|
2016 Journal Article Post-bariatric surgery changes in quinolinic and xanthurenic acid concentrations are associated with glucose homeostasisFavennec, Marie, Hennart, Benjamin, Verbanck, Marie, Pigeyre, Marie, Caiazzo, Robert, Raverdy, Violeta, Verkindt, Helene, Leloire, Audrey, Guillemin, Gilles J., Yengo, Loic, Allorge, Delphine, Froguel, Philippe, Pattou, Francois and Poulain-Godefroy, Odile (2016). Post-bariatric surgery changes in quinolinic and xanthurenic acid concentrations are associated with glucose homeostasis. Plos One, 11 (6) e0158051, e0158051. doi: 10.1371/journal.pone.0158051 |
|
2016 Journal Article KAT2B is required for pancreatic beta cell adaptation to metabolic stress by controlling the unfolded protein responseRabhi, Nabil, Denechaud, Pierre-Damien, Gromada, Xavier, Hannou, Sarah Anissa, Zhang, Hongbo, Rashid, Talha, Salas, Elisabet, Durand, Emmanuelle, Sand, Olivier, Bonnefond, Amelie, Yengo, Loic, Chavey, Carine, Bonner, Caroline, Kerr-Conte, Julie, Abderrahmani, Amar, Auwerx, Johan, Fajas, Lluis, Froguel, Philippe and Annicotte, Jean-Sebastien (2016). KAT2B is required for pancreatic beta cell adaptation to metabolic stress by controlling the unfolded protein response. Cell Reports, 15 (5), 1051-1061. doi: 10.1016/j.celrep.2016.03.079 |
|
2016 Journal Article Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanismsHorikoshi, Momoko, Pasquali, Lorenzo, Wiltshire, Steven, Huyghe, Jeroen R., Mahajan, Anubha, Asimit, Jennifer L., Ferreira, Teresa, Locke, Adam E., Robertson, Neil R., Wang, Xu, Sim, Xueling, Fujita, Hayato, Hara, Kazuo, Young, Robin, Zhang, Weihua, Choi, Sungkyoung, Chen, Han, Kaur, Ismeet, Takeuchi, Fumihiko, Fontanillas, Pierre, Thuillier, Dorothee, Yengo, Loic, Below, Jennifer E., Tam, Claudia H. T., Wu, Ying, Abecasis, Goncalo, Altshuler, David, Bell, Graeme I., Blangero, John ... Morris, Andrew P. (2016). Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Human Molecular Genetics, 25 (10) ddw048, 2070-2081. doi: 10.1093/hmg/ddw048 |
|
2016 Journal Article New loci for body fat percentage reveal link between adiposity and cardiometabolic disease riskLu, Yingchang, Day, Felix R., Gustafsson, Stefan, Buchkovich, Martin L., Na, Jianbo, Bataille, Veronique, Cousminer, Diana L., Dastani, Zari, Drong, Alexander W., Esko, Tonu, Evans, David M., Falchi, Mario, Feitosa, Mary F., Ferreira, Teresa, Hedman, Asa K., Haring, Robin, Hysi, Pirro G., Iles, Mark M., Justice, Anne E., Kanoni, Stavroula, Lagou, Vasiliki, Li, Rui, Li, Xin, Locke, Adam, Lu, Chen, Magi, Reedik, Perry, John R. B., Pers, Tune H., Qi, Qibin ... Loos, Ruth J. F. (2016). New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications, 7 (1) 10495, 10495-10495. doi: 10.1038/ncomms10495 |
|
2016 Journal Article Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney functionPattaro, Cristian, Teumer, Alexander, Gorski, Mathias, Chu, Audrey Y., Li, Man, Mijatovic, Vladan, Garnaas, Maija, Tin, Adrienne, Sorice, Rossella, Li, Yong, Taliun, Daniel, Olden, Matthias, Foster, Meredith, Yang, Qiong, Chen, Ming-Huei, Pers, Tune H., Johnson, Andrew D., Ko, Yi-An, Fuchsberger, Christian, Tayo, Bamidele, Nalls, Michael, Feitosa, Mary F., Isaacs, Aaron, Dehghan, Abbas, d'Adamo, Pio, Adeyemo, Adebowale, Dieffenbach, Aida Karina, Zonderman, Alan B., Nolte, Ilja M. ... Fox, Caroline S. (2016). Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nature Communications, 7 (1) 10023. doi: 10.1038/ncomms10023 |
