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Dr Julie Wixey
Dr

Julie Wixey

Email: 
Phone: 
+61 7 334 66027

Overview

Background

Dr Julie Wixey is a Senior Research Fellow at the Perinatal Research Centre and Group Leader in fetal growth restriction research at The University of Queensland Centre for Clinical Research (UQCCR). She currently holds an NHMRC Investigator grant (2023-2027). Her research focusses on mechanisms, detection, and treatment of brain injury in fetally growth restricted babies.

Fetal growth restriction (FGR), where a fetus fails to grow normally in utero, is a leading cause of death and long-term disability with around 32 million babies born FGR globally each year. The fetal brain is particularly vulnerable to FGR conditions, and adverse outcomes cause life-long difficulties ranging from schooling and behavioural issues to cerebral palsy. These disabilities occur in up to 50% of FGR infants and have significant impacts on their lives. There is no treatment to protect the FGR newborn brain.

Dr Wixey is investigating how inflammation is associated with brain injury in the growth restricted newborn. She is examining novel detection methods of brain injury and applying different treatments to the clinically relevant growth restriction animal model, targeting both inflammation and blood brain barrier integrity to protect the vulnerable newborn brain.

Research Projects

• Mechanisms of brain injury in growth restriction

• Novel detection methods of brain injury in the growth restricted newborn using blood biomarkers

• Treatments to protect the growth restricted newborn from adverse brain outcomes

Availability

Dr Julie Wixey is:
Available for supervision
Media expert

Qualifications

  • Bachelor (Honours) of Science (Advanced), James Cook University
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Neonatal brain injury

  • Neuroinflammation

  • Neuroprotection

Research impacts

My research, using the clinically relevant animal model of fetal growth restriction (FGR), has:

1) provided new evidence that brain injury persists even after the FGR baby is born, and

2) demonstrated treating after birth protects the FGR brain.

My work exposed a novel opportunity to treat FGR newborns after birth by targeting inflammation to protect the FGR newborn brain. This attracted significant media attention with 16 national and international media outlets citing these publications. My ABC interview resulted in online and radio releases. Articles reporting on this research include Medical Xpress (United Kingdom), Readers Digest (Canada), Sydney Morning Herald, and The Age reflect interest extending from scientists to clinicians and general public.

Works

Search Professor Julie Wixey’s works on UQ eSpace

68 works between 2001 and 2024

1 - 20 of 68 works

2024

Journal Article

The search for blood biomarkers that indicate risk of adverse neurodevelopmental outcomes in fetal growth restriction

Musco, Hannah, Beecher, Kate, Chand, Kirat K., Boyd, Roslyn N., Colditz, Paul B. and Wixey, Julie A. (2024). The search for blood biomarkers that indicate risk of adverse neurodevelopmental outcomes in fetal growth restriction. Frontiers in Pediatrics, 12 1396102, 1-7. doi: 10.3389/fped.2024.1396102

The search for blood biomarkers that indicate risk of adverse neurodevelopmental outcomes in fetal growth restriction

2023

Journal Article

CSF1R inhibition promotes neuroinflammation and behavioural deficits during graft-versus-host disease in mice

Adams, Rachael C, Carter-Cusack, Dylan, Llanes, Genesis T, Hunter, Christopher R., Vinnakota, Janaki Manoja, Ruitenberg, Marc J, Vukovic, Jana, Bertolino, Patrick, Chand, Kirat K., Wixey, Julie A., Nayler, Samuel P., Hill, Geoffrey R, Furlan, Scott N, Zeiser, Robert and MacDonald, Kelli P.A. (2023). CSF1R inhibition promotes neuroinflammation and behavioural deficits during graft-versus-host disease in mice. Blood Journal, 142 (Supplement 1), 2052-2052. doi: 10.1182/blood.2023022040

CSF1R inhibition promotes neuroinflammation and behavioural deficits during graft-versus-host disease in mice

2023

Journal Article

Early evolution of glial morphology and inflammatory cytokines following hypoxic-ischemic injury in the newborn piglet brain

Teo, Elliot J., Chand, Kirat. K., Miller, Stephanie M., Wixey, Julie A., Colditz, Paul B. and Bjorkman, S. Tracey. (2023). Early evolution of glial morphology and inflammatory cytokines following hypoxic-ischemic injury in the newborn piglet brain. Scientific Reports, 13 (1) 282, 1-14. doi: 10.1038/s41598-022-27034-9

Early evolution of glial morphology and inflammatory cytokines following hypoxic-ischemic injury in the newborn piglet brain

