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2016 Journal Article KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preferenceSchumann, Gunter, Liu, Chunyu, O'Reilly, Paul, Gao, He, Song, Parkyong, Xu, Bing, Ruggeri, Barbara, Amin, Najaf, Jia, Tianye, Preis, Sarah, Lepe, Marcelo Segura, Akira, Shizuo, Barbieri, Caterina, Baumeister, Sebastian, Cauchi, Stephane, Clarke, Toni-Kim, Enroth, Stefan, Fischer, Krista, Hallfors, Jenni, Harris, Sarah E., Hieber, Saskia, Hofer, Edith, Hottenga, Jouke-Jan, Johansson, Asa, Joshi, PeterK., Kaartinen, Niina, Laitinen, Jaana, Lemaitre, Rozenn, Loukola, Anu ... Elliott, Paul (2016). KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. Proceedings of the National Academy of Sciences, 113 (50), 14372-14377. doi: 10.1073/pnas.1611243113 |
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2016 Journal Article Associations between type 2 diabetes-related genetic scores and metabolic traits, in obese and normal-weight youthsMorandi, Anita, Bonnefond, Amelie, Lobbens, Stephane, Yengo, Loic, del Giudice, Emanuele Miraglia, Grandone, Anna, Levy-Marchal, Claire, Weill, Jacques, Maffeis, Claudio and Froguel, Philippe (2016). Associations between type 2 diabetes-related genetic scores and metabolic traits, in obese and normal-weight youths. Journal of Clinical Endocrinology and Metabolism, 101 (11), 4244-4250. doi: 10.1210/jc.2016-2432 |
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2016 Journal Article Genome-wide analysis identifies 12 loci influencing human reproductive behaviorBarban, Nicola, Jansen, Rick, de Vlaming, Ronald, Vaez, Ahmad, Mandemakers, Jornt J., Tropf, Felix C., Shen, Xia, Wilson, James F., Chasman, Daniel I., Nolte, Illa M., Tragante, Vinicius, van der Laan, Sander W., Perry, John R. B., Kong, Augustine, Ahluwalia, Tarunveer S., Albrecht, Eva, Yerges-Armstrong, Laura, Atzmon, Gil, Auro, Kirsi, Ayers, Kristin, Bakshi, Andrew, Ben-Avraham, Danny, Berger, Klaus, Bergman, Aviv, Bertram, Lars, Bielak, Lawrence F., Bjornsdottir, Gyda, Bonder, Marc Jan, Broer, Linda ... Mills, Melinda C. (2016). Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature Genetics, 48 (12), 1462-1472. doi: 10.1038/ng.3698 |
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2016 Journal Article Detection of human adaptation during the past 2000 yearsField, Yair, Boyle, Evan A., Telis, Natalie, Gao, Ziyue, Gaulton, Kyle J., Golan, David, Yengo, Loic, Rocheleau, Ghislain, Froguel, Philippe, McCarthy, Mark I. and Pritchard, Jonathan K. (2016). Detection of human adaptation during the past 2000 years. Science, 354 (6313), 1-10. doi: 10.1126/science.aag0776 |
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2016 Journal Article Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profilingYengo, Loic, Arredouani, Abdelilah, Marre, Michel, Roussel, Ronan, Vaxillaire, Martine, Falchi, Mario, Haoudi, Abdelali, Tichet, Jean, Balkau, Beverley, Bonnefond, Amelie and Froguel, Philippe (2016). Impact of statistical models on the prediction of type 2 diabetes using non-targeted metabolomics profiling. Molecular Metabolism, 5 (10), 918-925. doi: 10.1016/j.molmet.2016.08.011 |
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2016 Journal Article The genetics of blood pressure regulation and its target organs from association studies in 342,415 individualsEhret, G.B., Ferreira, T., Chasman, D.I., Jackson, A.U., Schmidt, E.M., Johnson, T., Thorleifsson, G., Luan, J., Donnelly, L.A., Kanoni, S., Petersen, A.-K., Pihur, V., Strawbridge, R.J., Shungin, D., Hughes, M.F., Meirelles, O., Kaakinen, M., Bouatia-Naji, N., Kristiansson, K., Shah, S., Kleber, M.E., Guo, X., Lyytikainen, L.-P., Fava, C., Eriksson, N., Nolte, I.M., Magnusson, P.K., Salfati, E.L., Rallidis, L.S. ... Munroe, P.B. (2016). The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nature Genetics, 48 (10), 1171-1184. doi: 10.1038/ng.3667 |
