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2020 Journal Article Sphingolipids metabolism alteration in the central nervous system: Amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseasesBouscary, Alexandra, Quessada, Cyril, René, Frédérique, Spedding, Michael, Turner, Bradley J., Henriques, Alexandre, Ngo, Shyuan T. and Loeffler, Jean-Philippe (2020). Sphingolipids metabolism alteration in the central nervous system: Amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases. Seminars in Cell and Developmental Biology, 112, 82-91. doi: 10.1016/j.semcdb.2020.10.008 |
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2020 Journal Article Drug repositioning in neurodegeneration: an overview of the use of ambroxol in neurodegenerative diseasesBouscary, Alexandra, Quessada, Cyril, René, Frédérique, Spedding, Michael, Henriques, Alexandre, Ngo, Shyuan and Loeffler, Jean-Philippe (2020). Drug repositioning in neurodegeneration: an overview of the use of ambroxol in neurodegenerative diseases. European Journal of Pharmacology, 884 173446, 173446. doi: 10.1016/j.ejphar.2020.173446 |
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2020 Journal Article Genome-wide meta-analysis finds the ACSL5-ZDHHC6 locus is associated with ALS and links weight loss to the disease geneticsIacoangeli, Alfredo, Lin, Tian, Al Khleifat, Ahmad, Jones, Ashley R., Opie-Martin, Sarah, Coleman, Jonathan R.I., Shatunov, Aleksey, Sproviero, William, Williams, Kelly L., Garton, Fleur, Restuadi, Restuadi, Henders, Anjali K., Mather, Karen A., Needham, Merilee, Mathers, Susan, Nicholson, Garth A., Rowe, Dominic B., Henderson, Robert, McCombe, Pamela A., Pamphlett, Roger, Blair, Ian P., Schultz, David, Sachdev, Perminder S., Newhouse, Stephen J., Proitsi, Petroula, Fogh, Isabella, Ngo, Shyuan T., Dobson, Richard J.B., Wray, Naomi R. ... Al-Chalabi, Ammar (2020). Genome-wide meta-analysis finds the ACSL5-ZDHHC6 locus is associated with ALS and links weight loss to the disease genetics. Cell Reports, 33 (4) 108323, 1-9. doi: 10.1016/j.celrep.2020.108323 |
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2020 Journal Article Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosisSteyn, Frederik J., Li, Rui, Kirk, Siobhan E., Tefera, Tesfaye W, Xie, Teresa Y., Tracey, Timothy J., Kelk, Dean, Wimberger, Elyse, Garton, Fleur C., Roberts, Llion, Chapman, Sarah E., Coombes, Jeff S., Leevy, W. Matthew, Ferri, Alberto, Valle, Cristiana, René, Frédérique, Loeffler, Jean-Philippe, McCombe, Pamela A., Henderson, Robert D. and Ngo, Shyuan T. (2020). Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis. Brain Communications, 2 (2) fcaa154, fcaa154. doi: 10.1093/braincomms/fcaa154 |
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2020 Journal Article The role of lipids in the central nervous system and their pathological implications in amyotrophic lateral sclerosisTracey, T. J., Kirk, S. E., Steyn, F. J. and Ngo, S. T. (2020). The role of lipids in the central nervous system and their pathological implications in amyotrophic lateral sclerosis. Seminars in Cell and Developmental Biology, 112, 69-81. doi: 10.1016/j.semcdb.2020.08.012 |
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2020 Journal Article Prognostic value of weight loss in patients with amyotrophic lateral sclerosisSteyn, Frederik J and Ngo, Shyuan T (2020). Prognostic value of weight loss in patients with amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 91 (8), 813-813. doi: 10.1136/jnnp-2020-323440 |
