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Dr Amy Hanna
Dr

Amy Hanna

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+61 7 344 33572

Overview

Background

Dr Amy Hanna’s research expertise includes functional characterization of skeletal and cardiac muscle, and investigation of the mechanisms underlying muscle function in health and disease. Amy is a Research Fellow in the laboratory of Assoc Prof Nathan Palpant at the University of Queensland's Institute for Molecular Bioscience. Amy obtained her PhD in 2014 at the John Curtin School of Medical Research under the supervision of Assoc Prof Nicole Beard and Professor Angela Dulhunty, investigating mechanisms of anthracycline-mediated cardiotoxicity using a combination of electrophysiology and calcium imaging in isolated cardiomyocytes. In 2014 Amy was awarded the Frank Fenner medal for most outstanding PhD thesis at JCSMR. Following completion of her PhD, Amy relocated to the United States to complete postdoctoral studies with Professor Susan Hamilton at Baylor College of Medicine. At BCM, Amy developed a strong interest in muscle diseases linked to calcium mishandling and protein quality control, including congenital myopathy and dilated cardiomyopathy. Amy has been an invited speaker at national and international conferences, and was co-chair of the 2019 Gordon Research Seminar of Muscle EC Coupling. Amy is currently funded by the Muscular Dystrophy Association and the Australian Functional Genomics Network.

Availability

Dr Amy Hanna is:
Available for supervision

Works

Search Professor Amy Hanna’s works on UQ eSpace

20 works between 2009 and 2024

1 - 20 of 20 works

2024

Conference Publication

Dissecting the Role of Hopx Variants in Cardiac Remodelling and Dysfunction

Hanna, A., Negi, S., Outhwaite, J., Cheng, T., Tan, C., Chen, J., Fatkin, D., Haas, J. and Palpant, N. (2024). Dissecting the Role of Hopx Variants in Cardiac Remodelling and Dysfunction. International Clinical Cardiovascular Genetics Conference 2024, Brisbane, QLD Australia, 8-10 May 2024. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2024.04.189

Dissecting the Role of Hopx Variants in Cardiac Remodelling and Dysfunction

Featured

2024

Journal Article

Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction

Redd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E and Palpant, Nathan J (2024). Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal, 45 (17), 1571-1574. doi: 10.1093/eurheartj/ehad793

Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction

2023

Journal Article

Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads

Lee, Chang Seok, Jung, Sung Yun, Yee, Rachel Sue Zhen, Agha, Nadia H., Hong, Jin, Chang, Ting, Babcock, Lyle W., Fleischman, Jorie D., Clayton, Benjamin, Hanna, Amy D., Ward, Christopher S., Lanza, Denise, Hurley, Ayrea E., Zhang, Pumin, Wehrens, Xander H. T., Lagor, William R., Rodney, George G. and Hamilton, Susan L. (2023). Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads. Communications Biology, 6 (1) 942, 1-19. doi: 10.1038/s42003-023-05330-y

Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads

2021

Journal Article

Untargeted metabolomics profiling of skeletal muscle samples from malignant hyperthermia susceptible patients

Bojko, Barbara, Vasiljevic, Tijana, Boyaci, Ezel, Roszkowska, Anna, Kraeva, Natalia, Ibarra Moreno, Carlos A, Koivu, Annabel, Wąsowicz, Marcin, Hanna, Amy, Hamilton, Susan, Riazi, Sheila and Pawliszyn, Janusz (2021). Untargeted metabolomics profiling of skeletal muscle samples from malignant hyperthermia susceptible patients. Canadian Journal of Anaesthesia, 68 (6), 761-772. doi: 10.1007/s12630-020-01895-y

Untargeted metabolomics profiling of skeletal muscle samples from malignant hyperthermia susceptible patients

2021

Journal Article

Pathological mechanisms of vacuolar aggregate myopathy arising from a Casq1 mutation

Hanna, Amy D., Lee, Chang Seok, Babcock, Lyle, Wang, Hui, Recio, Joseph and Hamilton, Susan L. (2021). Pathological mechanisms of vacuolar aggregate myopathy arising from a Casq1 mutation. The FASEB Journal, 35 (5) e21349, 1-20. doi: 10.1096/fj.202001653RR

Pathological mechanisms of vacuolar aggregate myopathy arising from a Casq1 mutation

2020

Journal Article

MyoSight-semi-automated image analysis of skeletal muscle cross sections

Babcock, Lyle W., Hanna, Amy D., Agha, Nadia H. and Hamilton, Susan L. (2020). MyoSight-semi-automated image analysis of skeletal muscle cross sections. Skeletal Muscle, 10 (1) 33, 1-11. doi: 10.1186/s13395-020-00250-5

