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Dr Kirat Chand
Dr

Kirat Chand

Email: 
Phone: 
+61 7 334 66016

Overview

Background

Dr Kirat Chand is a Research Fellow at the Perinatal Research Centre at The University of Queensland Centre for Clinical Research (UQCCR). His field of expertise include the establishment of synaptic connections, neurodevelopment and cellular changes associated with injury in the neonatal brain. His current work investigates the evolution of brain injury in fetal growth restricted newborns (FGR) with a particular interest in understanding mechanisms to develop better detection and treatment strategies for FGR newborns. FGR is the second leading cause of perinatal morbidity and mortality, with around 32 million babies born FGR globally each year. FGR is commonly caused by placental insufficiency, resulting in an inadequate supply of oxygen and nutrients to the foetus. The brain is particularly vulnerable to FGR conditions and adverse outcomes in these children range from mild learning difficulties, to neurobehavioral issues, and in some cases cerebral palsy. Currently there are no interventions available to protect the FGR brain. Using the pre-clinical pig model of FGR, we are able to examine perturbations to white and grey matter regions of the newborn brain, with the aim of developing appropriate therapeutic strategies to aid this vulnerable population.

Availability

Dr Kirat Chand is:
Available for supervision

Qualifications

  • Doctor of Philosophy, The University of Queensland

Works

Search Professor Kirat Chand’s works on UQ eSpace

32 works between 2015 and 2024

1 - 20 of 32 works

2024

Journal Article

The search for blood biomarkers that indicate risk of adverse neurodevelopmental outcomes in fetal growth restriction

Musco, Hannah, Beecher, Kate, Chand, Kirat K., Boyd, Roslyn N., Colditz, Paul B. and Wixey, Julie A. (2024). The search for blood biomarkers that indicate risk of adverse neurodevelopmental outcomes in fetal growth restriction. Frontiers in Pediatrics, 12 1396102, 1-7. doi: 10.3389/fped.2024.1396102

The search for blood biomarkers that indicate risk of adverse neurodevelopmental outcomes in fetal growth restriction

2023

Journal Article

CSF1R inhibition promotes neuroinflammation and behavioural deficits during graft-versus-host disease in mice

Adams, Rachael C, Carter-Cusack, Dylan, Llanes, Genesis T, Hunter, Christopher R., Vinnakota, Janaki Manoja, Ruitenberg, Marc J, Vukovic, Jana, Bertolino, Patrick, Chand, Kirat K., Wixey, Julie A., Nayler, Samuel P., Hill, Geoffrey R, Furlan, Scott N, Zeiser, Robert and MacDonald, Kelli P.A. (2023). CSF1R inhibition promotes neuroinflammation and behavioural deficits during graft-versus-host disease in mice. Blood Journal, 142 (Supplement 1), 2052-2052. doi: 10.1182/blood.2023022040

CSF1R inhibition promotes neuroinflammation and behavioural deficits during graft-versus-host disease in mice

2023

Journal Article

Early evolution of glial morphology and inflammatory cytokines following hypoxic-ischemic injury in the newborn piglet brain

Teo, Elliot J., Chand, Kirat. K., Miller, Stephanie M., Wixey, Julie A., Colditz, Paul B. and Bjorkman, S. Tracey. (2023). Early evolution of glial morphology and inflammatory cytokines following hypoxic-ischemic injury in the newborn piglet brain. Scientific Reports, 13 (1) 282, 1-14. doi: 10.1038/s41598-022-27034-9

Early evolution of glial morphology and inflammatory cytokines following hypoxic-ischemic injury in the newborn piglet brain

2023

Conference Publication

CSF1R inhibition promotes neuroinflammation and behavioural deficits during graftversus-host disease in mice

Adams, Rachael C., Carter-Cusack, Dylan, Llanes, Genesis T., Hunter, Christopher R., Vinnakota, Janaki Manoja, Ruitenberg, Marc, Vukovic, Jana, Bertolino, Patrick, Chand, Kirat K., Wixey, Julie A., Nayler, Samuel P., Hill, Geoffrey R., Furlan, Scott N., Zeiser, Robert and MacDonald, Kelli P. A. (2023). CSF1R inhibition promotes neuroinflammation and behavioural deficits during graftversus-host disease in mice. 65th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA, United States, 9-12 December 2023. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2023-184841

CSF1R inhibition promotes neuroinflammation and behavioural deficits during graftversus-host disease in mice

2023

Journal Article

Combined human endothelial colony-forming cells and mesenchymal stromal cells as a neuroprotectant in fetal growth-restricted newborns

Chand, Kirat, Patel, Jatin, Matthews, Kate, Nano, Rachel, Musco, Hannah, Khosrotehrani, Kiarash, Colditz, Paul and Wixey, Julie (2023). Combined human endothelial colony-forming cells and mesenchymal stromal cells as a neuroprotectant in fetal growth-restricted newborns. IBRO Neuroscience Reports, 15, S171-S171. doi: 10.1016/j.ibneur.2023.08.249

