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2023 Journal Article Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiationChen, Zhian, Cui, Yanfang, Yao, Yin, Liu, Bo, Yunis, Joseph, Gao, Xin, Wang, Naiqi, Cañete, Pablo F., Tuong, Zewen Kelvin, Sun, Hongjian, Wang, Hao, Yang, Siling, Wang, Runli, Leong, Yew Ann, Simon Davis, David, Qin, Jiahuan, Liang, Kaili, Deng, Jun, Wang, Conan K., Huang, Yen-Hua, Roco, Jonathan A., Nettelfield, Sam, Zhu, Huaming, Xu, Huajun, Yu, Zhijia, Craik, David, Liu, Zheng, Qi, Hai, Parish, Christopher and Yu, Di (2023). Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Science immunology, 8 (80) eadd1728, 1-17. doi: 10.1126/sciimmunol.add1728 |
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2023 Journal Article Dimensionality reduction under scrutinyYang, Yang, Tuong, Zewen K. and Yu, Di (2023). Dimensionality reduction under scrutiny. Nature Computational Science, 3 (1), 8-9. doi: 10.1038/s43588-022-00383-1 |
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2022 Journal Article A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fatesHe, Peng, Lim, Kyungtae, Sun, Dawei, Pett, Jan Patrick, Jeng, Quitz, Polanski, Krzysztof, Dong, Ziqi, Bolt, Liam, Richardson, Laura, Mamanova, Lira, Dabrowska, Monika, Wilbrey-Clark, Anna, Madissoon, Elo, Tuong, Zewen Kelvin, Dann, Emma, Suo, Chenqu, Goh, Isaac, Yoshida, Masahiro, Nikolić, Marko Z., Janes, Sam M., He, Xiaoling, Barker, Roger A., Teichmann, Sarah A., Marioni, John C., Meyer, Kerstin B. and Rawlins, Emma L. (2022). A human fetal lung cell atlas uncovers proximal-distal gradients of differentiation and key regulators of epithelial fates. Cell, 185 (25), 4841-4860.e25. doi: 10.1016/j.cell.2022.11.005 |
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2022 Journal Article Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritisRichoz, Nathan, Tuong, Zewen K., Loudon, Kevin W., Patiño-Martínez, Eduardo, Ferdinand, John R., Portet, Anaïs, Bashant, Kathleen R., Thevenon, Emeline, Rucci, Francesca, Hoyler, Thomas, Junt, Tobias, Kaplan, Mariana J., Siegel, Richard M. and Clatworthy, Menna R. (2022). Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis. JCI Insight, 7 (21) e159751, 1-19. doi: 10.1172/jci.insight.159751 |
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2022 Journal Article Obesity is associated with attenuated tissue immunity in COVID-19Guo, Shuang A., Bowyer, Georgina S., Ferdinand, John R., Maes, Mailis, Tuong, Zewen K., Gillman, Eleanor, Liao, Mingfeng, Lindeboom, Rik G H, Yoshida, Masahiro, Worlock, Kaylee, Gopee, Hudaa, Stephenson, Emily, Gao, Catherine A, Lyons, Paul A, Smith, Kenneth G C, Haniffa, Muzlifah, Meyer, Kerstin B, Nikolić, Marko Z, Zhang, Zheng, Wunderink, Richard G, Misharin, Alexander V, Dougan, Gordon, Navapurkar, Vilas, Teichmann, Sarah A, Conway Morris, Andrew and Clatworthy, Menna R (2022). Obesity is associated with attenuated tissue immunity in COVID-19. American Journal of Respiratory and Critical Care Medicine, 207 (5), 566-576. doi: 10.1164/rccm.202204-0751OC |
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2022 Journal Article Fracture hematoma micro-architecture influences transcriptional profile and plays a crucial role in determining bone healing outcomesWoloszyk, Anna, Tuong, Zewen K., Perez, Louis, Aguilar, Leonardo, Bankole, Abraham I., Evans, Christopher H. and Glatt, Vaida (2022). Fracture hematoma micro-architecture influences transcriptional profile and plays a crucial role in determining bone healing outcomes. Biomaterials Advances, 139 213027, 1-15. doi: 10.1016/j.bioadv.2022.213027 |
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2022 Journal Article A robust experimental and computational analysis framework at multiple resolutions, modalities and coveragesTran, M., Yoon, S., Teoh, M., Andersen, S., Lam, PY., Purdue, B. W., Raghubar, A., Hanson, S.J., Devitt, K., Jones, K., Walters, S., Monkman, J., Kulasinghe, A., Tuong, Z.K., Soyer, H.P., Frazer, I. H. and Nguyen, Q. (2022). A robust experimental and computational analysis framework at multiple resolutions, modalities and coverages. Frontiers in Immunology, 13 911873, 911873. doi: 10.3389/fimmu.2022.911873 |
