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2017 Journal Article Modulation of antigen presenting cell functions during chronic HPV infectionBashaw, Abate Assefa, Leggatt, Graham R., Chandra, Janin, Tuong, Zewen K. and Frazer, Ian H. (2017). Modulation of antigen presenting cell functions during chronic HPV infection. Papillomavirus Research, 4, 58-65. doi: 10.1016/j.pvr.2017.08.002 |
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2017 Journal Article Interferon-gamma derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicityBhat, Purnima, Leggatt, Graham, Waterhouse, Nigel and Frazer, Ian H. (2017). Interferon-gamma derived from cytotoxic lymphocytes directly enhances their motility and cytotoxicity. Cell Death and Disease, 8 (6) e2836, e2836.1-e2836.11. doi: 10.1038/cddis.2017.67 |
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2017 Journal Article Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patientsLinedale, Richard, Schmidt, Campbell, King, Brigid T., Ganko, Annabelle G., Simpson, Fiona, Panizza, Benedict J. and Graham R. Leggatt (2017). Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients. PLoS One, 12 (4) e0175755, e0175755.1-e0175755.13. doi: 10.1371/journal.pone.0175755 |
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2017 Journal Article HPV16-E7-specific activated CD8 T cells in E7 transgenic skin and skin graftsJazayeri, Seyed D., Kuo, Paula, Leggatt, Graham R. and Frazer, Ian (2017). HPV16-E7-specific activated CD8 T cells in E7 transgenic skin and skin grafts. Frontiers in Immunology, 8 (MAY) 524, 524. doi: 10.3389/fimmu.2017.00524 |
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2017 Journal Article DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejectionChandra, Janin, Dutton, Julie L., Li, Bo, Woo, Wai-Ping, Xu, Yan, Tolley, Lynn K., Yong, Michelle, Wells, James W., Leggatt, Graham R., Finlayson, Neil and Frazer, Ian H. (2017). DNA vaccine encoding HPV16 oncogenes E6 and E7 induces potent cell-mediated and humoral immunity which protects in tumor challenge and drives E7-expressing skin graft rejection. Journal of Immunotherapy, 40 (2), 62-70. doi: 10.1097/CJI.0000000000000156 |
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2016 Journal Article Control of B-cell lymphoma by therapeutic vaccination and acquisition of immune resistance is independent of direct tumour IFN-gamma signallingRearden, Rory, Sah, Amelia, Doff, Brianna, Kobayashi, Takumi, McKee, Sara J., Leggatt, Graham R. and Mattarollo, Stephen R. (2016). Control of B-cell lymphoma by therapeutic vaccination and acquisition of immune resistance is independent of direct tumour IFN-gamma signalling. Immunology and Cell Biology, 94 (6), 554-562. doi: 10.1038/icb.2016.9 |
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2016 Journal Article Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spreadChawla, Sharad, Warren, Timothy A., Wockner, Leesa F., Lambie, Duncan L. J., Brown, Ian S., Martin, Thomas P. C., Khanna, Rajiv, Leggatt, Graham R. and Panizza, Benedict J. (2016). Galectin-1 is associated with poor prognosis in patients with cutaneous head and neck cancer with perineural spread. Cancer Immunology, Immunotherapy, 65 (2), 213-222. doi: 10.1007/s00262-015-1788-z |
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2015 Journal Article Aurora A is critical for survival in HPV-transformed cervical cancerGabrielli, Brian, Bokhari, Fawzi, Ranall, Max V., Oo, Zay Yar, Stevenson, Alexander J., Wang, Weili, Murrell, Melanie, Shaikh, Mushfiq, Fallaha, Sora, Clarke, Daniel, Kelly, Madison, Sedelies, Karin, Christensen, Melinda, McKee, Sara, Leggatt, Graham, Leo, Paul, Skalamera, Dubravka, Soyer, H. Peter, Gonda, Thomas J. and McMillan, Nigel A. J. (2015). Aurora A is critical for survival in HPV-transformed cervical cancer. Molecular Cancer Therapeutics, 14 (12), 2753-2761. doi: 10.1158/1535-7163.MCT-15-0506 |
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2015 Journal Article Langerhans cell homeostasis and activation is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermisAbd Warif, Nor Malia, Stoitzner, Patrizia, Leggatt, Graham R., Mattarollo, Stephen R., Frazer, Ian H. and Hibma, Merilyn H. (2015). Langerhans cell homeostasis and activation is altered in hyperplastic human papillomavirus type 16 E7 expressing epidermis. PLoS One, 10 (5) e0127155, e0127155-e0127155. doi: 10.1371/journal.pone.0127155 |