|
2016 Journal Article Genome-wide association analysis identifies three new susceptibility loci for childhood body mass indexFelix, Janine F., Bradfield, Jonathan P., Monnereau, Claire, van der Valk, Ralf J. P., Stergiakouli, Evie, Chesi, Alessandra, Gaillard, Romy, Feenstra, Bjarke, Thiering, Elisabeth, Kreiner-Moller, Eskil, Mahajan, Anubha, Pitkanen, Niina, Joro, Raimo, Cavadino, Alana, Huikari, Ville, Franks, Steve, Groen-Blokhuis, Maria M., Cousminer, Diana L., Marsh, Julie A., Lehtimaki, Terho, Curtin, John A., Vioque, Jesus, Ahluwalia, Tarunveer S., Myhre, Ronny, Price, Thomas S., Vilor-Tejedor, Natalia, Yengo, Loic, Grarup, Niels, Ntalla, Ioanna ... Jaddoe, Vincent W. V. (2016). Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Human Molecular Genetics, 25 (2), 389-403. doi: 10.1093/hmg/ddv472 |
|
2015 Journal Article Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility lociGaulton, Kyle J., Ferreira, Teresa, Lee, Yeji, Raimondo, Anne, Maegi, Reedik, Reschen, Michael E., Mahajan, Anubha, Locke, Adam, Rayner, N. William, Robertson, Neil, Scott, Robert A., Prokopenko, Inga, Scott, Laura J., Green, Todd, Sparso, Thomas, Thuillier, Dorothee, Yengo, Loic, Grallert, Harald, Wahl, Simone, Franberg, Mattias, Strawbridge, Rona J., Kestler, Hans, Chheda, Himanshu, Eisele, Lewin, Gustafsson, Stefan, Steinthorsdottir, Valgerdur, Thorleifsson, Gudmar, Qi, Lu, Karssen, Lennart C. ... Morris, Andrew P. (2015). Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics, 47 (12), 1415-1425. doi: 10.1038/ng.3437 |
|
2015 Journal Article The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activationFavennec, Marie, Hennart, Benjamin, Caiazzo, Robert, Leloire, Audrey, Yengo, Loic, Verbanck, Marie, Arredouani, Abdelilah, Marre, Michel, Pigeyre, Marie, Bessede, Alban, Guillemin, Gilles J., Chinetti, Giulia, Staels, Bart, Pattou, Francois, Balkau, Beverley, Allorge, Delphine, Froguel, Philippe and Poulain-Godefroy, Odile (2015). The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation. Obesity, 23 (10), 2066-2074. doi: 10.1002/oby.21199 |
|
2015 Journal Article The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction studyWinkler, Thomas W., Justice, Anne E., Graff, Mariaelisa, Barata, Llilda, Feitosa, Mary F., Chu, Su, Czajkowski, Jacek, Esko, Tonu, Fall, Tove, Kilpelainen, Tuomas O., Lu, Yingchang, Magi, Reedik, Mihailov, Evelin, Pers, Tune H., Rueeger, Sina, Teumer, Alexander, Ehret, Georg B., Ferreira, Teresa, Heard-Costa, Nancy L., Karjalainen, Juha, Lagou, Vasiliki, Mahajan, Anubha, Neinast, Michael D., Prokopenko, Inga, Simino, Jeannette, Teslovich, Tanya M., Jansen, Rick, Westra, Harm-Jan, White, Charles C. ... Loos, Ruth J. F. (2015). The influence of age and sex on genetic associations with adult body size and shape: a large-scale genome-wide interaction study. PL o S Genetics, 11 (10) e1005378, 1-42. doi: 10.1371/journal.pgen.1005378 |
|