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2016 Journal Article Genomic insights into the origin of farming in the ancient Near EastLazaridis, Iosif, Nadel, Dani, Rollefson, Gary, Merrett, Deborah C., Rohland, Nadin, Mallick, Swapan, Fernandes, Daniel, Novak, Mario, Gamarra, Beatriz, Sirak, Kendra, Connell, Sarah, Stewardson, Kristin, Harney, Eadaoin, Fu, Qiaomei, Gonzalez-Fortes, Gloria, Jones, Eppie R., Roodenberg, Songul Alpaslan, Lengyel, Gyorgy, Bocquentin, Fanny, Gasparian, Boris, Monge, Janet M., Gregg, Michael, Eshed, Vered, Mizrahi, Ahuva-Sivan, Meiklejohn, Christopher, Gerritsen, Fokke, Bejenaru, Luminita, Blueher, Matthias, Campbell, Archie ... Reich, David (2016). Genomic insights into the origin of farming in the ancient Near East. Nature, 536 (7617), 419-424. doi: 10.1038/nature19310 |
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2016 Journal Article Variable clustering in high-dimensional linear regression: The R package clereYengo, Loic, Jacques, Julien, Biernacki, Christophe and Canouil, Mickael (2016). Variable clustering in high-dimensional linear regression: The R package clere. The R Journal, 8 (1), 92-106. doi: 10.32614/rj-2016-006 |
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2016 Journal Article The genetic architecture of type 2 diabetesFuchsberger, Christian, Flannick, Jason, Teslovich, Tanya M., Mahajan, Anubha, Agarwala, Vineeta, Gaulton, Kyle J., Ma, Clement, Fontanillas, Pierre, Moutsianas, Loukas, McCarthy, Davis J., Rivas, Manuel A., Perry, John R. B., Sim, Xueling, Blackwell, Thomas W., Robertson, Neil R., Rayner, N. William, Cingolani, Pablo, Locke, Adam E., Tajes, Juan Fernandez, Highland, Heather M., Dupuis, Josee, Chines, Peter S., Lindgren, Cecilia M., Hartl, Christopher, Jackson, Anne U., Chen, Han, Huyghe, Jeroen R., van de Bunt, Martijn, Pearson, Richard D. ... McCarthy, Mark I. (2016). The genetic architecture of type 2 diabetes. Nature, 536 (7614), 41-47. doi: 10.1038/nature18642 |
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2016 Journal Article Post-bariatric surgery changes in quinolinic and xanthurenic acid concentrations are associated with glucose homeostasisFavennec, Marie, Hennart, Benjamin, Verbanck, Marie, Pigeyre, Marie, Caiazzo, Robert, Raverdy, Violeta, Verkindt, Helene, Leloire, Audrey, Guillemin, Gilles J., Yengo, Loic, Allorge, Delphine, Froguel, Philippe, Pattou, Francois and Poulain-Godefroy, Odile (2016). Post-bariatric surgery changes in quinolinic and xanthurenic acid concentrations are associated with glucose homeostasis. Plos One, 11 (6) e0158051, e0158051. doi: 10.1371/journal.pone.0158051 |
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2016 Journal Article Erratum: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (PLoS Genet (2015) 11:10 (e1005378) DOI: 10.1371/journal.pgen.1005378)Winkler, Thomas W., Justice, Anne E., Graff, Mariaelisa, Barata, Llilda, Feitosa, Mary F., Chu, Su, Czajkowski, Jacek, Esko, Tõnu, Fall, Tove, Kilpeläinen, Tuomas O., Lu, Yingchang, Mägi, Reedik, Mihailov, Evelin, Pers, Tune H., Rüeger, Sina, Teumer, Alexander, Ehret, Georg B., Ferreira, Teresa, Heard-Costa, Nancy L., Karjalainen, Juha, Lagou, Vasiliki, Mahajan, Anubha, Neinast, Michael D., Prokopenko, Inga, Simino, Jeannette, Teslovich, Tanya M., Jansen, Rick, Westra, Harm-Jan, White, Charles C. ... Loos, Ruth J.F. (2016). Erratum: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study (PLoS Genet (2015) 11:10 (e1005378) DOI: 10.1371/journal.pgen.1005378). PLoS Genetics, 12 (6) e1006166. doi: 10.1371/JOURNAL.PGEN.1006166 |
