Professor Richard Lewis
Professor

Richard Lewis

Email: 
Phone: 
+61 7 334 62984

Background

Professor Lewis started working on toxins during his PhD studies at the University of Queensland, where he researched the nature and pharmacology of ciguatoxins responsible for ciguatera fish poisoning. After 10 years with the Queensland Department of Primary Industry following this line of research, he moved back to The University of Queensland to initiate research into the phamacology of conotoxins, small venom peptides produced by carnivorous cone snails. This research led to the isolation and characterisation of several new classes of conotoxins, including two (w-CVID and Xen2174) that were developed clinically. His current research focusses on the discovery, evolution and structure-function of venom peptides, especially those with potential for the treatment of difficult to manage pain.

Availability

Professor Richard Lewis is:
Available for supervision
Media expert

Fields of research

Biological Sciences Medicinal and biomolecular chemistry Pharmacology and pharmaceutical sciences

Qualifications

  • Bachelor of Science, James Cook University
  • Doctor of Philosophy, The University of Queensland

Research interests

  • Molecular Pharmacology

    Currently we are investigating conotoxins that selectively target the nicotinic acetylcholine and NMDA receptors, the voltage sensitive calcium and sodium channels, and the noradrenaline transporter. Complimentary interactions between conotoxins and their receptor are being established to better understand where and how they act at the molecular level. The aim of this research is to develop research tools and potential therapeutics for poorly treated diseases such as chronic pain. This research involves assay-guided isolation of venom peptides, peptide synthesis, tissue pharmacology, radioligand binding and electrophysiological studies, as well as receptor mutagenesis, modelling and docking. Specific projects include: <li>Discovery of novel bioactive peptides (conotoxins or conopeptides) from Cone snail venom. The nicotinic acetylcholine receptor is a nonselective cation channel stimulated by acetylcholine and selectively inhibited by �-conotoxins. <li>We have discovered several new �-conotoxins using receptors expressed in oocytes to guide crude venom fractionation. Several had unusual structure and subtype selectivity. Homology modelling and docking studies are allowing us to understand, at the molecular level, how these selectivity differences arise <li>The NMDA receptor, an important non-selective cation channel in the brain, is inhibited by conantokins. Using conantokin analogues, we recently found that specific subtypes of the NMDA receptor are lost in Alzheimer's disease. Currently we are trying to establish their identity to better understand how Alzheimer's disease develops <li>The voltage sensitive N-type calcium channel, a neuronal calcium channel found in pathways involved in the transmission of painful stimuli, is inhibited by �-conotoxins. We recently identified a novel variant of this channel using CVID. This variant is currently under investigation to understand its role in chronic pain <li>The voltage sensitive sodium channels, particularly those found in neurons inhibited by �-conotoxins, are also under investigation. We have established that �-conotoxins selectively target persistent forms of the TTX-sensitive sodium channel. The nature and role of these sodium channels is currently under investigation <li>The noradrenaline transporter (NET) is the primary route of noradrenaline removal from synapses. We have identified �-conotoxins as the first peptide inhibitor of NET, and its effectiveness in treating neuropathic pain and depression. We are presently establishing the complimentary interactions between �-conotoxins and NET to understand where and how they act at the molecular level. Our research has led to the formation of the biotechnology company Xenome Ltd. Xenome is focused on discovering and developing new pharmaceuticals from the venom of Australian animals.

Research impacts

Professor Lewis' research on novel analgaesics from Australian venomous animals has the potential to change the way severe pain is currently treated. His research on ciguatera has the potential to improve the management of this severe illness associated with the consumption of tropical reef fish that affects ~50,000 people per annum.