2015 Journal Article Directional dominance on stature and cognition in diverse human populationsJoshi, Peter K., Esko, Tonu, Mattsson, Hannele, Eklund, Niina, Gandin, Ilaria, Nutile, Teresa, Jackson, Anne U., Schurmann, Claudia, Smith, Albert V., Zhang, Weihua, Okada, Yukinori, Stancakova, Alena, Faul, Jessica D., Zhao, Wei, Bartz, Traci M., Concas, Maria Pina, Franceschini, Nora, Enroth, Stefan, Vitart, Veronique, Trompet, Stella, Guo, Xiuqing, Chasman, Daniel I., O'Connel, Jeffrey R., Corre, Tanguy, Nongmaithem, Suraj S., Chen, Yuning, Mangino, Massimo, Ruggiero, Daniela, Traglia, Michela ... Wilson, James F. (2015). Directional dominance on stature and cognition in diverse human populations. Nature, 523 (7561), 459-462. doi: 10.1038/nature14618 |
|
2015 Journal Article Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: A nested case-control studyChambers, John C., Loh, Marie, Lehne, Benjamin, Drong, Alexander, Kriebel, Jennifer, Motta, Valeria, Wahl, Simone, Elliott, Hannah R., Rota, Federica, Scott, William R., Zhang, Weihua, Tan, Sian-Tsung, Campanella, Gianluca, Chadeau-Hyam, Marc, Yengo, Loic, Richmond, Rebecca C., Adamowicz-Brice, Martyna, Afzal, Uzma, Bozaoglu, Kiymet, Mok, Zuan Yu, Ng, Hong Kiat, Pattou, Francois, Prokisch, Holger, Rozario, Michelle Ann, Tarantini, Letizia, Abbott, James, Ala-Korpela, Mika, Albetti, Benedetta, Ammerpohl, Ole ... Kooner, Jaspal S. (2015). Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: A nested case-control study. Lancet Diabetes and Endocrinology, 3 (7), 526-534. doi: 10.1016/S2213-8587(15)00127-8 |
|
2015 Journal Article The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasisBonnefond, Amelie, Yengo, Loic, Le May, Cedric, Fumeron, Frederic, Marre, Michel, Balkau, Beverley, Charpentier, Guillaume, Franc, Sylvia, Froguel, Philippe and Cariou, Bertrand (2015). The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis. Diabetologia, 58 (9), 2051-2055. doi: 10.1007/s00125-015-3659-8 |
|
2015 Journal Article Genetic studies of body mass index yield new insights for obesity biologyLocke, Adam E., Kahali, Bratati, Berndt, Sonja I., Justice, Anne E., Pers, Tune H., Day, Felix R., Powell, Corey, Vedantam, Sailaja, Buchkovich, Martin L., Yang, Jian, Croteau-Chonka, Damien C., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Kutalik, Zoltán, Luan, Jian'an, Mägi, Reedik, Randall, Joshua C., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Faul, Jessica D., Smith, Jennifer A., Zhao, Jing Hua, Zhao, Wei, Chen, Jin, Fehrmann, Rudolf, Hedman, Asa K. ... Shah, Sonia (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518 (7538), 197-206. doi: 10.1038/nature14177 |
|
2015 Journal Article New genetic loci link adipose and insulin biology to body fat distributionShungin, Dmitry, Winkler, Thomas W, Croteau-Chonka, Damien C, Ferreira, Teresa, Locke, Adam E, Magi, Reedik, Strawbridge, Rona J, Pers, Tune H, Fischer, Krista, Justice, Anne E, Workalemahu, Tsegaselassie, Wu, Joseph M.W, Buchkovich, Martin L, Heard-Costa, Nancy L, Roman, Tamara S, Drong, Alexander W, Song, Ci, Gustafsson, Stefan, Day, Felix R, Esko, Tonu, Fall, Tove, Kutalik, Zoltan, Luan, Jian'an, Randall, Joshua C, Scherag, Andre, Vedantam, Sailaja, Wood, Andrew R, Chen, Jin, Fehrmann, Rudolf ... Shah, Sonia (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518 (7538), 187-196. doi: 10.1038/nature14132 |
