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2014 Journal Article Decatenation checkpoint defective melanomas are dependent on PI3K for survivalBrooks, Kelly, Ranall, Max, Spoerri, Loredana, Stevenson, Alex, Gunasingh, Gency, Pavey, Sandra, Meunier, Fred, Gonda, Thomas J. and Gabrielli, Brian (2014). Decatenation checkpoint defective melanomas are dependent on PI3K for survival. Pigment Cell and Melanoma Research, 27 (5), 813-821. doi: 10.1111/pcmr.12268 |
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2014 Journal Article Rapid mapping of interactions between human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopySierecki, Emma, Stevers, Loes M., Giles, Nichole, Polinkovsky, Mark E., Moustaqil, Mehdi, Mureev, Sergey, Johnston, Wayne A., Dahmer-Heath, Mareike, Skalamera, Duka, Gonda, Thomas J., Gabrielli, Brian, Collins, Brett M., Alexandrov, Kirill and Gambin, Yann (2014). Rapid mapping of interactions between human SNX-BAR proteins measured in vitro by AlphaScreen and single-molecule spectroscopy. Molecular and Cellular Proteomics, 13 (9), 2233-2245. doi: 10.1074/mcp.M113.037275 |
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2014 Journal Article Phenotypic characterization of nevus and tumor patterns in MITF E318K mutation carrier melanoma patientsSturm, Richard A., Fox, Carly, McClenahan, Phil, Jagirdar, Kasturee, Ibarrola-Villava, Maider, Banan, Parastoo, Abbott, Nicola C., Ribas, Gloria, Gabrielli, Brian, Duffy, David L. and Soyer, H. Peter (2014). Phenotypic characterization of nevus and tumor patterns in MITF E318K mutation carrier melanoma patients. Journal of Investigative Dermatology, 134 (1), 141-149. doi: 10.1038/jid.2013.272 |
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2014 Conference Publication Synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancerGabrielli, B., Bokhari, F., Ranall, M., Stevenson, A., Murell, M., Kelly, M., McKee, S., Leggatt, G., Gonda, T. and McMillan, N. (2014). Synthetic lethal screen identifies Aurora A as a selective target in HPV driven cervical cancer. 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Barcelona Spain, 18-21 November 2014. Abingdon, Oxford, United Kingdom: Elsevier. doi: 10.1016/S0959-8049(14)70420-4 |
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2013 Journal Article DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.Pavey, Sandra, Spoerri, Loredana, Haass, Nikolas K. and Gabrielli, Brian (2013). DNA repair and cell cycle checkpoint defects as drivers and therapeutic targets in melanoma.. Pigment Cell and Melanoma Research, 26 (6), 805-816. doi: 10.1111/pcmr.12136 |
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2013 Journal Article CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar fociBoutros, Rose, Mondesert, Odile, Lorenzo, Corinne, Astuti, Puji, McArthur, Grant, Chircop, Megan, Ducommun, Bernard and Gabrielli, Brian (2013). CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci. PLoS One, 8 (7) e67822, e67822.1-e67822.13. doi: 10.1371/journal.pone.0067822 |
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2013 Journal Article Defective decatenation checkpoint function is a common feature of melanomaBrooks, Kelly, Chia, Kee Ming, Spoerri, Loredana, Mukhopadhyay, Pamela, Wigan, Matthew, Stark, Mitchell, Pavey, Sandra and Gabrielli, Brian (2013). Defective decatenation checkpoint function is a common feature of melanoma. Journal of Investigative Dermatology, 134 (1), 150-158. doi: 10.1038/jid.2013.264 |
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2013 Journal Article Oxidative stress and cell senescence combine to cause maximal renal Tubular Epithelial Cell Dysfunction and loss in an in vitro Model of Kidney DiseaseSmall, David M., Bennett, Nigel C., Roy, Sandrine, Gabrielli, Brian G., Johnson, David W. and Gobe, Glenda C. (2013). Oxidative stress and cell senescence combine to cause maximal renal Tubular Epithelial Cell Dysfunction and loss in an in vitro Model of Kidney Disease. Nephron Experimental Nephrology, 122 (3-4), 123-130. doi: 10.1159/000350726 |
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2013 Journal Article Truncated MEK1 is required for transient activation of MAPK signalling in G2 phase cellsPike, Tanya, Widberg, Charlotte, Goodall, Andrew, Payne, Elizabeth, Giles, Nichole, Hancock, John and Gabrielli, Brian (2013). Truncated MEK1 is required for transient activation of MAPK signalling in G2 phase cells. Cellular Signalling, 25 (6), 1423-1428. doi: 10.1016/j.cellsig.2013.03.014 |
