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Dr Kirat Chand
Dr

Kirat Chand

Email: 
Phone: 
+61 7 334 66016

Overview

Background

Dr Kirat Chand is a Research Fellow at the Perinatal Research Centre at The University of Queensland Centre for Clinical Research (UQCCR). His field of expertise include the establishment of synaptic connections, neurodevelopment and cellular changes associated with injury in the neonatal brain. His current work investigates the evolution of brain injury in fetal growth restricted newborns (FGR) with a particular interest in understanding mechanisms to develop better detection and treatment strategies for FGR newborns. FGR is the second leading cause of perinatal morbidity and mortality, with around 32 million babies born FGR globally each year. FGR is commonly caused by placental insufficiency, resulting in an inadequate supply of oxygen and nutrients to the foetus. The brain is particularly vulnerable to FGR conditions and adverse outcomes in these children range from mild learning difficulties, to neurobehavioral issues, and in some cases cerebral palsy. Currently there are no interventions available to protect the FGR brain. Using the pre-clinical pig model of FGR, we are able to examine perturbations to white and grey matter regions of the newborn brain, with the aim of developing appropriate therapeutic strategies to aid this vulnerable population.

Availability

Dr Kirat Chand is:
Available for supervision

Qualifications

  • Doctor of Philosophy, The University of Queensland

Works

Search Professor Kirat Chand’s works on UQ eSpace

32 works between 2015 and 2024

21 - 32 of 32 works

2017

Journal Article

Functional decline at the aging neuromuscular junction is associated with altered laminin-α4 expression

Lee, Kah Meng, Chand, Kirat K., Hammond, Luke A., Lavidis, Nickolas A. and Noakes , Peter G. (2017). Functional decline at the aging neuromuscular junction is associated with altered laminin-α4 expression. Aging, 9 (3), 880-899. doi: 10.18632/aging.101198

Functional decline at the aging neuromuscular junction is associated with altered laminin-α4 expression

2017

Conference Publication

Inflammation and blood-brain barrier disruption occurs rapidly following neonatal hypoxic-ischaemic encephalopathy

Goasdoue, K., Miller, S., Chand, K., Wixey, J., Colditz, P. and Bjorkman, S. T. (2017). Inflammation and blood-brain barrier disruption occurs rapidly following neonatal hypoxic-ischaemic encephalopathy. Queensland Perinatal Consortium, Brisbane, Australia, 20 July 2017.

Inflammation and blood-brain barrier disruption occurs rapidly following neonatal hypoxic-ischaemic encephalopathy

2017

Conference Publication

Neuroinflammation in the IUGR piglet model

Sukumar, K., Chand, K., Miller, S., Goasdoue, K., Colditz, P., Bjorkman, S. T. and Wixey, J. (2017). Neuroinflammation in the IUGR piglet model. Queensland Perinatal Consortium, Translational Research Institute, Brisbane, 20 July 2017.

Neuroinflammation in the IUGR piglet model

2017

Conference Publication

Anti-inflammatory treatment to reduce brain injury in the growth restricted neonate

Wixey, Julie, Sukumar, Kishen, Miller, Stephanie, Goasdoue, Kate, Colditz, Paul, Bjorkman, Stella Tracey and Chand, Kirat (2017). Anti-inflammatory treatment to reduce brain injury in the growth restricted neonate. 31st Annual Fetal and Neonatal Workshop of Australia and New Zealand, Canberra, ACT, Australia, 30-31 March 2017.

Anti-inflammatory treatment to reduce brain injury in the growth restricted neonate

2016

Journal Article

Loss of laminin-alpha4 results in pre- and postsynaptic modifications at the neuromuscular junction

Chand, Kirat K., Lee, Kah Meng, Lavidis, Nickolas A. and Noakes, P. G. (2016). Loss of laminin-alpha4 results in pre- and postsynaptic modifications at the neuromuscular junction. FASEB Journal, 31 (4), 1323-1336. doi: 10.1096/fj.201600899R

Loss of laminin-alpha4 results in pre- and postsynaptic modifications at the neuromuscular junction

2016

Journal Article

Neonatal seizures are associated with redistribution and loss of GABAA α-subunits in the hypoxic-ischaemic pig

Miller, Stephanie M., Sullivan, Susan M., Ireland, Zoe, Chand, Kirat K., Colditz, Paul B. and Bjorkman, S. Tracey (2016). Neonatal seizures are associated with redistribution and loss of GABAA α-subunits in the hypoxic-ischaemic pig. Journal of Neurochemistry, 139 (3), 471-484. doi: 10.1111/jnc.13746

Neonatal seizures are associated with redistribution and loss of GABAA α-subunits in the hypoxic-ischaemic pig

