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2021 Journal Article Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagyWookey, Peter, Gupta, Pragya, Bittencourt, Lucas, Cheung, Shane, Hare, David and Furness, Sebastian (2021). Methods to measure calcitonin receptor activity, up-regulated in cell stress, apoptosis and autophagy. F1000Research, 10 1019, 1-6. doi: 10.12688/f1000research.72845.1 |
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2021 Journal Article Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivityMobbs, Jesse I., Belousoff, Matthew J., Harikumar, Kaleeckal G., Piper, Sarah J., Xu, Xiaomeng, Furness, Sebastian G. B., Venugopal, Hari, Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Thal, David M., Miller, Laurence J. and Sexton, Patrick M. (2021). Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. PLOS Biology, 19 (6) e3001295, e3001295. doi: 10.1371/journal.pbio.3001295 |
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2021 Journal Article AM833 is a novel agonist of calcitonin family G protein–coupled receptors: pharmacological comparison with six selective and nonselective agonistsFletcher, Madeleine M., Keov, Peter, Truong, Tin T., Mennen, Grace, Hick, Caroline A., Zhao, Peishen, Furness, Sebastian G.B., Kruse, Thomas, Clausen, Trine R., Wootten, Denise and Sexton, Patrick M. (2021). AM833 is a novel agonist of calcitonin family G protein–coupled receptors: pharmacological comparison with six selective and nonselective agonists. Journal of Pharmacology and Experimental Therapeutics, 377 (3), 417-440. doi: 10.1124/jpet.121.000567 |
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2021 Journal Article Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centersFurness, John B., Pustovit, Ruslan V., Syder, Andrew J., Ringuet, Mitchell T., Yoo, Eun Ji, Fanjul, Andrea, Wykosky, Jill, Fothergill, Linda J., Whitfield, Emily A. and Furness, Sebastian G. B. (2021). Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers. Neurogastroenterology and Motility, 33 (5) e14051. doi: 10.1111/nmo.14051 |
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2020 Journal Article Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelinLiu, Mengjie, Whitfield, Emily A., Fothergill, Linda J., Furness, John B., Wade, John D., Furness, Sebastian G.B. and Hossain, Mohammed Akhter (2020). Design, synthesis and characterization of a fluorescently labeled functional analog of full-length human ghrelin. Biochemical and Biophysical Research Communications, 533 (3), 559-564. doi: 10.1016/j.bbrc.2020.09.028 |
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2020 Journal Article Differential GLP-1R binding and activation by peptide and non-peptide agonistsZhang, Xin, Belousoff, Matthew J., Zhao, Peishen, Kooistra, Albert J., Truong, Tin T., Ang, Sheng Yu, Underwood, Christina Rye, Egebjerg, Thomas, Šenel, Petr, Stewart, Gregory D., Liang, Yi-Lynn, Glukhova, Alisa, Venugopal, Hari, Christopoulos, Arthur, Furness, Sebastian G.B., Miller, Laurence J., Reedtz-Runge, Steffen, Langmead, Christopher J., Gloriam, David E., Danev, Radostin, Sexton, Patrick M. and Wootten, Denise (2020). Differential GLP-1R binding and activation by peptide and non-peptide agonists. Molecular Cell, 80 (3), 485-500.e7. doi: 10.1016/j.molcel.2020.09.020 |
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2020 Journal Article Structure and dynamics of the active Gs-coupled human secretin receptorDong, Maoqing, Deganutti, Giuseppe, Piper, Sarah J., Liang, Yi-Lynn, Khoshouei, Maryam, Belousoff, Matthew J., Harikumar, Kaleeckal G., Reynolds, Christopher A., Glukhova, Alisa, Furness, Sebastian G. B., Christopoulos, Arthur, Danev, Radostin, Wootten, Denise, Sexton, Patrick M. and Miller, Laurence J. (2020). Structure and dynamics of the active Gs-coupled human secretin receptor. Nature Communications, 11 (1) 4137, 4137. doi: 10.1038/s41467-020-17791-4 |
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2020 Conference Publication Evidence that Dopamine is the Physiological Agonist of Spinal Gherlin Receptors and Acts Through Heteromeric Dopamine D2/ Ghrelin ReceptorsFurness, Sebastian, Pustovit, Ruslan, Ringuet, Mitchell, Molero, Juan, Fothergill, Linda and Furness, John (2020). Evidence that Dopamine is the Physiological Agonist of Spinal Gherlin Receptors and Acts Through Heteromeric Dopamine D2/ Ghrelin Receptors. Annual Meeting on Experimental Biology, San Diego Ca, Apr 04-07, 2020. HOBOKEN: WILEY. doi: 10.1096/fasebj.2020.34.s1.04678 |
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2020 Journal Article Structure and dynamics of adrenomedullin receptors AM1 and AM2 reveal key mechanisms in the control of receptor phenotype by receptor activity-modifying proteinsLiang, Yi-Lynn, Belousoff, Matthew J., Fletcher, Madeleine M., Zhang, Xin, Khoshouei, Maryam, Deganutti, Giuseppe, Koole, Cassandra, Furness, Sebastian G. B., Miller, Laurence J., Hay, Debbie L., Christopoulos, Arthur, Reynolds, Christopher A., Danev, Radostin, Wootten, Denise and Sexton, Patrick M. (2020). Structure and dynamics of adrenomedullin receptors AM1 and AM2 reveal key mechanisms in the control of receptor phenotype by receptor activity-modifying proteins. ACS Pharmacology and Translational Science, 3 (2), 263-284. doi: 10.1021/acsptsci.9b00080 |