Combined human endothelial colony-forming cells and mesenchymal stromal cells as a neuroprotectant in fetal growth-restricted newborns

2023

Journal Article

Effects of fetal growth restriction on the perinatal neurovascular unit and possible treatment targets

Wu, Bing Anthony, Chand, Kirat K., Bell, Alexander, Miller, Suzanne L., Colditz, Paul B., Malhotra, Atul and Wixey, Julie A. (2023). Effects of fetal growth restriction on the perinatal neurovascular unit and possible treatment targets. Pediatric Research, 95 (1), 59-69. doi: 10.1038/s41390-023-02805-w

Effects of fetal growth restriction on the perinatal neurovascular unit and possible treatment targets

2023

Journal Article

Advances in neonatal cell therapies: Proceedings of the First Neonatal Cell Therapies Symposium (2022)

Malhotra, Atul, Thebaud, Bernard, Paton, Madison C. B., Fleiss, Bobbi, Papagianis, Paris, Baker, Elizabeth, Bennet, Laura, Yawno, Tamara, Elwood, Ngaire, Campbell, Belinda, Chand, Kirat, Zhou, Lindsay, Penny, Tayla, Nguyen, Timothy, Pepe, Salvatore, Gunn, Alistair J. and McDonald, Courtney A. (2023). Advances in neonatal cell therapies: Proceedings of the First Neonatal Cell Therapies Symposium (2022). Pediatric Research, 94 (5), 1631-1638. doi: 10.1038/s41390-023-02707-x

Advances in neonatal cell therapies: Proceedings of the First Neonatal Cell Therapies Symposium (2022)

2023

Journal Article

Blood biomarkers in the fetally growth restricted and small for gestational age neonate: associations with brain injury

Musco, Hannah, Beecher, Kate, Chand, Kirat K, Colditz, Paul B. and Wixey, Julie A. (2023). Blood biomarkers in the fetally growth restricted and small for gestational age neonate: associations with brain injury. Developmental Neuroscience, 46 (2), 1-14. doi: 10.1159/000530492

Blood biomarkers in the fetally growth restricted and small for gestational age neonate: associations with brain injury

2022

Journal Article

Author Correction: Tick holocyclotoxins trigger host paralysis by presynaptic inhibition

Chand, Kirat K., Lee, Kah Meng, Lavidis, Nickolas A., Rodriguez-Valle, Manuel, Ijaz, Hina, Koehbach, Johannes, Clark, Richard J., Lew-Tabor, Ala and Noakes, Peter G. (2022). Author Correction: Tick holocyclotoxins trigger host paralysis by presynaptic inhibition. Scientific Reports, 12 (1) 20636, 1-1. doi: 10.1038/s41598-022-24528-4

Author Correction: Tick holocyclotoxins trigger host paralysis by presynaptic inhibition

2022

Journal Article

Stem cell therapy for neuroprotection in the growth-restricted newborn

Chand, Kirat, Nano, Rachel, Wixey, Julie and Patel, Jatin (2022). Stem cell therapy for neuroprotection in the growth-restricted newborn. Stem Cells Translational Medicine, 11 (4), 372-382. doi: 10.1093/stcltm/szac005

Stem cell therapy for neuroprotection in the growth-restricted newborn

2022

Journal Article

Brain outcomes in runted piglets: a translational model of fetal growth restriction

Chand, Kirat K., Pannek, Kerstin, Colditz, Paul B. and Wixey, Julie A. (2022). Brain outcomes in runted piglets: a translational model of fetal growth restriction. Developmental Neuroscience, 44 (4-5), 1-11. doi: 10.1159/000523995

Brain outcomes in runted piglets: a translational model of fetal growth restriction

2022

Journal Article

Neurovascular unit alterations in the growth-restricted newborn are improved following Ibuprofen treatment

Chand, Kirat K., Miller, Stephanie M., Cowin, Gary J., Mohanty, Lipsa, Pienaar, Jany, Colditz, Paul B., Bjorkman, Stella Tracey and Wixey, Julie A. (2022). Neurovascular unit alterations in the growth-restricted newborn are improved following Ibuprofen treatment. Molecular Neurobiology, 59 (2), 1018-1040. doi: 10.1007/s12035-021-02654-w

Neurovascular unit alterations in the growth-restricted newborn are improved following Ibuprofen treatment

2021

Journal Article

Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn

Chand, Kirat K., Patel, Jatin, Bjorkman, S. T., Sim, Seen-Ling, Miller, Stephanie M., Teo, Elliot, Jones, Lara, Sun, Jane, Colditz, Paul B., Khosrotehrani, Kiarash and Wixey, Julie A. (2021). Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn. npj Regenerative Medicine, 6 (1) 75, 75. doi: 10.1038/s41536-021-00185-5

Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn

2019

Journal Article

Ibuprofen treatment reduces the neuroinflammatory response and associated neuronal and white matter impairment in the growth restricted newborn

