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2020 Journal Article Antibody/ligand-target receptor internalization assay protocol using fresh human or murine tumor ex vivo samplesJoseph, Shannon R., Lum, Benedict, Banushi, Blerida, Barry, Rachael, Panizza, Benedict, Walpole, Euan and Simpson, Fiona (2020). Antibody/ligand-target receptor internalization assay protocol using fresh human or murine tumor ex vivo samples. STAR Protocols, 1 (2) 100087, 100087. doi: 10.1016/j.xpro.2020.100087 |
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2020 Journal Article Scientifically based combination therapies with immuno‐oncology checkpoint inhibitorsChew, Hui Yi, Dolcetti, Riccardo and Simpson, Fiona (2020). Scientifically based combination therapies with immuno‐oncology checkpoint inhibitors. British Journal of Clinical Pharmacology, 86 (9) bcp.14338, 1711-1725. doi: 10.1111/bcp.14338 |
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2020 Journal Article Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating AntibodiesChew, Hui Yi, De Lima, Priscila O., Gonzalez Cruz, Jazmina L., Banushi, Blerida, Echejoh, Godwins, Hu, Lingbo, Joseph, Shannon R., Lum, Benedict, Rae, James, O'Donnell, Jake S., Merida de Long, Lilia, Okano, Satomi, King, Brigid, Barry, Rachael, Moi, Davide, Mazzieri, Roberta, Thomas, Ranjeny, Souza-Fonseca-Guimaraes, Fernando, Foote, Matthew, McCluskey, Adam, Robinson, Phillip J., Frazer, Ian H., Saunders, Nicholas A., Parton, Robert G., Dolcetti, Riccardo, Cuff, Katharine, Martin, Jennifer H., Panizza, Benedict, Walpole, Euan ... Simpson, Fiona (2020). Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies. Cell, 180 (5), 895-914.e27. doi: 10.1016/j.cell.2020.02.019 |
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2020 Journal Article Immune checkpoint inhibitors in advanced nasopharyngeal carcinoma: Beyond an era of chemoradiation?Masterson, Liam, Howard, James, Gonzalez-Cruz, Jazmina, Jackson, Christopher, Barnett, Catherine, Overton, Lewis, Liu, Howard, Ladwa, Rahul, Simpson, Fiona, McGrath, Margie, Wallwork, Ben, Jones, Terry, Ottensmeier, Christian, Chua, Melvin L. K., Perry, Chris, Khanna, Rajiv, Panizza, Benedict, Porceddu, Sandro and Lechner, Matt (2020). Immune checkpoint inhibitors in advanced nasopharyngeal carcinoma: Beyond an era of chemoradiation?. International Journal of Cancer, 146 (8) ijc.32869, 2305-2314. doi: 10.1002/ijc.32869 |
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2020 Journal Article Epidermal Growth Factor Receptor’s Function in Cutaneous Squamous Cell Carcinoma and Its Role as a Therapeutic Target in the Age of Immunotherapiesde Lima, Priscila Oliveira, Joseph, Shannon, Panizza, Benedict and Simpson, Fiona (2020). Epidermal Growth Factor Receptor’s Function in Cutaneous Squamous Cell Carcinoma and Its Role as a Therapeutic Target in the Age of Immunotherapies. Current Treatment Options in Oncology, 21 (1) 9, 9. doi: 10.1007/s11864-019-0697-3 |
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2019 Journal Article Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stageTuong, Zewen, Lewandowski, Andrew, Bridge, Jennifer, Gonzalez-Cruz, Jazmina, Yamada, Miko, Lambie, Duncan, Lewandowski, Richard, Steptoe, Raymond, Leggatt, Graham, Simpson, Fiona, Frazer, Ian, Soyer, Peter and Wells, James W. (2019). Cytokine/chemokine profiles in squamous cell carcinoma correlate with precancerous and cancerous disease stage. Scientific Reports, 9 (1) 17754, 17754. doi: 10.1038/s41598-019-54435-0 |
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2018 Journal Article An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomesJoseph, Shannon R., Gaffney, Daniel, Barry, Rachael, Hu, Lingbo, Banushi, Blerida, Wells, James W., Lambie, Duncan, Strutton, Geoff, Porceddu, Sandro V., Burmeister, Bryan, Leggatt, Graham R., Schaider, Helmut, Dolcetti, Riccardo, Frazer, Ian H., Saunders, Nicholas A., Foote, Matthew, Soyer, H. Peter and Simpson, Fiona (2018). An ex vivo human tumour assay reveals distinct patterns of EGFR trafficking in squamous cell carcinoma correlating to therapeutic outcomes. Journal of Investigative Dermatology, 139 (1), 213-223. doi: 10.1016/j.jid.2018.06.190 |