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2020 Journal Article Activation of the GLP-1 receptor by a non-peptidic agonistZhao, Peishen, Liang, Yi-Lynn, Belousoff, Matthew J., Deganutti, Giuseppe, Fletcher, Madeleine M., Willard, Francis S., Bell, Michael G., Christe, Michael E., Sloop, Kyle W., Inoue, Asuka, Truong, Tin T., Clydesdale, Lachlan, Furness, Sebastian G. B., Christopoulos, Arthur, Wang, Ming-Wei, Miller, Laurence J., Reynolds, Christopher A., Danev, Radostin, Sexton, Patrick M. and Wootten, Denise (2020). Activation of the GLP-1 receptor by a non-peptidic agonist. Nature, 577 (7790), 432-436. doi: 10.1038/s41586-019-1902-z |
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2020 Journal Article Building the case for the calcitonin receptor as a viable target for the treatment of glioblastomaGupta, Pragya, Furness, Sebastian G. B., Bittencourt, Lucas, Hare, David L. and Wookey, Peter J. (2020). Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma. Therapeutic Advances in Medical Oncology, 12 1758835920978110, 175883592097811. doi: 10.1177/1758835920978110 |
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2019 Journal Article The nature of efficacy at G protein-coupled receptorsZhao, Peishen and Furness, Sebastian G.B. (2019). The nature of efficacy at G protein-coupled receptors. Biochemical Pharmacology, 170 113647, 1-13. doi: 10.1016/j.bcp.2019.113647 |
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2019 Journal Article TrkB agonist LM22A-4 increases oligodendroglial populations during myelin repair in the corpus callosumNguyen, Huynh T. H., Wood, Rhiannon J., Prawdiuk, Alexa R., Furness, Sebastian G. B., Xiao, Junhua, Murray, Simon S. and Fletcher, Jessica L. (2019). TrkB agonist LM22A-4 increases oligodendroglial populations during myelin repair in the corpus callosum. Frontiers in Molecular Neuroscience, 12 205, 1-12. doi: 10.3389/fnmol.2019.00205 |
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2019 Journal Article Conformational transitions and the activation of heterotrimeric G proteins by G protein-coupled receptorsDraper-Joyce, Christopher and Furness, Sebastian George Barton (2019). Conformational transitions and the activation of heterotrimeric G proteins by G protein-coupled receptors. ACS Pharmacology and Translational Science, 2 (4), 285-290. doi: 10.1021/acsptsci.9b00054 |
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2019 Journal Article Deconvoluting the molecular control of binding and signaling at the amylin 3 receptor: RAMP3 alters signal propagation through extracellular loops of the calcitonin receptorPham, Vi, Zhu, Yue, Dal Maso, Emma, Reynolds, Christopher A., Deganutti, Giuseppe, Atanasio, Silvia, Hick, Caroline A., Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L., Furness, Sebastian G. B., Wang, Ming-Wei, Wootten, Denise and Sexton, Patrick M. (2019). Deconvoluting the molecular control of binding and signaling at the amylin 3 receptor: RAMP3 alters signal propagation through extracellular loops of the calcitonin receptor. ACS Pharmacology and Translational Science, 2 (3), 183-197. doi: 10.1021/acsptsci.9b00010 |
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2019 Journal Article Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomasOstrovskaya, Anna, Hick, Caroline, Hutchinson, Dana S., Stringer, Brett W., Wookey, Peter J., Wootten, Denise, Sexton, Patrick M. and Furness, Sebastian G.B. (2019). Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas. BMC Cancer, 19 (1) 157, 157. doi: 10.1186/s12885-019-5369-y |
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2019 Journal Article The molecular control of calcitonin receptor signalingdal Maso, Emma, Glukhova, Alisa, Zhu, Yue, Garcia-Nafria, Javier, Tate, Christopher G., Atanasio, Silvia, Reynolds, Christopher A., Ramírez-Aportela, Erney, Carazo, Jose-Maria, Hick, Caroline A., Furness, Sebastian G. B., Hay, Debbie L., Liang, Yi-Lynn, Miller, Laurence J., Christopoulos, Arthur, Wang, Ming-Wei, Wootten, Denise and Sexton, Patrick M. (2019). The molecular control of calcitonin receptor signaling. ACS Pharmacology and Translational Science, 2 (1), 31-51. doi: 10.1021/acsptsci.8b00056 |
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2018 Journal Article Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1Furness, S. G. B., Christopoulos, A., Sexton, P. M. and Wootten, D. (2018). Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1. Biochemical Pharmacology, 156, 223-240. doi: 10.1016/j.bcp.2018.08.033 |
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2018 Journal Article Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determinationLiang, Yi-Lynn, Zhao, Peishen, Draper-Joyce, Christopher, Baltos, Jo-Anne, Glukhova, Alisa, Truong, Tin T., May, Lauren T., Christopoulos, Arthur, Wootten, Denise, Sexton, Patrick M. and Furness, Sebastian G. B. (2018). Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination. ACS Pharmacology and Translational Science, 1 (1), 12-20. doi: 10.1021/acsptsci.8b00017 |
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2018 Journal Article Structure of the adenosine-bound human adenosine A1 receptor–Gi complexDraper-Joyce, Christopher J., Khoshouei, Maryam, Thal, David M., Liang, Yi-Lynn, Nguyen, Anh T. N., Furness, Sebastian G. B., Venugopal, Hariprasad, Baltos, Jo-Anne, Plitzko, Jürgen M., Danev, Radostin, Baumeister, Wolfgang, May, Lauren T., Wootten, Denise, Sexton, Patrick M., Glukhova, Alisa and Christopoulos, Arthur (2018). Structure of the adenosine-bound human adenosine A1 receptor–Gi complex. Nature, 558 (7711), 559-563. doi: 10.1038/s41586-018-0236-6 |
