Overview
Background
Dr. Halley Ravuri completed his Bachelor of Veterinary Science degree from the Orissa University of Agriculture and Technology, and a Master in Pharmacology and Toxicology from the Birsa Agricultural University, India. He recently finished his PhD in Veterinary Science at UQ in 2022. Before his PhD, he worked as a Research Associate in various research organizations for four years in India. His primary research was focused on developing cancer models for glioma (brain cancer), breast cancer, and melanoma in laboratory rodents, and investigating the efficacy of nano-particulated anticancer compounds. He is very experienced in maintaining, experimenting on laboratory rodents and has hands-on experience in research methodologies including ELISA, PCR, western blot analysis, histopathology, and bioanalytical analysis using HPLC instrumentation
His doctoral research was focused on transdermal drug delivery of nonsteroidal anti-inflammatory drugs (NSAIDs) in veterinary species and evaluating the efficacy of novel transdermal formulations using mass spectrometry-based plasma proteomics and lipidomics. He has garnered tremendous interest and expertise in the use of advanced mass spectrometry instruments including LC-MS/MS, GC-MS, and LC-TOF-MS, for enabling both targeted and discovery analysis of proteins, drugs, and lipid metabolites in animal plasma/serum. He has also worked as a technical assistant at the Analytical Service Unit, School of Agriculture and Food Sciences, UQ, using mass spectrometry for the analysis of pesticides, and fatty acid composition in milk, soils, and food samples.
Dr. Halley Ravuri is working at The School of Biomedical Sciences, Faculty of Medicine, UQ – as a Postdoctoral Research Fellow, under the supervision of Prof. Mark Midwinter. His current research goals are to characterize endothelial glycocalyx metabolites in serum/plasma using advanced mass spectrometry techniques, and also explore the pathophysiology of trauma and hemorrhagic shock using a proteomics-based approach. He also has a keen interest in exploring alternative in-vitro techniques to investigate endothelial glycocalyx, and examining the role of exosomes in trauma/hemorrhagic shock in animals and humans. His long-term goal is to establish himself as a translational proteomics expert in the field of plasma biomarker discovery and establish novel mass spectrometry methods and data analysis pipelines to improve the application of mass spectrometry research in the veterinary and translation biomedical sciences. He is an advocate of the use of mass spectrometry-based proteomics to contribute to the field of “One Health”; using veterinary species as translational models for studying human diseases. His future research goals include exploring viral proteomics to investigate and understand the virulence of viruses, characterise viral antibodies using mass spectrometry and studying physiological responses in animals, humans, and model organisms.
Availability
- Dr Halley Ravuri is:
- Available for supervision
Qualifications
- Bachelor of Veterinary Sciences, Orissa University of Agriculture and Technology
- Masters (Research) of Veterinary Pharmacology, Birsa Agricultural University
- Doctor of Philosophy of Veterinary Science, The University of Queensland
Research interests
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Mass spectrometry-based plasma proteomics, especially DIA mass spectrometry
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Mass spectrometry-based plasma metabolomic and lipidomic analysis
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In-vitro characterisation of endothelial cell-lines for studying role of glycocalyx
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Investigating role of extracellular vesicles in metabolic and inflammatory diseases in both human and animals
Works
Search Professor Halley Ravuri’s works on UQ eSpace
2025
Journal Article
Efficacy of transdermal ketoprofen on surgical inflammation in dogs
Ravuri, H.G., Sadowski, P., Satake, N. and Mills, P.C. (2025). Efficacy of transdermal ketoprofen on surgical inflammation in dogs. Research in Veterinary Science, 183 105512, 105512. doi: 10.1016/j.rvsc.2024.105512
2024
Journal Article