Search Professor Richard Lewis’s works on UQ eSpace

473 works between 1981 and 2024
All (473) Journal Article (361) Book Chapter (21) Conference Publication (90) Book (1)

1 - 20 of 473 works

2024

Journal Article

Novel scorpion toxin ω-Buthitoxin-Hf1a selectively inhibits calcium influx via CaV3.3 and CaV3.2 and alleviates allodynia in a mouse model of acute postsurgical pain

Wang, Dan, Herzig, Volker, Dekan, Zoltan, Rosengren, K. Johan, Payne, Colton D., Hasan, Md. Mahadhi, Zhuang, Jiajie, Bourinet, Emmanuel, Ragnarsson, Lotten, Alewood, Paul F. and Lewis, Richard J. (2024). Novel scorpion toxin ω-Buthitoxin-Hf1a selectively inhibits calcium influx via CaV3.3 and CaV3.2 and alleviates allodynia in a mouse model of acute postsurgical pain. International Journal of Molecular Sciences, 25 (9) 4745. doi: 10.3390/ijms25094745

Novel scorpion toxin ω-Buthitoxin-Hf1a selectively inhibits calcium influx via CaV3.3 and CaV3.2 and alleviates allodynia in a mouse model of acute postsurgical pain

2024

Journal Article

HSQC spectra simulation and matching for molecular identification

Priessner, Martin, Lewis, Richard J., Johansson, Magnus J., Goodman, Jonathan M., Janet, Jon Paul and Tomberg, Anna (2024). HSQC spectra simulation and matching for molecular identification. Journal of Chemical Information and Modeling, 64 (8), 3180-3191. doi: 10.1021/acs.jcim.3c01735

HSQC spectra simulation and matching for molecular identification

2024

Journal Article

Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin

Narjes, Frank, Edfeldt, Fredrik, Petersen, Jens, Oster, Linda, Hamblet, Corinne, Bird, James, Bold, Peter, Rae, Rebecca, Back, Elisabeth, Stomilovic, Stina, Zlatoidsky, Pavol, Svensson, Tor, Hidestal, Lotta, Kunalingam, Lavaniya, Shamovsky, Igor, De Maria, Leonardo, Gordon, Euan, Lewis, Richard J., Watcham, Sophie, van Rietschoten, Katerine, Mudd, Gemma E., Harrison, Helen, Chen, Liuhong and Skynner, Michael J. (2024). Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin. Journal of Medicinal Chemistry, 67 (3), 2220-2235. doi: 10.1021/acs.jmedchem.3c02163

Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin

2024

Journal Article

Inhibition of N-Type Calcium Channels by Phenoxyaniline and Sulfonamide Analogues

Bispat, Anjie, Cardoso, Fernanda, Hasan, Md. Mahadhi, Dongol, Yashad, Wilcox, Ricki, Lewis, Richard, Duggan, Peter James and Tuck, Kellie (2024). Inhibition of N-Type Calcium Channels by Phenoxyaniline and Sulfonamide Analogues. RSC Medicinal Chemistry, 15 (3), 916-936. doi: 10.1039/d3md00714f

Inhibition of N-Type Calcium Channels by Phenoxyaniline and Sulfonamide Analogues

2024

Journal Article

N-Sulfonylphenoxazines as neuronal calcium ion channel blockers

Schmit, Matthieu, Hasan, Md. Mahadhi, Dongol, Yashad, Cardoso, Fernanda C., Kuiper, Michael J., Lewis, Richard J., Duggan, Peter J. and Tuck, Kellie L. (2024). N-Sulfonylphenoxazines as neuronal calcium ion channel blockers. RSC Medicinal Chemistry, 15 (7), 2400-2412. doi: 10.1039/d4md00336e

N-Sulfonylphenoxazines as neuronal calcium ion channel blockers

2023

Journal Article

Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes

Dongol, Yashad, Wilson, David T., Daly, Norelle L., Cardoso, Fernanda C. and Lewis, Richard J. (2023). Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes. Frontiers in Pharmacology, 14 1277143, 1-13. doi: 10.3389/fphar.2023.1277143

Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes

2023

Journal Article

Development of a selective peptide κ-opioid receptor antagonist by late-stage functionalization with cysteine staples

Muratspahić, Edin, White, Andrew M., Ciotu, Cosmin I., Hochrainer, Nadine, Tomašević, Nataša, Koehbach, Johannes, Lewis, Richard J., Spetea, Mariana, Fischer, Michael J. M., Craik, David J. and Gruber, Christian W. (2023). Development of a selective peptide κ-opioid receptor antagonist by late-stage functionalization with cysteine staples. Journal of Medicinal Chemistry, 66 (17), 11843-11854. doi: 10.1021/acs.jmedchem.3c00426

Development of a selective peptide κ-opioid receptor antagonist by late-stage functionalization with cysteine staples

