|
2025 Journal Article Abstract A118: Targeting Replication Stress Promotes Anti-tumour Immune Responses that are Suppressed by Tumour-associated Myeloid cellsZeng, Zhen, Bhatt, Ritu, Gandini, Anastasia, Cruz, Jazmina Gonzalez, Proctor, Martina, Irvine, Katharine, Dolcetti, Riccardo, Wells, James and Gabrielli, Brian (2025). Abstract A118: Targeting Replication Stress Promotes Anti-tumour Immune Responses that are Suppressed by Tumour-associated Myeloid cells. Cancer Immunology Research, 13 (2_Supplement), A118-A118. doi: 10.1158/2326-6074.io2025-a118 |
|
2025 Journal Article Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cellsVora, Shivam, Chatterjee, Saptarshi, Andrew, Ariel, Kumar, Ramyashree Prasanna, Proctor, Martina, Zeng, Zhen, Bhatt, Rituparna, Nazareth, Deborah, Fernando, Madushan, Jones, Mathew J. K., He, Yaowu, Hooper, John D., McMillan, Nigel A. J., Urosevic, Jelena, Saeh, Jamal, Travers, Jon, Cimini, Daniela, Chen, Jing and Gabrielli, Brian (2025). Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells. Cell Death & Disease, 16 (1) 7, 7-1. doi: 10.1038/s41419-024-07329-7 |
|
2024 Journal Article Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibitionVora, Shivam, Andrew, Ariel, Kumar, Ramyashree Prasanna, Nazareth, Deborah, Bonfim-Melo, Alexis, Lim, Yoon, Ong, Xin Yee, Fernando, Madushan, He, Yaowu, Hooper, John D., McMillan, Nigel A. J., Urosevic, Jelena, Travers, Jon, Saeh, Jamal, Kumar, Sharad, Jones, Mathew J. K. and Gabrielli, Brian (2024). Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition. Cell Death & Disease, 15 (11) 810. doi: 10.1038/s41419-024-07204-5 |
|
2024 Journal Article The ATM Ser49Cys variant effects ATM function as a regulator of oncogene-induced senescenceAtkinson, Caroline, McInerney-Leo, Aideen, Proctor, Martina, Lanagan, Catherine, Stevenson, Alexander, Dehkhoda, Farhad, Caole, Mary, Maas, Ellie, Ainger, Stephen, Pritchard, Antonia, Johansson, Peter, Leo, Paul, Hayward, Nicholas, Sturm, Richard, Duncan, Emma and Gabrielli, Brian (2024). The ATM Ser49Cys variant effects ATM function as a regulator of oncogene-induced senescence. International Journal of Molecular Sciences, 25 (3) 1664, 1-12. doi: 10.3390/ijms25031664 |
|
2024 Journal Article Checkpoint kinase 1 inhibitor + low‐dose hydroxyurea efficiently kills BRAF inhibitor‐ and immune checkpoint inhibitor‐resistant melanomasZeng, Zhen, Ngo, Hung Long, Proctor, Martina, Rizos, Helen, Dolcetti, Riccardo, Cruz, Jazmina Gonzalez, Wells, James W. and Gabrielli, Brian (2024). Checkpoint kinase 1 inhibitor + low‐dose hydroxyurea efficiently kills BRAF inhibitor‐ and immune checkpoint inhibitor‐resistant melanomas. Pigment Cell and Melanoma Research, 37 (1), 45-50. doi: 10.1111/pcmr.13120 |
|
2024 Journal Article Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cellsShah, Esha T., Molloy, Christopher, Gough, Madeline, Kryza, Thomas, Samuel, Selwin G., Tucker, Amos, Bhatia, Maneet, Ferguson, Genevieve, Heyman, Rebecca, Vora, Shivam, Monkman, James, Bolderson, Emma, Kulasinghe, Arutha, He, Yaowu, Gabrielli, Brian, Hooper, John D., Richard, Derek J., O’Byrne, Kenneth J. and Adams, Mark N. (2024). Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells. British Journal of Cancer, 130 (7), 1196-1205. doi: 10.1038/s41416-024-02584-z |