|
2015 Journal Article Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican childrenMejia-Bentez, Maria A., Bonnefond, Amelie, Yengo, Loic, Huyvaert, Marlene, Dechaume, Aurelie, Peralta-Romero, Jesus, Kluender-Kluender, Miguel, Garcia Mena, Jaime, Moustafa, Julia S. El-Sayed, Falchi, Mario, Cruz, Miguel and Froguel, Philippe (2015). Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children. Diabetologia, 58 (2), 290-294. doi: 10.1007/s00125-014-3441-3 |
|
2014 Journal Article Defining the role of common variation in the genomic and biological architecture of adult human heightWood, Andrew R., Esko, Tonu, Yang, Jian, Vedantam, Sailaja, Pers, Tune H., Gustafsson, Stefan, Chu, Audrey Y., Estrada, Karol, Luan, Jian'an, Kutalik, Zoltan, Amin, Najaf, Buchkovich, Martin L., Croteau-Chonka, Damien C., Day, Felix R., Duan, Yanan, Fall, Tove, Fehrmann, Rudolf, Ferreira, Teresa, Jackson, Anne U., Karjalainen, Juha, Lo, Ken Sin, Locke, Adam E., Magi, Reedik, Mihailov, Evelin, Porcu, Evelin, Randall, Joshua C., Scherag, Andre, Vinkhuyzen, Anne A. E., Westra, Harm-Jan ... Frayling, Timothy M. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46 (11), 1173-1186. doi: 10.1038/ng.3097 |
|
2014 Journal Article Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR studyVaxillaire, Martine, Yengo, Loic, Lobbens, Stephane, Rocheleau, Ghislain, Eury, Elodie, Lantieri, Olivier, Marre, Michel, Balkau, Beverley, Bonnefond, Amelie and Froguel, Philippe (2014). Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study. Diabetologia, 57 (8), 1601-1610. doi: 10.1007/s00125-014-3277-x |
|
2014 Journal Article Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk - results from the EPIC cohort studyDik, Vincent K., Bueno-de-Mesquita, H. B(as), Van Oijen, Martijn G. H., Siersema, Peter D., Uiterwaal, Cuno S. P. M., Van Gils, Carla H., Van Duijnhoven, Fraenzel J. B., Cauchi, Stephane, Yengo, Loic, Froguel, Philippe, Overvad, Kim, Bech, Bodil H., Tjonneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Racine, Antoine, Fagherazzi, Guy, Kuehn, Tilman, Campa, Daniele, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Peppa, Eleni, Oikonomou, Eleni, Palli, Domenico, Grioni, Sara, Vineis, Paolo, Tumino, Rosaria, Panico, Salvatore ... Riboli, Elio (2014). Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk - results from the EPIC cohort study. International Journal of Cancer, 135 (2), 401-412. doi: 10.1002/ijc.28655 |
|
2014 Journal Article Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patientsRouskas, Konstantinos, Cauchi, Stephane, Raverdy, Violeta, Yengo, Loic, Froguel, Philippe and Pattou, Francois (2014). Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients. Surgery for Obesity and Related Diseases, 10 (4), 679-683. doi: 10.1016/j.soard.2013.12.016 |
|
2014 Journal Article Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibilityDIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium, Shah, Sonia and Yengo, Loic (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics, 46 (3), 234-246. doi: 10.1038/ng.2897 |
