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2005 Journal Article Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individualsJekimovs, C. R., Chen, X., Arnold, J., Gatei, M., Richardson, D. J., kConFab Investigators, Spurdle, A. B., Khanna, K. K. and Chenevix-Trench, G. (2005). Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals. British Journal Of Cancer, 92 (4), 784-790. doi: 10.1038/sj.bjc.6602381 |
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2005 Journal Article Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesisFabbro, Megan, Zhou, Bin-Bing, Takahasi, Mikiko, Sarcevic, Boris, Lal, Preeti, Graham, Mark E., Gabrielli, Brian G., Robinson, Phillip J., Nigg, Erich A., Ono, Yoshitaka and Khanna, Kum Kum (2005). Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis. Developmental Cell, 9 (4), 477-488. doi: 10.1016/j.devcel.2005.09.003 |
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2004 Journal Article Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2AGoodarzi, Aaron A, Jonnalagadda, Jyoti C., Douglas, Pauline, Young, David, Ye, Ruiqiong, Moorhead, Greg B. G., Lees-Miller, Susan P. and Khanna, Kum Kum (2004). Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A. The EMBO Journal, 23 (22), 4451-4461. doi: 10.1038/sj.emboj.7600455 |
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2004 Journal Article ATM and Genome Maintenance: Defining Its Role in Breast Cancer SusceptibilityKhanna, Kum Kum and Chenevix-Trench, Georgia (2004). ATM and Genome Maintenance: Defining Its Role in Breast Cancer Susceptibility. Journal of Mammary Gland Biology and Neoplasia, 9 (3), 247-262. doi: 10.1023/B:JOMG.0000048772.92326.a1 |
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2004 Journal Article Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaksBuscemi, Giacomo, Perego, Paola, Carenini, Nives, Nakanishi, Makoto, Chessa, Luciana, Chen, Junjie, Khanna, Kum Kum and Delia, Domenico (2004). Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. Oncogene, 23 (46), 7691-7700. doi: 10.1038/sj.onc.1207986 |
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2004 Journal Article BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damageFabbro, Megan, Savage, Kienan, Hobson, Karen, Deans, Andrew J., Powell, Simon N., McArthur, Grant A. and Khanna, Kum Kum (2004). BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. The Journal of Biological Chemistry., 279 (30), 31251-31258. doi: 10.1074/jbc.M405372200 |
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2003 Journal Article Suppression of tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1Krause, Darren R., Jonnalagadda,Jyoti C., Gatei, Magtouf H., Sillje, Herman H. W., Zhou, Bin-Bing, Nigg, Erich A. and Khanna, Kumkum (2003). Suppression of tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1. Oncogene, 22 (38), 5927-5937. doi: 10.1038/sj.onc.1206691 |
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2003 Journal Article Role of tumor suppressors in DNA damage responseZhou, Bin-Bing S., Mattern, Michael R. and Khanna, Kum Kum (2003). Role of tumor suppressors in DNA damage response. Methods in Molecular Biology, 223, 39-50. doi: 10.1385/1592593291 |
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2003 Journal Article Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiationGatei, Magtouf, Sloper, Katie, Sorensen, Claus, Syljuasen, Randi, Falck, Jacob, Hobson, Karen, Savage, Kienan, Lukas, Jiri, Zhou, Bin-Bing, Bartek, Jiri and Khanna, Kum Kum (2003). Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. Journal of Biological Chemistry, 278 (17), 14806-14811. doi: 10.1074/jbc.M210862200 |
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2003 Journal Article Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25ASorensen, Claus Storgaard, Syluasen, Randi G., Falck, Jacob, Schroeder, Tine, Ronnstrand, Lars, Khanna, Kum Kum, Zhou, Bin-Bing, Bartek, Jiri and Lukas, Jiri (2003). Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A. Cancer Cell, 3 (3), 247-258. doi: 10.1016/S1535-6108(03)00048-5 |
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2002 Journal Article Dominant negative ATM mutations in breast cancer familiesChenevix-Trench, Georgia, Spurdle, Amanda B., Gatei, Magtouf, Kelly, Helena, Marsh, Anna, Chen, Xiaoqing, Donn, Karen, Cummings, Margaret C., Nyholt, Dale, Jenkins, Mark A., Scott, Clare, Pupo, Gulietta M., Dork, Thilo, Bendix, Regina, Kirk, Judy, Tucker, Katherine, McCredie, Margaret R. E., Hopper, John L., Sambrook, Joseph, Mann, Graham J. and Khanna, Kum Kum (2002). Dominant negative ATM mutations in breast cancer families. Journal of the National Cancer Institute, 94 (3), 205-215. doi: 10.1093/jnci/94.3.205 |
