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2014 Journal Article Bioengineering virus-like particles as vaccinesLua, Linda H. L., Connors, Natalie K., Sainsbury, Frank, Chuan, Yap P., Wibowo, Nani and Middelberg, Anton P. J. (2014). Bioengineering virus-like particles as vaccines. Biotechnology and Bioengineering, 111 (3), 425-440. doi: 10.1002/bit.25159 |
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2013 Journal Article Microbially synthesized modular virus-like particles and capsomeres displaying group A streptococcus hypervariable antigenic determinantsChuan, Yap P., Wibowo, Nani, Connors, Natalie K., Wu, Yang, Hughes, Fiona K., Batzloff, Michael R., Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Microbially synthesized modular virus-like particles and capsomeres displaying group A streptococcus hypervariable antigenic determinants. Biotechnology and Bioengineering, Early View (6), 1-9. doi: 10.1002/bit.25172 |
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2013 Journal Article Virus-like particle bioprocessing: challenges and opportunitiesMiddelberg, Anton P. J. and Lua, Linda H. L. (2013). Virus-like particle bioprocessing: challenges and opportunities. Pharmaceutical Bioprocessing, 1 (5), 407-409. doi: 10.4155/pbp.13.49 |
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2013 Journal Article Sensitivity of immune response quality to influenza helix 190 antigen structure displayed on a modular virus-like particleAnggraeni, Melisa R., Connors, Natalie K., Wu, Yang, Chuan, Yap P., Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Sensitivity of immune response quality to influenza helix 190 antigen structure displayed on a modular virus-like particle. Vaccine, 31 (40), 4428-4435. doi: 10.1016/j.vaccine.2013.06.087 |
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2013 Journal Article Improved fusion tag cleavage strategies in the downstream processing of self-assembling virus-like particle vaccinesConnors, Natalie K., Wu, Yang, Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Improved fusion tag cleavage strategies in the downstream processing of self-assembling virus-like particle vaccines. Food and Bioproducts Processing, 92 (2), 143-151. doi: 10.1016/j.fbp.2013.08.012 |
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2013 Journal Article Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccineChuan, Yap P., Rivera-Hernandez, Tania, Wibowo, Nani, Connors, Natalie K., Wu, Yang, Hughes, Fiona K., Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccine. Biotechnology and Bioengineering, 110 (9), 2343-2351. doi: 10.1002/bit.24907 |
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2013 Journal Article Virus-like particle formulation optimization by miniaturized high-throughput screeningMohr, Johannes, Chuan, Yap P., Wu, Yang, Lua, Linda H. L. and Middelberg, Anton P. J. (2013). Virus-like particle formulation optimization by miniaturized high-throughput screening. Methods, 60 (3), 248-256. doi: 10.1016/j.ymeth.2013.04.019 |
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2013 Journal Article Molecular Energetics in the Capsomere of Virus-Like Particle Revealed by Molecular Dynamics SimulationsZhang, Lin, Tang, Ronghong, Bai, Shu, Connors, Natalie K., Lua, Linda H. L., Chuan, Yap P., Middelberg, Anton P. J. and Sun, Yan (2013). Molecular Energetics in the Capsomere of Virus-Like Particle Revealed by Molecular Dynamics Simulations. Journal of Physical Chemistry B, 117 (18), 5411-5421. doi: 10.1021/jp311170w |
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2013 Journal Article Self-adjuvanting modular virus-like particles for mucosal vaccination against group A streptococcus (GAS)Rivera-Hernandez, Tania, Hartas, Jon, Wu, Yang, Chuan, Yap P., Lua, Linda H. L., Good, Michael, Batzloff, Michael R. and Middelberg, Anton P. J. (2013). Self-adjuvanting modular virus-like particles for mucosal vaccination against group A streptococcus (GAS). Vaccine, 31 (15), 1950-1955. doi: 10.1016/j.vaccine.2013.02.013 |
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2013 Journal Article The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidizedChen, Kai-En, Richards, Ayanthi A., Caradoc-Davies, Tom T., Vajjhala, Parimala R., Robin, Gautier, Lua, Linda H. L., Hill, Justine M., Schroder, Kate, Sweet, Matthew J., Kellie, Stuart, Kobe, Bostjan and Martin, Jennifer (2013). The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. Acta Crystallographica Section D: Biological Crystallography, 69 (5), 774-784. doi: 10.1107/S0907444913001558 |