Strategies to improve the transdermal delivery of poorly water-soluble non-steroidal anti-inflammatory drugs
Balmanno, Alexandra, Falconer, James R., Ravuri, Halley G. and Mills, Paul C. (2024). Strategies to improve the transdermal delivery of poorly water-soluble non-steroidal anti-inflammatory drugs. Pharmaceutics, 16 (5) 675, 1-27. doi: 10.3390/pharmaceutics16050675
2023
Conference Publication
Proteomics to test the efficacy of novel transdermal NSAIDs
Mills, P. C., Ravuri, H. G. and Sadowsk, P. (2023). Proteomics to test the efficacy of novel transdermal NSAIDs. 15th International Congress of the European Association for Veterinary Pharmacology and Toxicology, Bruges, Belgium, 2–5 July 2023. Hoboken, NJ, United States: Wiley. doi: 10.1111/jvp.13272
2022
Journal Article
Plasma proteomic changes in response to surgical trauma and a novel transdermal analgesic treatment in dogs
Ravuri, Halley Gora, Sadowski, Pawel, Noor, Zainab, Satake, Nana and Mills, Paul C (2022). Plasma proteomic changes in response to surgical trauma and a novel transdermal analgesic treatment in dogs. Journal of Proteomics, 265 104648, 104648. doi: 10.1016/j.jprot.2022.104648
2022
Other Outputs
Efficacy of transdermally delivered non-steroidal anti-inflammatory drugs (NSAID’s) in dogs
Ravuri, Halley Gora (2022). Efficacy of transdermally delivered non-steroidal anti-inflammatory drugs (NSAID’s) in dogs. PhD Thesis, School of Veterinary Science, The University of Queensland. doi: 10.14264/6a57fbf
2022
Journal Article
Pharmacokinetic evaluation of a novel transdermal ketoprofen formulation in healthy dogs
Ravuri, Halley Gora, Satake, Nana, Balmanno, Alexandra, Skinner, Jazmine, Kempster, Samantha and Mills, Paul C. (2022). Pharmacokinetic evaluation of a novel transdermal ketoprofen formulation in healthy dogs. Pharmaceutics, 14 (3) 646, 646. doi: 10.3390/pharmaceutics14030646
2022
Journal Article
Data-independent acquisition enables robust quantification of 400 proteins in non-depleted canine plasma
Ravuri, Halley Gora, Noor, Zainab, Mills, Paul C., Satake, Nana and Sadowski, Pawel (2022). Data-independent acquisition enables robust quantification of 400 proteins in non-depleted canine plasma. Proteomes, 10 (1) 9, 9. doi: 10.3390/proteomes10010009
2021
Journal Article
Correction: The unintended mitochondrial uncoupling effects of the FDA-approved anti-helminth drug nitazoxanide mitigates experimental parkinsonism in mice
Amireddy, Niharika, Puttapaka, Srinivas N., Vinnakota, Ravali L., Ravuri, Halley G., Thonda, Swaroop and Kalivendi, Shasi V. (2021). Correction: The unintended mitochondrial uncoupling effects of the FDA-approved anti-helminth drug nitazoxanide mitigates experimental parkinsonism in mice. Journal of Biological Chemistry, 297 (1) 100864, 1-1. doi: 10.1016/j.jbc.2021.100864
2019
Conference Publication
Comprehensive dog plasma spectral libraries for SWATH-MS data acquisition
Ravuri, Halley, Satake, Nana, Mills, Paul C. and Sadowski, Pawel (2019). Comprehensive dog plasma spectral libraries for SWATH-MS data acquisition. Human Proteome Organisation World Congress (HUPO), Adelaide, SA Australia, 15-18 September 2019.
2019
Journal Article
Dual targeting of folate receptor-expressing glioma tumor-associated macrophages and epithelial cells in the brain using a carbon nanosphere-cationic folate nanoconjugate
Elechalawar, Chandra Kumar, Bhattacharya, Dwaipayan, Ahmed, Mohammed Tanveer, Gora, Halley, Sridharan, Kathyayani, Chaturbedy, Piyush, Sinha, Sarmistha Halder, Chandra Sekhar Jaggarapu, Madhan Mohan, Narayan, Kumar Pranav, Chakravarty, Sumana, Eswaramoorthy, Muthusamy, Kundu, Tapas Kumar and Banerjee, Rajkumar (2019). Dual targeting of folate receptor-expressing glioma tumor-associated macrophages and epithelial cells in the brain using a carbon nanosphere-cationic folate nanoconjugate. Nanoscale Advances, 1 (9), 3555-3567. doi: 10.1039/c9na00056a
2018
Conference Publication
Generation of dog spectral library for plasma proteins: using SWATH-MS technique
Ravuri, Halley Gora, Satake, Nana, Sadowski, Pawel and Mills, Paul C. (2018). Generation of dog spectral library for plasma proteins: using SWATH-MS technique. 3rd Queensland Mass Spectrometry Conference, Brisbane, QLD Australia, 6-7 December 2018.
