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2018 Journal Article Structure of the adenosine-bound human adenosine A1 receptor–Gi complexDraper-Joyce, Christopher J., Khoshouei, Maryam, Thal, David M., Liang, Yi-Lynn, Nguyen, Anh T. N., Furness, Sebastian G. B., Venugopal, Hariprasad, Baltos, Jo-Anne, Plitzko, Jürgen M., Danev, Radostin, Baumeister, Wolfgang, May, Lauren T., Wootten, Denise, Sexton, Patrick M., Glukhova, Alisa and Christopoulos, Arthur (2018). Structure of the adenosine-bound human adenosine A1 receptor–Gi complex. Nature, 558 (7711), 559-563. doi: 10.1038/s41586-018-0236-6 |
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2018 Journal Article Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacyDal Maso, Emma, Zhu, Yue, Pham, Vi, Reynolds, Christopher A., Deganutti, Giuseppe, Hick, Caroline A., Yang, Dehua, Christopoulos, Arthur, Hay, Debbie L., Wang, Ming-Wei, Sexton, Patrick M., Furness, Sebastian G.B. and Wootten, Denise (2018). Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy. Biochemical Pharmacology, 150, 214-244. doi: 10.1016/j.bcp.2018.02.005 |
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2018 Journal Article Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complexLiang, Yi-Lynn, Khoshouei, Maryam, Glukhova, Alisa, Furness, Sebastian G. B., Zhao, Peishen, Clydesdale, Lachlan, Koole, Cassandra, Truong, Tin T., Thal, David M., Lei, Saifei, Radjainia, Mazdak, Danev, Radostin, Baumeister, Wolfgang, Wang, Ming-Wei, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M. and Wootten, Denise (2018). Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex. Nature, 555 (7694), 121-125. doi: 10.1038/nature25773 |
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2018 Journal Article Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphismsDal Maso, Emma, Just, Rasmus, Hick, Caroline, Christopoulos, Arthur, Sexton, Patrick M., Wootten, Denise and Furness, Sebastian G.B. (2018). Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms. Biochemical Pharmacology, 148, 111-129. doi: 10.1016/j.bcp.2017.12.016 |
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2017 Journal Article Coding GPCR-G protein specificityFurness, Sebastian G.B. and Sexton, Patrick M. (2017). Coding GPCR-G protein specificity. Cell Research, 27 (10), 1193-1194. doi: 10.1038/cr.2017.92 |
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2017 Journal Article Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastomaGilabert-Oriol, Roger, Furness, Sebastian G. B., Stringer, Brett W., Weng, Alexander, Fuchs, Hendrik, Day, Bryan W., Kourakis, Angela, Boyd, Andrew W., Hare, David L., Thakur, Mayank, Johns, Terrance G. and Wookey, Peter J. (2017). Dianthin-30 or gelonin versus monomethyl auristatin E, each configured with an anti-calcitonin receptor antibody, are differentially potent in vitro in high-grade glioma cell lines derived from glioblastoma. Cancer Immunology, Immunotherapy, 66 (9), 1217-1228. doi: 10.1007/s00262-017-2013-z |
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2017 Journal Article Phase-plate cryo-EM structure of a class B GPCR-G-protein complexLiang, Yi-Lynn, Khoshouei, Maryam, Radjainia, Mazdak, Zhang, Yan, Glukhova, Alisa, Tarrasch, Jeffrey, Thal, David M., Furness, Sebastian G. B., Christopoulos, George, Coudrat, Thomas, Danev, Radostin, Baumeister, Wolfgang, Miller, Laurence J., Christopoulos, Arthur, Kobilka, Brian K., Wootten, Denise, Skiniotis, Georgios and Sexton, Patrick M. (2017). Phase-plate cryo-EM structure of a class B GPCR-G-protein complex. Nature, 546 (7656), 118-123. doi: 10.1038/nature22327 |
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2017 Journal Article What determines the magnitude of cellular response for activation of G protein-coupled receptors?Furness, Sebastian G. B., Wootten, Denise and Sexton, Patrick M (2017). What determines the magnitude of cellular response for activation of G protein-coupled receptors?. Cell Cycle, 16 (5), 392-394. doi: 10.1080/15384101.2016.1271634 |
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2017 Book Chapter CalcitoninOstrovskaya, A., Findlay, D. M., Sexton, P. M. and Furness, S. G. B. (2017). Calcitonin. Reference module in neuroscience and biobehavioral psychology. (pp. - ) Amsterdam, Netherlands: Elsevier. doi: 10.1016/b978-0-12-809324-5.03223-5 |
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2016 Journal Article Ligand-dependent modulation of G protein conformation alters drug efficacyFurness, Sebastian George Barton, Liang, Yi-Lynn, Nowell, Cameron James, Halls, Michelle Louise, Wookey, Peter John, Dal Maso, Emma, Inoue, Asuka, Christopoulos, Arthur, Wootten, Denise and Sexton, Patrick Michael (2016). Ligand-dependent modulation of G protein conformation alters drug efficacy. Cell, 167 (3), 739-749. doi: 10.1016/j.cell.2016.09.021 |
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2016 Journal Article Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptorWootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Furness, Sebastian G. B., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2016). Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor. Biochemical Pharmacology, 118, 68-87. doi: 10.1016/j.bcp.2016.08.015 |
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2016 Journal Article The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonismWootten, Denise, Reynolds, Christopher A, Smith, Kevin J, Mobarec, Juan C, Koole, Cassandra, Savage, Emilia E, Pabreja, Kavita, Simms, John, Sridhar, Rohan, Furness, Sebastian G B, Liu, Mengjie, Thompson, Philip E, Miller, Laurence J, Christopoulos, Arthur and Sexton, Patrick M (2016). The extracellular surface of the GLP-1 receptor is a molecular trigger for biased agonism. Cell, 165 (7), 1632-1643. doi: 10.1016/j.cell.2016.05.023 |
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2016 Journal Article A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from Class B crystal structuresWootten, Denise, Reynolds, Christopher A., Koole, Cassandra, Smith, Kevin J., Mobarec, Juan C., Simms, John, Quon, Tezz, Coudrat, Thomas, Furness, Sebastian G. B., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2016). A hydrogen-bonded polar network in the core of the glucagon-like peptide-1 receptor is a fulcrum for biased agonism: lessons from Class B crystal structures. Molecular Pharmacology, 89 (3), 335-47. doi: 10.1124/mol.115.101246 |
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2016 Journal Article A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell deathFurness, S.G.B., Hare, D.L., Kourakis, A., Turnley, A.M. and Wookey, P.J. (2016). A novel ligand of calcitonin receptor reveals a potential new sensor that modulates programmed cell death. Cell Death Discovery, 2 (1) 16062, 1-9. doi: 10.1038/cddiscovery.2016.62 |
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2015 Journal Article Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimeticsCook, A. E., Mistry, S. N., Gregory, K. J., Furness, S. G. B., Sexton, P. M., Scammells, P. J., Conigrave, A. D., Christopoulos, A. and Leach, K. (2015). Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. British Journal of Pharmacology, 172 (1), 185-200. doi: 10.1111/bph.12937 |
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2014 Journal Article Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand biasAndreassen, Kim Vietz, Hjuler, Sara Toftegaard, Furness, Sebastian G., Sexton, Patrick M., Christopoulos, Arthur, Nosjean, Olivier, Karsdal, Morten Asser and Henriksen, Kim (2014). Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias. PLoS One, 9 (3) e92042, e92042. doi: 10.1371/journal.pone.0092042 |
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2014 Journal Article Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activationPabreja, K., Mohd, M. A., Koole, C., Wootten, D. and Furness, S. G.B. (2014). Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP-1R activation. British Journal of Pharmacology, 171 (5), 1114-1128. doi: 10.1111/bph.12313 |
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2013 Journal Article A simple method to generate stable cell lines for the analysis of transient protein-protein interactionsSavage, Emilia Elizabeth, Wootten, Denise, Christopoulos, Arthur, Sexton, Patrick Michael and Furness, Sebastian George Barton (2013). A simple method to generate stable cell lines for the analysis of transient protein-protein interactions. BioTechniques, 54 (4), 217-221. doi: 10.2144/000114013 |
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2013 Conference Publication Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) functionKoole, Cassandra, Pabreja, Kavita, Savage, Emilia E., Wootten, Denise, Furness, Sebastian G. B., Miller, Laurence J., Christopoulos, Arthur and Sexton, Patrick M. (2013). Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function. Biochemical Society Meeting, London, United Kingdom: Portland Press. doi: 10.1042/BST20120236 |
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2012 Journal Article Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signalingHao, Nan, Lee, Kian Leong, Furness, Sebastian G. B., Bosdotter, Cecilia, Poellinger, Lorenz and Whitelaw, Murray L. (2012). Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling. Molecular Pharmacology, 82 (6), 1082-1093. doi: 10.1124/mol.112.078873 |
