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2015 Journal Article Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stabilityHossain, Mohammed Akhter, Haugaard-Kedstrom, Linda M., Rosengren, K. Johan, Bathgate, Ross A. D. and Wade, John D. (2015). Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability. Organic and Biomolecular Chemistry, 13 (44), 10895-10903. doi: 10.1039/c5ob01539a |
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2015 Journal Article Isolation, characterization, and synthesis of the barrettides: disulfide-containing peptides from the marine sponge Geodia barrettiCarstens, Bodil B., Rosengren, K. Johan, Gunasekera, Sunithi, Schempp, Stefanie, Bohlin, Lars, Dahlstrom, Mia, Clark, Richard J. and Goransson, Ulf (2015). Isolation, characterization, and synthesis of the barrettides: disulfide-containing peptides from the marine sponge Geodia barretti. Journal of Natural Products, 78 (8), 1886-1893. doi: 10.1021/acs.jnatprod.5b00210 |
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2015 Journal Article Identification, Characterization, and Three-Dimensional Structure of the Novel Circular Bacteriocin, Enterocin NKR-5-3B, from Enterococcus faeciumHimeno, Kohei, Rosengren, K. Johan, Inoue, Tomoko, Perez, Rodney H., Colgrave, Michelle L., Lee, Han Siean, Chan, Lai Y., Henriques, Sonia Troeira, Fujita, Koji, Ishibashi, Naoki, Zendo, Takeshi, Wilaipun, Pongtep, Nakayama, Jiro, Leelawatcharamas, Vichien, Jikuya, Hiroyuki, Craik, David J. and Sonomoto, Kenji (2015). Identification, Characterization, and Three-Dimensional Structure of the Novel Circular Bacteriocin, Enterocin NKR-5-3B, from Enterococcus faecium. Biochemistry, 54 (31), 4863-4876. doi: 10.1021/acs.biochem.5b00196 |
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2015 Journal Article Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriensCardoso, Fernanda C., Deka, Zoltan, Rosengren, K. Johan, Erickson, Andelain, Vetter, Irina, Deuis, Jennifer R., Herzig, Volker, Alewood, Paul F., King, Glenn F. and Lewis, Richard J. (2015). Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens. Molecular Pharmacology, 88 (2), 291-303. doi: 10.1124/mol.115.098178 |
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2015 Journal Article Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibitionde Veer, Simon J., Swedberg, Joakim E., Akcan, Muharrem, Rosengren, K. Johan, Brattsand, Maria, Craik, David J. and Harris, Jonathan M. (2015). Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition. Biochemical Journal, 469 (2), 243-253. doi: 10.1042/BJ20150412 |
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2015 Journal Article Synthesis and pharmacological characterization of a europium-labelled single-chain antagonist for binding studies of the relaxin-3 receptor RXFP3Haugaard-Kedstrom, Linda M, Wong, Lillian L. L, Bathgate, Ross A. D and Rosengren, K. Johan (2015). Synthesis and pharmacological characterization of a europium-labelled single-chain antagonist for binding studies of the relaxin-3 receptor RXFP3. Amino Acids, 47 (6) 1961, 1267-1271. doi: 10.1007/s00726-015-1961-x |
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2015 Journal Article A cactus-derived toxin-like cystine knot peptide with selective antimicrobial activityAboye, Teshome L, Stromstedt, Adam A, Gunasekera, Sunithi, Bruhn, Jan G, El-Seedi, Hesham, Rosengren K.J. and Goransson, Ulf (2015). A cactus-derived toxin-like cystine knot peptide with selective antimicrobial activity. ChemBioChem, 16 (7), 1068-1077. doi: 10.1002/cbic.201402704 |
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2015 Journal Article Solution structure, aggregation behavior, and flexibility of human relaxin-2Haugaard-Kedstrom, Linda, Hossain, Mohammed Akhter, Daly, Norelle L., Bathgate, Ross A. D., Rinderknecht, Ernst, Wade, John D., Craik, David J. and Rosengren, Karl Johan (2015). Solution structure, aggregation behavior, and flexibility of human relaxin-2. ACS Chemical Biology, 10 (3), 891-900. doi: 10.1021/cb500918v |
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2015 Journal Article Stabilization of the Cysteine-Rich Conotoxin MrIA by Using a 1,2,3-Triazole as a Disulfide Bond MimeticGori, Alessandro, Wang, Ching-I A., Harvey, Peta J., Rosengren, K. Johan, Bhola, Rebecca F., Gelmi, Maria L., Longhi, Renato, Christie, Macdonald J., Lewis, Richard J., Alewood, Paul F. and Brust, Andreas (2015). Stabilization of the Cysteine-Rich Conotoxin MrIA by Using a 1,2,3-Triazole as a Disulfide Bond Mimetic. Angewandte Chemie - International Edition, 54 (4), 1361-1364. doi: 10.1002/anie.201409678 |
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2014 Journal Article Insights into the molecular flexibility of theta-defensins by NMR relaxation analysisConibear, Anne C., Wang, Conan K., Bi, Tao, Rosengren, K. Johan, Camarero, Julio A. and Craik, David J. (2014). Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis. Journal of Physical Chemistry B, 118 (49), 14257-14266. doi: 10.1021/jp507754c |
