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2025 Journal Article Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU studyRoberts, Jason A., Sime, Fekade B., Lipman, Jeffrey, Hernández-Mitre, María Patricia, Baptista, João Pedro, Brüggemann, Roger J., Darvall, Jai, De Waele, Jan J., Dimopoulos, George, Lefrant, Jean-Yves, Mat Nor, Mohd Basri, Rello, Jordi, Seoane, Leonardo, Slavin, Monica A., Valkonen, Miia, Venditti, Mario, Ceccarelli, Giancarlo, Wong, Wai Tat, Zeitlinger, Markus and Roger, Claire (2025). Are contemporary antifungal doses sufficient for critically ill patients? Outcomes from an international, multicenter pharmacokinetics study for Screening Antifungal Exposure in Intensive Care Units—the SAFE-ICU study. Intensive Care Medicine, 1-16. doi: 10.1007/s00134-025-07793-5 |
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2025 Journal Article 211. Defining Optimal Sampling Times for Cefepime Therapeutic Drug Monitoring in Clinical PracticeRhodes, Nathaniel J, Smith, Brandon, Shields, Ryan K, Pan, Samantha, Weslander, Erin, Galvin, Shannon, Hughes, Jasmine, Hughes, Maria-Stephanie, Sime, Fekade B, Roberts, Jason A, Kiel, Patrick J, Neely, Michael N and Scheetz, Marc H (2025). 211. Defining Optimal Sampling Times for Cefepime Therapeutic Drug Monitoring in Clinical Practice. Open Forum Infectious Diseases, 12 (Supplement_1). doi: 10.1093/ofid/ofae631.069 |
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2024 Journal Article A pooled pharmacokinetic analysis for piperacillin/tazobactam across different patient populations: From premature infants to the elderlyKong, Daming, Roberts, Jason A., Lipman, Jeffrey, Taccone, Fabio Silvio, Cohen-Wolkowiez, Michael, Sime, Fekade B., Tsai, Danny, De Cock, Pieter A. J. G., Jaruratanasirikul, Sutep, Dhaese, Sofie A. M., Udy, Andrew A., Felton, Timothy W., Michelet, Robin, Thibault, Celine, Koomen, Jeroen V., Eleveld, Douglas J., Struys, Michel M. R. F., De Waele, Jan J., Colin, Pieter J., Damen, Caroline and PIP/TAZ Consortium (2024). A pooled pharmacokinetic analysis for piperacillin/tazobactam across different patient populations: From premature infants to the elderly. Clinical Pharmacokinetics, 64 (1) 769329, 107-126. doi: 10.1007/s40262-024-01460-6 |
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2024 Journal Article A systematic review and individual bacterial species level meta-analysis of in vitro studies on the efficacy of ceftazidime/avibactam combined with other antimicrobials against carbapenem-resistant Gram-negative bacteriaAssefa, Getnet M., Roberts, Jason A., Aslan, Abdullah T., Mohammed, Solomon A. and Sime, Fekade B. (2024). A systematic review and individual bacterial species level meta-analysis of in vitro studies on the efficacy of ceftazidime/avibactam combined with other antimicrobials against carbapenem-resistant Gram-negative bacteria. Journal of Antimicrobial Chemotherapy, 80 (2), 334-346. doi: 10.1093/jac/dkae451 |
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2024 Journal Article Dynamic in vitro PK/PD infection models for the development and optimisation of antimicrobial regimens: A narrative reviewWale, Yalew M., Roberts, Jason A. and Sime, Fekade B. (2024). Dynamic in vitro PK/PD infection models for the development and optimisation of antimicrobial regimens: A narrative review. Antibiotics, 13 (12) 1201, 1-23. doi: 10.3390/antibiotics13121201 |
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2024 Journal Article A review of antimicrobial stability testing guidance for outpatient parenteral antimicrobial therapy programmes: is it time for global harmonization of testing frameworks?Naicker, Saiyuri, Roberts, Jason A., Cheng, Vesa, Parker, Suzanne L., Seaton, R. Andrew, Gilchrist, Mark and Sime, Fekade B. (2024). A review of antimicrobial stability testing guidance for outpatient parenteral antimicrobial therapy programmes: is it time for global harmonization of testing frameworks?. JAC-Antimicrobial Resistance, 6 (6) dlae186, 1-11. doi: 10.1093/jacamr/dlae186 |
