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2019 Journal Article mCSM-PPI2: predicting the effects of mutations on protein–protein interactionsRodrigues, Carlos H. M., Myung, Yoochan, Pires, Douglas E. V. and Ascher, David B. (2019). mCSM-PPI2: predicting the effects of mutations on protein–protein interactions. Nucleic Acids Research, 47 (W1), W338-W344. doi: 10.1093/nar/gkz383 |
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2019 Journal Article MTR-Viewer: identifying regions within genes under purifying selectionSilk, Michael, Petrovski, Slavé and Ascher, David B (2019). MTR-Viewer: identifying regions within genes under purifying selection. Nucleic Acids Research, 47 (W1), W121-W126. doi: 10.1093/nar/gkz457 |
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2019 Journal Article Homogentisate 1,2-dioxygenase (HGD) gene variants, their analysis and genotype-phenotype correlations in the largest cohort of patients with AKUAscher, David B, Spiga, Ottavia, Sekelska, Martina, Pires, Douglas E V, Bernini, Andrea, Tiezzi, Monica, Kralovicova, Jana, Borovska, Ivana, Soltysova, Andrea, Olsson, Birgitta, Galderisi, Silvia, Cicaloni, Vittoria, Ranganath, Lakshminarayan, Santucci, Annalisa and Zatkova, Andrea (2019). Homogentisate 1,2-dioxygenase (HGD) gene variants, their analysis and genotype-phenotype correlations in the largest cohort of patients with AKU. European Journal of Human Genetics : EJHG, 27 (6), 888-902. doi: 10.1038/s41431-019-0354-0 |
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2019 Journal Article Empirical ways to identify novel Bedaquiline resistance mutations in AtpEKarmakar, Malancha, Rodrigues, Carlos H M, Holt, Kathryn E, Dunstan, Sarah J, Denholm, Justin and Ascher, David B (2019). Empirical ways to identify novel Bedaquiline resistance mutations in AtpE. PloS one, 14 (5) e0217169, e0217169. doi: 10.1371/journal.pone.0217169 |
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2019 Journal Article Human LC3 and GABARAP subfamily members achieve functional specificity via specific structural modulationsJatana, Nidhi, Ascher, David B., Pires, Douglas E.V., Gokhale, Rajesh S. and Thukral, Lipi (2019). Human LC3 and GABARAP subfamily members achieve functional specificity via specific structural modulations. Autophagy, 16 (2), 239-255. doi: 10.1080/15548627.2019.1606636 |
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2019 Journal Article A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in ratsKaminskas, Lisa M., Williams, Charlotte C., Leong, Nathania J., Chan, Linda J., Butcher, Neville J., Feeney, Orlagh M., Porter, Christopher J.H., Tyssen, David, Tachedjian, Gilda and Ascher, David B. (2019). A 30 kDa polyethylene glycol-enfuvirtide complex enhances the exposure of enfuvirtide in lymphatic viral reservoirs in rats. European Journal of Pharmaceutics and Biopharmaceutics, 137, 218-226. doi: 10.1016/j.ejpb.2019.03.008 |
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2018 Journal Article Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosisPortelli, Stephanie, Phelan, Jody E., Ascher, David B., Clark, Taane G. and Furnham, Nicholas (2018). Understanding molecular consequences of putative drug resistant mutations in Mycobacterium tuberculosis. Scientific Reports, 8 (1) 15356. doi: 10.1038/s41598-018-33370-6 |
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2018 Journal Article Structural and biochemical insights into the function and evolution of sulfoquinovosidasesAbayakoon, Palika, Jin, Yi, Lingford, James P., Petricevic, Marija, John, Alan, Ryan, Eileen, Wai-Ying Mui, Janice, Pires, Douglas E.V., Ascher, David B., Davies, Gideon J., Goddard-Borger, Ethan D. and Williams, Spencer J. (2018). Structural and biochemical insights into the function and evolution of sulfoquinovosidases. ACS Central Science, 4 (9), 1266-1273. doi: 10.1021/acscentsci.8b00453 |
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2018 Journal Article Analysis of a novel pncA mutation for susceptibility to pyrazinamide therapyKarmakar, Malancha, Globan, Maria, Fyfe, Janet A. M., Stinear, Timothy P., Johnson, Paul D. R., Holmes, Natasha E., Denholm, Justin T. and Ascher, David B. (2018). Analysis of a novel pncA mutation for susceptibility to pyrazinamide therapy. American Journal of Respiratory and Critical Care Medicine, 198 (4), 541-544. doi: 10.1164/rccm.201712-2572le |
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2018 Journal Article Kinact: a computational approach for predicting activating missense mutations in protein kinasesRodrigues, Carlos H.M., Ascher, David B. and Pires, Douglas E.V. (2018). Kinact: a computational approach for predicting activating missense mutations in protein kinases. Nucleic Acids Research, 46 (W1), W127-W132. doi: 10.1093/nar/gky375 |
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2018 Journal Article Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in VietnamHolt, Kathryn E, McAdam, Paul, Thai, Phan Vuong Khac, Thuong, Nguyen Thuy Thuong, Ha, Dang Thi Minh, Lan, Nguyen Ngoc, Lan, Nguyen Huu, Nhu, Nguyen Thi Quynh, Hai, Hoang Thanh, Ha, Vu Thi Ngoc, Thwaites, Guy, Edwards, David J, Nath, Artika P, Pham, Kym, Ascher, David B, Farrar, Jeremy, Khor, Chiea Chuen, Teo, Yik Ying, Inouye, Michael, Caws, Maxine and Dunstan, Sarah J (2018). Frequent transmission of the Mycobacterium tuberculosis Beijing lineage and positive selection for the EsxW Beijing variant in Vietnam. Nature Genetics, 50 (6), 849-856. doi: 10.1038/s41588-018-0117-9 |
