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2001 Journal Article The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent mannerYe, R. Q., Bodero, A., Zhou, B. B., Khanna, K. K., Lavin, M. F. and Lees-Miller, S. P. (2001). The plant isoflavenoid genistein activates p53 and Chk2 in an ATM-dependent manner. Journal of Biological Chemistry, 276 (7), 4828-4833. doi: 10.1074/jbc.M004894200 |
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2001 Journal Article DNA double-strand breaks: signaling, repair and the cancer connectionJackson, S.P. and Khanna, K. (2001). DNA double-strand breaks: signaling, repair and the cancer connection. Nature Genetics, 27 (3), 247-254. doi: 10.1038/85798 |
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2000 Journal Article Defective radiation signal transduction in ataxia-telangiectasia cellsYan, J., Khanna, K. K. and Lavin, M. F. (2000). Defective radiation signal transduction in ataxia-telangiectasia cells. International Journal of Radiation Biology, 76 (8), 1025-1035. |
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2000 Journal Article Purification and characterization of ATM from human placentaChan, D., Son, S-C., Block, W., Ye, R., Khanna, K. K., Wold, M. S., Douglas, P. J. G., Goodarzi, A. A., Pelley, J., Taya, Y., Lavin, M. F. and Lees-Miller, S. P. (2000). Purification and characterization of ATM from human placenta. Journal of Biological Chemistry, 275 (11), 7803-7810. doi: 10.1074/jbc.275.11.7803 |
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2000 Journal Article Role for ATM in DNA damage-induced phosphorylation of BRCA1Gatei, M., Scott, S. P., Filippovitch, I., Soronika, N., Lavin, M. F., Weber, B. and Khanna, K. (2000). Role for ATM in DNA damage-induced phosphorylation of BRCA1. Cancer Research, 60 (12), 3299-3304. |
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2000 Journal Article p73 is up-regulated in a subset of hepatocellular carcinomasHerath, NI, Kew, MC, Whitehall, VLJ, Walsh, MD, Jass, JR, Khanna, KK, Young, J, Powell, LW, Leggett, BA and Macdonald, GA (2000). p73 is up-regulated in a subset of hepatocellular carcinomas. Hepatology, 31 (3), 601-605. doi: 10.1002/hep.510310309 |
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2000 Journal Article Functional characterisation of cultured cells derived from an intraepidermal carcinoma of the skin (IEC-1)Dicker, A., Serewko, M. S., Dahler, A. L., Khanna, K. K., Kaur, P., Li, A., Strutton, G. and Saunders, N. A. (2000). Functional characterisation of cultured cells derived from an intraepidermal carcinoma of the skin (IEC-1). Experimental Cell Research, 258 (2), 352-360. doi: 10.1006/excr.2000.4944 |
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2000 Journal Article Cancer risk and the ATM gene: a continuing debateKhanna, Kum Kum (2000). Cancer risk and the ATM gene: a continuing debate. Journal of the National Cancer Institute, 92 (10), 795-802. doi: 10.1093/jnci/92.10.795 |
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2000 Journal Article ATM-dependent phosphorylation of nibrin in response to radiation exposureGatei, M., Young, D., Cerosaletti, K. M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M. F., Gatti, R. A., Concannon, P. and Khanna, K. (2000). ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nature Genetics, 25 (1), 115-119. doi: 10.1038/75508 |
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2000 Journal Article Caffeine abolishes the mammalian G2/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activityZhou, B., Chaturvedi, P.S., Spring, K., Scott, S. P., Johanson, R. A., Mishra, R.G., Mattern, M. R., Winkler, J. D. and Khanna, K. K. (2000). Caffeine abolishes the mammalian G2/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase activity. Journal of Biological Chemistry, 275 (14), 10342-10348. doi: 10.1074/jbc.275.14.10342 |
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2000 Journal Article Defective radiation signal transduction in ataxia-telangiectasia cellsYan, J., Khanna, K. K. and Lavin, M. F. (2000). Defective radiation signal transduction in ataxia-telangiectasia cells. International Journal of Radiation Biology, 76 (8), 1025-1035. doi: 10.1080/09553000050111497 |
