Overview
Background
Dr Kirat Chand is a Research Fellow at the Perinatal Research Centre at The University of Queensland Centre for Clinical Research (UQCCR). His field of expertise include the establishment of synaptic connections, neurodevelopment and cellular changes associated with injury in the neonatal brain. His current work investigates the evolution of brain injury in fetal growth restricted newborns (FGR) with a particular interest in understanding mechanisms to develop better detection and treatment strategies for FGR newborns. FGR is the second leading cause of perinatal morbidity and mortality, with around 32 million babies born FGR globally each year. FGR is commonly caused by placental insufficiency, resulting in an inadequate supply of oxygen and nutrients to the foetus. The brain is particularly vulnerable to FGR conditions and adverse outcomes in these children range from mild learning difficulties, to neurobehavioral issues, and in some cases cerebral palsy. Currently there are no interventions available to protect the FGR brain. Using the pre-clinical pig model of FGR, we are able to examine perturbations to white and grey matter regions of the newborn brain, with the aim of developing appropriate therapeutic strategies to aid this vulnerable population.
Availability
- Dr Kirat Chand is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Kirat Chand’s works on UQ eSpace
2018
Journal Article
Defects in synaptic transmission at the neuromuscular junction precedes motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis
Chand, Kirat K., Lee, Kah Meng, Lee, John D., Qiu, Hao, Willis, Emily F., Lavidis, Nickolas A., Hilliard, Massimo A. and Noakes, Peter G. (2018). Defects in synaptic transmission at the neuromuscular junction precedes motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 32 (5), fj201700835R-2689. doi: 10.1096/fj.201700835R
2017
Journal Article
Neuroinflammation in intrauterine growth restriction
Wixey, Julie A., Chand, Kirat K., Colditz, Paul B. and Bjorkman, S. Tracey (2017). Neuroinflammation in intrauterine growth restriction. Placenta, 54, 117-124. doi: 10.1016/j.placenta.2016.11.012
2017
Journal Article
Functional decline at the aging neuromuscular junction is associated with altered laminin-α4 expression
Lee, Kah Meng, Chand, Kirat K., Hammond, Luke A., Lavidis, Nickolas A. and Noakes , Peter G. (2017). Functional decline at the aging neuromuscular junction is associated with altered laminin-α4 expression. Aging, 9 (3), 880-899. doi: 10.18632/aging.101198
2017
Conference Publication
Inflammation and blood-brain barrier disruption occurs rapidly following neonatal hypoxic-ischaemic encephalopathy
Goasdoue, K., Miller, S., Chand, K., Wixey, J., Colditz, P. and Bjorkman, S. T. (2017). Inflammation and blood-brain barrier disruption occurs rapidly following neonatal hypoxic-ischaemic encephalopathy. Queensland Perinatal Consortium, Brisbane, Australia, 20 July 2017.
2017
Conference Publication
Neuroinflammation in the IUGR piglet model
Sukumar, K., Chand, K., Miller, S., Goasdoue, K., Colditz, P., Bjorkman, S. T. and Wixey, J. (2017). Neuroinflammation in the IUGR piglet model. Queensland Perinatal Consortium, Translational Research Institute, Brisbane, 20 July 2017.
2017
Conference Publication
Anti-inflammatory treatment to reduce brain injury in the growth restricted neonate
Wixey, Julie, Sukumar, Kishen, Miller, Stephanie, Goasdoue, Kate, Colditz, Paul, Bjorkman, Stella Tracey and Chand, Kirat (2017). Anti-inflammatory treatment to reduce brain injury in the growth restricted neonate. 31st Annual Fetal and Neonatal Workshop of Australia and New Zealand, Canberra, ACT, Australia, 30-31 March 2017.