2018
Journal Article
Design of multifunctional peptide collaborated and docetaxel loaded lipid nanoparticles for antiglioma therapy
Kadari, Amrita, Pooja, Deep, Gora, Ravuri Halley, Gudem, Sagarika, Kolapalli, Venkata Ramana Murthy, Kulhari, Hitesh and Sistla, Ramakrishna (2018). Design of multifunctional peptide collaborated and docetaxel loaded lipid nanoparticles for antiglioma therapy. European Journal of Pharmaceutics and Biopharmaceutics, 132, 168-179. doi: 10.1016/j.ejpb.2018.09.012
2018
Journal Article
Supplementation of oat (Avena sativa L.) extract abates alcohol-induced acute liver injury in a mouse model
Mir, Salma Mukhtar, Sahu, Bidya Dhar, Koneru, Meghana, Kuncha, Madhusudana, Jerald, Mahesh Kumar, Ravuri, Halley Gora, Kanjilal, Sanjit and Sistla, Ramakrishna (2018). Supplementation of oat (Avena sativa L.) extract abates alcohol-induced acute liver injury in a mouse model. Nutrition Research, 54, 80-92. doi: 10.1016/j.nutres.2018.04.002
2018
Journal Article
Ferulic acid protects lipopolysaccharide-induced acute kidney injury by suppressing inflammatory events and upregulating antioxidant defenses in Balb/c mice
Mir, Salma Mukhtar, Ravuri, Halley Gora, Pradhan, Raj Kumar, Narra, Sairam, Kumar, Jerald Mahesh, Kuncha, Madhusudana, Kanjilal, Sanjit and Sistla, Ramakrishna (2018). Ferulic acid protects lipopolysaccharide-induced acute kidney injury by suppressing inflammatory events and upregulating antioxidant defenses in Balb/c mice. Biomedicine and Pharmacotherapy, 100, 304-315. doi: 10.1016/j.biopha.2018.01.169
2018
Journal Article
Fabrication of surfactant-stabilized nanosuspension of naringenin to surpass its poor physiochemical properties and low oral bioavailability
Singh, Mayank Kumar, Pooja, Deep, Ravuri, Halley Gora, Gunukula, Anusha, Kulhari, Hitesh and Sistla, Ramakrishna (2018). Fabrication of surfactant-stabilized nanosuspension of naringenin to surpass its poor physiochemical properties and low oral bioavailability. Phytomedicine, 40, 48-54. doi: 10.1016/j.phymed.2017.12.021
2018
Journal Article
Oestrogen receptor-mediated liposomal drug delivery for treating melanoma
Ganguly, Anirban, Rachamalla, Hari Krishna Reddy, Bhattacharya, Dwaipayan, Bhamidipati, Keerti, Pal, Abhishek, Ravuri, Halley Gora, Chakravarty, Sumana, Adhikari, Susanta Sekhar and Banerjee, Rajkumar (2018). Oestrogen receptor-mediated liposomal drug delivery for treating melanoma. Journal of Drug Targeting, 26 (5-6), 481-493. doi: 10.1080/1061186x.2018.1433679
2017
Journal Article
Capsaicin, the pungent principle of peppers, ameliorates alcohol-induced acute liver injury in mice via modulation of matrix metalloproteinases
Koneru, Meghana, Sahu, Bidya Dhar, Mir, Salma Mukhtar, Ravuri, Halley Gora, Kuncha, Madhusudana, Kumar, Jerald Mahesh, Kilari, Eswar Kumar and Sistla, Ramakrishna (2017). Capsaicin, the pungent principle of peppers, ameliorates alcohol-induced acute liver injury in mice via modulation of matrix metalloproteinases. Canadian Journal of Physiology and Pharmacology, 96 (4), 419-427. doi: 10.1139/cjpp-2017-0473
2017
Journal Article
Large Amino Acid Transporter 1 Selective Liposomes of l-DOPA Functionalized Amphiphile for Combating Glioblastoma
Bhunia, Sukanya, Vangala, Venugopal, Bhattacharya, Dwaipayan, Ravuri, Halley Gora, Kuncha, Madhusudana, Chakravarty, Sumana, Sistla, Ramakrishna and Chaudhuri, Arabinda (2017). Large Amino Acid Transporter 1 Selective Liposomes of l-DOPA Functionalized Amphiphile for Combating Glioblastoma. Molecular Pharmaceutics, 14 (11), 3834-3847. doi: 10.1021/acs.molpharmaceut.7b00569
2017
Journal Article
Polydatin alleviates alcohol-induced acute liver injury in mice: Relevance of matrix metalloproteinases (MMPs) and hepatic antioxidants
Koneru, Meghana, Sahu, Bidya Dhar, Gudem, Sagarika, Kuncha, Madhusudana, Ravuri, Halley Gora, Kumar, Jerald Mahesh, Kilari, Eswar Kumar and Sistla, Ramakrishna (2017). Polydatin alleviates alcohol-induced acute liver injury in mice: Relevance of matrix metalloproteinases (MMPs) and hepatic antioxidants. Phytomedicine, 27, 23-32. doi: 10.1016/j.phymed.2017.01.013
2015
Journal Article
Bacteriological analysis of drinking water from different sources in and around Ranchi, Jharkhand
Kerketta, Priscilla, Gora, Ravuri Halley, Baxla, Sushma Lalita, Kumari, Suruchi and Yadava, Rajendra (2015). Bacteriological analysis of drinking water from different sources in and around Ranchi, Jharkhand. Journal of Pure and Applied Microbiology, 9 (Special Edition), 327-332.
Supervision
Availability
- Dr Halley Ravuri is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
The development and optimization of a transdermal firocoxib microemulsion gel for dogs
Associate Advisor
Other advisors: Dr James Robert Falconer, Professor Paul Mills
Completed supervision
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2024
Doctor Philosophy
The development and optimization of a transdermal firocoxib microemulsion gel for dogs
Associate Advisor
Other advisors: Dr James Robert Falconer, Professor Paul Mills
Media
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