|
2022 Journal Article Repurposing of commercially existing molecular target therapies to boost the clinical efficacy of immune checkpoint blockadeSinha, Debottam, Moseley, Philip, Lu, Xuehan, Wright, Quentin, Gabrielli, Brian, Frazer, Ian H. and Cruz, Jazmina L. G. (2022). Repurposing of commercially existing molecular target therapies to boost the clinical efficacy of immune checkpoint blockade. Cancers, 14 (24) 6150, 1-26. doi: 10.3390/cancers14246150 |
|
2021 Journal Article Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour RegressionProctor, Martina, Gonzalez Cruz, Jazmina L., Daignault-Mill, Sheena M., Veitch, Margaret, Zeng, Bijun, Ehmann, Anna, Sabdia, Muhammed, Snell, Cameron, Keane, Colm, Dolcetti, Riccardo, Haass, Nikolas K., Wells, James W. and Gabrielli, Brian (2021). Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression. Cancers, 13 (15) 3733, 1-19. doi: 10.3390/cancers13153733 |
|
2021 Journal Article Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumoursFernando, Madushan, Duijf, Pascal H. G., Proctor, Martina, Stevenson, Alexander J., Ehmann, Anna, Vora, Shivam, Skalamera, Dubravka, Adams, Mark and Gabrielli, Brian (2021). Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours. Oncogenesis, 10 (5) 41, 41. doi: 10.1038/s41389-021-00329-8 |
|
2020 Journal Article Smart drug combinations for cervical cancer: dual targeting of Bcl-2 family of proteins and aurora kinasesYumol, Jacklyn, Gabrielli, Brian, Tayyar, Yaman, McMillan, Nigel Aj and Idris, Adi (2020). Smart drug combinations for cervical cancer: dual targeting of Bcl-2 family of proteins and aurora kinases. American Journal of Cancer Research, 10 (10), 3406-3414. |
|
2020 Journal Article Unexpected high levels of BRN2/POU3F2 expression in human dermal melanocytic neviChitsazan, Arash, Lambie, Duncan, Ferguson, Blake, Handoko, Herlina Y., Gabrielli, Brian, Walker, Graeme J. and Boyle, Glen M. (2020). Unexpected high levels of BRN2/POU3F2 expression in human dermal melanocytic nevi. Journal of Investigative Dermatology, 140 (6), 1299-1302.e4. doi: 10.1016/j.jid.2019.12.007 |
|
2019 Journal Article Melanoma mutations modify melanocyte dynamics in co-culture with keratinocytes or fibroblastsŠkalamera, Dubravka, Stevenson, Alexander J., Ehmann, Anna, Ainger, Stephen A., Lanagan, Catherine, Sturm, Richard A. and Gabrielli, Brian (2019). Melanoma mutations modify melanocyte dynamics in co-culture with keratinocytes or fibroblasts. Journal of Cell Science, 132 (24) jcs234716, jcs234716. doi: 10.1242/jcs.234716 |
|
2019 Journal Article Multiple interaction nodes define the post-replication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation loadPavey, Sandra, Pinder, Alex, Fernando, Winnie, D'Arcy, Nicholas, Matigian, Nicholas, Skalamera, Dubravka, Lê Cao, Kim-Anh, Loo-Oey, Dorothy, Hill, Michelle M., Stark, Mitchell, Kimlin, Michael, Burgess, Andrew, Cloonan, Nicole, Sturm, Richard A. and Gabrielli, Brian (2019). Multiple interaction nodes define the post-replication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load. Molecular Oncology, 14 (1) 1878-0261.12601, 22-41. doi: 10.1002/1878-0261.12601 |
|
