Overview
Background
Dr Veronica is an Advance Queensland Industry Research Fellow, under the supervision of Professor Esteban Marcellin and Professor Lars Nielsen. She received her Biotechnology Engineering degree at the University of Chile in 2007 and completed her Ph.D. in Systems Biology at The University of Queensland in 2014. After completing her Ph.D. she performed 2 years of postdoctoral training at The University of Queensland, as part of a collaboration project with Universidad de Chile. Both Ph.D. studies and postdoctoral training were financially supported by the Chilean Government, under a competitive scholarship and fellowship, respectively. Later she worked as a Postdoctoral Research Fellow- Biopharmaceutical Upstream Bioprocessing at the ARC Training Centre for Biopharmaceutical Innovation (CBI), The University of Queensland.
She has some teaching experience. She had performed tutorial teaching in several courses at Universidad de Chile and the University of Queensland. In 2016 she was in charge of the Beer and Biofuels practical, part of the subject: Biomolecular Engineering (CHEE4020) of the chemical engineering department at The University of Queensland. In 2023 she gave an invited speaker lecture about cell culture optimization at the Biologics course (BIOT7018) at The University of Queensland.
Her research focuses on the improvement of biopharmaceutical production using mammalian cells. She is specifically interested in (1) the development of computational tools for metabolic systems biology, and (2) the improvement of upstream bioprocess. On the tools side, she has worked on the integration of thermodynamic principles and omics datasets into genome-scale models to estimate metabolic flux distributions; and developed a method for the estimation of dynamic metabolic fluxes. She has used these tools to describe experimental mammalian cells data and to guide the improvement of biopharmaceutical production processes. She has also been involved in the development of the latest human and CHO genome-scale models. On the process side, she worked on the improvement of a high cell density culture, using systems biology tools to develop a cell line adapted to high cell density and to develop an improved upstream bioprocess.
Her current project focuses on the development of a platform to generate good producer cell factories of difficult-to-express proteins.
Availability
- Dr Verónica Martinez Salazar is:
- Available for supervision
Fields of research
Qualifications
- Doctor of Philosophy, The University of Queensland
Research interests
-
Computacional System Biology
-
Cell culture upstream bioprocess optimization
Works
Search Professor Verónica Martinez Salazar’s works on UQ eSpace
2008
Conference Publication
A comparative study of cell growth and adenovirus production using suspension and stationary cell culture
Andrews, Barbara A., Martinez, Veronica, Asenjo, Juan A. and Gerdtzen, Ziomara P. (2008). A comparative study of cell growth and adenovirus production using suspension and stationary cell culture. 13th International Biotechnology Symposium and Exhibition, Dalian, China, 12-17 October 2008 . Amsterdam, Netherlands: Elsevier . doi: 10.1016/j.jbiotec.2008.07.285
2007
Conference Publication
Media optimization and metabolic flux analysis of HEK293 cells for adenovirus production
Martinez, Veronica, Gerdtzen, Ziomara P., Asenjo, Juan A. and Andrews, Barbara A. (2007). Media optimization and metabolic flux analysis of HEK293 cells for adenovirus production. 13th European Congress on Biotechnology (ECB 13), Barcelona, Spain, 16-19 September 2007. Amsterdam, The Netherlands: Elsevier . doi: 10.1016/j.jbiotec.2007.07.360
Supervision
Availability
- Dr Verónica Martinez Salazar is:
- Available for supervision
Before you email them, read our advice on how to contact a supervisor.
Available projects
-
CHO genome wide CRISPR screening for genes that enable higher yields of bispecific antibodies
-
Development of analytical tools for high-throughput identification and characterization of bispecific antibodies
Supervision history
Completed supervision
-
2023
Doctor Philosophy
Exploring Metabolic Demands of High Cell Density Chinese Hamster Ovary Cell Culture - Studying Apoptosis Resistance in Perfusion Culture
Principal Advisor
Other advisors: Professor Esteban Marcellin, Dr Gert Talbo
-
2023
Doctor Philosophy
Modelling and characterising life and death of mammalian suspension cultures
Associate Advisor
Other advisors: Professor Lars Nielsen, Dr Gert Talbo, Professor Esteban Marcellin
-
2022
Doctor Philosophy
Cell Line Development for High Density Culture of CHO Cells in Perfusion: Applications of Apoptosis Resistance
Associate Advisor
Other advisors: Professor Peter Gray, Professor Esteban Marcellin
Media
Enquiries
For media enquiries about Dr Verónica Martinez Salazar's areas of expertise, story ideas and help finding experts, contact our Media team: