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2020 Journal Article Building the case for the calcitonin receptor as a viable target for the treatment of glioblastomaGupta, Pragya, Furness, Sebastian G. B., Bittencourt, Lucas, Hare, David L. and Wookey, Peter J. (2020). Building the case for the calcitonin receptor as a viable target for the treatment of glioblastoma. Therapeutic Advances in Medical Oncology, 12, 175883592097811. doi: 10.1177/1758835920978110 |
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2019 Journal Article The nature of efficacy at G protein-coupled receptorsZhao, Peishen and Furness, Sebastian G.B. (2019). The nature of efficacy at G protein-coupled receptors. Biochemical Pharmacology, 170 113647, 1-13. doi: 10.1016/j.bcp.2019.113647 |
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2019 Journal Article TrkB agonist LM22A-4 increases oligodendroglial populations during myelin repair in the corpus callosumNguyen, Huynh T. H., Wood, Rhiannon J., Prawdiuk, Alexa R., Furness, Sebastian G. B., Xiao, Junhua, Murray, Simon S. and Fletcher, Jessica L. (2019). TrkB agonist LM22A-4 increases oligodendroglial populations during myelin repair in the corpus callosum. Frontiers in Molecular Neuroscience, 12 205, 1-12. doi: 10.3389/fnmol.2019.00205 |
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2019 Journal Article Conformational transitions and the activation of heterotrimeric G proteins by G protein-coupled receptorsDraper-Joyce, Christopher and Furness, Sebastian George Barton (2019). Conformational transitions and the activation of heterotrimeric G proteins by G protein-coupled receptors. ACS Pharmacology and Translational Science, 2 (4), 285-290. doi: 10.1021/acsptsci.9b00054 |
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2019 Journal Article Deconvoluting the molecular control of binding and signaling at the amylin 3 receptor: RAMP3 alters signal propagation through extracellular loops of the calcitonin receptorPham, Vi, Zhu, Yue, Dal Maso, Emma, Reynolds, Christopher A., Deganutti, Giuseppe, Atanasio, Silvia, Hick, Caroline A., Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L., Furness, Sebastian G. B., Wang, Ming-Wei, Wootten, Denise and Sexton, Patrick M. (2019). Deconvoluting the molecular control of binding and signaling at the amylin 3 receptor: RAMP3 alters signal propagation through extracellular loops of the calcitonin receptor. ACS Pharmacology and Translational Science, 2 (3), 183-197. doi: 10.1021/acsptsci.9b00010 |
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2019 Journal Article Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomasOstrovskaya, Anna, Hick, Caroline, Hutchinson, Dana S., Stringer, Brett W., Wookey, Peter J., Wootten, Denise, Sexton, Patrick M. and Furness, Sebastian G.B. (2019). Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas. BMC Cancer, 19 (1) 157, 157. doi: 10.1186/s12885-019-5369-y |
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2019 Journal Article The molecular control of calcitonin receptor signalingdal Maso, Emma, Glukhova, Alisa, Zhu, Yue, Garcia-Nafria, Javier, Tate, Christopher G., Atanasio, Silvia, Reynolds, Christopher A., Ramírez-Aportela, Erney, Carazo, Jose-Maria, Hick, Caroline A., Furness, Sebastian G. B., Hay, Debbie L., Liang, Yi-Lynn, Miller, Laurence J., Christopoulos, Arthur, Wang, Ming-Wei, Wootten, Denise and Sexton, Patrick M. (2019). The molecular control of calcitonin receptor signaling. ACS Pharmacology and Translational Science, 2 (1), 31-51. doi: 10.1021/acsptsci.8b00056 |
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2018 Journal Article Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1Furness, S. G. B., Christopoulos, A., Sexton, P. M. and Wootten, D. (2018). Differential engagement of polar networks in the glucagon-like peptide 1 receptor by endogenous variants of the glucagon-like peptide 1. Biochemical Pharmacology, 156, 223-240. doi: 10.1016/j.bcp.2018.08.033 |
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2018 Journal Article Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determinationLiang, Yi-Lynn, Zhao, Peishen, Draper-Joyce, Christopher, Baltos, Jo-Anne, Glukhova, Alisa, Truong, Tin T., May, Lauren T., Christopoulos, Arthur, Wootten, Denise, Sexton, Patrick M. and Furness, Sebastian G. B. (2018). Dominant negative G proteins enhance formation and purification of agonist-GPCR-G protein complexes for structure determination. ACS Pharmacology and Translational Science, 1 (1), 12-20. doi: 10.1021/acsptsci.8b00017 |