2016

Journal Article

Tick holocyclotoxins trigger host paralysis by presynaptic inhibition

Chand, Kirat K., Lee, Kah Meng, Lavidis, Nickolas A., Rodriguez-Valle, Manuel, Ijaz, Hina, Koehbach, Johannes, Clark, Richard J., Lew-Tabor, Ala and Noakes, Peter G. (2016). Tick holocyclotoxins trigger host paralysis by presynaptic inhibition. Scientific Reports, 6 (1) 29446, 29446. doi: 10.1038/srep29446

Tick holocyclotoxins trigger host paralysis by presynaptic inhibition

2016

Conference Publication

Neuroinflammatory response in the growth restricted neonate

Wixey, Julie, Muller, Camille, Chand, Kirat, Sullivan, Susan, Colditz, Paul and Bjorkman, Stella Tracey (2016). Neuroinflammatory response in the growth restricted neonate. Australasian Neuroscience Society Annual Scientific Meeting, Hobart, TAS Australia, 4-7 December 2016.

Neuroinflammatory response in the growth restricted neonate

2016

Conference Publication

Pilot trial of early blood transfusions for supporting cardiovascular function and cerebral oxygen delivery in preterm piglets

Eiby, Yvonne, Bjorkman, Tracey, Wixey, Julie, Chand, Kirat, Colditz, Paul and Lingwood, Barbara (2016). Pilot trial of early blood transfusions for supporting cardiovascular function and cerebral oxygen delivery in preterm piglets. 30th Annual meeting Fetal and Neonatal Workshop of Australia and New Zealand, Magnetic Island, QLD, Australia, 19-21 May 2016.

Pilot trial of early blood transfusions for supporting cardiovascular function and cerebral oxygen delivery in preterm piglets

2016

Conference Publication

Investigation of the impact of seizures on disruption to the blood-brain barrier following neonatal hypoxia-ischaemia

Goasdoue, Kate, Miller, Stephanie, Chand, Kirat, Wixey, Julie, Colditz, Paul and Bjorkman, Tracey (2016). Investigation of the impact of seizures on disruption to the blood-brain barrier following neonatal hypoxia-ischaemia. Queensland Perinatal Consortium, Brisbane, Queensland, Australia: University of Queensland, 15 July, 2016.

Investigation of the impact of seizures on disruption to the blood-brain barrier following neonatal hypoxia-ischaemia

2015

Other Outputs

The functional role of laminins-α4 and -β2 in development of the neuromuscular junction

Chand, Kirat Kishore (2015). The functional role of laminins-α4 and -β2 in development of the neuromuscular junction. PhD Thesis, School of Biomedical Sciences, The University of Queensland. doi: 10.14264/uql.2015.339

The functional role of laminins-α4 and -β2 in development of the neuromuscular junction

2015

Journal Article

Loss of β2-laminin alters calcium sensitivity and voltage gated calcium channel maturation of neurotransmission at the neuromuscular junction

Chand, Kirat K., Lee, Kah Meng, Schenning, Mitja P., Lavidis, Nickolas A. and Noakes, Peter G. (2015). Loss of β2-laminin alters calcium sensitivity and voltage gated calcium channel maturation of neurotransmission at the neuromuscular junction. Journal of Physiology, 593 (1), 245-265. doi: 10.1113/jphysiol.2014.284133

Loss of β2-laminin alters calcium sensitivity and voltage gated calcium channel maturation of neurotransmission at the neuromuscular junction

Funding

Current funding

  • 2021 - 2025
    Long-term protection in the growth restricted newborn
    Cerebral Palsy Alliance
    Open grant

Past funding

  • 2020 - 2022
    Targeting the NLRP3-inflammasome in IUGR brain injury
    RL Cooper Medical Research Foundation Limited
    Open grant
  • 2020 - 2021
    The right cell - which stem cells provide optimal neuroprotection in the growth restricted newborn?
    UQ Early Career Researcher
    Open grant
  • 2019
    Is the blood brain barrier disrupted in intrauterine growth restricted newborns?
    Metro North Hospital and Health Service
    Open grant
  • 2018 - 2021
    Contribution of systemic inflammatory response to brain injury in growth restricted newborns
    NHMRC Project Grant
    Open grant
  • 2016 - 2017
    Novel approaches to protecting the newborn brain
    Royal Brisbane and Women's Hospital Foundation
    Open grant

Supervision

Availability

Dr Kirat Chand is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Examining long-term neuroprotection in the growth restricted newborn

    Associate Advisor

    Other advisors: Dr Julie Wixey

  • Doctor Philosophy

    Blood biomarkers to detect brain injury in the growth restricted newborn

    Associate Advisor

    Other advisors: Dr Julie Wixey

Completed supervision

Media

Enquiries

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