2023

Journal Article

Ciguatera fish poisoning in the Caribbean Sea and Atlantic Ocean: reconciling the multiplicity of ciguatoxins and analytical chemistry approach for public health safety

Pottier, Ivannah, Lewis, Richard J. and Vernoux, Jean-Paul (2023). Ciguatera fish poisoning in the Caribbean Sea and Atlantic Ocean: reconciling the multiplicity of ciguatoxins and analytical chemistry approach for public health safety. Toxins, 15 (7) 453, 1-40. doi: 10.3390/toxins15070453

Ciguatera fish poisoning in the Caribbean Sea and Atlantic Ocean: reconciling the multiplicity of ciguatoxins and analytical chemistry approach for public health safety

2023

Journal Article

Coordinated adaptations define the ontogenetic shift from worm-to fish-hunting in a venomous cone snail

Rogalski, Aymeric, Himaya, S. W. A. and Lewis, Richard J. (2023). Coordinated adaptations define the ontogenetic shift from worm-to fish-hunting in a venomous cone snail. Nature Communications, 14 (1) 3287, 1-11. doi: 10.1038/s41467-023-38924-5

Coordinated adaptations define the ontogenetic shift from worm-to fish-hunting in a venomous cone snail

2023

Journal Article

The T type calcium channel CaV3.2 regulates bladder afferent responses to mechanical stimuli

Grundy, Luke, Tay, Cindy, Christie, Stewart, Harrington, Andrea M., Castro, Joel, Cardoso, Fernanda C., Lewis, Richard J., Zagorodnyuk, Vladimir and Brierley, Stuart M. (2023). The T type calcium channel CaV3.2 regulates bladder afferent responses to mechanical stimuli. Pain, 164 (5), 1012-1026. doi: 10.1097/j.pain.0000000000002795

The T type calcium channel CaV3.2 regulates bladder afferent responses to mechanical stimuli

2023

Journal Article

Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors

Ho, Thao NT, Abraham, Nikita and Lewis, Richard J. (2023). Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors. Frontiers in Pharmacology, 14 1170514, 1170514. doi: 10.3389/fphar.2023.1170514

Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors

2023

Journal Article

Model of the origin of a ciguatoxic grouper (Plectropomus leopardus)

Holmes, Michael J. and Lewis, Richard J. (2023). Model of the origin of a ciguatoxic grouper (Plectropomus leopardus). Toxins, 15 (3) 230, 1-20. doi: 10.3390/toxins15030230

Model of the origin of a ciguatoxic grouper (Plectropomus leopardus)

2023

Journal Article

"Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction" (vol 65, pg 2204, 2022)

Begnini, Fabio, Geschwindner, Stefan, Johansson, Patrik, Wissler, Lisa, Lewis, Richard J., Danelius, Emma, Luttens, Andreas, Matricon, Pierre, Carlsson, Jens, Lenders, Stijn, Koenig, Beate, Friedel, Anna, Sjoe, Peter, Schiesser, Stefan and Kihlberg, Jan (2023). "Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction" (vol 65, pg 2204, 2022). Journal of Medicinal Chemistry, 66 (3), 2204-2204. doi: 10.1021/acs.jmedchem.3c00037

"Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction" (vol 65, pg 2204, 2022)

2022

Journal Article

Bimodal cell size and fusing cells observed in a clonal culture of the ciguatoxin-producing benthic dinoflagellate Gambierdiscus (WC1/1)

Holmes, Michael J. and Lewis, Richard J. (2022). Bimodal cell size and fusing cells observed in a clonal culture of the ciguatoxin-producing benthic dinoflagellate Gambierdiscus (WC1/1). Toxins, 14 (11) 767, 1-8. doi: 10.3390/toxins14110767

Bimodal cell size and fusing cells observed in a clonal culture of the ciguatoxin-producing benthic dinoflagellate Gambierdiscus (WC1/1)

2022

Journal Article

The deadly toxin arsenal of the tree-dwelling Australian funnel-web spiders

Cardoso, Fernanda C., Pineda, Sandy S., Herzig, Volker, Sunagar, Kartik, Shaikh, Naeem Yusuf, Jin, Ai-Hua, King, Glenn F., Alewood, Paul F., Lewis, Richard J. and Dutertre, Sébastien (2022). The deadly toxin arsenal of the tree-dwelling Australian funnel-web spiders. International Journal of Molecular Sciences, 23 (21) 13077, 13077. doi: 10.3390/ijms232113077