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2012 Journal Article Modular engineering of a microbially-produced viral capsomere vaccine for influenzaWibowo, Nani, Chuan, Yap P., Lua, Linda H. L. and Middelberg, Anton P. J. (2012). Modular engineering of a microbially-produced viral capsomere vaccine for influenza. Chemical Engineering Science, 103, 12-20. doi: 10.1016/j.ces.2012.04.001 |
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2011 Journal Article A microbial platform for rapid and low-cost virus-like particle and capsomere vaccinesMiddelberg, Anton P.J., Rivera-Hernandez, Tania, Wibowo, Nani, Lua, Linda H.L., Fan, Yuanyuan, Magor, Graham, Chang, Cindy, Chuan, Yap P., Good, Michael F. and Batzloff, Michael R. (2011). A microbial platform for rapid and low-cost virus-like particle and capsomere vaccines. Vaccine, 29 (41), 7154-7162. doi: 10.1016/j.vaccine.2011.05.075 |
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2011 Journal Article A new bioproduction route for a novel antimicrobial peptideTay, Derrick Kok Sing, Rajagopalan, Gobinath, Li, Xiang, Chen, Yu, Linda H.L. Lua and Leong, Susanna Su Jan (2011). A new bioproduction route for a novel antimicrobial peptide. Biotechnology and Bioengineering, 108 (3), 572-581. doi: 10.1002/bit.22970 |
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2011 Journal Article Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formationHu, Shu-Hong, Christie, Michelle P., Saez, Natalie J., Latham, Catherine F., Jarrott, Russell, Lua, Linda H. L., Collins, Brett M. and Martin, Jennifer L. (2011). Possible roles for Munc18-1 domain 3a and Syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proceedings of the National Academy of Sciences of the United States of America, 108 (3), 1040-1045. doi: 10.1073/pnas.0914906108 |
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2010 Journal Article Virus assembly occurs following a pH- or Ca2+-triggered switch in the thermodynamic attraction between structural protein capsomeresChuan, Yap P., Fan, Yuan Y., Lua, Linda H.L. and Middelberg, Anton P.J. (2010). Virus assembly occurs following a pH- or Ca2+-triggered switch in the thermodynamic attraction between structural protein capsomeres. Journal of The Royal Society Interface, 7 (44), 409-421. doi: 10.1098/rsif.2009.0175 |
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2009 Journal Article The Chromatography-Free Release, Isolation and Purification of Recombinant Peptide for Fibril Self-AssemblyHartmann, B. M., Kaar, W., Yoo, I. K., Lua, L. H. L., Falconer, R. J. and Middelberg, A. P. J. (2009). The Chromatography-Free Release, Isolation and Purification of Recombinant Peptide for Fibril Self-Assembly. Biotechnology and Bioengineering, 104 (5), 973-985. doi: 10.1002/bit.22447 |
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2009 Journal Article Affinity purification of viral protein having heterogeneous quaternary structure: Modeling the impact of soluble aggregates on chromatographic performanceLipin, D.I., Raj, A., Lua, L.H.L. and Middelberg, A.P.J. (2009). Affinity purification of viral protein having heterogeneous quaternary structure: Modeling the impact of soluble aggregates on chromatographic performance. Journal of Chromatography A, 1216 (30), 5696-5708. doi: 10.1016/j.chroma.2009.05.082 |
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2009 Journal Article Quantitative characterization of virus-like particles by asymmetrical flow field flow fractionation, electrospray differential mobility analysis, and transmission electron microscopyPease, Leonard F., Lipin, Daniel I., Tsai, De-Hao, Zachariah, Michael R., Lua, Linda H. L., Tarlov, Michael J. and Middelberg, Anton P. J. (2009). Quantitative characterization of virus-like particles by asymmetrical flow field flow fractionation, electrospray differential mobility analysis, and transmission electron microscopy. Biotechnology and Bioengineering, 102 (3), 845-855. doi: 10.1002/bit.22085 |
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2009 Journal Article Microbial bio-production of a recombinant stimuli-responsive biosurfactantKaar, W., Hartmann, B. M., Fan, Y., Zeng, B., Lua, L. H. L., Dexter, A. F., Falconer, R. J. and Middelberg, A. P. J. (2009). Microbial bio-production of a recombinant stimuli-responsive biosurfactant. Biotechnology and bioengineering, 102 (1), 176-187. doi: 10.1002/bit.22037 |
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2008 Journal Article Encapsulation of DNA and non-viral protein changes the structure of murine polyomavirus virus-like particlesLipin, D. I., Chuan, Y. P., Lua, L. H. L. and Middelberg, A. P. J. (2008). Encapsulation of DNA and non-viral protein changes the structure of murine polyomavirus virus-like particles. Archives of Virology, 153 (11), 2027-2039. doi: 10.1007/s00705-008-0220-9 |