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2024 Journal Article Outpatient parenteral antimicrobial therapy with carbapenems: a systematic reviewWolie, Z. T., Roberts, J. A., Wale, Y. M., Unwin, S., McCarthy, K. and Sime, F. B. (2024). Outpatient parenteral antimicrobial therapy with carbapenems: a systematic review. Journal of Infection, 89 (5) 106299, 106299. doi: 10.1016/j.jinf.2024.106299 |
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2024 Journal Article Is there evidence on the optimal duration of aminoglycoside therapy in beta-lactam/aminoglycoside combination regimens used for the treatment of Gram-negative bacterial infections? -A Systematic ReviewWale, Yalew M., Roberts, Jason A., Wolie, Zenaw T. and Sime, Fekade B. (2024). Is there evidence on the optimal duration of aminoglycoside therapy in beta-lactam/aminoglycoside combination regimens used for the treatment of Gram-negative bacterial infections? -A Systematic Review. International Journal of Antimicrobial Agents, 64 (4) 107297, 107297. doi: 10.1016/j.ijantimicag.2024.107297 |
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2024 Journal Article Safety and efficacy of outpatient parenteral antimicrobial therapy: a systematic review and meta-analysis of randomized clinical trialsMohammed, Solomon Ahmed, Roberts, Jason A, Cotta, Menino Osbert, Rogers, Benjamin, Pollard, James, Assefa, Getnet Mengistu, Erku, Daniel and Sime, Fekade B (2024). Safety and efficacy of outpatient parenteral antimicrobial therapy: a systematic review and meta-analysis of randomized clinical trials. International Journal of Antimicrobial Agents, 64 (2) 107263, 107263. doi: 10.1016/j.ijantimicag.2024.107263 |
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2024 Journal Article Editorial: Commercialization and industrialization of pharmacology of infectious diseases: 2022Huang, Yanqin, Nang, Sue C., Lin, Yu-Wei and Sime, Fekade (2024). Editorial: Commercialization and industrialization of pharmacology of infectious diseases: 2022. Frontiers in Pharmacology, 15 1438072. doi: 10.3389/fphar.2024.1438072 |
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2024 Journal Article Current practices and challenges of outpatient parenteral antimicrobial therapy: a narrative reviewWolie, Zenaw T., Roberts, Jason A., Gilchrist, Mark, McCarthy, Kate and Sime, Fekade B. (2024). Current practices and challenges of outpatient parenteral antimicrobial therapy: a narrative review. Journal of Antimicrobial Chemotherapy, 79 (9), 2083-2102. doi: 10.1093/jac/dkae177 |
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2024 Journal Article Barriers and facilitators for the implementation and expansion of outpatient parenteral antimicrobial therapy: systematic reviewMohammed, Solomon Ahmed, Cotta, Menino Osbert, Assefa, Getnet Mengistu, Erku, Daniel and Sime, Fekade (2024). Barriers and facilitators for the implementation and expansion of outpatient parenteral antimicrobial therapy: systematic review. Journal of Hospital Infection, 147, 1-16. doi: 10.1016/j.jhin.2024.02.006 |
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2024 Journal Article Evaluation of the stability of ceftazidime/avibactam in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy utilizing a national stability protocol frameworkNaicker, Saiyuri, Roberts, Jason A., Won, Hayoung, Wallis, Steven C., Unwin, Sean, Jamieson, Conor, Hills, Tim, Gilchrist, Mark, Santillo, Mark, Seaton, R. Andrew, Drummond, Felicity and Sime, Fekade B. (2024). Evaluation of the stability of ceftazidime/avibactam in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy utilizing a national stability protocol framework. JAC-Antimicrobial Resistance, 6 (2) dlae056, 1-10. doi: 10.1093/jacamr/dlae056 |