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2016 Journal Article KAT2B is required for pancreatic beta cell adaptation to metabolic stress by controlling the unfolded protein responseRabhi, Nabil, Denechaud, Pierre-Damien, Gromada, Xavier, Hannou, Sarah Anissa, Zhang, Hongbo, Rashid, Talha, Salas, Elisabet, Durand, Emmanuelle, Sand, Olivier, Bonnefond, Amelie, Yengo, Loic, Chavey, Carine, Bonner, Caroline, Kerr-Conte, Julie, Abderrahmani, Amar, Auwerx, Johan, Fajas, Lluis, Froguel, Philippe and Annicotte, Jean-Sebastien (2016). KAT2B is required for pancreatic beta cell adaptation to metabolic stress by controlling the unfolded protein response. Cell Reports, 15 (5), 1051-1061. doi: 10.1016/j.celrep.2016.03.079 |
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2016 Journal Article Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanismsHorikoshi, Momoko, Pasquali, Lorenzo, Wiltshire, Steven, Huyghe, Jeroen R., Mahajan, Anubha, Asimit, Jennifer L., Ferreira, Teresa, Locke, Adam E., Robertson, Neil R., Wang, Xu, Sim, Xueling, Fujita, Hayato, Hara, Kazuo, Young, Robin, Zhang, Weihua, Choi, Sungkyoung, Chen, Han, Kaur, Ismeet, Takeuchi, Fumihiko, Fontanillas, Pierre, Thuillier, Dorothee, Yengo, Loic, Below, Jennifer E., Tam, Claudia H. T., Wu, Ying, Abecasis, Goncalo, Altshuler, David, Bell, Graeme I., Blangero, John ... Morris, Andrew P. (2016). Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Human Molecular Genetics, 25 (10) ddw048, 2070-2081. doi: 10.1093/hmg/ddw048 |
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2016 Journal Article New loci for body fat percentage reveal link between adiposity and cardiometabolic disease riskLu, Yingchang, Day, Felix R., Gustafsson, Stefan, Buchkovich, Martin L., Na, Jianbo, Bataille, Veronique, Cousminer, Diana L., Dastani, Zari, Drong, Alexander W., Esko, Tonu, Evans, David M., Falchi, Mario, Feitosa, Mary F., Ferreira, Teresa, Hedman, Asa K., Haring, Robin, Hysi, Pirro G., Iles, Mark M., Justice, Anne E., Kanoni, Stavroula, Lagou, Vasiliki, Li, Rui, Li, Xin, Locke, Adam, Lu, Chen, Magi, Reedik, Perry, John R. B., Pers, Tune H., Qi, Qibin ... Loos, Ruth J. F. (2016). New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications, 7 (1) 10495, 10495-10495. doi: 10.1038/ncomms10495 |
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2016 Journal Article Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney functionPattaro, Cristian, Teumer, Alexander, Gorski, Mathias, Chu, Audrey Y., Li, Man, Mijatovic, Vladan, Garnaas, Maija, Tin, Adrienne, Sorice, Rossella, Li, Yong, Taliun, Daniel, Olden, Matthias, Foster, Meredith, Yang, Qiong, Chen, Ming-Huei, Pers, Tune H., Johnson, Andrew D., Ko, Yi-An, Fuchsberger, Christian, Tayo, Bamidele, Nalls, Michael, Feitosa, Mary F., Isaacs, Aaron, Dehghan, Abbas, d'Adamo, Pio, Adeyemo, Adebowale, Dieffenbach, Aida Karina, Zonderman, Alan B., Nolte, Ilja M. ... Fox, Caroline S. (2016). Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nature Communications, 7 (1) 10023. doi: 10.1038/ncomms10023 |
