
Overview
Background
Dr Julie Wixey is a Senior Research Fellow at the Perinatal Research Centre and Group Leader in fetal growth restriction research at The University of Queensland Centre for Clinical Research (UQCCR). She currently holds an NHMRC Investigator grant (2023-2027). Her research focusses on mechanisms, detection, and treatment of brain injury in fetally growth restricted babies.
Fetal growth restriction (FGR), where a fetus fails to grow normally in utero, is a leading cause of death and long-term disability with around 32 million babies born FGR globally each year. The fetal brain is particularly vulnerable to FGR conditions, and adverse outcomes cause life-long difficulties ranging from schooling and behavioural issues to cerebral palsy. These disabilities occur in up to 50% of FGR infants and have significant impacts on their lives. There is no treatment to protect the FGR newborn brain.
Dr Wixey is investigating how inflammation is associated with brain injury in the growth restricted newborn. She is examining novel detection methods of brain injury and applying different treatments to the clinically relevant growth restriction animal model, targeting both inflammation and blood brain barrier integrity to protect the vulnerable newborn brain.
Research Projects
• Mechanisms of brain injury in growth restriction
• Novel detection methods of brain injury in the growth restricted newborn using blood biomarkers
• Treatments to protect the growth restricted newborn from adverse brain outcomes
Availability
- Dr Julie Wixey is:
- Available for supervision
- Media expert
Qualifications
- Bachelor (Honours) of Science (Advanced), James Cook University
- Doctor of Philosophy, The University of Queensland
Research interests
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Neonatal brain injury
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Neuroinflammation
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Neuroprotection
Research impacts
My research, using the clinically relevant animal model of fetal growth restriction (FGR), has:
1) provided new evidence that brain injury persists even after the FGR baby is born, and
2) demonstrated treating after birth protects the FGR brain.
My work exposed a novel opportunity to treat FGR newborns after birth by targeting inflammation to protect the FGR newborn brain. This attracted significant media attention with 16 national and international media outlets citing these publications. My ABC interview resulted in online and radio releases. Articles reporting on this research include Medical Xpress (United Kingdom), Readers Digest (Canada), Sydney Morning Herald, and The Age reflect interest extending from scientists to clinicians and general public.
Works
Search Professor Julie Wixey’s works on UQ eSpace
2025
Journal Article
Nano-formulated curcumin uptake and biodistribution in the fetal growth restricted newborn piglet brain
Xu, Nuo, Wixey, Julie, Chand, Kirat, Wong, Megan and Nance, Elizabeth (2025). Nano-formulated curcumin uptake and biodistribution in the fetal growth restricted newborn piglet brain. Drug Delivery and Translational Research. doi: 10.1007/s13346-025-01830-y
2025
Journal Article
Updates on neonatal cell and novel therapeutics: Proceedings of the Second Neonatal Cell Therapies Symposium (2024)
Paton, Madison C. B., Benders, Manon, Blatch-Williams, Remy, Dallimore, Elizabeth, Edwards, Adam, Elwood, Ngaire, Facer, Kylie, Finch-Edmondson, Megan, Garrity, Natasha, Gordon, Adrienne, Hunt, Rod W., Jenkin, Graham, Mcdonald, Courtney A., Moore, Justin, Nold, Marcel F., Novak, Iona, Popat, Himanshu, Salomon, Carlos, Sato, Yoshiaki, Tolcos, Mary, Wixey, Julie A., Yawno, Tamara, Zhou, Lindsay and Malhotra, Atul (2025). Updates on neonatal cell and novel therapeutics: Proceedings of the Second Neonatal Cell Therapies Symposium (2024). Pediatric Research 09636897231214370. doi: 10.1038/s41390-025-03856-x
2024
Journal Article
The search for blood biomarkers that indicate risk of adverse neurodevelopmental outcomes in fetal growth restriction
Musco, Hannah, Beecher, Kate, Chand, Kirat K., Boyd, Roslyn N., Colditz, Paul B. and Wixey, Julie A. (2024). The search for blood biomarkers that indicate risk of adverse neurodevelopmental outcomes in fetal growth restriction. Frontiers in Pediatrics, 12 1396102, 1-7. doi: 10.3389/fped.2024.1396102
2024
Journal Article
CSF1R inhibition promotes neuroinflammation and behavioural deficits during graft-versus-host disease in mice