The deadly toxin arsenal of the tree-dwelling Australian funnel-web spiders

2022

Journal Article

Synthesis of full-length homodimer αD-VxXXB that targets human α7 nicotinic acetylcholine receptors

Ho, Thao N. T., Abraham, Nikita and Lewis, Richard J. (2022). Synthesis of full-length homodimer αD-VxXXB that targets human α7 nicotinic acetylcholine receptors. RSC Medicinal Chemistry, 13 (11), 1410-1419. doi: 10.1039/d2md00188h

Synthesis of full-length homodimer αD-VxXXB that targets human α7 nicotinic acetylcholine receptors

2022

Journal Article

Origin of ciguateric fish: quantitative modelling of the flow of ciguatoxin through a marine food chain

Holmes, Michael J. and Lewis, Richard J. (2022). Origin of ciguateric fish: quantitative modelling of the flow of ciguatoxin through a marine food chain. Toxins, 14 (8) 534, 1-11. doi: 10.3390/toxins14080534

Origin of ciguateric fish: quantitative modelling of the flow of ciguatoxin through a marine food chain

2022

Journal Article

Diindolylmethane derivatives: new selective blockers for T-type calcium channels

Wang, Dan, Neupane, Pratik, Ragnarsson, Lotten, Capon, Robert and Lewis, Richard (2022). Diindolylmethane derivatives: new selective blockers for T-type calcium channels. Membranes, 12 (8) 749, 1-13. doi: 10.3390/membranes12080749

Diindolylmethane derivatives: new selective blockers for T-type calcium channels

2022

Journal Article

The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF <sup>V600E</sup>

Moral‐Sanz, Javier, Fernandez‐Rojo, Manuel A., Colmenarejo, Gonzalo, Kurdyukov, Sergey, Brust, Andreas, Ragnarsson, Lotten, Andersson, Åsa, Vila, Sabela F., Cabezas‐Sainz, Pablo, Wilhelm, Patrick, Vela‐Sebastian, Ana, Fernández‐Carrasco, Isabel, Chin, Yanni K. Y., López‐ Mancheño, Yaiza, Smallwood, Taylor B., Clark, Richard J., Fry, Bryan G., King, Glenn F., Ramm, Grant A., Alewood, Paul F., Lewis, Richard J., Mulvenna, Jason P., Boyle, Glen M., Sanchez, Laura E., Neely, G. Gregory, Miles, John J. and Ikonomopoulou, Maria P. (2022). The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF V600E. British Journal of Pharmacology, 179 (20), 4878-4896. doi: 10.1111/bph.15923

The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF <sup>V600E</sup>

2022

Journal Article

Editorial: Pharmacological Aspects of Ligand-Gated Ion Channels as Targets of Natural and Synthetic Agents

Mattei, César, Tricoire-Leignel, Hélène, Legros, Christian, Lewis, Richard J. and Molgó, Jordi (2022). Editorial: Pharmacological Aspects of Ligand-Gated Ion Channels as Targets of Natural and Synthetic Agents. Frontiers in Neuroscience, 16 895299, 895299. doi: 10.3389/fnins.2022.895299

Editorial: Pharmacological Aspects of Ligand-Gated Ion Channels as Targets of Natural and Synthetic Agents

Current funding

  • 2024 - 2025
    Super-resolution platform to accelerate biological and molecular research
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant