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2020 Journal Article Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1G93A Mice Predates Disease Onset and Is A Promising Therapeutic TargetScaricamazza, Silvia, Salvatori, Illari, Giacovazzo, Giacomo, Loeffler, Jean Philippe, Renè, Frederique, Rosina, Marco, Quessada, Cyril, Proietti, Daisy, Heil, Constantin, Rossi, Simona, Battistini, Stefania, Giannini, Fabio, Volpi, Nila, Steyn, Frederik J., Ngo, Shyuan T., Ferraro, Elisabetta, Madaro, Luca, Coccurello, Roberto, Valle, Cristiana and Ferri, Alberto (2020). Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1G93A Mice Predates Disease Onset and Is A Promising Therapeutic Target. iScience, 23 (5) 101087, 101087. doi: 10.1016/j.isci.2020.101087 |
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2020 Journal Article Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosisNabais, Marta F., Lin, Tian, Benyamin, Beben, Williams, Kelly L., Garton, Fleur C., Vinkhuyzen, Anna A. E., Zhang, Futao, Vallerga, Costanza L., Restuadi, Restuadi, Freydenzon, Anna, Zwamborn, Ramona A. J., Hop, Paul J., Robinson, Matthew R., Gratten, Jacob, Visscher, Peter M., Hannon, Eilis, Mill, Jonathan, Brown, Matthew A., Laing, Nigel G., Mather, Karen A., Sachdev, Perminder S., Ngo, Shyuan T., Steyn, Frederik J., Wallace, Leanne, Henders, Anjali K., Needham, Merrilee, Veldink, Jan H., Mathers, Susan, Nicholson, Garth ... Wray, Naomi R. (2020). Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis. npj Genomic Medicine, 5 (1) 10, 1-9. doi: 10.1038/s41525-020-0118-3 |
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2020 Journal Article Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosisMcGill, Raquel B., Steyn, Frederik J., Ngo, Shyuan T., Thorpe, Kathryn A., Heggie, Susan, Ruitenberg, Marc J., Henderson, Robert D., McCombe, Pamela A. and Woodruff, Trent M. (2020). Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis. Brain Communications, 2 (1) fcaa013, fcaa013. doi: 10.1093/braincomms/fcaa013 |
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2020 Journal Article Progression and survival of patients with motor neuron disease relative to their fecal microbiotaNgo, Shyuan T., Restuadi, Restuadi, McCrea, Allan F., Van Eijk, Ruben P., Garton, Fleur, Henderson, Robert D., Wray, Naomi R., McCombe, Pamela A. and Steyn, Frederik J. (2020). Progression and survival of patients with motor neuron disease relative to their fecal microbiota. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 21 (7-8), 1-14. doi: 10.1080/21678421.2020.1772825 |
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2019 Journal Article Gut microbiota in ALS: possible role in pathogenesis?McCombe, Pamela A., Henderson, Robert D., Lee, Aven, Lee, John D., Woodruff, Trent M., Restuadi, Restuadi, McRae, Allan, Wray, Naomi R., Ngo, Shyuan and Steyn, Frederik J. (2019). Gut microbiota in ALS: possible role in pathogenesis?. Expert Review of Neurotherapeutics, 19 (9), 1-21. doi: 10.1080/14737175.2019.1623026 |
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2019 Journal Article Loss of appetite is associated with a loss of weight and fat mass in patients with amyotrophic lateral sclerosisNgo, Shyuan T., Van Eijk, Ruben P. A., Chachay, V. , Van Den Berg, Leonard H., Mccombe, Pamela A., Henderson, Robert D. and Steyn, Frederik J. (2019). Loss of appetite is associated with a loss of weight and fat mass in patients with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 20 (7-8), 1-9. doi: 10.1080/21678421.2019.1621346 |
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2019 Journal Article Biomarkers of metabolism in amyotrophic lateral sclerosisKirk, Siobhan E., Tracey, Timothy J., Steyn, Frederik J. and Ngo, Shyuan T. (2019). Biomarkers of metabolism in amyotrophic lateral sclerosis. Frontiers in Neurology, 10 191, 191. doi: 10.3389/fneur.2019.00191 |