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2002 Journal Article Expression of a truncated Brca1 protein delays lactational mammary development in transgenic miceBrown, M. A., Nicolai, H., Howe, K., Katagiri, T., Lalani, E., Simpson, K. J., Manning, N. W., Deans, A., Chen, P., Khanna, K. K., Wati, M. R., Griffiths, B. L., Xu, C. F., Stamp, G. W. H. and Solomon, E. (2002). Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice. Transgenic Research, 11 (5), 467-478. doi: 10.1023/A:1020348025139 |
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2002 Journal Article No evidence for association of ataxia-telangiectasia mutated gene T2119C and C3161G amino acid substitution variants with risk of breast cancerSpurdle, Amanda B., Hopper, John L., Chen, Xiaoqing, McCredie, Margaret R. E., Giles, Graham G., Newmann, Beth, Chenevix-Trench, Georgia and Khanna, KumKum (2002). No evidence for association of ataxia-telangiectasia mutated gene T2119C and C3161G amino acid substitution variants with risk of breast cancer. Breast Cancer Research, 4 (6) R15, R15/1-R15/6. doi: 10.1186/bcr534 |
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2001 Journal Article Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites - In vivo assessment using phospho-specific antibodiesGatei, Magtouf, Zhou, Bin-Bing, Hobson, Karen, Scott, Shaun, Young, David and Khanna, Kum Kum (2001). Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites - In vivo assessment using phospho-specific antibodies. Journal of Biological Chemistry, 276 (20), 17276-17280. doi: 10.1074/jbc.M011681200 |
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2001 Journal Article UV-induced hyperphosphorylation of replication protein A depends on DNA replication and expression of ATM proteinOakley, G. G., Loberg, L. I., Yao, J. Q., Risinger, M. A., Yunker, R. L., Zernik-Kobak, M., Khanna, K. K., Lavin, M. F., Carty, M. P. and Dixon, K. (2001). UV-induced hyperphosphorylation of replication protein A depends on DNA replication and expression of ATM protein. Molecular Biology of The Cell, 12 (5), 1199-1213. doi: 10.1091/mbc.12.5.1199 |
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2001 Journal Article Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasiaGueven, Nuri, Keating, Katherine E., Chen, Philip, Fukao, Toshiyuki, Khanna, Kum Kum, Watters, Dianne, Rodemann, Peter H. and Lavin, Martin F. (2001). Epidermal growth factor sensitizes cells to ionizing radiation by down-regulating protein mutated in ataxia-telangiectasia. Journal of Biological Chemistry, 276 (12), 8884-8891. doi: 10.1074/jbc.M006190200 |
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2001 Journal Article Chk2 activation dependence on Nbs1 after DNA damageBuscemi, G., Savio, C., Zannini, L., Micciche, F., Masnada, D., Nakanishi, M., Tauchi, H., Komatsu, S., Mizutani, S., Khanna, K., Chen, P., Concannon, P., Chessa, L. and Delia, D. (2001). Chk2 activation dependence on Nbs1 after DNA damage. Molecular & Cellular Biology, 21 (15), 5214-5222. doi: 10.1128/MCB.21.15.5214-5222.2001 |
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2001 Journal Article ATM, a central controller of cellular responses to DNA damageKhanna, K. K., Lavin, M. F., Jackson, S. P. and Mulhern, T. D. (2001). ATM, a central controller of cellular responses to DNA damage. Cell Death And Differentiation, 8 (11), 1052-1065. doi: 10.1038/sj.cdd.4400874 |
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2001 Journal Article Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acidGatei, M., Shkedy, D., Khanna, K. K., Uziel, T., Shiloh, Y., Pandita, T. K., Lavin, M. F. and Rotman, G. (2001). Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid. Oncogene, 20 (3), 289-294. doi: 10.1038/sj.onc.1204111 |
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2001 Journal Article The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent mannerYe, R. Q., Bodero, A., Zhou, B. B., Khanna, K. K., Lavin, M. F. and Lees-Miller, S. P. (2001). The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner. Journal of Biological Chemistry, 276 (7), 4828-4833. doi: 10.1074/jbc.M004894200 |
