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2025 Journal Article Abstract A118: Targeting Replication Stress Promotes Anti-tumour Immune Responses that are Suppressed by Tumour-associated Myeloid cellsZeng, Zhen, Bhatt, Ritu, Gandini, Anastasia, Cruz, Jazmina Gonzalez, Proctor, Martina, Irvine, Katharine, Dolcetti, Riccardo, Wells, James and Gabrielli, Brian (2025). Abstract A118: Targeting Replication Stress Promotes Anti-tumour Immune Responses that are Suppressed by Tumour-associated Myeloid cells. Cancer Immunology Research, 13 (2_Supplement), A118-A118. doi: 10.1158/2326-6074.io2025-a118 |
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2025 Journal Article Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cellsVora, Shivam, Chatterjee, Saptarshi, Andrew, Ariel, Kumar, Ramyashree Prasanna, Proctor, Martina, Zeng, Zhen, Bhatt, Rituparna, Nazareth, Deborah, Fernando, Madushan, Jones, Mathew J. K., He, Yaowu, Hooper, John D., McMillan, Nigel A. J., Urosevic, Jelena, Saeh, Jamal, Travers, Jon, Cimini, Daniela, Chen, Jing and Gabrielli, Brian (2025). Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells. Cell Death & Disease, 16 (1) 7, 7-1. doi: 10.1038/s41419-024-07329-7 |
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2024 Journal Article Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibitionVora, Shivam, Andrew, Ariel, Kumar, Ramyashree Prasanna, Nazareth, Deborah, Bonfim-Melo, Alexis, Lim, Yoon, Ong, Xin Yee, Fernando, Madushan, He, Yaowu, Hooper, John D., McMillan, Nigel AJ, Urosevic, Jelena, Travers, Jon, Saeh, Jamal, Kumar, Sharad, Jones, Mathew JK and Gabrielli, Brian (2024). Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition. Cell Death & Disease, 15 (11) 810, 810. doi: 10.1038/s41419-024-07204-5 |
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2024 Journal Article The ATM Ser49Cys variant effects ATM function as a regulator of oncogene-induced senescenceAtkinson, Caroline, McInerney-Leo, Aideen, Proctor, Martina, Lanagan, Catherine, Stevenson, Alexander, Dehkhoda, Farhad, Caole, Mary, Maas, Ellie, Ainger, Stephen, Pritchard, Antonia, Johansson, Peter, Leo, Paul, Hayward, Nicholas, Sturm, Richard, Duncan, Emma and Gabrielli, Brian (2024). The ATM Ser49Cys variant effects ATM function as a regulator of oncogene-induced senescence. International Journal of Molecular Sciences, 25 (3) 1664, 1-12. doi: 10.3390/ijms25031664 |
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2024 Journal Article Checkpoint kinase 1 inhibitor + low‐dose hydroxyurea efficiently kills BRAF inhibitor‐ and immune checkpoint inhibitor‐resistant melanomasZeng, Zhen, Ngo, Hung Long, Proctor, Martina, Rizos, Helen, Dolcetti, Riccardo, Cruz, Jazmina Gonzalez, Wells, James W. and Gabrielli, Brian (2024). Checkpoint kinase 1 inhibitor + low‐dose hydroxyurea efficiently kills BRAF inhibitor‐ and immune checkpoint inhibitor‐resistant melanomas. Pigment Cell and Melanoma Research, 37 (1), 45-50. doi: 10.1111/pcmr.13120 |
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2024 Journal Article Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cellsShah, Esha T., Molloy, Christopher, Gough, Madeline, Kryza, Thomas, Samuel, Selwin G., Tucker, Amos, Bhatia, Maneet, Ferguson, Genevieve, Heyman, Rebecca, Vora, Shivam, Monkman, James, Bolderson, Emma, Kulasinghe, Arutha, He, Yaowu, Gabrielli, Brian, Hooper, John D., Richard, Derek J., O’Byrne, Kenneth J. and Adams, Mark N. (2024). Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells. British Journal of Cancer, 130 (7), 1196-1205. doi: 10.1038/s41416-024-02584-z |
