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2025 Journal Article Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesisOngaro, Luisina, Zhou, Xiang, Wang, Ying, Schultz, Hailey, Zhou, Ziyue, Buddle, Evan R. S., Brûlé, Emilie, Lin, Yeu-Farn, Schang, Gauthier, Hagg, Adam, Castonguay, Roselyne, Liu, Yewei, Su, Gloria H., Seidah, Nabil G., Ray, Kevin C., Karp, Seth J., Boehm, Ulrich, Ruf-Zamojski, Frederique, Sealfon, Stuart C., Walton, Kelly L., Lee, Se-Jin and Bernard, Daniel J. (2025). Muscle-derived myostatin is a major endocrine driver of follicle-stimulating hormone synthesis. Science, 387 (6731), 329-336. doi: 10.1126/science.adi4736 |
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2023 Journal Article Targeting activins and inhibins to treat reproductive disorders and cancer cachexiaHagg, Adam, O'Shea, Eliza, Harrison, Craig A. and Walton, Kelly Louise (2023). Targeting activins and inhibins to treat reproductive disorders and cancer cachexia. Journal of Endocrinology, 258 (1) e220290, 1-15. doi: 10.1530/joe-22-0290 |
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2021 Journal Article Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexiaSartori, Roberta, Hagg, Adam, Zampieri, Sandra, Armani, Andrea, Winbanks, Catherine E., Viana, Lais R., Haidar, Mouna, Watt, Kevin, Qian, Hongwei, Pezzini, Camilla, Zanganeh, Pardis, Turner, Bradley J., Larsson, Anna, Zanchettin, Gianpietro, Pierobon, Elisa S., Moletta, Lucia, Valmasoni, Michele, Ponzoni, Alberto, Attar, Shady, Da Dalt, Gianfranco, Sperti, Cosimo, Kustermann, Monika, Thomson, Rachel E., Larsson, Lars, Loveland, Kate L., Costelli, Paola, Megighian, Aram, Merigliano, Stefano, Penna, Fabio ... Sandri, Marco (2021). Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia. Science Translational Medicine, 13 (605) eaay9592. doi: 10.1126/scitranslmed.aay9592 |
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2021 Journal Article Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic diseaseWatt, K., Henstridge, D. C., Ziemann, M., Sim, C. B., Montgomery, M. K., Samocha-Bonet, D., Parker, B. L., Dodd, G. T., Bond, S. T., Salmi, T. M., Lee, R. S., Thomson, R. E., Hagg, A., Davey, J. R., Qian, H., Koopman, R., El-Osta, A., Greenfield, J. R., Watt, M. J., Febbraio, M. A., Drew, B. G., Cox, A. G., Porrello, E. R., Harvey, K. F. and Gregorevic, P. (2021). Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease. Nature Communications, 12 (1) 2887. doi: 10.1038/s41467-021-23240-7 |
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2021 Journal Article Dynamic changes to the skeletal muscle proteome and ubiquitinome induced by the E3 ligase, ASB2βGoodman, Craig A., Davey, Jonathan R., Hagg, Adam, Parker, Benjamin L. and Gregorevic, Paul (2021). Dynamic changes to the skeletal muscle proteome and ubiquitinome induced by the E3 ligase, ASB2β. Molecular and Cellular Proteomics, 20 100050, 100050. doi: 10.1016/j.mcpro.2021.100050 |
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2020 Journal Article TMEPAI/PMEPA1 is a positive regulator of skeletal muscle massHagg, Adam, Kharoud, Swati, Goodchild, Georgia, Goodman, Craig A., Chen, Justin L., Thomson, Rachel E., Qian, Hongwei, Gregorevic, Paul, Harrison, Craig A. and Walton, Kelly L. (2020). TMEPAI/PMEPA1 is a positive regulator of skeletal muscle mass. Frontiers in Physiology, 11 560225, 560225. doi: 10.3389/fphys.2020.560225 |
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2020 Journal Article Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetesDavey, Jonathan R., Estevez, Emma, Thomson, Rachel E., Whitham, Martin, Watt, Kevin I., Hagg, Adam, Qian, Hongwei, Henstridge, Darren C., Ludlow, Helen, Hedger, Mark P., McGee, Sean L., Coughlan, Melinda T., Febbraio, Mark A. and Gregorevic, Paul (2020). Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes. The FASEB Journal, 34 (4), 5697-5714. doi: 10.1096/fj.201802059rrr |
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2019 Journal Article Activin A–induced cachectic wasting is attenuated by systemic delivery of its cognate propeptide in male miceWalton, Kelly L., Chen, Justin L., Arnold, Quinn, Kelly, Emily, La, Mylinh, Lu, Louis, Lovrecz, George, Hagg, Adam, Colgan, Timothy D., Qian, Hongwei, Gregorevic, Paul and Harrison, Craig A. (2019). Activin A–induced cachectic wasting is attenuated by systemic delivery of its cognate propeptide in male mice. Endocrinology, 160 (10), 2417-2426. doi: 10.1210/en.2019-00257 |