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1999 Journal Article Frequent loss of heterozygosity at 1p36 in ovarian adenocarcinomas but the gene encoding p73 is unlikely to be the targetImyanitov, Evgeny N., Birrell, Geoff W., Filippovich, Igor, Sorokina, Natasha, Arnold, Jeremy, Mould, Michelle A., Wright, Kim, Walsh, Michael, Mok, Samuel C ., Lavin, Martin F., Chenevix-Trench, Georgia and Khanna, Kum Kum (1999). Frequent loss of heterozygosity at 1p36 in ovarian adenocarcinomas but the gene encoding p73 is unlikely to be the target. Oncogene, 18 (32), 4640-4642. doi: 10.1038/sj.onc.1202863 |
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1999 Journal Article CHK1 complements the G2/M Chek point defect and radio sensitivityof ataxia-telangiectasiaChen, P., Gatei, M., O'Connell, M. J., Khanna, K. K., Bugg, S. J., Hogg, A., Scott, S. P., Hobson, K. and Lavin, M. F. (1999). CHK1 complements the G2/M Chek point defect and radio sensitivityof ataxia-telangiectasia. Oncogene, 18 (1), 249-256. doi: 10.1038/sj.onc.1202257 |
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1999 Journal Article ATM: The protein encoded by the gene mutilated in the radio sensitive syndrome ataxia - telangiectasiaLavin, M. F. and Khanna, K. K. (1999). ATM: The protein encoded by the gene mutilated in the radio sensitive syndrome ataxia - telangiectasia. International Journal of Radiation Biology, 75 (10), 1201-1214. |
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1998 Journal Article Calpain activation is upstream of caspases in radiation-induced apoptosisWaterhouse, Nigel J., Finucane, Debra M., Green, Douglas R., Elce, John S., Kumar, Sharad, Alnemri, Emad S., Litwack, Gerald, Khanna, Kumkum, Lavin, Martin F. and Watters, Dianne J. (1998). Calpain activation is upstream of caspases in radiation-induced apoptosis. Cell Death and Differentiation, 5 (12), 1051-1061. doi: 10.1038/sj.cdd.4400425 |
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1998 Journal Article Cloning and expression of the ataxia-telangiectasia gene in baculovirusScott, SP, Zhang, N, Khanna, KK, Khromykh, A, Hobson, K, Watters, D and Lavin, MF (1998). Cloning and expression of the ataxia-telangiectasia gene in baculovirus. Biochemical and Biophysical Research Communications, 245 (1), 144-148. doi: 10.1006/bbrc.1998.8137 |
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1998 Journal Article ATM associates with and phosphorylates p53: Mapping the region of interactionKhanna K.K., Keating K.E., Kozlov S., Scott S., Gatei M., Hobson K., Taya Y., Gabrielli B., Chan D., Lees-Miller S.P. and Lavin M.F. (1998). ATM associates with and phosphorylates p53: Mapping the region of interaction. Nature Genetics, 20 (4), 398-400. doi: 10.1038/3882 |
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1997 Journal Article Interaction between ATM protein and c-Abl in response to DNA damageShafman, T, Khanna, KK, Kedar, P, Spring, K, Kozlov, S, Yen, T, Hobson, K, Gatei, M, Zhang, N, Watters, D, Egerton, M, Shiloh, Y, Kharbanda, S, Kufe, D and Lavin, MF (1997). Interaction between ATM protein and c-Abl in response to DNA damage. Nature, 387 (6632), 520-523. doi: 10.1038/387520a0 |
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1997 Journal Article Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal formsWatters, D, Khanna, KK, Beamish, H, Birrell, G, Spring, K, Kedar, P, Gatei, M, Stenzel, D, Hobson, K, Kozlov, S, Zhang, N, Farrell, A, Ramsay, J, Gatti, R and Lavin, M (1997). Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms. Oncogene, 14 (16), 1911-1921. doi: 10.1038/sj.onc.1201037 |
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1997 Journal Article Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cellsKhanna, KK, Yan, J, Watters, D, Hobson, K, Beamish, H, Spring, K, Shiloh, Y, Gatti, RA and Lavin, MF (1997). Defective signaling through the B cell antigen receptor in Epstein-Barr virus-transformed ataxia-telangiectasia cells. Journal of Biological Chemistry, 272 (14), 9489-9495. doi: 10.1074/jbc.272.14.9489 |