2023

Conference Publication

CSF1R inhibition promotes neuroinflammation and behavioural deficits during graftversus-host disease in mice

Adams, Rachael C., Carter-Cusack, Dylan, Llanes, Genesis T., Hunter, Christopher R., Vinnakota, Janaki Manoja, Ruitenberg, Marc, Vukovic, Jana, Bertolino, Patrick, Chand, Kirat K., Wixey, Julie A., Nayler, Samuel P., Hill, Geoffrey R., Furlan, Scott N., Zeiser, Robert and MacDonald, Kelli P. A. (2023). CSF1R inhibition promotes neuroinflammation and behavioural deficits during graftversus-host disease in mice. 65th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA, United States, 9-12 December 2023. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2023-184841

CSF1R inhibition promotes neuroinflammation and behavioural deficits during graftversus-host disease in mice

2023

Journal Article

Combined human endothelial colony-forming cells and mesenchymal stromal cells as a neuroprotectant in fetal growth-restricted newborns

Chand, Kirat, Patel, Jatin, Matthews, Kate, Nano, Rachel, Musco, Hannah, Khosrotehrani, Kiarash, Colditz, Paul and Wixey, Julie (2023). Combined human endothelial colony-forming cells and mesenchymal stromal cells as a neuroprotectant in fetal growth-restricted newborns. IBRO Neuroscience Reports, 15, S171-S171. doi: 10.1016/j.ibneur.2023.08.249

Combined human endothelial colony-forming cells and mesenchymal stromal cells as a neuroprotectant in fetal growth-restricted newborns

2023

Journal Article

Effects of fetal growth restriction on the perinatal neurovascular unit and possible treatment targets

Wu, Bing Anthony, Chand, Kirat K., Bell, Alexander, Miller, Suzanne L., Colditz, Paul B., Malhotra, Atul and Wixey, Julie A. (2023). Effects of fetal growth restriction on the perinatal neurovascular unit and possible treatment targets. Pediatric Research, 95 (1), 59-69. doi: 10.1038/s41390-023-02805-w

Effects of fetal growth restriction on the perinatal neurovascular unit and possible treatment targets

2023

Journal Article

Blood biomarkers in the fetally growth restricted and small for gestational age neonate: associations with brain injury

Musco, Hannah, Beecher, Kate, Chand, Kirat K, Colditz, Paul B. and Wixey, Julie A. (2023). Blood biomarkers in the fetally growth restricted and small for gestational age neonate: associations with brain injury. Developmental Neuroscience, 46 (2), 1-14. doi: 10.1159/000530492

Blood biomarkers in the fetally growth restricted and small for gestational age neonate: associations with brain injury

2023

Journal Article

Could serotonin play a role in abnormal brain outcomes in fetal growth restriction?

Beecher, Kate and Wixey, Julie (2023). Could serotonin play a role in abnormal brain outcomes in fetal growth restriction?. Neural Regeneration Research, 18 (3), 543-544. doi: 10.4103/1673-5374.346481

Could serotonin play a role in abnormal brain outcomes in fetal growth restriction?

2023

Journal Article

Understanding the timing of brain injury in fetal growth restriction: lessons from a model of spontaneous growth restriction in piglets

Musco, Hannah and Wixey, Julie A. (2023). Understanding the timing of brain injury in fetal growth restriction: lessons from a model of spontaneous growth restriction in piglets. Neural Regeneration Research, 18 (2), 322-323. doi: 10.4103/1673-5374.343909

Understanding the timing of brain injury in fetal growth restriction: lessons from a model of spontaneous growth restriction in piglets

2022

Journal Article

Editorial: visibility matters – women in neonatology

McGillick, Erin V., Gizzi, Camilla, Volpe, MaryAnn, Nakstad, Britt, Kooi, Elisabeth M. W., Wixey, Julie and Tolcos, Mary (2022). Editorial: visibility matters – women in neonatology. Frontiers in Pediatrics, 10 1059426, 1-3. doi: 10.3389/fped.2022.1059426

Editorial: visibility matters – women in neonatology

2022

Journal Article

Stem cell therapy for neuroprotection in the growth-restricted newborn

Chand, Kirat, Nano, Rachel, Wixey, Julie and Patel, Jatin (2022). Stem cell therapy for neuroprotection in the growth-restricted newborn. Stem Cells Translational Medicine, 11 (4), 372-382. doi: 10.1093/stcltm/szac005

Stem cell therapy for neuroprotection in the growth-restricted newborn

2022

Journal Article

Brain outcomes in runted piglets: a translational model of fetal growth restriction