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2018 Journal Article Molecular characterization of latent GDF8 reveals mechanisms of activationWalker, Ryan G., McCoy, Jason C., Czepnik, Magdalena, Mills, Melanie J., Hagg, Adam, Walton, Kelly L., Cotton, Thomas R., Hyvönen, Marko, Lee, Richard T., Gregorevic, Paul, Harrison, Craig A. and Thompson, Thomas B. (2018). Molecular characterization of latent GDF8 reveals mechanisms of activation. Proceedings of the National Academy of Sciences of the United States of America, 115 (5), E866-E875. doi: 10.1073/pnas.1714622115 |
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2017 Journal Article Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and diseaseChen, Justin L., Walton, Kelly L., Hagg, Adam, Colgan, Timothy D., Johnson, Katharine, Qian, Hongwei, Gregorevic, Paul and Harrison, Craig A. (2017). Specific targeting of TGF-β family ligands demonstrates distinct roles in the regulation of muscle mass in health and disease. Proceedings of the National Academy of Sciences of the United States of America, 114 (26), E5266-E5275. doi: 10.1073/pnas.1620013114 |
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2016 Journal Article Differential effects of IL6 and activin A in the development of cancer-associated cachexiaChen, Justin L., Walton, Kelly L., Qian, Hongwei, Colgan, Timothy D., Hagg, Adam, Watt, Matthew J., Harrison, Craig A. and Gregorevic, Paul (2016). Differential effects of IL6 and activin A in the development of cancer-associated cachexia. Cancer Research, 76 (18), 5372-5382. doi: 10.1158/0008-5472.CAN-15-3152 |
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2016 Journal Article Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in miceWinbanks, Catherine E., Murphy, Kate T., Bernardo, Bianca C., Qian, Hongwei, Liu, Yingying, Sepulveda, Patricio V., Beyer, Claudia, Hagg, Adam, Thomson, Rachel E., Chen, Justin L., Walton, Kelly L., Loveland, Kate L., McMullen, Julie R., Rodgers, Buel D., Harrison, Craig A., Lynch, Gordon S. and Gregorevic, Paul (2016). Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice. Science Translational Medicine, 8 (348) 348ra98. doi: 10.1126/scitranslmed.aac4976 |
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2016 Journal Article Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre sizeHagg, Adam, Colgan, Timothy D., Thomson, Rachel E., Qian, Hongwei, Lynch, Gordon S. and Gregorevic, Paul (2016). Using AAV vectors expressing the β2-adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size. Scientific Reports, 6 (1) 23042, 23042. doi: 10.1038/srep23042 |
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2015 Journal Article Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomySepulveda, Patricio V., Lamon, Severine, Hagg, Adam, Thomson, Rachel E., Winbanks, Catherine E., Qian, Hongwei, Bruce, Clinton R., Russell, Aaron P. and Gregorevic, Paul (2015). Evaluation of follistatin as a therapeutic in models of skeletal muscle atrophy associated with denervation and tenotomy. Scientific Reports, 5 (1) 17535, 17535. doi: 10.1038/srep17535 |
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2015 Journal Article The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre sizeWatt, K. I., Turner, B. J., Hagg, A., Zhang, X., Davey, J. R., Qian, H., Beyer, C., Winbanks, C. E., Harvey, K. F. and Gregorevic, P. (2015). The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size. Nature Communications, 6 (1) 6048, 6048. doi: 10.1038/ncomms7048 |
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2013 Journal Article miR-206 represses hypertrophy of myogenic cells but not muscle fibers via inhibition of HDAC4Winbanks, Catherine E., Beyer, Claudia, Hagg, Adam, Qian, Hongwei, Sepulveda, Patricio V. and Gregorevic, Paul (2013). miR-206 represses hypertrophy of myogenic cells but not muscle fibers via inhibition of HDAC4. PLoS One, 8 (9) e73589, e73589. doi: 10.1371/journal.pone.0073589 |
