions and modification of signalling involving the ghrelin receptor, GHSR1aRinguet, Mitchell Ty, Furness, John Barton and Furness, Sebastian George Barton (2022). G protein‐coupled receptor interactions and modification of signalling involving the ghrelin receptor, GHSR1a. Journal of Neuroendocrinology, 34 (9) e13077, 1-14. doi: 10.1111/jne.13077 |
|
2022 Journal Article Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptorsPiper, Noah B.C., Whitfield, Emily A., Stewart, Gregory D., Xu, Xiaomeng and Furness, Sebastian G.B. (2022). Targeting appetite and satiety in diabetes and obesity, via G protein-coupled receptors. Biochemical Pharmacology, 202 115115, 1-21. doi: 10.1016/j.bcp.2022.115115 |
|
2021 Journal Article Discovery of a positive allosteric modulator of cholecystokinin action at CCK1R in normal and elevated cholesterolHarikumar, Kaleeckal G., Coudrat, Thomas, Desai, Aditya J., Dong, Maoqing, Dengler, Daniela G., Furness, Sebastian G. B., Christopoulos, Arthur, Wootten, Denise, Sergienko, Eduard A., Sexton, Patrick M. and Miller, Laurence J. (2021). Discovery of a positive allosteric modulator of cholecystokinin action at CCK1R in normal and elevated cholesterol. Frontiers in Endocrinology, 12 789957. doi: 10.3389/fendo.2021.789957 |
|
2021 Journal Article Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagyWookey, Peter, Gupta, Pragya, Bittencourt, Lucas, Cheung, Shane, Hare, David and Furness, Sebastian (2021). Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy. F1000Research, 10 1019, 1-6. doi: 10.12688/f1000research.72845.1 |