Past funding

  • 2020
    Electrophysiology Platform for Ion-channel Characterisation
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2020 - 2023
    Conotoxin diversification and evolution of venom peptides in cone snails
    ARC Discovery Projects
    Open grant
  • 2020 - 2023
    Novel multifunctional analgesic sodium channel inhibitors
    NHMRC IDEAS Grants
    Open grant
  • 2019 - 2023
    Seafood Safety: High throughput diagnostics for ciguatoxin risk assessment (ARC Linkage Project administered by University of Technology Sydney)
    University of Technology Sydney
    Open grant
  • 2019
    Chemical Purification Network
    UQ Major Equipment and Infrastructure
    Open grant
  • 2019
    In vivo imaging system for tracking inflammation, infection, cancer, pain and bioactive molecules
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2019
    Development of dual Nav1.1/1.7 inhibitors for the treatment of IBS-related pain
    UniQuest Pty Ltd
    Open grant
  • 2018
    High-throughput ion channel pharmacology
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018
    Multichannel peptide synthesiser to accelerate UQ's biodiscovery pipeline and peptide drug development programs
    UQ Major Equipment and Infrastructure
    Open grant
  • 2018 - 2020
    Novel non-opioid analgesics
    NHMRC Development Grant
    Open grant
  • 2018 - 2020
    Silencing visceral nociceptors by targeting NaV1.1: A novel therapeutic approach for treating Irritable Bowel Syndrome (NHMRC Project Grant led by The Flinders University of South Australia)
    Flinders University
    Open grant
  • 2017
    Deep Protein Sequencing, Structure and Quantification Facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2017 - 2024
    ACRF Cancer Ultrastructure and Function Facility
    Australian Cancer Research Foundation
    Open grant
  • 2017 - 2022
    Discovery and development of novel venom peptide analgesics
    NHMRC Research Fellowship
    Open grant
  • 2017 - 2020
    Evolution of defensive and predatory venom in cone snails
    ARC Discovery Projects
    Open grant
  • 2016
    4D Mass Spectrometer
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Integrative blood coagulation research core facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016
    Novel Pain therapeutics discovery: Probing molecular mechanisms
    NHMRC Equipment Grant
    Open grant
  • 2016
    Patch-clamp electrophysiology platform for drug and insecticide discovery
    UQ Major Equipment and Infrastructure
    Open grant
  • 2016 - 2019
    Structure and function of predatory and defensive venoms in cone snails
    ARC Discovery Projects
    Open grant
  • 2015 - 2016
    A multi-omics platform for molecular evolution and developmental biology
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2015 - 2019
    Ion channel modulators of pain pathways
    NHMRC Program Grant
    Open grant
  • 2015
    Murine behavioural phenotyping facility
    UQ Major Equipment and Infrastructure
    Open grant
  • 2014 - 2017
    Discovery and characterisation of novel spider-venom peptides targeting the human Nav1.7 channel
    ARC Linkage Projects
    Open grant
  • 2013 - 2017
    A VAST potential for ion channel drug discovery
    ARC Linkage Projects
    Open grant
  • 2013 - 2014
    IMB Alchemia collaborative project on pain therapeutics
    UniQuest Pty Ltd
    Open grant
  • 2013 - 2018
    Efficacy Profiling Innovation in Novel Pain Therapeutics Discovery
    ARC Linkage Projects
    Open grant
  • 2012 - 2016
    NHMRC Research Fellowship (PRF)
    NHMRC Research Fellowship
    Open grant
  • 2012 - 2014
    Probing norepinephrine transporter (NET) structure-function
    ARC Discovery Projects
    Open grant
  • 2012
    Quantitave real-time PCR instrumentation for rapid, high-throughput gene expression studies.
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    Development of novel analgesics for the treatment of chronic pain
    UQ FirstLink Scheme
    Open grant
  • 2011 - 2012
    High-throughput, high resolution protein-peptide sequencing and quantification facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2011 - 2014
    Development of potent and specific modulators of the human sodium channel Nav1.7
    ARC Discovery Projects
    Open grant
  • 2011
    Quantitative real-time PCR instrumentation for rapid, high-throughput gene expression studies
    UQ Major Equipment and Infrastructure
    Open grant
  • 2011 - 2013
    Role of extracellular surface residues in agonist activation of the alpha1 adrenoceptor
    NHMRC Project Grant