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2022 Journal Article Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defenceRiding, Alexandra M., Loudon, Kevin W., Guo, Andrew, Ferdinand, John R., Lok, Laurence S.C., Richoz, Nathan, Stewart, Andrew, Castro-Dopico, Tomas, Tuong, Zewen Kelvin, Fiancette, Remi, Bowyer, Georgina S., Fleming, Aaron, Gillman, Eleanor S., Suchanek, Ondrej, Mahbubani, Krishnaa T., Saeb-Parsy, Kourosh, Withers, David, Dougan, Gordan, Clare, Simon and Clatworthy, Menna R. (2022). Group 3 innate lymphocytes make a distinct contribution to type 17 immunity in bladder defence. iScience, 25 (7) 104660, 1-30. doi: 10.1016/j.isci.2022.104660 |
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2022 Journal Article Mapping the developing human immune system across organsSuo, Chenqu, Dann, Emma, Goh, Issac, Jardine, Laura, Kleshchevnikov, Vitalii, Park, Jong-Eun, Botting, Rachel A., Stephenson, Emily, Engelbert, Justin, Tuong, Zewen Kelvin, Polanski, Krzysztof, Yayon, Nadav, Xu, Chuan, Suchanek, Ondrej, Elmentaite, Rasa, Domínguez Conde, Cecilia, He, Peng, Pritchard, Sophie, Miah, Mohi, Moldovan, Corina, Steemers, Alexander S., Mazin, Pavel, Prete, Martin, Horsfall, Dave, Marioni, John C., Clatworthy, Menna R., Haniffa, Muzlifah and Teichmann, Sarah A. (2022). Mapping the developing human immune system across organs. Science, 376 (6597) eabo0510, eabo0510-+. doi: 10.1126/science.abo0510 |
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2022 Journal Article GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humansYao, Yikun, Du Jiang, Ping, Chao, Brittany N., Cagdas, Deniz, Kubo, Satoshi, Balasubramaniyam, Arasu, Zhang, Yu, Shadur, Bella, NaserEddin, Adeeb, Folio, Les R., Schwarz, Benjamin, Bohrnsen, Eric, Zheng, Lixin, Lynberg, Matthew, Gottlieb, Simone, Leney-Greene, Michael A., Park, Ann Y., Tezcan, Ilhan, Akdogan, Ali, Gocmen, Rahsan, Onder, Sevgen, Rosenberg, Avi, Soilleux, Elizabeth J., Johnson, Errin, Jackson, Peter K., Demeter, Janos, Chauvin, Samuel D., Paul, Florian, Selbach, Matthias ... Lenardo, Michael J. (2022). GIMAP6 regulates autophagy, immune competence, and inflammation in mice and humans. Journal of Experimental Medicine, 219 (6) e20201405, 1-29. doi: 10.1084/jem.20201405 |
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2022 Journal Article Cross-tissue immune cell analysis reveals tissue-specific features in humansDomínguez Conde, C., Xu, C., Jarvis, L. B., Rainbow, D. B., Wells, S. B., Gomes, T., Howlett, S. K., Suchanek, O., Polanski, K., King, H. W., Mamanova, L., Huang, N., Szabo, P. A., Richardson, L., Bolt, L., Fasouli, E. S., Mahbubani, K. T., Prete, M., Tuck, L., Richoz, N., Tuong, Z. K., Campos, L., Mousa, H. S., Needham, E. J., Pritchard, S., Li, T., Elmentaite, R., Park, J., Rahmani, E. ... Teichmann, S. A. (2022). Cross-tissue immune cell analysis reveals tissue-specific features in humans. Science, 376 (6594) eabl5197, eabl5197-+. doi: 10.1126/science.abl5197 |
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2022 Journal Article In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissueLi, Zhi, Tuong, Zewen K., Dean, Isaac, Willis, Claire, Gaspal, Fabrina, Fiancette, Rémi, Idris, Suaad, Kennedy, Bethany, Ferdinand, John R., Peñalver, Ana, Cabantous, Mia, Murtuza Baker, Syed, Fry, Jeremy W., Carlesso, Gianluca, Hammond, Scott A., Dovedi, Simon J., Hepworth, Matthew R., Clatworthy, Menna R. and Withers, David R. (2022). In vivo labeling reveals continuous trafficking of TCF-1+ T cells between tumor and lymphoid tissue. Journal of Experimental Medicine, 219 (6) e20210749, 1-27. doi: 10.1084/jem.20210749 |
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2022 Journal Article The impact of hypoxia on B cells in COVID-19Kotagiri, Prasanti, Mescia, Federica, Hanson, Aimee L., Turner, Lorinda, Bergamaschi, Laura, Peñalver, Ana, Richoz, Nathan, Moore, Stephen D., Ortmann, Brian M., Dunmore, Benjamin J., Morgan, Michael D., Tuong, Zewen Kelvin, Göttgens, Berthold, Toshner, Mark, Hess, Christoph, Maxwell, Patrick. H., Clatworthy, Menna. R., Nathan, James A., Bradley, John R., Lyons, Paul A., Burrows, Natalie and Smith, Kenneth G.C. (2022). The impact of hypoxia on B cells in COVID-19. eBioMedicine, 77 103878, 103878. doi: 10.1016/j.ebiom.2022.103878 |