2016
Journal Article
Loss of laminin-alpha4 results in pre- and postsynaptic modifications at the neuromuscular junction
Chand, Kirat K., Lee, Kah Meng, Lavidis, Nickolas A. and Noakes, P. G. (2016). Loss of laminin-alpha4 results in pre- and postsynaptic modifications at the neuromuscular junction. FASEB Journal, 31 (4), 1323-1336. doi: 10.1096/fj.201600899R
2016
Journal Article
Neonatal seizures are associated with redistribution and loss of GABAA α-subunits in the hypoxic-ischaemic pig
Miller, Stephanie M., Sullivan, Susan M., Ireland, Zoe, Chand, Kirat K., Colditz, Paul B. and Bjorkman, S. Tracey (2016). Neonatal seizures are associated with redistribution and loss of GABAA α-subunits in the hypoxic-ischaemic pig. Journal of Neurochemistry, 139 (3), 471-484. doi: 10.1111/jnc.13746
2016
Journal Article
Tick holocyclotoxins trigger host paralysis by presynaptic inhibition
Chand, Kirat K., Lee, Kah Meng, Lavidis, Nickolas A., Rodriguez-Valle, Manuel, Ijaz, Hina, Koehbach, Johannes, Clark, Richard J., Lew-Tabor, Ala and Noakes, Peter G. (2016). Tick holocyclotoxins trigger host paralysis by presynaptic inhibition. Scientific Reports, 6 (1) 29446, 29446. doi: 10.1038/srep29446
2016
Conference Publication
Investigation of the impact of seizures on disruption to the blood-brain barrier following neonatal hypoxia-ischaemia
Goasdoue, Kate, Miller, Stephanie, Chand, Kirat, Wixey, Julie, Colditz, Paul and Bjorkman, Tracey (2016). Investigation of the impact of seizures on disruption to the blood-brain barrier following neonatal hypoxia-ischaemia. Queensland Perinatal Consortium, Brisbane, Queensland, Australia: University of Queensland, 15 July, 2016.
2016
Conference Publication
Neuroinflammatory response in the growth restricted neonate
Wixey, Julie, Muller, Camille, Chand, Kirat, Sullivan, Susan, Colditz, Paul and Bjorkman, Stella Tracey (2016). Neuroinflammatory response in the growth restricted neonate. Australasian Neuroscience Society Annual Scientific Meeting, Hobart, TAS Australia, 4-7 December 2016.
2016
Conference Publication
Pilot trial of early blood transfusions for supporting cardiovascular function and cerebral oxygen delivery in preterm piglets
Eiby, Yvonne, Bjorkman, Tracey, Wixey, Julie, Chand, Kirat, Colditz, Paul and Lingwood, Barbara (2016). Pilot trial of early blood transfusions for supporting cardiovascular function and cerebral oxygen delivery in preterm piglets. 30th Annual meeting Fetal and Neonatal Workshop of Australia and New Zealand, Magnetic Island, QLD, Australia, 19-21 May 2016.
2015
Other Outputs
The functional role of laminins-α4 and -β2 in development of the neuromuscular junction
Chand, Kirat Kishore (2015). The functional role of laminins-α4 and -β2 in development of the neuromuscular junction. PhD Thesis, School of Biomedical Sciences, The University of Queensland. doi: 10.14264/uql.2015.339
2015
Journal Article
Loss of β2-laminin alters calcium sensitivity and voltage gated calcium channel maturation of neurotransmission at the neuromuscular junction
Chand, Kirat K., Lee, Kah Meng, Schenning, Mitja P., Lavidis, Nickolas A. and Noakes, Peter G. (2015). Loss of β2-laminin alters calcium sensitivity and voltage gated calcium channel maturation of neurotransmission at the neuromuscular junction. Journal of Physiology, 593 (1), 245-265. doi: 10.1113/jphysiol.2014.284133
Funding
Current funding
Past funding
Supervision
Availability
- Dr Kirat Chand is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Examining long-term neuroprotection in the growth restricted newborn
Associate Advisor
Other advisors: Dr Julie Wixey
-
Doctor Philosophy
Blood biomarkers to detect brain injury in the growth restricted newborn
Associate Advisor
Other advisors: Dr Aven Lee, Dr Julie Wixey
Completed supervision
-
2023
Doctor Philosophy
Neurovascular unit alterations following neonatal hypoxic-ischemic encephalopathy; potential of stem cells as a therapy
Associate Advisor
Media
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