Adams, Rachael C., Carter-Cusack, Dylan, Llanes, Genesis T., Hunter, Christopher R., Vinnakota, Janaki Manoja, Ruitenberg, Marc J., Vukovic, Jana, Bertolino, Patrick, Chand, Kirat K., Wixey, Julie A., Nayler, Samuel P., Hill, Geoffrey R., Furlan, Scott N., Zeiser, Robert and MacDonald, Kelli P.A. (2024). CSF1R inhibition promotes neuroinflammation and behavioural deficits during graft-versus-host disease in mice. Blood Journal, 143 (10), 912-929. doi: 10.1182/blood.2023022040
2023
Journal Article
Early evolution of glial morphology and inflammatory cytokines following hypoxic-ischemic injury in the newborn piglet brain
Teo, Elliot J., Chand, Kirat. K., Miller, Stephanie M., Wixey, Julie A., Colditz, Paul B. and Bjorkman, S. Tracey. (2023). Early evolution of glial morphology and inflammatory cytokines following hypoxic-ischemic injury in the newborn piglet brain. Scientific Reports, 13 (1) 282, 1-14. doi: 10.1038/s41598-022-27034-9
2023
Conference Publication
CSF1R inhibition promotes neuroinflammation and behavioural deficits during graftversus-host disease in mice
Adams, Rachael C., Carter-Cusack, Dylan, Llanes, Genesis T., Hunter, Christopher R., Vinnakota, Janaki Manoja, Ruitenberg, Marc, Vukovic, Jana, Bertolino, Patrick, Chand, Kirat K., Wixey, Julie A., Nayler, Samuel P., Hill, Geoffrey R., Furlan, Scott N., Zeiser, Robert and MacDonald, Kelli P. A. (2023). CSF1R inhibition promotes neuroinflammation and behavioural deficits during graftversus-host disease in mice. 65th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA, United States, 9-12 December 2023. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood-2023-184841
2023
Journal Article
Combined human endothelial colony-forming cells and mesenchymal stromal cells as a neuroprotectant in fetal growth-restricted newborns
Chand, Kirat, Patel, Jatin, Matthews, Kate, Nano, Rachel, Musco, Hannah, Khosrotehrani, Kiarash, Colditz, Paul and Wixey, Julie (2023). Combined human endothelial colony-forming cells and mesenchymal stromal cells as a neuroprotectant in fetal growth-restricted newborns. IBRO Neuroscience Reports, 15, S171-S171. doi: 10.1016/j.ibneur.2023.08.249
2023
Journal Article
Effects of fetal growth restriction on the perinatal neurovascular unit and possible treatment targets
Wu, Bing Anthony, Chand, Kirat K., Bell, Alexander, Miller, Suzanne L., Colditz, Paul B., Malhotra, Atul and Wixey, Julie A. (2023). Effects of fetal growth restriction on the perinatal neurovascular unit and possible treatment targets. Pediatric Research, 95 (1), 59-69. doi: 10.1038/s41390-023-02805-w
2023
Journal Article
Blood biomarkers in the fetally growth restricted and small for gestational age neonate: associations with brain injury
Musco, Hannah, Beecher, Kate, Chand, Kirat K, Colditz, Paul B. and Wixey, Julie A. (2023). Blood biomarkers in the fetally growth restricted and small for gestational age neonate: associations with brain injury. Developmental Neuroscience, 46 (2), 1-14. doi: 10.1159/000530492
2023
Journal Article
Could serotonin play a role in abnormal brain outcomes in fetal growth restriction?
Beecher, Kate and Wixey, Julie (2023). Could serotonin play a role in abnormal brain outcomes in fetal growth restriction?. Neural Regeneration Research, 18 (3), 543-544. doi: 10.4103/1673-5374.346481
2023
Journal Article
Understanding the timing of brain injury in fetal growth restriction: lessons from a model of spontaneous growth restriction in piglets
Musco, Hannah and Wixey, Julie A. (2023). Understanding the timing of brain injury in fetal growth restriction: lessons from a model of spontaneous growth restriction in piglets. Neural Regeneration Research, 18 (2), 322-323. doi: 10.4103/1673-5374.343909
2022
Journal Article
Editorial: visibility matters – women in neonatology
McGillick, Erin V., Gizzi, Camilla, Volpe, MaryAnn, Nakstad, Britt, Kooi, Elisabeth M. W., Wixey, Julie and Tolcos, Mary (2022). Editorial: visibility matters – women in neonatology. Frontiers in Pediatrics, 10 1059426, 1-3. doi: 10.3389/fped.2022.1059426
2022
Journal Article
Stem cell therapy for neuroprotection in the growth-restricted newborn
Chand, Kirat, Nano, Rachel, Wixey, Julie and Patel, Jatin (2022). Stem cell therapy for neuroprotection in the growth-restricted newborn. Stem Cells Translational Medicine, 11 (4), 372-382. doi: 10.1093/stcltm/szac005
2022
Journal Article
Brain outcomes in runted piglets: a translational model of fetal growth restriction