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2023 Conference Publication MITF-mediated changes of tumour architecture, tensile stress and in extracellular matrix (ECM) control intratumour heterogeneity in melanomaSpoerri, L., Tonnessen-Murray, C. A., Beaumont, K. A., Hill, D. S., Jurek, R. J., Gunasingh, G., Vanwalleghem, G., Daignault, S., Fane, M. E., Schaider, H., Smith, A., Stehbens, S. J., Weninger, W., Scott, E. E., Gabrielli, B. and Haass, N. (2023). MITF-mediated changes of tumour architecture, tensile stress and in extracellular matrix (ECM) control intratumour heterogeneity in melanoma. Meeting of the Arbeitsgemeinschaft Dermatologische Forschung (ADF), Berlin, Germany, 11-14 March 2020. Chichester, West Sussex United Kingdom: Wiley-Blackwell. |
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2022 Journal Article Repurposing of commercially existing molecular target therapies to boost the clinical efficacy of immune checkpoint blockadeSinha, Debottam, Moseley, Philip, Lu, Xuehan, Wright, Quentin, Gabrielli, Brian, Frazer, Ian H. and Cruz, Jazmina L. G. (2022). Repurposing of commercially existing molecular target therapies to boost the clinical efficacy of immune checkpoint blockade. Cancers, 14 (24) 6150, 1-26. doi: 10.3390/cancers14246150 |
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2021 Journal Article Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour RegressionProctor, Martina, Gonzalez Cruz, Jazmina L., Daignault-Mill, Sheena M., Veitch, Margaret, Zeng, Bijun, Ehmann, Anna, Sabdia, Muhammed, Snell, Cameron, Keane, Colm, Dolcetti, Riccardo, Haass, Nikolas K., Wells, James W. and Gabrielli, Brian (2021). Targeting Replication Stress Using CHK1 Inhibitor Promotes Innate and NKT Cell Immune Responses and Tumour Regression. Cancers, 13 (15) 3733, 1-19. doi: 10.3390/cancers13153733 |
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2021 Journal Article Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumoursFernando, Madushan, Duijf, Pascal H. G., Proctor, Martina, Stevenson, Alexander J., Ehmann, Anna, Vora, Shivam, Skalamera, Dubravka, Adams, Mark and Gabrielli, Brian (2021). Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours. Oncogenesis, 10 (5) 41, 41. doi: 10.1038/s41389-021-00329-8 |
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2020 Journal Article Smart drug combinations for cervical cancer: dual targeting of Bcl-2 family of proteins and aurora kinasesYumol, Jacklyn, Gabrielli, Brian, Tayyar, Yaman, McMillan, Nigel Aj and Idris, Adi (2020). Smart drug combinations for cervical cancer: dual targeting of Bcl-2 family of proteins and aurora kinases. American Journal of Cancer Research, 10 (10), 3406-3414. |
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2020 Journal Article Unexpected high levels of BRN2/POU3F2 expression in human dermal melanocytic neviChitsazan, Arash, Lambie, Duncan, Ferguson, Blake, Handoko, Herlina Y., Gabrielli, Brian, Walker, Graeme J. and Boyle, Glen M. (2020). Unexpected high levels of BRN2/POU3F2 expression in human dermal melanocytic nevi. Journal of Investigative Dermatology, 140 (6), 1299-1302.e4. doi: 10.1016/j.jid.2019.12.007 |
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2019 Conference Publication Inhibition of Aurora B kinase activity triggers senescence that can be bypassed by blocking p53 and RB function, promoting replication stressAndrews, Ariel, Kumar, Ramyashree Prasanna, Nazareth, Deborah, Ehmann, Anna, Hooper, John, McMillan, Nigel and Gabrielli, Brian (2019). Inhibition of Aurora B kinase activity triggers senescence that can be bypassed by blocking p53 and RB function, promoting replication stress. AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, MA USA, 26-30 October 2019. Philadelphia, PA USA: American Association for Cancer Research. doi: 10.1158/1535-7163.TARG-19-A060 |