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2018 Journal Article Clinically-relevant rapamycin treatment regimens enhance CD8+ effector memory T cell function in the skin and allow their infiltration into cutaneous squamous cell carcinomaJung, Ji-Won, Veitch, Margaret, Bridge, Jennifer A., Overgaard, Nana H., Cruz, Jazmina L., Linedale, Richard, Franklin, Michael E., Saunders, Nicholas A., Simpson, Fiona, Frazer, Ian H., Steptoe, Raymond J. and Wells, James W. (2018). Clinically-relevant rapamycin treatment regimens enhance CD8+ effector memory T cell function in the skin and allow their infiltration into cutaneous squamous cell carcinoma. OncoImmunology, 7 (9) e1479627, 1-16. doi: 10.1080/2162402X.2018.1479627 |
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2018 Journal Article Characterization of 7A7, an anti-mouse EGFR monoclonal antibody proposed to be the mouse equivalent of cetuximabHe, Xuzhi, Cruz, Jazmina L., Joseph, Shannon, Pett, Nicola, Chew, Hui Yi, Tuong, Zewen K., Okano, Satomi, Kelly, Gabrielle, Veitch, Margaret, Simpson, Fiona and Wells, James W. (2018). Characterization of 7A7, an anti-mouse EGFR monoclonal antibody proposed to be the mouse equivalent of cetuximab. Oncotarget, 9 (15), 12250-12260. doi: 10.18632/oncotarget.24242 |
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2017 Journal Article Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patientsLinedale, Richard, Schmidt, Campbell, King, Brigid T., Ganko, Annabelle G., Simpson, Fiona, Panizza, Benedict J. and Graham R. Leggatt (2017). Elevated frequencies of CD8 T cells expressing PD-1, CTLA-4 and Tim-3 within tumour from perineural squamous cell carcinoma patients. PLoS One, 12 (4) e0175755, e0175755.1-e0175755.13. doi: 10.1371/journal.pone.0175755 |
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2016 Journal Article The voltage gated Ca2+-channel Cav3.2 and therapeutic responses in breast cancerPera, Elena, Kaemmerer, Elke, Milevskiy, Michael J. G., Yapa, Kunsala T. D. S., O'Donnell, Jake S., Brown, Melissa A., Simpson, Fiona, Peters, Amelia A., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). The voltage gated Ca2+-channel Cav3.2 and therapeutic responses in breast cancer. Cancer Cell International, 16 (24) 24, 24. doi: 10.1186/s12935-016-0299-0 |
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2015 Journal Article RacGAP1 is a novel downstream effector of E2F7-dependent resistance to doxorubicin and is prognostic for overall survival in squamous cell carcinomaHazar-Rethinam, Mehlika, de Long, Lilia Merida, Gannon, Orla M., Boros, Samuel, Vargas, Ana Cristina, Dzienis, Marcin, Mukhopadhyay, Pamela, Saenz-Ponce, Natalia, Dantzic, Daniel D. E., Simpson, Fiona and Saunders, Nicholas A. (2015). RacGAP1 is a novel downstream effector of E2F7-dependent resistance to doxorubicin and is prognostic for overall survival in squamous cell carcinoma. Molecular Cancer Therapeutics, 14 (8), 1939-1950. doi: 10.1158/1535-7163.MCT-15-0076 |
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2015 Journal Article Phenothiazine-derived antipsychotic drugs inhibit dynamin and vlathrin-mediated endocytosisDaniel, James A., Chau, Ngoc, Abdel-Hamid, Mohammed K., Hu, Lingbo, von Kleist, Lisa, Whiting, Ainslie, Krishnan, Sai, Maamary, Peter, Joseph, Shannon R., Simpson, Fiona, Haucke, Volker, McCluskey, Adam and Robinson, Philip J. (2015). Phenothiazine-derived antipsychotic drugs inhibit dynamin and vlathrin-mediated endocytosis. Traffic, 16 (6), 635-654. doi: 10.1111/tra.12272 |
