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2016 Journal Article The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonismWootten, Denise, Reynolds, Christopher A, Smith, Kevin J, Mobarec, Juan C, Koole, Cassandra, Savage, Emilia E, Pabreja, Kavita, Simms, John, Sridhar, Rohan, Furness, Sebastian G B, Liu, Mengjie, Thompson, Philip E, Miller, Laurence J, Christopoulos, Arthur and Sexton, Patrick M (2016). The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism. Cell, 165 (7), 1632-1643. doi: 10.1016/j.cell.2016.05.023 |
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2016 Journal Article A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from Class B crystal structuresWootten, Denise, Reynolds, Christopher A., Koole, Cassandra, Smith, Kevin J., Mobarec, Juan C., Simms, John, Quon, Tezz, Coudrat, Thomas, Furness, Sebastian G. B., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2016). A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from Class B crystal structures. Molecular Pharmacology, 89 (3), 335-47. doi: 10.1124/mol.115.101246 |
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2016 Journal Article A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell deathFurness, S.G.B., Hare, D.L., Kourakis, A., Turnley, A.M. and Wookey, P.J. (2016). A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death. Cell Death Discovery, 2 (1) 16062, 1-9. doi: 10.1038/cddiscovery.2016.62 |
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2015 Journal Article Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimeticsCook, A. E., Mistry, S. N., Gregory, K. J., Furness, S. G. B., Sexton, P. M., Scammells, P. J., Conigrave, A. D., Christopoulos, A. and Leach, K. (2015). Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. British Journal of Pharmacology, 172 (1), 185-200. doi: 10.1111/bph.12937 |
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2014 Journal Article Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand biasAndreassen, Kim Vietz, Hjuler, Sara Toftegaard, Furness, Sebastian G., Sexton, Patrick M., Christopoulos, Arthur, Nosjean, Olivier, Karsdal, Morten Asser and Henriksen, Kim (2014). Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias. PLoS One, 9 (3) e92042, e92042. doi: 10.1371/journal.pone.0092042 |
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2014 Journal Article Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activationPabreja, K., Mohd, M. A., Koole, C., Wootten, D. and Furness, S. G.B. (2014). Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation. British Journal of Pharmacology, 171 (5), 1114-1128. doi: 10.1111/bph.12313 |
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2013 Journal Article A simple method to generate stable cell lines for the analysis of transient protein-protein interactionsSavage, Emilia Elizabeth, Wootten, Denise, Christopoulos, Arthur, Sexton, Patrick Michael and Furness, Sebastian George Barton (2013). A simple method to generate stable cell lines for the analysis of transient protein-protein interactions. BioTechniques, 54 (4), 217-221. doi: 10.2144/000114013 |
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2013 Conference Publication Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) functionKoole, Cassandra, Pabreja, Kavita, Savage, Emilia E., Wootten, Denise, Furness, Sebastian G. B., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2013). Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function. Biochemical Society Meeting, London, United Kingdom: Portland Press. doi: 10.1042/BST20120236 |
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2012 Journal Article Small molecule allosteric modulation of the glucagon-like peptide-1 receptor enhances the insulinotropic effect of oxyntomodulinWillard, Francis S., Wootten, Denise, Showalter, Aaron D., Savage, Emilia E., Ficorilli, James, Farb, Thomas B., Bokvist, Krister, Alsina-Fernandez, Jorge, Furness, Sebastian G. B., Christopoulos, Arthur, Sexton, Patrick M. and Sloop, Kyle W. (2012). Small molecule allosteric modulation of the glucagon-like peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin. Molecular Pharmacology, 82 (6), 1066-1073. doi: 10.1124/mol.112.080432 |
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2012 Journal Article Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signalingHao, Nan, Lee, Kian Leong, Furness, Sebastian G. B., Bosdotter, Cecilia, Poellinger, Lorenz and Whitelaw, Murray L. (2012). Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling. Molecular Pharmacology, 82 (6), 1082-1093. doi: 10.1124/mol.112.078873 |