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2019 Journal Article Melanoma mutations modify melanocyte dynamics in co-culture with keratinocytes or fibroblastsŠkalamera, Dubravka, Stevenson, Alexander J., Ehmann, Anna, Ainger, Stephen A., Lanagan, Catherine, Sturm, Richard A. and Gabrielli, Brian (2019). Melanoma mutations modify melanocyte dynamics in co-culture with keratinocytes or fibroblasts. Journal of Cell Science, 132 (24) jcs234716, jcs234716. doi: 10.1242/jcs.234716 |
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2019 Journal Article Multiple interaction nodes define the post-replication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation loadPavey, Sandra, Pinder, Alex, Fernando, Winnie, D'Arcy, Nicholas, Matigian, Nicholas, Skalamera, Dubravka, Lê Cao, Kim-Anh, Loo-Oey, Dorothy, Hill, Michelle M., Stark, Mitchell, Kimlin, Michael, Burgess, Andrew, Cloonan, Nicole, Sturm, Richard A. and Gabrielli, Brian (2019). Multiple interaction nodes define the post-replication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load. Molecular Oncology, 14 (1) 1878-0261.12601, 22-41. doi: 10.1002/1878-0261.12601 |
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2019 Journal Article Everything in moderation: lessons learned by exploiting moderate replication stress in cancerNazareth, Deborah, Jones, Matthew J.K. and Gabrielli, Brian (2019). Everything in moderation: lessons learned by exploiting moderate replication stress in cancer. Cancers, 11 (9) 1320, 1320. doi: 10.3390/cancers11091320 |
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2019 Journal Article Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabineOo, Zay Yar, Proctor, Martina, Stevenson, Alexander J., Nazareth, Deborah, Fernando, Madushan, Daignault, Sheena M., Lanagan, Catherine, Walpole, Sebastian, Bonazzi, Vanessa, Škalamera, Dubravka, Snell, Cameron, Haass, Nikolas K., Larsen, Jill E. and Gabrielli, Brian (2019). Combined use of subclinical hydroxyurea and CHK1 inhibitor effectively controls melanoma and lung cancer progression, with reduced normal tissue toxicity compared to gemcitabine. Molecular Oncology, 13 (7) 1878-0261.12497, 1503-1518. doi: 10.1002/1878-0261.12497 |
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2019 Conference Publication Bortezomib-induced immunogenic cell death enhances immune response in melanomaDaignault, S. M., Ju, R., Spoerri, L., Stehbens, S. J., Hill, D. S., Gabrielli, B., Dolcetti, R. and Haass, N. K. (2019). Bortezomib-induced immunogenic cell death enhances immune response in melanoma. Society for Investigative Dermatology (SID) Meeting, Chicago, IL United States, 8-11 May 2019. London, United Kingdom: Nature Publishing Group. doi: 10.1016/j.jid.2019.03.907 |
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2019 Conference Publication Subclinical doses and choice of replication stress inducer in combination with CHK1 inhibitors for optimal tumor control and immune responses in vitro and in vivoOo, Zay Yar, Proctor, Martina, Stevenson, Alex, Nazareth, Deborah, Larsen, Jill, Haass, Nikolas and Gabrielli, Brian G. (2019). Subclinical doses and choice of replication stress inducer in combination with CHK1 inhibitors for optimal tumor control and immune responses in vitro and in vivo. AACR Annual Meeting on Bioinformatics, Convergence Science, and Systems Biology, Atlanta Ga, Mar 29-Apr 03, 2019. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1538-7445.AM2019-1236 |
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2018 Journal Article Aurora kinases are a novel therapeutic target for HPV-positive head and neck cancersShaikh, Mushfiq H., Idris, Adi, Johnson, Newell W., Fallaha, Sora, Clarke, Daniel T.W., Martin, David, Morgan, Iain M., Gabrielli, Brian and McMillan, Nigel A. J. (2018). Aurora kinases are a novel therapeutic target for HPV-positive head and neck cancers. Oral Oncology, 86, 105-112. doi: 10.1016/j.oraloncology.2018.09.006 |