Chand, Kirat K., Pannek, Kerstin, Colditz, Paul B. and Wixey, Julie A. (2022). Brain outcomes in runted piglets: a translational model of fetal growth restriction. Developmental Neuroscience, 44 (4-5), 1-11. doi: 10.1159/000523995

Brain outcomes in runted piglets: a translational model of fetal growth restriction

2022

Journal Article

Electroencephalographic studies in growth-restricted and small-for-gestational-age neonates

Stevenson, Nathan J., Lai, Melissa M., Starkman, Hava E., Colditz, Paul B. and Wixey, Julie A. (2022). Electroencephalographic studies in growth-restricted and small-for-gestational-age neonates. Pediatric Research, 92 (6), 1-8. doi: 10.1038/s41390-022-01992-2

Electroencephalographic studies in growth-restricted and small-for-gestational-age neonates

2022

Journal Article

Neurovascular unit alterations in the growth-restricted newborn are improved following Ibuprofen treatment

Chand, Kirat K., Miller, Stephanie M., Cowin, Gary J., Mohanty, Lipsa, Pienaar, Jany, Colditz, Paul B., Bjorkman, Stella Tracey and Wixey, Julie A. (2022). Neurovascular unit alterations in the growth-restricted newborn are improved following Ibuprofen treatment. Molecular Neurobiology, 59 (2), 1018-1040. doi: 10.1007/s12035-021-02654-w

Neurovascular unit alterations in the growth-restricted newborn are improved following Ibuprofen treatment

2021

Journal Article

Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn

Chand, Kirat K., Patel, Jatin, Bjorkman, S. T., Sim, Seen-Ling, Miller, Stephanie M., Teo, Elliot, Jones, Lara, Sun, Jane, Colditz, Paul B., Khosrotehrani, Kiarash and Wixey, Julie A. (2021). Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn. npj Regenerative Medicine, 6 (1) 75, 75. doi: 10.1038/s41536-021-00185-5

Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn

2021

Journal Article

Editorial: Pathomechanisms and treatments to protect the preterm, fetal growth restricted and neonatal encephalopathic brain

Fleiss, Bobbi, Murray, Deidre M., Bjorkman, S. Tracey and Wixey, Julie A. (2021). Editorial: Pathomechanisms and treatments to protect the preterm, fetal growth restricted and neonatal encephalopathic brain. Frontiers in Neurology, 12 755617, 755617. doi: 10.3389/fneur.2021.755617

Editorial: Pathomechanisms and treatments to protect the preterm, fetal growth restricted and neonatal encephalopathic brain

2021

Journal Article

Combined hypothermia and mesenchymal stem cells in animal models of neonatal hypoxic–ischaemic encephalopathy: a systematic review

Teo, Elliot J., Jones, Lara E., Wixey, Julie A., Boyd, Roslyn N., Colditz, Paul B. and Bjorkman, S. Tracey (2021). Combined hypothermia and mesenchymal stem cells in animal models of neonatal hypoxic–ischaemic encephalopathy: a systematic review. Pediatric Research, 92 (1), 25-31. doi: 10.1038/s41390-021-01716-y

Combined hypothermia and mesenchymal stem cells in animal models of neonatal hypoxic–ischaemic encephalopathy: a systematic review

2021

Journal Article

Improving brain outcomes in the growth restricted newborn: treating after birth

Wixey, Julie A and Bjorkman, Stella Tracey (2021). Improving brain outcomes in the growth restricted newborn: treating after birth. Neural Regeneration Research, 16 (5), 978-979. doi: 10.4103/1673-5374.297069

Improving brain outcomes in the growth restricted newborn: treating after birth

2020

Journal Article

Hypoxia-ischemia in the immature rodent brain impairs serotonergic neuronal function in certain dorsal raphé nuclei

Reinebrant, Hanna, Wixey, Julie and Buller, Kathryn M. (2020). Hypoxia-ischemia in the immature rodent brain impairs serotonergic neuronal function in certain dorsal raphé nuclei. Neural Regeneration Research, 15 (3), 457-463. doi: 10.4103/1673-5374.266067

Hypoxia-ischemia in the immature rodent brain impairs serotonergic neuronal function in certain dorsal raphé nuclei

2019

Journal Article

Ibuprofen treatment reduces the neuroinflammatory response and associated neuronal and white matter impairment in the growth restricted newborn