MyoSight-semi-automated image analysis of skeletal muscle cross sections

2020

Journal Article

Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation

Wang, Hui J., Lee, Chang Seok, Yee, Rachel Sue Zhen, Groom, Linda, Friedman, Inbar, Babcock, Lyle, Georgiou, Dimitra K., Hong, Jin, Hanna, Amy D., Recio, Joseph, Choi, Jong Min, Chang, Ting, Agha, Nadia H., Romero, Jonathan, Sarkar, Poonam, Voermans, Nicol, Gaber, M. Waleed, Jung, Sung Yun, Baker, Matthew L., Pautler, Robia G., Dirksen, Robert T., Riazi, Sheila and Hamilton, Susan L. (2020). Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation. Nature Communications, 11 (1) 5099, 1-20. doi: 10.1038/s41467-020-18865-z

Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation

2019

Journal Article

TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia

Vanden Abeele, Fabien, Lotteau, Sabine, Ducreux, Sylvie, Dubois, Charlotte, Monnier, Nicole, Hanna, Amy, Gkika, Dimitra, Romestaing, Caroline, Noyer, Lucile, Flourakis, Matthieu, Tessier, Nolwenn, Al-Mawla, Ribal, Chouabe, Christophe, Lefai, Etienne, Lunardi, Joël, Hamilton, Susan, Fauré, Julien, Van Coppenolle, Fabien and Prevarskaya, Natalia (2019). TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia. Genetics in Medicine, 21 (2), 441-450. doi: 10.1038/s41436-018-0066-9

TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia

2017

Journal Article

The anthracycline metabolite doxorubicinol abolishes RyR2 sensitivity to physiological changes in luminal Ca2+ through an interaction with calsequestrin

Hanna, Amy D., Lam, Alexander, Thekkedam, Chris, Willemse, Hermia, Dulhunty, Angela F. and Beard, Nicole A. (2017). The anthracycline metabolite doxorubicinol abolishes RyR2 sensitivity to physiological changes in luminal Ca2+ through an interaction with calsequestrin. Molecular Pharmacology, 92 (5), 576-587. doi: 10.1124/mol.117.108183

The anthracycline metabolite doxorubicinol abolishes RyR2 sensitivity to physiological changes in luminal Ca2+ through an interaction with calsequestrin

2017

Journal Article

A chemical chaperone improves muscle function in mice with a RyR1 mutation

Lee, Chang Seok, Hanna, Amy D., Wang, Hui, Dagnino-Acosta, Adan, Joshi, Aditya D., Knoblauch, Mark, Xia, Yan, Georgiou, Dimitra K., Xu, Jianjun, Long, Cheng, Amano, Hisayuki, Reynolds, Corey, Dong, Keke, Martin, John C., Lagor, William R., Rodney, George G., Sahin, Ergun, Sewry, Caroline and Hamilton, Susan L. (2017). A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nature Communications, 8 (1) 14659, 1-15. doi: 10.1038/ncomms14659

A chemical chaperone improves muscle function in mice with a RyR1 mutation

2016

Book Chapter

Ryanodine Receptor Channelopathies in Skeletal and Cardiac Muscle

Hanna, A.D., Sharp, L.J. and Hamilton, S.L. (2016). Ryanodine Receptor Channelopathies in Skeletal and Cardiac Muscle. Ion Channels in Health and Disease. (pp. 53-84) London, United Kingdom: Academic Press. doi: 10.1016/b978-0-12-802002-9.00003-0

Ryanodine Receptor Channelopathies in Skeletal and Cardiac Muscle

2015

Journal Article

The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function

Pedrotti, Simona, Giudice, Jimena, Dagnino-Acosta, Adan, Knoblauch, Mark, Singh, Ravi K, Hanna, Amy, Mo, Qianxing, Hicks, John, Hamilton, Susan and Cooper, Thomas A (2015). The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function. Human Molecular Genetics, 24 (8), 2360-74. doi: 10.1093/hmg/ddv003

The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function

2015

Journal Article

Ca2+ permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca2+ signaling to sustain muscle function