2019 Journal Article Everything in moderation: lessons learned by exploiting moderate replication stress in cancerNazareth, Deborah, Jones, Matthew J.K. and Gabrielli, Brian (2019). Everything in moderation: lessons learned by exploiting moderate replication stress in cancer. Cancers, 11 (9) 1320, 1320. doi: 10.3390/cancers11091320 |
|
2019 Journal Article Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabineOo, Zay Yar, Proctor, Martina, Stevenson, Alexander J., Nazareth, Deborah, Fernando, Madushan, Daignault, Sheena M., Lanagan, Catherine, Walpole, Sebastian, Bonazzi, Vanessa, Škalamera, Dubravka, Snell, Cameron, Haass, Nikolas K., Larsen, Jill E. and Gabrielli, Brian (2019). Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine. Molecular Oncology, 13 (7) 1878-0261.12497, 1503-1518. doi: 10.1002/1878-0261.12497 |
|
2018 Journal Article Aurora kinases are a novel therapeutic target for HPV-positive head and neck cancersShaikh, Mushfiq H., Idris, Adi, Johnson, Newell W., Fallaha, Sora, Clarke, Daniel T.W., Martin, David, Morgan, Iain M., Gabrielli, Brian and McMillan, Nigel A. J. (2018). Aurora kinases are a novel therapeutic target for HPV-positive head and neck cancers. Oral Oncology, 86, 105-112. doi: 10.1016/j.oraloncology.2018.09.006 |
|
2018 Journal Article Pathway dysregulation analysis of the nucleotide excision repair mechanisms reveals it is not a common feature of melanomasD’Arcy, Nicholas, Matigian, Nicholas, Lê Cao, Kim-Anh and Gabrielli, Brian (2018). Pathway dysregulation analysis of the nucleotide excision repair mechanisms reveals it is not a common feature of melanomas. Pigment Cell & Melanoma Research, 32 (2), 336-338. doi: 10.1111/pcmr.12740 |
|
2018 Journal Article CEP55 is a determinant of cell fate during perturbed mitosis in breast cancerKalimutho, Murugan, Sinha, Debottam, Jeffery, Jessie, Nones, Katia, Srihari, Sriganesh, Fernando, Winnie C., Duijf, Pascal H. G., Vennin, Claire, Raninga, Prahlad, Nanayakkara, Devathri, Mittal, Deepak, Saunus, Jodi M., Lakhani, Sunil R., López, J Alejandro, Spring, Kevin J., Timpson, Paul, Gabrielli, Brian, Waddell, Nicola and Khanna, Kum Kum (2018). CEP55 is a determinant of cell fate during perturbed mitosis in breast cancer. EMBO Molecular Medicine, 10 (9) e8566. doi: 10.15252/emmm.201708566 |
|
2018 Journal Article Endogenous replication stress marks melanomas sensitive to CHEK1 inhibitors in vivoOo, Zay Yar, Stevenson, Alexander J., Proctor, Martina A., Daignault, Sheena M., Walpole, Sebastian, Lanagan, Catherine, Chen, James, Skalamera, Dubravka, Spoerri, Loredana, Ainger, Stephen, Sturm, Richard A, Haass, Nikolas K and Gabrielli, Brian (2018). Endogenous replication stress marks melanomas sensitive to CHEK1 inhibitors in vivo. Clinical Cancer Research, 24 (12), 2901-2912. doi: 10.1158/1078-0432.CCR-17-2701 |
|
2018 Journal Article Mechanism of action of the third generation benzopyrans and evaluation of their broad anti-cancer activity in vitro and in vivoStevenson, Alexander J., Ager, Eleanor I., Proctor, Martina A., Škalamera, Dubravka, Heaton, Andrew, Brown, David and Gabrielli, Brian G. (2018). Mechanism of action of the third generation benzopyrans and evaluation of their broad anti-cancer activity in vitro and in vivo. Scientific Reports, 8 (1) 22882, 5144. doi: 10.1038/s41598-018-22882-w |