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2015 Journal Article Recent progress in vaccination against human papillomavirus-mediated cervical cancerMcKee, Sara J., Bergot, Anne-Sophie and Leggatt, Graham R. (2015). Recent progress in vaccination against human papillomavirus-mediated cervical cancer. Reviews in Medical Virology, 25 (S1), 54-71. doi: 10.1002/rmv.1824 |
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2015 Journal Article NKT cell-targeted vaccination plus anti-4-1BB antibody generates persistent CD8 T cell immunity against B cell lymphomaKobayashi, Takumi, Doff, Brianna L., Rearden, Rory C., Leggatt, Graham R. and Mattarollo, Stephen R. (2015). NKT cell-targeted vaccination plus anti-4-1BB antibody generates persistent CD8 T cell immunity against B cell lymphoma. Oncoimmunology, 4 (3) e990793, e990793-1-e990793-11. doi: 10.4161/2162402X.2014.990793 |
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2014 Journal Article HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cellsBergot, Anne-Sophie, Ford, Neill, Leggatt, Graham R., Wells, James W., Frazer, Ian H. and Grimbaldeston, Michele A. (2014). HPV16-E7 expression in squamous epithelium creates a local immune suppressive environment via CCL2- and CCL5- mediated recruitment of mast cells. PLoS Pathogens, 10 (10) e1004466, 1-11. doi: 10.1371/journal.ppat.1004466 |
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2014 Journal Article Peptide dose and/or structure in vaccines as a determinant of T cell responsesLeggatt, Graham R. (2014). Peptide dose and/or structure in vaccines as a determinant of T cell responses. Vaccines, 2 (3), 537-548. doi: 10.3390/vaccines2030537 |
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2014 Journal Article Immunosuppressive roles of natural killer T (NKT) cells in the skinMcKee, Sara J., Mattarollo, Stephen R. and Leggatt, Graham R. (2014). Immunosuppressive roles of natural killer T (NKT) cells in the skin. Journal of Leukocyte Biology, 96 (1), 49-54. doi: 10.1189/jlb.4RU0114-001R |
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2014 Journal Article Correction: the kinematics of cytotoxic lymphocytes influence their ability to kill target cellsBhat, Purnima, Leggatt, Graham, Matthaei, Klaus I. and Frazer, Ian H. (2014). Correction: the kinematics of cytotoxic lymphocytes influence their ability to kill target cells. PLoS One, 9 (6) e101381, e101381. doi: 10.1371/journal.pone.0101381 |
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2014 Journal Article The kinematics of cytotoxic lymphocytes influence their ability to kill target cellsBhat, Purnima, Leggatt, Graham, Matthaei, Klaus I. and Frazer, Ian H. (2014). The kinematics of cytotoxic lymphocytes influence their ability to kill target cells. PLoS One, 9 (5) e95248, e95248.1-e95248.11. doi: 10.1371/journal.pone.0095248 |
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2013 Journal Article Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7Mittal, Deepak, Kassianos, Andrew. J, Tran, Lee S., Bergot, Anne-Sophie, Gosmann, Christina, Hofmann, Janin, Blumenthal, Antje, Leggatt, Graham R. and Frazer, Ian H. (2013). Indoleamine 2,3-dioxygenase activity contributes to local immune suppression in the skin expressing human papillomavirus oncoprotein E7. Journal of Investigative Dermatology, 133 (12), 2686-2694. doi: 10.1038/jid.2013.222 |
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2013 Journal Article Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytesChoyce, Allison, Yong, Michelle, Narayan, Sharmal, Mattarollo, Stephen R., Liem, Amy, Lambert, Paul F., Frazer, Ian H. and Leggatt, Graham R. (2013). Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes. PLoS One, 8 (2) e57798, e57798.1-e57798.8. doi: 10.1371/journal.pone.0057798 |
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2012 Journal Article A Combination of Local Inflammation and Central Memory T Cells Potentiates Immunotherapy in the SkinFiorenza, Salvatore, Kenna, Tony J., Comerford, Iain, McColl, Shaun, Steptoe, Raymond J., Leggatt, Graham R. and Frazer, Ian H. (2012). A Combination of Local Inflammation and Central Memory T Cells Potentiates Immunotherapy in the Skin. Journal of Immunology, 189 (12), 5622-5631. doi: 10.4049/jimmunol.1200709 |
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2012 Journal Article Impact of sex steroid ablation on viral, tumour and vaccine responses in aged miceHeng, Tracy S. P., Reiseger, Jessica J., Fletcher, Anne L., Leggatt, Graham R., White, Olivia J., Vlahos, Katerina, Frazer, Ian H., Turner, Stephen J. and Boyd, Richard L. (2012). Impact of sex steroid ablation on viral, tumour and vaccine responses in aged mice. PLoS One, 7 (8) e42677, e42677.1-e42677.11. doi: 10.1371/journal.pone.0042677 |
