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2015 Journal Article Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: A nested case-control studyChambers, John C., Loh, Marie, Lehne, Benjamin, Drong, Alexander, Kriebel, Jennifer, Motta, Valeria, Wahl, Simone, Elliott, Hannah R., Rota, Federica, Scott, William R., Zhang, Weihua, Tan, Sian-Tsung, Campanella, Gianluca, Chadeau-Hyam, Marc, Yengo, Loic, Richmond, Rebecca C., Adamowicz-Brice, Martyna, Afzal, Uzma, Bozaoglu, Kiymet, Mok, Zuan Yu, Ng, Hong Kiat, Pattou, Francois, Prokisch, Holger, Rozario, Michelle Ann, Tarantini, Letizia, Abbott, James, Ala-Korpela, Mika, Albetti, Benedetta, Ammerpohl, Ole ... Kooner, Jaspal S. (2015). Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: A nested case-control study. Lancet Diabetes and Endocrinology, 3 (7), 526-534. doi: 10.1016/S2213-8587(15)00127-8 |
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2015 Journal Article The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasisBonnefond, Amelie, Yengo, Loic, Le May, Cedric, Fumeron, Frederic, Marre, Michel, Balkau, Beverley, Charpentier, Guillaume, Franc, Sylvia, Froguel, Philippe and Cariou, Bertrand (2015). The loss-of-function PCSK9 p.R46L genetic variant does not alter glucose homeostasis. Diabetologia, 58 (9), 2051-2055. doi: 10.1007/s00125-015-3659-8 |
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2015 Journal Article New genetic loci link adipose and insulin biology to body fat distributionShungin, Dmitry, Winkler, Thomas W, Croteau-Chonka, Damien C, Ferreira, Teresa, Locke, Adam E, Magi, Reedik, Strawbridge, Rona J, Pers, Tune H, Fischer, Krista, Justice, Anne E, Workalemahu, Tsegaselassie, Wu, Joseph M.W, Buchkovich, Martin L, Heard-Costa, Nancy L, Roman, Tamara S, Drong, Alexander W, Song, Ci, Gustafsson, Stefan, Day, Felix R, Esko, Tonu, Fall, Tove, Kutalik, Zoltan, Luan, Jian'an, Randall, Joshua C, Scherag, Andre, Vedantam, Sailaja, Wood, Andrew R, Chen, Jin, Fehrmann, Rudolf ... Shah, Sonia (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518 (7538), 187-196. doi: 10.1038/nature14132 |
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2015 Journal Article Genetic studies of body mass index yield new insights for obesity biologyLocke, Adam E., Kahali, Bratati, Berndt, Sonja I., Justice, Anne E., Pers, Tune H., Day, Felix R., Powell, Corey, Vedantam, Sailaja, Buchkovich, Martin L., Yang, Jian, Croteau-Chonka, Damien C., Esko, Tonu, Fall, Tove, Ferreira, Teresa, Gustafsson, Stefan, Kutalik, Zoltán, Luan, Jian'an, Mägi, Reedik, Randall, Joshua C., Winkler, Thomas W., Wood, Andrew R., Workalemahu, Tsegaselassie, Faul, Jessica D., Smith, Jennifer A., Zhao, Jing Hua, Zhao, Wei, Chen, Jin, Fehrmann, Rudolf, Hedman, Asa K. ... Shah, Sonia (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518 (7538), 197-206. doi: 10.1038/nature14177 |
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2015 Journal Article Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican childrenMejia-Bentez, Maria A., Bonnefond, Amelie, Yengo, Loic, Huyvaert, Marlene, Dechaume, Aurelie, Peralta-Romero, Jesus, Kluender-Kluender, Miguel, Garcia Mena, Jaime, Moustafa, Julia S. El-Sayed, Falchi, Mario, Cruz, Miguel and Froguel, Philippe (2015). Beneficial effect of a high number of copies of salivary amylase AMY1 gene on obesity risk in Mexican children. Diabetologia, 58 (2), 290-294. doi: 10.1007/s00125-014-3441-3 |
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2014 Journal Article Defining the role of common variation in the genomic and biological architecture of adult human heightWood, Andrew R., Esko, Tonu, Yang, Jian, Vedantam, Sailaja, Pers, Tune H., Gustafsson, Stefan, Chu, Audrey Y., Estrada, Karol, Luan, Jian'an, Kutalik, Zoltan, Amin, Najaf, Buchkovich, Martin L., Croteau-Chonka, Damien C., Day, Felix R., Duan, Yanan, Fall, Tove, Fehrmann, Rudolf, Ferreira, Teresa, Jackson, Anne U., Karjalainen, Juha, Lo, Ken Sin, Locke, Adam E., Magi, Reedik, Mihailov, Evelin, Porcu, Evelin, Randall, Joshua C., Scherag, Andre, Vinkhuyzen, Anne A. E., Westra, Harm-Jan ... Frayling, Timothy M. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46 (11), 1173-1186. doi: 10.1038/ng.3097 |
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2014 Journal Article Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR studyVaxillaire, Martine, Yengo, Loic, Lobbens, Stephane, Rocheleau, Ghislain, Eury, Elodie, Lantieri, Olivier, Marre, Michel, Balkau, Beverley, Bonnefond, Amelie and Froguel, Philippe (2014). Type 2 diabetes-related genetic risk scores associated with variations in fasting plasma glucose and development of impaired glucose homeostasis in the prospective DESIR study. Diabetologia, 57 (8), 1601-1610. doi: 10.1007/s00125-014-3277-x |