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2014 Journal Article Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J miceSmith, Craig M., Chua, Berenice E., Zhang, Cary, Walker, Andrew W., Haidar, Mouna, Hawkes, David, Shabanpoor, Fazel, Hossain, Mohammad Akhter, Wade, John D., Rosengren, K. Johan and Gundlach, Andrew L. (2014). Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice. Behavioural Brain Research, 268, 117-126. doi: 10.1016/j.bbr.2014.03.037 |
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2014 Journal Article Evolutionary origins of a bioactive peptide buried within preproalbuminElliott, Alysha G., Delay, Christina, Liu, Huanle, Phua, Zaiyang, Rosengren, K. Johan, Benfield, Aurelie H., Panero, Jose L., Colgrave, Michelle L., Jayasena, Achala S., Dunse, Kerry M., Anderson, Marilyn A., Schilling, Edward E., Ortiz-Barrientos, Daniel, Craik, David J. and Mylne, Joshua S. (2014). Evolutionary origins of a bioactive peptide buried within preproalbumin. The Plant Cell, 26 (3), 981-995. doi: 10.1105/tpc.114.123620 |
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2014 Journal Article Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitroSchroeder, Christina I., Swedberg, Joakim E., Withka, Jane M., Rosengren, K. Johan, Akcan, Muharrem, Clayton, Daniel J., Daly, Norelle L., Cheneval, Olivier, Borzilleri, Kris A., Griffor, Matt, Stock, Ingrid, Colless, Barbara, Walsh, Phillip, Sunderland, Phillip, Reyes, Allan, Dullea, Robert, Ammirati, Mark, Liu, Shenping, McClure, Kim F., Tu, Meihua, Bhattacharya, Samit K., Liras, Spiros, Price, David A. and Craik, David J. (2014). Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro. Chemistry and Biology, 21 (2), 284-294. doi: 10.1016/j.chembiol.2013.11.014 |
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2014 Journal Article The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motifConibear, Anne C., Bochen, Alexander, Rosengren, K. Johan, Stupar, Petar, Wang, Conan, Kessler, Horst and Craik, David J. (2014). The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif. ChemBioChem, 15 (3), 451-459. doi: 10.1002/cbic.201300568 |
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2014 Journal Article Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2. Angewandte Chemie, 126 (4), 1035-1038. doi: 10.1002/ange.201308898 |
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2014 Journal Article Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2Schroeder, Christina I., Rash, Lachlan D., Vila-Farrés, Xavier, Rosengren, K. Johan, Mobli, Mehdi, King, Glenn F., Alewood, Paul F., Craik, David J. and Durek, Thomas (2014). Chemical synthesis, 3D structure and ASIC binding site of mambalgin-2. Angewandte Chemie International Edition, 53 (4), 1017-1020. doi: 10.1002/anie.201308898 |
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2014 Journal Article Solution structure, membrane interactions and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoniJia, Xinying, Schulte, Leigh, Loukas, Alex, Pickering, Darren, Pearson, Mark, Mobli, Mehdi, Jones, Alun, Rosengren, Karl J., Daly, Norelle L., Gobert, Geoffrey N., Jones, Malcolm K., Craik, David J. and Mulvenna, Jason (2014). Solution structure, membrane interactions and protein binding partners of the tetraspanin Sm-TSP-2, a vaccine antigen from the human blood fluke Schistosoma mansoni. Journal of Biological Chemistry, 289 (10), 1-26. doi: 10.1074/jbc.M113.531558 |
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2014 Journal Article Semienzymatic cyclization of disulfide-rich peptides using sortase AJia, Xinying, Kwon, Soohyun, Wang, Ching-I Anderson, Huang, Yen-Hua, Chan, Lai Y., Tan, Chia Chia, Rosengren, K. Johan, Mulvenna, Jason P., Schroeder, Christina I. and Craik, David J. (2014). Semienzymatic cyclization of disulfide-rich peptides using sortase A. Journal of Biological Chemistry, Papers in Press (10), 1-25. doi: 10.1074/jbc.M113.539262 |
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2014 Journal Article Seed storage albumins: Biosynthesis, trafficking and structuresMylne, Joshua S., Hara-Nishimura, Ikuko and Rosengren, K. Johan (2014). Seed storage albumins: Biosynthesis, trafficking and structures. Functional Plant Biology, 41 (7), 671-677. doi: 10.1071/FP14035 |
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2014 Journal Article Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping PharmacophoresJensen, Jonas E., Cristofori-Armstrong, Ben, Anangi, Raveendra, Rosengren, K. Johan, Lau, Carus H. Y., Mobli, Mehdi, Brust, Andreas, Alewood, Paul F., King, Glenn F. and Rash, Lachlan D. (2014). Understanding the Molecular Basis of Toxin Promiscuity: The Analgesic Sea Anemone Peptide APETx2 Interacts with Acid-Sensing Ion Channel 3 and hERG Channels via Overlapping Pharmacophores. Journal of Medicinal Chemistry, 57 (21), 9195-9203. doi: 10.1021/jm501400p |