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2022 Journal Article B cell receptor repertoire kinetics after SARS-CoV-2 infection and vaccinationKotagiri, Prasanti, Mescia, Federica, Rae, William M., Bergamaschi, Laura, Tuong, Zewen K., Turner, Lorinda, Hunter, Kelvin, Gerber, Pehuén P., Hosmillo, Myra, Hess, Christoph, Clatworthy, Menna R., Goodfellow, Ian G., Matheson, Nicholas J., McKinney, Eoin F., Wills, Mark R., Gupta, Ravindra K., Bradley, John R., Bashford-Rogers, Rachael J.M., Lyons, Paul A. and Smith, Kenneth G.C. (2022). B cell receptor repertoire kinetics after SARS-CoV-2 infection and vaccination. Cell Reports, 38 (7) 110393, 110393. doi: 10.1016/j.celrep.2022.110393 |
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2022 Journal Article Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activityUzzan, Mathieu, Martin, Jerome C., Mesin, Luka, Livanos, Alexandra E., Castro-Dopico, Tomas, Huang, Ruiqi, Petralia, Francesca, Magri, Giuliana, Kumar, Shashi, Zhao, Qing, Rosenstein, Adam K., Tokuyama, Minami, Sharma, Keshav, Ungaro, Ryan, Kosoy, Roman, Jha, Divya, Fischer, Jeremy, Singh, Harpriya, Keir, Mary E., Ramamoorthi, Nandhini, Gorman, William E. O’, Cohen, Benjamin L., Rahman, Adeeb, Cossarini, Francesca, Seki, Akihiro, Leyre, Louise, Vaquero, Sonia Tejedor, Gurunathan, Sakteesh, Grasset, Emilie K. ... Mehandru, Saurabh (2022). Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity. Nature Medicine, 28 (4), 766-779. doi: 10.1038/s41591-022-01680-y |
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2022 Journal Article Secreted toxins from Staphylococcus aureus strains isolated from keratinocyte skin cancers mediate pro-tumorigenic inflammatory responses in the skinKrueger, Annika, Zaugg, Julian, Chisholm, Sarah, Linedale, Richard, Lachner, Nancy, Teoh, Siok Min, Tuong, Zewen K., Lukowski, Samuel W., Morrison, Mark, Soyer, H. Peter, Hugenholtz, Philip, Hill, Michelle M. and Frazer, Ian H. (2022). Secreted toxins from Staphylococcus aureus strains isolated from keratinocyte skin cancers mediate pro-tumorigenic inflammatory responses in the skin. Frontiers in Microbiology, 12 789042, 789042. doi: 10.3389/fmicb.2021.789042 |
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2022 Journal Article Epigenetics and tissue immunity—translating environmental cues into functional adaptations*Tuong, Zewen Kelvin, Stewart, Benjamin J., Guo, Shuang Andrew and Clatworthy, Menna R. (2022). Epigenetics and tissue immunity—translating environmental cues into functional adaptations*. Immunological Reviews, 305 (1), 111-136. doi: 10.1111/imr.13036 |
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2021 Journal Article Resolving the immune landscape of human prostate at a single-cell level in health and cancerTuong, Zewen Kelvin, Loudon, Kevin W., Berry, Brendan, Richoz, Nathan, Jones, Julia, Tan, Xiao, Nguyen, Quan, George, Anne, Hori, Satoshi, Field, Sarah, Lynch, Andy G., Kania, Katarzyna, Coupland, Paul, Babbage, Anne, Grenfell, Richard, Barrett, Tristan, Warren, Anne Y., Gnanapragasam, Vincent, Massie, Charlie and Clatworthy, Menna R. (2021). Resolving the immune landscape of human prostate at a single-cell level in health and cancer. Cell Reports, 37 (12) 110132, 110132. doi: 10.1016/j.celrep.2021.110132 |
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2021 Journal Article Aldehyde-driven transcriptional stress triggers an anorexic DNA damage responseMulderrig, Lee, Garaycoechea, Juan I., Tuong, Zewen K., Millington, Christopher L., Dingler, Felix A., Ferdinand, John R., Gaul, Liam, Tadross, John A., Arends, Mark J., O’Rahilly, Stephen, Crossan, Gerry P., Clatworthy, Menna R. and Patel, Ketan J. (2021). Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response. Nature, 600 (7887), 158-163. doi: 10.1038/s41586-021-04133-7 |
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2021 Journal Article A model of impaired Langerhans cell maturation associated with HPV induced epithelial hyperplasiaTuong, Zewen K., Lukowski, Samuel W., Nguyen, Quan H., Chandra, Janin, Zhou, Chenhao, Gillinder, Kevin, Bashaw, Abate A., Ferdinand, John R., Stewart, Benjamin J., Teoh, Siok Min, Hanson, Sarah J., Devitt, Katharina, Clatworthy, Menna R., Powell, Joseph E. and Frazer, Ian H. (2021). A model of impaired Langerhans cell maturation associated with HPV induced epithelial hyperplasia. iScience, 24 (11) 103326, 103326. doi: 10.1016/j.isci.2021.103326 |