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2015 Journal Article Does the nature of residual immune function explain the differential risk of non-melanoma skin cancer development in immunosuppressed organ transplant recipients?Jung, Ji-Won, Overgaard, Nana H., Burke, Michael T., Isbel, Nicole, Frazer, Ian H., Simpson, Fiona and Wells, James W. (2015). Does the nature of residual immune function explain the differential risk of non-melanoma skin cancer development in immunosuppressed organ transplant recipients?. International Journal of Cancer, 138 (2), 281-292. doi: 10.1002/ijc.29450 |
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2015 Journal Article A novel E2F/sphingosine kinase 1 axis regulates anthracycline response in squamous cell carcinomaHazar-Rethinam, Mehlika, Merida De Long, Lilia, Gannon, Orla M., Topkas, Eleni, Boros, Samuel, Vargas, Ana Cristina, Dzienis, Marcin, Mukhopadhyay, Pamela, Simpson, Fiona, Endo-Munoz, Liliana and Saunders, Nicholas A. (2015). A novel E2F/sphingosine kinase 1 axis regulates anthracycline response in squamous cell carcinoma. Clinical Cancer Research, 21 (2), 417-427. doi: 10.1158/1078-0432.CCR-14-1962 |
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2014 Journal Article Comparative Immune Phenotypic Analysis of Cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in Immune-Competent Individuals: Proportional Representation of CD8+ T-Cells but Not FoxP3+ Regulatory T-Cells Is Associated with Disease StageFreeman, Andrew, Bridge, Jennifer A., Maruthayanar, Pirashanthini, Overgaard, Nana H., Jung, Ji-Won, Simpson, Fiona, Prow, Tarl W., Soyer, H. Peter, Frazer, Ian H., Freeman, Michael and Wells, James W. (2014). Comparative Immune Phenotypic Analysis of Cutaneous Squamous Cell Carcinoma and Intraepidermal Carcinoma in Immune-Competent Individuals: Proportional Representation of CD8+ T-Cells but Not FoxP3+ Regulatory T-Cells Is Associated with Disease Stage. PLoS One, 9 (10) e110928, e110928.1-e110928.9. doi: 10.1371/journal.pone.0110928 |
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2014 Journal Article Phase II study of single-agent panitumumab in patients with incurable cutaneous squamous cell carcinomaFoote, M. C., McGrath, M., Guminski, A., Hughes, B. G. M., Meakin, J., Thomson, D., Zarate, D., Simpson, F. and Porceddu, S. V. (2014). Phase II study of single-agent panitumumab in patients with incurable cutaneous squamous cell carcinoma. Annals of Oncology, 25 (10), 2047-2052. doi: 10.1093/annonc/mdu368 |
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2014 Journal Article The epidermal growth factor receptor in squamous cell carcinoma: an emerging drug targetGaffney, Daniel C., Soyer, H. Peter and Simpson, Fiona (2014). The epidermal growth factor receptor in squamous cell carcinoma: an emerging drug target. Australasian Journal of Dermatology, 55 (1), 24-34. doi: 10.1111/ajd.12025 |
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2012 Journal Article Co-regulation of cell polarization and migration by caveolar proteins PTRF/cavin-1 and caveolin-1Hill, Michelle M., Daud, Noor Huda, Aung, Cho Sanda, Loo, Dorothy, Martin, Sally, Murphy, Samantha, Black, Debra M., Barry, Rachael, Simpson, Fiona, Liu, Libin, Pilch, Paul F, Hancock, John F., Marie-Odile Parat and Parton, Robert G. (2012). Co-regulation of cell polarization and migration by caveolar proteins PTRF/cavin-1 and caveolin-1. PLoS One, 7 (8) e43041, e43041.1-e43041.9. doi: 10.1371/journal.pone.0043041 |
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2012 Journal Article Role of intratumoural heterogeneity in cancer drug resistance: Molecular and clinical perspectivesSaunders, Nicholas A., Simpson, Fiona, Thompson, Erik W., Hill, Michelle M., Endo-Munoz, Liliana, Leggatt, Graham, Minchin, Rodney F. and Guminski, Alexander (2012). Role of intratumoural heterogeneity in cancer drug resistance: Molecular and clinical perspectives. EMBO Molecular Medicine, 4 (8), 675-684. doi: 10.1002/emmm.201101131 |