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2013 Conference Publication Chk1 inhibitor targets replicative stress in melanomasGabrielli, Brian G., Brooks, Kelly, Edwards, Brooke, Chen, James and Pavey, Sandra (2013). Chk1 inhibitor targets replicative stress in melanomas. 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington Dc, Apr 06-10, 2013. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1538-7445.AM2013-3425 |
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2013 Journal Article Similar, not the same: diverse roles and regulation of cyclin EsSpoerri, Loredana and Gabrielli, Brian (2013). Similar, not the same: diverse roles and regulation of cyclin Es. Cell Cycle, 12 (5), 715-715. doi: 10.4161/cc.23909 |
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2013 Journal Article MicroRNA-182-5-p targets a network of genes involved in DNA repairKrishnan, Keerthana, Steptoe, Anita L., Martin, Hilary C., Wani, Shivangi, Nones, Katia, Waddell, Nic, Mariasegaram, Mythily, Simpson, Peter T., Lakhani, Sunil R., Gabrielli, Brian, Vlassov, Alexander, Cloonan, Nicole and Grimmond, Sean M. (2013). MicroRNA-182-5-p targets a network of genes involved in DNA repair. RNA, 19 (2), 230-242. doi: 10.1261/rna.034926.112 |
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2013 Journal Article A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stressBrooks, K., Oakes, V., Edwards, B., Ranall, M., Leo, P., Pavey, S., Pinder, A., Beamish, H., Mukhopadhyay, P., Lambie, D. and Gabrielli, B. (2013). A potent Chk1 inhibitor is selectively cytotoxic in melanomas with high levels of replicative stress. Oncogene, 32 (6), 788-796. doi: 10.1038/onc.2012.72 |
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2012 Journal Article Generation of a genome scale lentiviral vector library for EF1α promoter-driven expression of hman ORFs and identification of human genes affecting viral titerSkalamera, Dubravka, Dahmer, Mareike, Purdon, Amy S., Wilson, Benjamin M., Ranall, Max V., Blumenthal, Antje, Gabrielli, Brian and Gonda, Thomas J. (2012). Generation of a genome scale lentiviral vector library for EF1α promoter-driven expression of hman ORFs and identification of human genes affecting viral titer. PloS One, 7 (12) e51733, e51733.1-e51733.15. doi: 10.1371/journal.pone.0051733 |
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2012 Journal Article Keeping replicative stress in ChkBrooks, Kelly and Gabrielli, Brian (2012). Keeping replicative stress in Chk. Cell Cycle, 11 (11), 2039-2040. doi: 10.4161/cc.20425 |
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2012 Journal Article A UVR-induced G2-phase checkpoint response to ssDNA gaps produced by replication fork bypass of unrepaired lesions is defective in melanomaWigan, Matthew, Pinder, Alex, Giles, Nichole, Pavey, Sandra, Burgess, Andrew, Wong, ShuShyan, Sturm, Rick A. and Gabrielli, Brian (2012). A UVR-induced G2-phase checkpoint response to ssDNA gaps produced by replication fork bypass of unrepaired lesions is defective in melanoma. Journal of Investigative Dermatology, 132 (6), 1681-1688. doi: 10.1038/jid.2012.41 |
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2012 Journal Article Defective cell cycle checkpoints as targets for anti-cancer therapiesGabrielli, Brian, Brooks, Kelly and Pavey, Sandra (2012). Defective cell cycle checkpoints as targets for anti-cancer therapies. Frontiers in Pharmacology, 3 (9) 9, 9.1-9.6. doi: 10.3389/fphar.2012.00009 |
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2012 Journal Article Multiple melanoma susceptibility factors function in an ultraviolet radiation response pathway in skinGiles, N., Pavey, S., Pinder, A. and Gabrielli, B. (2012). Multiple melanoma susceptibility factors function in an ultraviolet radiation response pathway in skin. British Journal of Dermatology, 166 (2), 362-371. doi: 10.1111/j.1365-2133.2011.10635.x |
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2012 Conference Publication Chk1 inhibitor targets replicative stress in melanomasGabrielli, B., Brooks, K., Oakes, V., Edwards, B., Chen, J. and Mukhopadhyay, P. (2012). Chk1 inhibitor targets replicative stress in melanomas. 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Dublin Ireland, 6-9 November 2012. Oxford, United Kingdom: Pergamon. doi: 10.1158/1538-7445.AM2013-3425 |
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2012 Journal Article Histone deacetylase inhibitors disrupt the mitotic spindle assembly checkpoint by targeting histone and nonhistone proteinsGabrielli, Brian and Brown, Melissa (2012). Histone deacetylase inhibitors disrupt the mitotic spindle assembly checkpoint by targeting histone and nonhistone proteins. Advances in Cancer Research, 116, 1-37. doi: 10.1016/B978-0-12-394387-3.00001-X |