Chand, Kirat K., Pannek, Kerstin, Colditz, Paul B. and Wixey, Julie A. (2022). Brain outcomes in runted piglets: a translational model of fetal growth restriction. Developmental Neuroscience, 44 (4-5), 1-11. doi: 10.1159/000523995
2022
Journal Article
Electroencephalographic studies in growth-restricted and small-for-gestational-age neonates
Stevenson, Nathan J., Lai, Melissa M., Starkman, Hava E., Colditz, Paul B. and Wixey, Julie A. (2022). Electroencephalographic studies in growth-restricted and small-for-gestational-age neonates. Pediatric Research, 92 (6), 1-8. doi: 10.1038/s41390-022-01992-2
2022
Journal Article
Neurovascular unit alterations in the growth-restricted newborn are improved following Ibuprofen treatment
Chand, Kirat K., Miller, Stephanie M., Cowin, Gary J., Mohanty, Lipsa, Pienaar, Jany, Colditz, Paul B., Bjorkman, Stella Tracey and Wixey, Julie A. (2022). Neurovascular unit alterations in the growth-restricted newborn are improved following Ibuprofen treatment. Molecular Neurobiology, 59 (2), 1018-1040. doi: 10.1007/s12035-021-02654-w
2021
Journal Article
Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn
Chand, Kirat K., Patel, Jatin, Bjorkman, S. T., Sim, Seen-Ling, Miller, Stephanie M., Teo, Elliot, Jones, Lara, Sun, Jane, Colditz, Paul B., Khosrotehrani, Kiarash and Wixey, Julie A. (2021). Combination of human endothelial colony-forming cells and mesenchymal stromal cells exert neuroprotective effects in the growth-restricted newborn. npj Regenerative Medicine, 6 (1) 75, 75. doi: 10.1038/s41536-021-00185-5
2021
Journal Article
Editorial: Pathomechanisms and treatments to protect the preterm, fetal growth restricted and neonatal encephalopathic brain
Fleiss, Bobbi, Murray, Deidre M., Bjorkman, S. Tracey and Wixey, Julie A. (2021). Editorial: Pathomechanisms and treatments to protect the preterm, fetal growth restricted and neonatal encephalopathic brain. Frontiers in Neurology, 12 755617, 755617. doi: 10.3389/fneur.2021.755617
2021
Journal Article
Combined hypothermia and mesenchymal stem cells in animal models of neonatal hypoxic–ischaemic encephalopathy: a systematic review
Teo, Elliot J., Jones, Lara E., Wixey, Julie A., Boyd, Roslyn N., Colditz, Paul B. and Bjorkman, S. Tracey (2021). Combined hypothermia and mesenchymal stem cells in animal models of neonatal hypoxic–ischaemic encephalopathy: a systematic review. Pediatric Research, 92 (1), 25-31. doi: 10.1038/s41390-021-01716-y
2021
Journal Article
Improving brain outcomes in the growth restricted newborn: treating after birth
Wixey, Julie A and Bjorkman, Stella Tracey (2021). Improving brain outcomes in the growth restricted newborn: treating after birth. Neural Regeneration Research, 16 (5), 978-979. doi: 10.4103/1673-5374.297069
Funding
Current funding
Supervision
Availability
- Dr Julie Wixey is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
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Long-term neuroprotection in the growth restricted newborn
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Blood biomarkers to detect adverse brain outcomes in fetal growth restriction
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Novel targeted therapies to improve brain outcomes in growth restricted newborns
Supervision history
Current supervision
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Doctor Philosophy
Examining long-term neuroprotection in the growth restricted newborn
Principal Advisor
Other advisors: Dr Kirat Chand
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Doctor Philosophy
Genetics of affective disorders, personality traits, and responses to treatment
Principal Advisor
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Doctor Philosophy
Blood biomarkers to detect brain injury in the growth restricted newborn
Principal Advisor
Other advisors: Dr Aven Lee, Dr Kirat Chand
Completed supervision
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2022
Doctor Philosophy
A novel stem cell therapy for the treatment of hypoxic-ischaemic encephalopathy of the newborn
Associate Advisor
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2019
Doctor Philosophy
Blood-brain barrier disruption in a model of neonatal hypoxic ischaemic encephalopathy
Associate Advisor
Media
Enquiries
Contact Dr Julie Wixey directly for media enquiries about:
- Biomarkers to detect newborn brain injury
- Growth restriction
- Neonatal brain injury
- Neuroinflammation
- Perinatal neuroscience
- Preterm birth
- treatments for newborn brain injury
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