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2018 Journal Article Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulationHnízda, Aleš, Fábry, Milan, Moriyama, Takaya, Pachl, Petr, Kugler, Michael, Brinsa, Vítězslav, Ascher, David B, Carroll, William L, Novák, Petr, Žaliová, Markéta, Trka, Jan, Řezáčová, Pavlína, Yang, Jun J and Veverka, Václav (2018). Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation. Leukemia, 32 (6), 1393-1403. doi: 10.1038/s41375-018-0073-5 |
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2018 Journal Article Tumour risks and genotype-phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes , andAndrews, Katrina A, Ascher, David B, Pires, Douglas Eduardo Valente, Barnes, Daniel R, Vialard, Lindsey, Casey, Ruth T, Bradshaw, Nicola, Adlard, Julian, Aylwin, Simon, Brennan, Paul, Brewer, Carole, Cole, Trevor, Cook, Jackie A, Davidson, Rosemarie, Donaldson, Alan, Fryer, Alan, Greenhalgh, Lynn, Hodgson, Shirley V, Irving, Richard, Lalloo, Fiona, McConachie, Michelle, McConnell, Vivienne P M, Morrison, Patrick J, Murday, Victoria, Park, Soo-Mi, Simpson, Helen L, Snape, Katie, Stewart, Susan, Tomkins, Susan E ... Maher, Eamonn R (2018). Tumour risks and genotype-phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes , and . Journal of Medical Genetics, 55 (6), 384-394. doi: 10.1136/jmedgenet-2017-105127 |
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2018 Journal Article DynaMut: predicting the impact of mutations on protein conformation, flexibility and stabilityRodrigues, Carlos H.M., Pires, Douglas E.V. and Ascher, David B. (2018). DynaMut: predicting the impact of mutations on protein conformation, flexibility and stability. Nucleic Acids Research, 46 (W1), W350-W355. doi: 10.1093/nar/gky300 |
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2018 Journal Article Fragment-based approach to targeting inosine-5'-monophosphate dehydrogenase (IMPDH) from Mycobacterium tuberculosisTrapero, Ana, Pacitto, Angela, Singh, Vinayak, Sabbah, Mohamad, Coyne, Anthony G, Mizrahi, Valerie, Blundell, Tom L, Ascher, David B and Abell, Chris (2018). Fragment-based approach to targeting inosine-5'-monophosphate dehydrogenase (IMPDH) from Mycobacterium tuberculosis. Journal of Medicinal Chemistry, 61 (7), 2806-2822. doi: 10.1021/acs.jmedchem.7b01622 |
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2018 Journal Article Structural implications of mutations conferring rifampin resistance in Mycobacterium lepraeVedithi, Sundeep Chaitanya, Malhotra, Sony, Das, Madhusmita, Daniel, Sheela, Kishore, Nanda, George, Anuja, Arumugam, Shantha, Rajan, Lakshmi, Ebenezer, Mannam, Ascher, David B, Arnold, Eddy and Blundell, Tom L (2018). Structural implications of mutations conferring rifampin resistance in Mycobacterium leprae. Scientific Reports, 8 (1) 5016. doi: 10.1038/s41598-018-23423-1 |
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2018 Journal Article Evolution of carbapenem resistance in Acinetobacter baumannii during a prolonged infectionHawkey, Jane, Ascher, David B, Judd, Louise M, Wick, Ryan R, Kostoulias, Xenia, Cleland, Heather, Spelman, Denis W, Padiglione, Alex, Peleg, Anton Y and Holt, Kathryn E (2018). Evolution of carbapenem resistance in Acinetobacter baumannii during a prolonged infection. Microbial Genomics, 4 (3) 000165. doi: 10.1099/mgen.0.000165 |
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2017 Journal Article A computational approach from gene to structure analysis of the human ABCA4 transporter involved in genetic retinal diseasesTrezza, Alfonso, Bernini, Andrea, Langella, Andrea, Ascher, David B, Pires, Douglas E V, Sodi, Andrea, Passerini, Ilaria, Pelo, Elisabetta, Rizzo, Stanislao, Niccolai, Neri and Spiga, Ottavia (2017). A computational approach from gene to structure analysis of the human ABCA4 transporter involved in genetic retinal diseases. Investigative Ophthalmology and Visual Science, 58 (12), 5320-5328. doi: 10.1167/iovs.17-22158 |
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2017 Journal Article Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretationTraynelis, Joshua, Silk, Michael, Wang, Quanli, Berkovic, Samuel F, Liu, Liping, Ascher, David B, Balding, David J and Petrovski, Slavé (2017). Optimizing genomic medicine in epilepsy through a gene-customized approach to missense variant interpretation. Genome Research, 27 (10), 1715-1729. doi: 10.1101/gr.226589.117 |
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2017 Journal Article Mutations at protein-protein interfaces: small changes over big surfaces have large impacts on human healthJubb, Harry C, Pandurangan, Arun P, Turner, Meghan A, Ochoa-Montaño, Bernardo, Blundell, Tom L and Ascher, David B (2017). Mutations at protein-protein interfaces: small changes over big surfaces have large impacts on human health. Progress in Biophysics and Molecular Biology, 128, 3-13. doi: 10.1016/j.pbiomolbio.2016.10.002 |