Lee, Chang Seok, Dagnino-Acosta, Adan, Yarotskyy, Viktor, Hanna, Amy, Lyfenko, Alla, Knoblauch, Mark, Georgiou, Dimitra K, Poché, Ross A, Swank, Michael W, Long, Cheng, Ismailov, Iskander I, Lanner, Johanna, Tran, Ted, Dong, KeKe, Rodney, George G, Dickinson, Mary E, Beeton, Christine, Zhang, Pumin, Dirksen, Robert T and Hamilton, Susan L (2015). Ca2+ permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca2+ signaling to sustain muscle function. Skeletal muscle, 5 4, 1-16. doi: 10.1186/s13395-014-0027-1

Ca2+ permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca2+ signaling to sustain muscle function

2014

Journal Article

Cardiac ryanodine receptor activation by a high Ca²⁺ store load is reversed in a reducing cytoplasmic redox environment

Hanna, Amy D., Lam, Alex, Thekkedam, Chris, Gallant, Esther M., Beard, Nicole A. and Dulhunty, Angela F. (2014). Cardiac ryanodine receptor activation by a high Ca²⁺ store load is reversed in a reducing cytoplasmic redox environment. Journal of Cell Science, 127 (Pt 20), 4531-4541. doi: 10.1242/jcs.156760

Cardiac ryanodine receptor activation by a high Ca²⁺ store load is reversed in a reducing cytoplasmic redox environment

2014

Journal Article

Adverse effects of doxorubicin and its metabolic product on cardiac RyR2 and SERCA2A

Hanna, Amy D., Lam, Alex, Tham, Steffi, Dulhunty, Angela F. and Beard, Nicole A. (2014). Adverse effects of doxorubicin and its metabolic product on cardiac RyR2 and SERCA2A. Molecular Pharmacology, 86 (4), 438-49. doi: 10.1124/mol.114.093849

Adverse effects of doxorubicin and its metabolic product on cardiac RyR2 and SERCA2A

2014

Journal Article

Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function

Lee, Chang Seok, Georgiou, Dimitra K., Dagnino-Acosta, Adan, Xu, Jianjun, Ismailov, Iskander I., Knoblauch, Mark, Monroe, Tanner O., Ji, RuiRui, Hanna, Amy D., Joshi, Aditya D., Long, Cheng, Oakes, Joshua, Ted Tran, , Corona, Benjamin T., Lorca, Sabina, Ingalls, Christopher P., Narkar, Vihang A., Lanner, Johanna T., Bayle, J. Henri, Durham, William J. and Hamilton, Susan L. (2014). Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function. Journal of Biological Chemistry, 289 (37), 25556-25570. doi: 10.1074/jbc.m114.586289

Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function

2012

Journal Article

Regulation and dysregulation of cardiac ryanodine receptor (RyR2) open probability during diastole in health and disease

Dulhunty, Angela F., Beard, Nicole A. and Hanna, Amy D. (2012). Regulation and dysregulation of cardiac ryanodine receptor (RyR2) open probability during diastole in health and disease. Journal of General Physiology, 140 (2), 87-92. doi: 10.1085/jgp.201210862

Regulation and dysregulation of cardiac ryanodine receptor (RyR2) open probability during diastole in health and disease

2012

Journal Article

Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output

Dulhunty, Angela F., Wium, Elize, Li, Linwei, Hanna, Amy D., Mirza, Shamaruh, Talukder, Sadik, Ghazali, Nuur A.A. and Beard, Nicole A. (2012). Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output. Clinical and Experimental Pharmacology and Physiology, 39 (5), 477-84. doi: 10.1111/j.1440-1681.2012.05704.x

Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output

2011

Journal Article

Multiple actions of the anthracycline daunorubicin on cardiac ryanodine receptors

Hanna, Amy D., Janczura, Marie, Cho, Eric, Dulhunty, Angela F. and Beard, Nicole A. (2011). Multiple actions of the anthracycline daunorubicin on cardiac ryanodine receptors. Molecular Pharmacology, 80 (3), 538-549. doi: 10.1124/mol.111.073478

Multiple actions of the anthracycline daunorubicin on cardiac ryanodine receptors

2009

Journal Article

Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle

Wei, Lan, Hanna, Amy D., Beard, Nicole A. and Dulhunty, Angela F. (2009). Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle. Cell Calcium, 45 (5), 474-84. doi: 10.1016/j.ceca.2009.03.006

Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle

Funding

Current funding

  • 2024 - 2025
    Characterization of Tnnc1 variant in cardiac and skeletal muscle function
    Australian Functional Genomics Network
    Open grant
  • 2022 - 2025
    Calcium regulation of ER stress and protein degradation congenital myopathy
    Muscular Dystrophy Association
    Open grant

Supervision

Availability

Dr Amy Hanna is:
Available for supervision

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Supervision history

Current supervision

Media

Enquiries

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