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2024 Conference Publication Dissecting the Role of Hopx Variants in Cardiac Remodelling and DysfunctionHanna, A., Negi, S., Outhwaite, J., Cheng, T., Tan, C., Chen, J., Fatkin, D., Haas, J. and Palpant, N. (2024). Dissecting the Role of Hopx Variants in Cardiac Remodelling and Dysfunction. International Clinical Cardiovascular Genetics Conference 2024, Brisbane, QLD Australia, 8-10 May 2024. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2024.04.189 |
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2024 Journal Article Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarctionRedd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E and Palpant, Nathan J (2024). Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal, 45 (17), 1571-1574. doi: 10.1093/eurheartj/ehad793 |
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2023 Journal Article Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyadsLee, Chang Seok, Jung, Sung Yun, Yee, Rachel Sue Zhen, Agha, Nadia H., Hong, Jin, Chang, Ting, Babcock, Lyle W., Fleischman, Jorie D., Clayton, Benjamin, Hanna, Amy D., Ward, Christopher S., Lanza, Denise, Hurley, Ayrea E., Zhang, Pumin, Wehrens, Xander H. T., Lagor, William R., Rodney, George G. and Hamilton, Susan L. (2023). Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads. Communications Biology, 6 (1) 942, 1-19. doi: 10.1038/s42003-023-05330-y |
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2021 Journal Article Untargeted metabolomics profiling of skeletal muscle samples from malignant hyperthermia susceptible patientsBojko, Barbara, Vasiljevic, Tijana, Boyaci, Ezel, Roszkowska, Anna, Kraeva, Natalia, Ibarra Moreno, Carlos A, Koivu, Annabel, Wąsowicz, Marcin, Hanna, Amy, Hamilton, Susan, Riazi, Sheila and Pawliszyn, Janusz (2021). Untargeted metabolomics profiling of skeletal muscle samples from malignant hyperthermia susceptible patients. Canadian Journal of Anaesthesia, 68 (6), 761-772. doi: 10.1007/s12630-020-01895-y |
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2021 Journal Article Pathological mechanisms of vacuolar aggregate myopathy arising from a Casq1 mutationHanna, Amy D., Lee, Chang Seok, Babcock, Lyle, Wang, Hui, Recio, Joseph and Hamilton, Susan L. (2021). Pathological mechanisms of vacuolar aggregate myopathy arising from a Casq1 mutation. The FASEB Journal, 35 (5) e21349, 1-20. doi: 10.1096/fj.202001653RR |
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2020 Journal Article MyoSight-semi-automated image analysis of skeletal muscle cross sectionsBabcock, Lyle W., Hanna, Amy D., Agha, Nadia H. and Hamilton, Susan L. (2020). MyoSight-semi-automated image analysis of skeletal muscle cross sections. Skeletal Muscle, 10 (1) 33, 1-11. doi: 10.1186/s13395-020-00250-5 |
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2020 Journal Article Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutationWang, Hui J., Lee, Chang Seok, Yee, Rachel Sue Zhen, Groom, Linda, Friedman, Inbar, Babcock, Lyle, Georgiou, Dimitra K., Hong, Jin, Hanna, Amy D., Recio, Joseph, Choi, Jong Min, Chang, Ting, Agha, Nadia H., Romero, Jonathan, Sarkar, Poonam, Voermans, Nicol, Gaber, M. Waleed, Jung, Sung Yun, Baker, Matthew L., Pautler, Robia G., Dirksen, Robert T., Riazi, Sheila and Hamilton, Susan L. (2020). Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation. Nature Communications, 11 (1) 5099, 1-20. doi: 10.1038/s41467-020-18865-z |
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2019 Journal Article TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermiaVanden Abeele, Fabien, Lotteau, Sabine, Ducreux, Sylvie, Dubois, Charlotte, Monnier, Nicole, Hanna, Amy, Gkika, Dimitra, Romestaing, Caroline, Noyer, Lucile, Flourakis, Matthieu, Tessier, Nolwenn, Al-Mawla, Ribal, Chouabe, Christophe, Lefai, Etienne, Lunardi, Joël, Hamilton, Susan, Fauré, Julien, Van Coppenolle, Fabien and Prevarskaya, Natalia (2019). TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia. Genetics in Medicine, 21 (2), 441-450. doi: 10.1038/s41436-018-0066-9 |
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2017 Journal Article The anthracycline metabolite doxorubicinol abolishes RyR2 sensitivity to physiological changes in luminal Ca2+ through an interaction with calsequestrinHanna, Amy D., Lam, Alexander, Thekkedam, Chris, Willemse, Hermia, Dulhunty, Angela F. and Beard, Nicole A. (2017). The anthracycline metabolite doxorubicinol abolishes RyR2 sensitivity to physiological changes in luminal Ca2+ through an interaction with calsequestrin. Molecular Pharmacology, 92 (5), 576-587. doi: 10.1124/mol.117.108183 |
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2017 Journal Article A chemical chaperone improves muscle function in mice with a RyR1 mutationLee, Chang Seok, Hanna, Amy D., Wang, Hui, Dagnino-Acosta, Adan, Joshi, Aditya D., Knoblauch, Mark, Xia, Yan, Georgiou, Dimitra K., Xu, Jianjun, Long, Cheng, Amano, Hisayuki, Reynolds, Corey, Dong, Keke, Martin, John C., Lagor, William R., Rodney, George G., Sahin, Ergun, Sewry, Caroline and Hamilton, Susan L. (2017). A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nature Communications, 8 (1) 14659, 1-15. doi: 10.1038/ncomms14659 |