Wixey, Julie A., Sukumar, Kishen R., Pretorius, Rinaldi, Lee, Kah Meng, Colditz, Paul B., Bjorkman, S. Tracey and Chand, Kirat K. (2019). Ibuprofen treatment reduces the neuroinflammatory response and associated neuronal and white matter impairment in the growth restricted newborn. Frontiers in Physiology, 10 (MAY) 541, 541. doi: 10.3389/fphys.2019.00541

Ibuprofen treatment reduces the neuroinflammatory response and associated neuronal and white matter impairment in the growth restricted newborn

2019

Journal Article

Neuropathology in intrauterine growth restricted newborn piglets is associated with glial activation and proinflammatory status in the brain

Wixey, Julie A., Lee, Kah Meng, Miller, Stephanie M., Goasdoue, Kate, Colditz, Paul B., Bjorkman, S.T. and Chand, Kirat K. (2019). Neuropathology in intrauterine growth restricted newborn piglets is associated with glial activation and proinflammatory status in the brain. Journal of Neuroinflammation, 16 (1) 5, 5. doi: 10.1186/s12974-018-1392-1

Neuropathology in intrauterine growth restricted newborn piglets is associated with glial activation and proinflammatory status in the brain

2019

Conference Publication

Seizures are associated with blood-brain barrier disruption in a piglet model of neonatal hypoxic-ischaemic encephalopathy

Goasdoue, Kate, Chand, Kirat Kishore, Miller, Stephanie Melita, Lee, Kah Meng, Colditz, Paul Bernard, Wixey, Julie Anne and Bjorkman, Stella Tracey (2019). Seizures are associated with blood-brain barrier disruption in a piglet model of neonatal hypoxic-ischaemic encephalopathy. 11th Hershey Conference on Developmental Brain Injury, Asilomar, CA, United States, 5-8 June 2018. Basel, Switzerland: S. Karger AG. doi: 10.1159/000499365

Seizures are associated with blood-brain barrier disruption in a piglet model of neonatal hypoxic-ischaemic encephalopathy

2018

Journal Article

Therapeutic potential to reduce brain injury in growth restricted newborns

Wixey, Julie A., Chand, Kirat K., Pham, Lily, Colditz, Paul B. and Bjorkman, S. Tracey (2018). Therapeutic potential to reduce brain injury in growth restricted newborns. Journal of Physiology, 596 (23), 5675-5686. doi: 10.1113/JP275428

Therapeutic potential to reduce brain injury in growth restricted newborns

2018

Journal Article

Disruption to the 5-HT7 Receptor Following Hypoxia-Ischemia in the Immature Rodent Brain

Wixey, Julie A, Reinebrant, Hanna E, Chand, Kirat K and Buller, Kathryn M (2018). Disruption to the 5-HT7 Receptor Following Hypoxia-Ischemia in the Immature Rodent Brain. Neurochemical research, 43 (3), 711-720. doi: 10.1007/s11064-018-2473-3

Disruption to the 5-HT7 Receptor Following Hypoxia-Ischemia in the Immature Rodent Brain

2018

Journal Article

Defects in synaptic transmission at the neuromuscular junction precedes motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis

Chand, Kirat K., Lee, Kah Meng, Lee, John D., Qiu, Hao, Willis, Emily F., Lavidis, Nickolas A., Hilliard, Massimo A. and Noakes, Peter G. (2018). Defects in synaptic transmission at the neuromuscular junction precedes motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 32 (5), fj201700835R-2689. doi: 10.1096/fj.201700835R

Defects in synaptic transmission at the neuromuscular junction precedes motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis

2017

Journal Article

Neuroinflammation in intrauterine growth restriction

Wixey, Julie A., Chand, Kirat K., Colditz, Paul B. and Bjorkman, S. Tracey (2017). Neuroinflammation in intrauterine growth restriction. Placenta, 54, 117-124. doi: 10.1016/j.placenta.2016.11.012

Neuroinflammation in intrauterine growth restriction

Funding

Current funding

  • 2021 - 2025
    Long-term protection in the growth restricted newborn
    Cerebral Palsy Alliance
    Open grant

Past funding

  • 2020 - 2022
    Targeting the NLRP3-inflammasome in IUGR brain injury
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2020 - 2021
    The right cell - which stem cells provide optimal neuroprotection in the growth restricted newborn?
    UQ Early Career Researcher
    Open grant
  • 2019
    Is the blood brain barrier disrupted in intrauterine growth restricted newborns?
    Metro North Hospital and Health Service
    Open grant
  • 2018 - 2021
    Contribution of systemic inflammatory response to brain injury in growth restricted newborns
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Novel approaches to protecting the newborn brain
    Royal Brisbane and Women's Hospital Foundation
    Open grant

Supervision

Availability

Dr Kirat Chand is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Examining long-term neuroprotection in the growth restricted newborn

    Associate Advisor

    Other advisors: Dr Julie Wixey

  • Doctor Philosophy

    Blood biomarkers to detect brain injury in the growth restricted newborn

    Associate Advisor

    Other advisors: Dr Julie Wixey

Completed supervision

Media

Enquiries

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