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2018 Journal Article Dysregulation of miRNA biogenesis machinery and miRNA/RNA ratio in skeletal muscle of ALS miceRussell, Aaron P, Ghobrial, Lobna, Ngo, Shyuan, Yerbury, Justin, Zacharewicz, Evelyn, Chung, Roger and Lamon, Séverine (2018). Dysregulation of miRNA biogenesis machinery and miRNA/RNA ratio in skeletal muscle of ALS mice. Muscle and Nerve, 57 (5), 838-847. doi: 10.1002/mus.26039 |
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2018 Journal Article Hypermetabolism in ALS is associated with greater functional decline and shorter survivalSteyn, Frederik J., Ioannides, Zara A., van Eijk, Ruben P. A., Heggie, Susan, Thorpe, Kathryn A., Ceslis, Amelia, Heshmat, Saman, Henders, Anjali K., Wray, Naomi R., van den Berg, Leonard H., Henderson, Robert D., McCombe, Pamela A. and Ngo, Shyuan T. (2018). Hypermetabolism in ALS is associated with greater functional decline and shorter survival. Journal of Neurology, Neurosurgery, and Psychiatry, 89 (10), jnnp-2017. doi: 10.1136/jnnp-2017-317887 |
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2018 Journal Article Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and DiseaseTracey, Timothy J., Steyn, Frederik J., Wolvetang, Ernst J. and Ngo, Shyuan T. (2018). Neuronal Lipid Metabolism: Multiple Pathways Driving Functional Outcomes in Health and Disease. Frontiers in Molecular Neuroscience, 11 10, 10. doi: 10.3389/fnmol.2018.00010 |
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2018 Journal Article Patient with ALS with a novel TBK1 mutation, widespread brain involvement, behaviour changes and metabolic dysfunctionMcCombe, Pamela A., Ngo, Shyuan T., Guo, Christine Cong, Fazlollahi, Amir, Bollmann, Saskia, Wang, Liting, Hu, Xintao, Barth, Markus, Salvado, Olivier, Davis, Mark, Ceslis, Amelia, Robinson, Gail, Henderson, Robert D. and Steyn, Frederik J. (2018). Patient with ALS with a novel TBK1 mutation, widespread brain involvement, behaviour changes and metabolic dysfunction. Journal of Neurology, Neurosurgery and Psychiatry, 90 (8), 952-954. doi: 10.1136/jnnp-2018-318823 |
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2017 Journal Article 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behaviorSteyn, Frederik J., Ngo, Shyuan T., Chen, Vicky Ping, Bailey-Downs, Lora C., Xie, Teresa Y., Ghadami, Martin, Brimijoin, Stephen, Freeman, Willard M., Rubinstein, Marcelo, Low, Malcolm J. and Stout, Michael B. (2017). 17α-estradiol acts through hypothalamic pro-opiomelanocortin expressing neurons to reduce feeding behavior. Aging Cell, 17 (1) e12703, 1-6. doi: 10.1111/acel.12703 |
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2017 Journal Article Endocrine rhythms of growth hormone release: insights from animal studiesSteyn, Frederik J. and Ngo, Shyuan T. (2017). Endocrine rhythms of growth hormone release: insights from animal studies. Best Practice and Research: Clinical Endocrinology and Metabolism, 31 (6), 521-533. doi: 10.1016/j.beem.2017.10.009 |
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2017 Journal Article Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosisBenyamin, Beben, He, Ji, Zhao, Qiongyi, Gratten, Jacob, Garton, Fleur, Leo, Paul J., Liu, Zhijun, Mangelsdorf, Marie, Al-Chalabi, Ammar, Anderson, Lisa, Butler, Timothy J., Chen, Lu, Chen, Xiang-Ding, Cremin, Katie, Deng, Hong-Weng, Devine, Matthew, Edson, Janette, Fifita, Jennifer A., Furlong, Sarah, Han, Ying-Ying, Harris, Jessica, Henders, Anjali K., Jeffree, Rosalind L., Jin, Zi-Bing, Li, Zhongshan, Li, Ting, Li, Mengmeng, Lin, Yong, Liu, Xiaolu ... Fan, Dongsheng (2017). Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis. Nature Communications, 8 (1) 611, 611. doi: 10.1038/s41467-017-00471-1 |