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2018 Journal Article Structure of the adenosine-bound human adenosine A1 receptor–Gi complexDraper-Joyce, Christopher J., Khoshouei, Maryam, Thal, David M., Liang, Yi-Lynn, Nguyen, Anh T. N., Furness, Sebastian G. B., Venugopal, Hariprasad, Baltos, Jo-Anne, Plitzko, Jürgen M., Danev, Radostin, Baumeister, Wolfgang, May, Lauren T., Wootten, Denise, Sexton, Patrick M., Glukhova, Alisa and Christopoulos, Arthur (2018). Structure of the adenosine-bound human adenosine A1 receptor–Gi complex. Nature, 558 (7711), 559-563. doi: 10.1038/s41586-018-0236-6 |
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2018 Journal Article Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacyDal Maso, Emma, Zhu, Yue, Pham, Vi, Reynolds, Christopher A., Deganutti, Giuseppe, Hick, Caroline A., Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L., Wang, Ming-Wei, Sexton, Patrick M., Furness, Sebastian G.B. and Wootten, Denise (2018). Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy. Biochemical Pharmacology, 150, 214-244. doi: 10.1016/j.bcp.2018.02.005 |
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2018 Journal Article Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complexLiang, Yi-Lynn, Khoshouei, Maryam, Glukhova, Alisa, Furness, Sebastian G. B., Zhao, Peishen, Clydesdale, Lachlan, Koole, Cassandra, Truong, Tin T., Thal, David M., Lei, Saifei, Radjainia, Mazdak, Danev, Radostin, Baumeister, Wolfgang, Wang, Ming-Wei, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M. and Wootten, Denise (2018). Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex. Nature, 555 (7694), 121-125. doi: 10.1038/nature25773 |
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2018 Journal Article Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphismsDal Maso, Emma, Just, Rasmus, Hick, Caroline, Christopoulos, Arthur, Sexton, Patrick M., Wootten, Denise and Furness, Sebastian G.B. (2018). Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms. Biochemical Pharmacology, 148, 111-129. doi: 10.1016/j.bcp.2017.12.016 |
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2017 Journal Article Coding GPCR-G protein specificityFurness, Sebastian G.B. and Sexton, Patrick M. (2017). Coding GPCR-G protein specificity. Cell Research, 27 (10), 1193-1194. doi: 10.1038/cr.2017.92 |
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2017 Journal Article Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastomaGilabert-Oriol, Roger, Furness, Sebastian G. B., Stringer, Brett W., Weng, Alexander, Fuchs, Hendrik, Day, Bryan W., Kourakis, Angela, Boyd, Andrew W., Hare, David L., Thakur, Mayank, Johns, Terrance G. and Wookey, Peter J. (2017). Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma. Cancer Immunology, Immunotherapy, 66 (9), 1217-1228. doi: 10.1007/s00262-017-2013-z |
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2017 Journal Article Phase-plate cryo-EM structure of a class B GPCR-G-protein complexLiang, Yi-Lynn, Khoshouei, Maryam, Radjainia, Mazdak, Zhang, Yan, Glukhova, Alisa, Tarrasch, Jeffrey, Thal, David M., Furness, Sebastian G. B., Christopoulos, George, Coudrat, Thomas, Danev, Radostin, Baumeister, Wolfgang, Miller, Laurence J., Christopoulos, Arthur, Kobilka, Brian K., Wootten, Denise, Skiniotis, Georgios and Sexton, Patrick M. (2017). Phase-plate cryo-EM structure of a class B GPCR-G-protein complex. Nature, 546 (7656), 118-123. doi: 10.1038/nature22327 |
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2017 Journal Article What determines the magnitude of cellular response for activation of G protein-coupled receptors?Furness, Sebastian G. B., Wootten, Denise and Sexton, Patrick M (2017). What determines the magnitude of cellular response for activation of G protein-coupled receptors?. Cell Cycle, 16 (5), 392-394. doi: 10.1080/15384101.2016.1271634 |
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2017 Book Chapter CalcitoninOstrovskaya, A., Findlay, D. M., Sexton, P. M. and Furness, S. G. B. (2017). Calcitonin. Reference module in neuroscience and biobehavioral psychology. (pp. - ) Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-12-809324-5.03223-5 |
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2016 Journal Article Ligand-dependent modulation of G protein conformation alters drug efficacyFurness, Sebastian George Barton, Liang, Yi-Lynn, Nowell, Cameron James, Halls, Michelle Louise, Wookey, Peter John, Dal Maso, Emma, Inoue, Asuka, Christopoulos, Arthur, Wootten, Denise and Sexton, Patrick Michael (2016). Ligand-dependent modulation of G protein conformation alters drug efficacy. Cell, 167 (3), 739-749. doi: 10.1016/j.cell.2016.09.021 |
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2016 Journal Article Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptorWootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Furness, Sebastian G. B., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2016). Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor. Biochemical Pharmacology, 118, 68-87. doi: 10.1016/j.bcp.2016.08.015 |