Wixey, Julie A., Sukumar, Kishen R., Pretorius, Rinaldi, Lee, Kah Meng, Colditz, Paul B., Bjorkman, S. Tracey and Chand, Kirat K. (2019). Ibuprofen treatment reduces the neuroinflammatory response and associated neuronal and white matter impairment in the growth restricted newborn. Frontiers in Physiology, 10 (MAY) 541, 541. doi: 10.3389/fphys.2019.00541

Ibuprofen treatment reduces the neuroinflammatory response and associated neuronal and white matter impairment in the growth restricted newborn

Funding

Current funding

  • 2023 - 2027
    Detection and treatment of brain injury in growth restricted newborns
    NHMRC Investigator Grants
    Open grant
  • 2021 - 2025
    Long-term protection in the growth restricted newborn
    Cerebral Palsy Alliance
    Open grant
  • 2020 - 2030
    To support the NeoBRAIN research at UQCCR
    Royal Brisbane and Women's Hospital Foundation
    Open grant

Past funding

  • 2022 - 2023
    Brain-specific blood biomarkers of injury in the growth restricted newborn
    Metro North Hospital and Health Service
    Open grant
  • 2021 - 2023
    Targeting injured brain cells to protect growth restricted infants
    The Children's Hospital Foundation
    Open grant
  • 2020 - 2022
    CASS Travel Grant
    The Cass Foundation Limited
    Open grant
  • 2020 - 2021
    Neurodevelopmental outcomes at 2 years following ibuprofen treatment for patent ductus arteriosus in the preterm small for gestational age newborn: potential for neuroprotection
    Metro North Hospital and Health Service
    Open grant
  • 2020 - 2021
    The right cell - which stem cells provide optimal neuroprotection in the growth restricted newborn?
    UQ Early Career Researcher
    Open grant
  • 2019 - 2020
    Does plasma protein fetuin protect the injured newborn brain?
    Metro North Hospital and Health Service
    Open grant
  • 2019
    Is the blood brain barrier disrupted in intrauterine growth restricted newborns?
    Metro North Hospital and Health Service
    Open grant
  • 2018 - 2019
    Inflammation in the growth restricted newborn brain
    Metro North Hospital and Health Service
    Open grant
  • 2018 - 2020
    Improving brain outcomes in the growth restricted newborn using placental stem cell treatment
    Financial Markets Foundation for Children
    Open grant
  • 2018
    A pre-clinical intensive care facility to research long-term outcomes in neonates
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    CO2 gas as adjunctive neuroprotective therapy for hypoxic ischaemic encephalopathy (HIE)
    Metro North Hospital and Health Service
    Open grant
  • 2018 - 2021
    Contribution of systemic inflammatory response to brain injury in growth restricted newborns
    NHMRC Project Grant
    Open grant
  • 2018 - 2021
    Stem cell treatment for neonatal hypoxic ischaemic encephalopathy
    NHMRC Project Grant
    Open grant
  • 2018
    Stem cell treatment to protect the growth restricted newborn brain
    Metro North Hospital and Health Service
    Open grant
  • 2017 - 2020
    Improving brain oxygen levels in babies using stem cell treatment
    The Children's Hospital Foundation
    Open grant
  • 2017 - 2019
    Reducing inflammation in growth restricted newborn babies
    The Children's Hospital Foundation
    Open grant
  • 2017
    A pre-clinical trial of blood transfusion to reduce preterm brain injury
    Royal Brisbane and Women's Hospital Foundation
    Open grant
  • 2016 - 2017
    Protecting growth restricted newborn brains by reducing inflammation
    Royal Brisbane and Women's Hospital Foundation
    Open grant

Supervision

Availability

Dr Julie Wixey is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Available projects

  • Long-term neuroprotection in the growth restricted newborn

  • Blood biomarkers to detect adverse brain outcomes in fetal growth restriction

  • Novel targeted therapies to improve brain outcomes in growth restricted newborns

Supervision history

Current supervision

  • Doctor Philosophy

    Blood biomarkers to detect brain injury in the growth restricted newborn

    Principal Advisor

    Other advisors: Dr Kirat Chand

  • Doctor Philosophy

    Examining long-term neuroprotection in the growth restricted newborn

    Principal Advisor

    Other advisors: Dr Kirat Chand

Completed supervision

Media

Enquiries

Contact Dr Julie Wixey directly for media enquiries about:

  • Biomarkers to detect newborn brain injury
  • Growth restriction
  • Neonatal brain injury
  • Neuroinflammation
  • Perinatal neuroscience
  • Preterm birth
  • treatments for newborn brain injury

Need help?

For help with finding experts, story ideas and media enquiries, contact our Media team:

communications@uq.edu.au