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2016 Book Chapter Ryanodine Receptor Channelopathies in Skeletal and Cardiac MuscleHanna, A.D., Sharp, L.J. and Hamilton, S.L. (2016). Ryanodine Receptor Channelopathies in Skeletal and Cardiac Muscle. Ion Channels in Health and Disease. (pp. 53-84) London, United Kingdom: Academic Press. doi: 10.1016/b978-0-12-802002-9.00003-0 |
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2015 Journal Article The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and functionPedrotti, Simona, Giudice, Jimena, Dagnino-Acosta, Adan, Knoblauch, Mark, Singh, Ravi K, Hanna, Amy, Mo, Qianxing, Hicks, John, Hamilton, Susan and Cooper, Thomas A (2015). The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function. Human Molecular Genetics, 24 (8), 2360-74. doi: 10.1093/hmg/ddv003 |
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2015 Journal Article Ca2+ permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca2+ signaling to sustain muscle functionLee, Chang Seok, Dagnino-Acosta, Adan, Yarotskyy, Viktor, Hanna, Amy, Lyfenko, Alla, Knoblauch, Mark, Georgiou, Dimitra K, Poché, Ross A, Swank, Michael W, Long, Cheng, Ismailov, Iskander I, Lanner, Johanna, Tran, Ted, Dong, KeKe, Rodney, George G, Dickinson, Mary E, Beeton, Christine, Zhang, Pumin, Dirksen, Robert T and Hamilton, Susan L (2015). Ca2+ permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca2+ signaling to sustain muscle function. Skeletal muscle, 5 4, 1-16. doi: 10.1186/s13395-014-0027-1 |
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2014 Journal Article Cardiac ryanodine receptor activation by a high Ca²⁺ store load is reversed in a reducing cytoplasmic redox environmentHanna, Amy D., Lam, Alex, Thekkedam, Chris, Gallant, Esther M., Beard, Nicole A. and Dulhunty, Angela F. (2014). Cardiac ryanodine receptor activation by a high Ca²⁺ store load is reversed in a reducing cytoplasmic redox environment. Journal of Cell Science, 127 (Pt 20), 4531-4541. doi: 10.1242/jcs.156760 |
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2014 Journal Article Adverse effects of doxorubicin and its metabolic product on cardiac RyR2 and SERCA2AHanna, Amy D., Lam, Alex, Tham, Steffi, Dulhunty, Angela F. and Beard, Nicole A. (2014). Adverse effects of doxorubicin and its metabolic product on cardiac RyR2 and SERCA2A. Molecular Pharmacology, 86 (4), 438-49. doi: 10.1124/mol.114.093849 |
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2014 Journal Article Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle functionLee, Chang Seok, Georgiou, Dimitra K., Dagnino-Acosta, Adan, Xu, Jianjun, Ismailov, Iskander I., Knoblauch, Mark, Monroe, Tanner O., Ji, RuiRui, Hanna, Amy D., Joshi, Aditya D., Long, Cheng, Oakes, Joshua, Ted Tran, , Corona, Benjamin T., Lorca, Sabina, Ingalls, Christopher P., Narkar, Vihang A., Lanner, Johanna T., Bayle, J. Henri, Durham, William J. and Hamilton, Susan L. (2014). Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function. Journal of Biological Chemistry, 289 (37), 25556-25570. doi: 10.1074/jbc.m114.586289 |
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2012 Journal Article Regulation and dysregulation of cardiac ryanodine receptor (RyR2) open probability during diastole in health and diseaseDulhunty, Angela F., Beard, Nicole A. and Hanna, Amy D. (2012). Regulation and dysregulation of cardiac ryanodine receptor (RyR2) open probability during diastole in health and disease. Journal of General Physiology, 140 (2), 87-92. doi: 10.1085/jgp.201210862 |
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2012 Journal Article Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac outputDulhunty, Angela F., Wium, Elize, Li, Linwei, Hanna, Amy D., Mirza, Shamaruh, Talukder, Sadik, Ghazali, Nuur A.A. and Beard, Nicole A. (2012). Proteins within the intracellular calcium store determine cardiac RyR channel activity and cardiac output. Clinical and Experimental Pharmacology and Physiology, 39 (5), 477-84. doi: 10.1111/j.1440-1681.2012.05704.x |
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2011 Journal Article Multiple actions of the anthracycline daunorubicin on cardiac ryanodine receptorsHanna, Amy D., Janczura, Marie, Cho, Eric, Dulhunty, Angela F. and Beard, Nicole A. (2011). Multiple actions of the anthracycline daunorubicin on cardiac ryanodine receptors. Molecular Pharmacology, 80 (3), 538-549. doi: 10.1124/mol.111.073478 |
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2009 Journal Article Unique isoform-specific properties of calsequestrin in the heart and skeletal muscleWei, Lan, Hanna, Amy D., Beard, Nicole A. and Dulhunty, Angela F. (2009). Unique isoform-specific properties of calsequestrin in the heart and skeletal muscle. Cell Calcium, 45 (5), 474-84. doi: 10.1016/j.ceca.2009.03.006 |