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2024 Journal Article What are the optimal pharmacokinetic/pharmacodynamic targets for β-lactamase inhibitors? A systematic reviewAssefa, Getnet M, Roberts, Jason A, Mohammed, Solomon A and Sime, Fekade B (2024). What are the optimal pharmacokinetic/pharmacodynamic targets for β-lactamase inhibitors? A systematic review. Journal of Antimicrobial Chemotherapy, 79 (5) dkae058, 946-958. doi: 10.1093/jac/dkae058 |
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2024 Journal Article The global epidemiology of ventilator-associated pneumonia caused by multi-drug resistant Pseudomonas aeruginosa: a systematic review and meta-analysisLi, Yixuan, Roberts, Jason A., Walker, Mikaela M., Aslan, Abdullah Tarik, Harris, Patrick N. A. and Sime, Fekade (2024). The global epidemiology of ventilator-associated pneumonia caused by multi-drug resistant Pseudomonas aeruginosa: a systematic review and meta-analysis. International Journal of Infectious Diseases, 139, 78-85. doi: 10.1016/j.ijid.2023.11.023 |
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2023 Journal Article Evaluation of the stability of aciclovir in elastomeric infusion devices used for outpatient parenteral antimicrobial therapySime, Fekade Bruck, Wallis, Steven, Jamieson, Conor, Hills, Tim, Gilchrist, Mark, Santillo, Mark, Seaton, R Andrew, Drummond, Felicity and Roberts, Jason (2023). Evaluation of the stability of aciclovir in elastomeric infusion devices used for outpatient parenteral antimicrobial therapy. European Journal of Hospital Pharmacy ejhpharm-2023-003784, ejhpharm-2023. doi: 10.1136/ejhpharm-2023-003784 |
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2023 Journal Article An in vitro dynamic bioreactor model for evaluating antimicrobial effectiveness on periodontal polymicrobial biofilms: a proof-of-concept studyRamachandra, Srinivas Sulugodu, Sime, Fekade Bruck, Naicker, Saiyuri, Han, Pingping, Lee, Ryan S.B., Wallis, Steven C., Roberts, Jason A. and Ivanovski, Sašo (2023). An in vitro dynamic bioreactor model for evaluating antimicrobial effectiveness on periodontal polymicrobial biofilms: a proof-of-concept study. Journal of Periodontology, 95 (4), 384-396. doi: 10.1002/JPER.23-0086 |
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2023 Journal Article A protocol for an international, multicentre pharmacokinetic study for Screening Antifungal Exposure in Intensive Care Units: The SAFE-ICU studyRoberts, Jason A., Sime, Fekade, Lipman, Jeffrey, Hernández-Mitre, Maria Patricia, Baptista, João Pedro, Brüggemann, Roger J., Darvall, Jai, De Waele, Jan J., Dimopoulos, George, Lefrant, Jean-Yves, Mat Nor, Mohd Basri, Rello, Jordi, Seoane, Leonardo, Slavin, Monica A., Valkonen, Miia, Venditti, Mario, Wong, Wai Tat, Zeitlinger, Markus and Roger, Claire (2023). A protocol for an international, multicentre pharmacokinetic study for Screening Antifungal Exposure in Intensive Care Units: The SAFE-ICU study. Critical Care and Resuscitation, 25 (1), 1-5. doi: 10.1016/j.ccrj.2023.04.002 |
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2023 Journal Article Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae—authors’ responseSumi, Chandra Datta, Roberts, Jason A and Sime, Fekade B (2023). Pharmacodynamic evaluation of intermittent versus extended and continuous infusions of piperacillin/tazobactam in a hollow-fibre infection model against Klebsiella pneumoniae—authors’ response. Journal of Antimicrobial Chemotherapy, 78 (3), 854-857. doi: 10.1093/jac/dkad017 |
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2022 Journal Article Current and emerging treatment options for multidrug resistant Escherichia coli urosepsis: a reviewWalker, Mikaela M., Roberts, Jason A., Rogers, Benjamin A., Harris, Patrick N. A. and Sime, Fekade B. (2022). Current and emerging treatment options for multidrug resistant Escherichia coli urosepsis: a review. Antibiotics, 11 (12) 1821, 1-20. doi: 10.3390/antibiotics11121821 |