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2012 Journal Article Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allosteryHarikumar, Kaleeckal G., Wootten, Denise, Pinon, Delia I., Koole, Cassandra, Ball, Alicja M., Furness, Sebastian G. B., Graham, Bim, Dong, Maoqing, Christopoulos, Arthur, Miller, Laurence J. and Sexton, Patrick M. (2012). Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery. Proceedings of the National Academy of Sciences of the United States of America, 109 (45), 18607-18612. doi: 10.1073/pnas.1205227109 |
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2012 Conference Publication Expression, function and targeting of calcitonin receptor in glioma cells of the brain tumour glioblastoma multiforme (GBM)Furness, S. (2012). Expression, function and targeting of calcitonin receptor in glioma cells of the brain tumour glioblastoma multiforme (GBM). 22nd International-Union-of-Biochemistry-and-Molecular-Biology (IUBMB) Congress/37th Federation-of-European-Biochemical-Societies (FEBS) Congress, Seville Spain, Sep 04-09, 2012. HOBOKEN: WILEY. |
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2012 Journal Article Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptorSato, Masaaki, Hutchinson, Dana S., Halls, Michelle L., Furness, Sebastian G. B., Bengtsson, Tore, Evans, Bronwyn A. and Summers, Roger J. (2012). Interaction with caveolin-1 modulates G protein coupling of mouse β3-adrenoceptor. Journal of Biological Chemistry, 287 (24), 20674-20688. doi: 10.1074/jbc.M111.280651 |
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2012 Journal Article The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172Wookey, Peter J., Mclean, Catriona A., Hwang, Peter, Furness, Sebastian G.B., Nguyen, Sandy, Kourakis, Angela, Hare, David L. and Rosenfeld, Jeffrey V. (2012). The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172. Histopathology, 60 (6), 895-910. doi: 10.1111/j.1365-2559.2011.04146.x |
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2012 Journal Article Consequences of splice variation on Secretin family G protein-coupled receptor functionFurness, Sebastian G.B., Wootten, Denise, Christopoulos, Arthur and Sexton, Patrick M. (2012). Consequences of splice variation on Secretin family G protein-coupled receptor function. British Journal of Pharmacology, 166 (1), 98-109. doi: 10.1111/j.1476-5381.2011.01571.x |
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2010 Journal Article Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activatorWhelan, Fiona, Hao, Nan, Furness, Sebastian G. B., Whitelaw, Murray L. and Chapman-Smith, Anne (2010). Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator. Molecular Pharmacology, 77 (6), 1037-1046. doi: 10.1124/mol.109.062927 |
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2009 Journal Article The pleiotropy of dioxin toxicity - Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological rolesFurness, Sebastian G.B. and Whelan, Fiona (2009). The pleiotropy of dioxin toxicity - Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles. Pharmacology and Therapeutics, 124 (3), 336-353. doi: 10.1016/j.pharmthera.2009.09.004 |
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2009 Book Chapter Understanding amylin receptorsJust, Rasmus, Simms, John, Furness, Sebastian G. B., Christopoulos, Arthur and Sexton, Patrick M. (2009). Understanding amylin receptors. The calcitonin gene-related peptide family. (pp. 41-57) Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/978-90-481-2909-6_3 |
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2009 Journal Article Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modificationsDave, Keyur A., Whelan, Fiona, Bindloss, Colleen, Furness, Sebastian G. B., Chapman-Smith, Anne, Whitelaw, Murray L. and Gorman, Jeffrey J. (2009). Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications. Molecular & Cellular Proteomics, 8 (4), 706-719. doi: 10.1074/mcp.M800459-MCP200 |
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2008 Journal Article Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptorsMorfis, Maria, Tilakaratne, Nanda, Furness, Sebastian G. B., Christopoulos, George, Werry, Tim D., Christopoulos, Arthur and Sexton, Patrick M. (2008). Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors. Endocrinology, 149 (11), 5423-5431. doi: 10.1210/en.2007-1735 |