    Open grant
  • 2010 - 2011
    Advanced molecular discovery and characterisation facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2010 - 2011
    Molecular Targets and Mechanisms involved in ciguatoxin-induced cold allodynia
    Go8 Australia - Germany Joint Research Co-operation Scheme
    Open grant
  • 2010
    Resonant waveguide label-free plate sensor
    UQ Major Equipment and Infrastructure
    Open grant
  • 2010 - 2014
    Venom peptide modulators of pain pathways
    NHMRC Program Grant
    Open grant
  • 2009
    Interactions between conotoxin rho-TIA and alpha1 adrenoceptor signalling
    UQ External Support Enabling Grant
    Open grant
  • 2009
    Robotics Instrumentation for High Throughput Sample preparation for Increased Productivity of the CIPDD/TetraQ's HPLC-MS/MS Systems for Quantitative Analysis of Organics in a Quality Systems NATA-Acc
    UQ Faculty Co-Funding
    Open grant
  • 2007 - 2011
    NHMRC Senior Research Fellowship
    NHMRC Research Fellowship
    Open grant
  • 2006 - 2007
    Binding affinity of CSIRO compounds to rat brain calcium ion channels using a radio-ligand displacement assay
    CSIRO
    Open grant
  • 2006
    Biomolecular discovery and analysis facility
    ARC Linkage Infrastructure, Equipment and Facilities
    Open grant
  • 2006 - 2008
    Novel Sodium Ion Channel Modulators From Australian Cephalopods
    ARC Discovery Projects
    Open grant
  • 2005 - 2007
    Covalent Hydrogen Bond Mimetics of Helical Peptide Hormones
    ARC Linkage Projects
    Open grant
  • 2005 - 2009
    Dissecting pain pathways with conopeptides
    NHMRC Program Grant
    Open grant
  • 2005
    NHMRC_Equipment Grant = High Throughput Screening
    NHMRC Equipment Grant
    Open grant
  • 2004 - 2007
    Anti cancer Agents from Australian Marine Biodiversity
    ARC Linkage Projects
    Open grant
  • 2004
    ARC Network in Imaging Science and Technology
    ARC Seed Funding for Research Networks
    Open grant
  • 2004 - 2006
    Selectivity and mode of action of Rho-Conopeptide TIA: a novel inhibitor of Alpha1-Adrenoceptors
    NHMRC Project Grant
    Open grant
  • 2003
    Unprecedented Alkaloid Hybrids that Selectively Modulate Various Cancers and the Central Nervous System
    University of Queensland Research Development Grants Scheme
    Open grant
  • 2002 - 2004
    Biocore 3000 for discovery and characterisation of novel pharmaceuticals
    Systemic Infrastucture Iniative
    Open grant
  • 2002 - 2006
    Conotoxins: Novel probes for ion channel structure and function
    ARC Discovery Projects
    Open grant
  • 2002 - 2004
    Engineering subtype selective inhibitors of voltage-sensitive sodium channels
    NHMRC Project Grant
    Open grant
  • 2001 - 2003
    Conantokin selectivity for different subtypes of the human N-methyl-D-aspartate receptor
    ARC Australian Research Council (Large grants)
    Open grant
  • 2001
    Conantokin selectivity for different subtypes of the human N-methyl-D-aspartate receptor
    University of Queensland Small Grants Scheme
    Open grant
  • 2001 - 2003
    Molecular Interactions of Novel Conotoxin Inhibitors of the Noradrenaline Transporter
    NHMRC Project Grant
    Open grant
  • 2000
    Defining conantakin selectivity at different subtypes of the human N-methyl-D-aspartate receptor
    UQ External Support Enabling Grant
    Open grant
  • 2000 - 2002
    Probing central and peripheral calcium channel subtypes with novel omega conotoxins
    NHMRC Project Grant
    Open grant
  • 1999 - 2001
    Characterisation of a-Conotoxin Probes that Differentiate Among Neuronal Nicotinic Acetylcholine Receptor Subtypes
    ARC Australian Research Council (Large grants)
    Open grant
  • 1997 - 2000
    Development of neuronal sodium channel antagonist for the treatment of neuropathic and chronic pain
    Department Industry Science & Tourism R&D "Start"
    Open grant
  • 1996 - 1998
    Mode of action and structure of novel sodium channel conopeptides
    ARC Australian Research Council (Large grants)
    Open grant

Availability

Professor Richard Lewis is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Completed supervision

Enquiries

Contact Professor Richard Lewis directly for media enquiries about:

  • Chronic pain
  • ciguatera
  • Cone snails
  • conotoxin evolution
  • conotoxins
  • drug development
  • fish poisoning
  • ion channel modulation
  • pain
  • Pain - chronic
  • pain treatment
  • peptides
  • Treatment of chronic pain
  • venom
  • Xenome

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