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2016 Journal Article Genome-wide association analysis identifies three new susceptibility loci for childhood body mass indexFelix, Janine F., Bradfield, Jonathan P., Monnereau, Claire, van der Valk, Ralf J. P., Stergiakouli, Evie, Chesi, Alessandra, Gaillard, Romy, Feenstra, Bjarke, Thiering, Elisabeth, Kreiner-Moller, Eskil, Mahajan, Anubha, Pitkanen, Niina, Joro, Raimo, Cavadino, Alana, Huikari, Ville, Franks, Steve, Groen-Blokhuis, Maria M., Cousminer, Diana L., Marsh, Julie A., Lehtimaki, Terho, Curtin, John A., Vioque, Jesus, Ahluwalia, Tarunveer S., Myhre, Ronny, Price, Thomas S., Vilor-Tejedor, Natalia, Yengo, Loic, Grarup, Niels, Ntalla, Ioanna ... Jaddoe, Vincent W. V. (2016). Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Human Molecular Genetics, 25 (2), 389-403. doi: 10.1093/hmg/ddv472 |
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2015 Journal Article Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility lociGaulton, Kyle J., Ferreira, Teresa, Lee, Yeji, Raimondo, Anne, Maegi, Reedik, Reschen, Michael E., Mahajan, Anubha, Locke, Adam, Rayner, N. William, Robertson, Neil, Scott, Robert A., Prokopenko, Inga, Scott, Laura J., Green, Todd, Sparso, Thomas, Thuillier, Dorothee, Yengo, Loic, Grallert, Harald, Wahl, Simone, Franberg, Mattias, Strawbridge, Rona J., Kestler, Hans, Chheda, Himanshu, Eisele, Lewin, Gustafsson, Stefan, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Qi, Lu, Karssen, Lennart C. ... Morris, Andrew P. (2015). Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics, 47 (12), 1415-1425. doi: 10.1038/ng.3437 |
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2015 Journal Article The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activationFavennec, Marie, Hennart, Benjamin, Caiazzo, Robert, Leloire, Audrey, Yengo, Loic, Verbanck, Marie, Arredouani, Abdelilah, Marre, Michel, Pigeyre, Marie, Bessede, Alban, Guillemin, Gilles J., Chinetti, Giulia, Staels, Bart, Pattou, Francois, Balkau, Beverley, Allorge, Delphine, Froguel, Philippe and Poulain-Godefroy, Odile (2015). The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation. Obesity, 23 (10), 2066-2074. doi: 10.1002/oby.21199 |
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2015 Journal Article The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction studyWinkler, Thomas W., Justice, Anne E., Graff, Mariaelisa, Barata, Llilda, Feitosa, Mary F., Chu, Su, Czajkowski, Jacek, Esko, Tonu, Fall, Tove, Kilpelainen, Tuomas O., Lu, Yingchang, Magi, Reedik, Mihailov, Evelin, Pers, Tune H., Rueeger, Sina, Teumer, Alexander, Ehret, Georg B., Ferreira, Teresa, Heard-Costa, Nancy L., Karjalainen, Juha, Lagou, Vasiliki, Mahajan, Anubha, Neinast, Michael D., Prokopenko, Inga, Simino, Jeannette, Teslovich, Tanya M., Jansen, Rick, Westra, Harm-Jan, White, Charles C. ... Loos, Ruth J. F. (2015). The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study. PL o S Genetics, 11 (10) e1005378, 1-42. doi: 10.1371/journal.pgen.1005378 |
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2015 Journal Article Directional dominance on stature and cognition in diverse human populationsJoshi, Peter K., Esko, Tonu, Mattsson, Hannele, Eklund, Niina, Gandin, Ilaria, Nutile, Teresa, Jackson, Anne U., Schurmann, Claudia, Smith, Albert V., Zhang, Weihua, Okada, Yukinori, Stancakova, Alena, Faul, Jessica D., Zhao, Wei, Bartz, Traci M., Concas, Maria Pina, Franceschini, Nora, Enroth, Stefan, Vitart, Veronique, Trompet, Stella, Guo, Xiuqing, Chasman, Daniel I., O'Connel, Jeffrey R., Corre, Tanguy, Nongmaithem, Suraj S., Chen, Yuning, Mangino, Massimo, Ruggiero, Daniela, Traglia, Michela ... Wilson, James F. (2015). Directional dominance on stature and cognition in diverse human populations. Nature, 523 (7561), 459-462. doi: 10.1038/nature14618 |