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2014 Journal Article Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk - results from the EPIC cohort studyDik, Vincent K., Bueno-de-Mesquita, H. B(as), Van Oijen, Martijn G. H., Siersema, Peter D., Uiterwaal, Cuno S. P. M., Van Gils, Carla H., Van Duijnhoven, Fraenzel J. B., Cauchi, Stephane, Yengo, Loic, Froguel, Philippe, Overvad, Kim, Bech, Bodil H., Tjonneland, Anne, Olsen, Anja, Boutron-Ruault, Marie-Christine, Racine, Antoine, Fagherazzi, Guy, Kuehn, Tilman, Campa, Daniele, Boeing, Heiner, Aleksandrova, Krasimira, Trichopoulou, Antonia, Peppa, Eleni, Oikonomou, Eleni, Palli, Domenico, Grioni, Sara, Vineis, Paolo, Tumino, Rosaria, Panico, Salvatore ... Riboli, Elio (2014). Coffee and tea consumption, genotype-based CYP1A2 and NAT2 activity and colorectal cancer risk - results from the EPIC cohort study. International Journal of Cancer, 135 (2), 401-412. doi: 10.1002/ijc.28655 |
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2014 Journal Article Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patientsRouskas, Konstantinos, Cauchi, Stephane, Raverdy, Violeta, Yengo, Loic, Froguel, Philippe and Pattou, Francois (2014). Weight loss independent association of TCF7 L2 gene polymorphism with fasting blood glucose after Roux-en-Y gastric bypass in type 2 diabetic patients. Surgery for Obesity and Related Diseases, 10 (4), 679-683. doi: 10.1016/j.soard.2013.12.016 |
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2014 Journal Article Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibilityDIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium, Shah, Sonia and Yengo, Loic (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics, 46 (3), 234-246. doi: 10.1038/ng.2897 |
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2013 Journal Article Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohortsBonnet, Fabrice, Roussel, Ronan, Natali, Andrea, Cauchi, Stephane, Petrie, John, Laville, Martine, Yengo, Loic, Froguel, Philippe, Lange, Celine, Lantieri, Olivier, Marre, Michel, Balkau, Beverley and Ferrannini, Ele (2013). Parental history of type 2 diabetes, TCF7L2 variant and lower insulin secretion are associated with incident hypertension. Data from the DESIR and RISC cohorts. Diabetologia, 56 (11), 2414-2423. doi: 10.1007/s00125-013-3021-y |
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2013 Journal Article Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populationsRobiou-du-Pont, Sebastien, Yengo, Loic, Vaillant, Emmanuel, Lobbens, Stephane, Durand, Emmanuelle, Horber, Fritz, Lantieri, Olivier, Marre, Michel, Balkau, Beverley, Froguel, Philippe and Meyre, David (2013). Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations. Journal of Molecular Medicine, 91 (9), 1109-1115. doi: 10.1007/s00109-013-1027-z |
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2013 Journal Article Association between large detectable clonal mosaicism and type 2 diabetes with vascular complicationsBonnefond, Amelie, Skrobek, Boris, Lobbens, Stephane, Eury, Elodie, Thuillier, Dorothee, Cauchi, Stephane, Lantieri, Olivier, Balkau, Beverley, Riboli, Elio, Marre, Michel, Charpentier, Guillaume, Yengo, Loic and Froguel, Philippe (2013). Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications. Nature Genetics, 45 (9), 1040-1043. doi: 10.1038/ng.2700 |
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2013 Journal Article Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disordersden Hoed, Marcel, Eijgelsheim, Mark, Esko, Tonu, Brundel, Bianca J. J. M., Peal, David S., Evans, David M., Nolte, Ilja M., Segre, Ayellet V., Holm, Hilma, Handsaker, Robert E., Westra, Harm-Jan, Johnson, Toby, Isaacs, Aaron, Yang, Jian, Lundby, Alicia, Zhao, Jing Hua, Kim, Young Jin, Go, Min Jin, Almgren, Peter, Bochud, Murielle, Boucher, Gabrielle, Cornelis, Marilyn C., Gudbjartsson, Daniel, Hadley, David, van der Harst, Pim, Hayward, Caroline, den Heijer, Martin, Igl, Wilmar, Jackson, Anne U. ... Loos, Ruth J. F. (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics, 45 (6), 621-634. doi: 10.1038/ng.2610 |
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2013 Journal Article Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous familyBonnefond, A., Vaillant, E., Philippe, J., Skrobek, B., Lobbens, S., Yengo, L., Huyvaert, M., Cave, H., Busiah, K., Scharfmann, R., Polak, M., Abdul-Rasoul, M., Froguel, P. and Vaxillaire, M. (2013). Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family. Diabetes and Metabolism, 39 (3), 276-280. doi: 10.1016/j.diabet.2013.02.007 |
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2013 Journal Article Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetesBonnefond, A., Yengo, L., Philippe, J., Dechaume, A., Ezzidi, I., Vaillant, E., Gjesing, A. P., Andersson, E. A., Czernichow, S., Hercberg, S., Hadjadj, S., Charpentier, G., Lantieri, O., Balkau, B., Marre, M., Pedersen, O., Hansen, T., Froguel, P. and Vaxillaire, M. (2013). Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes. Diabetologia, 56 (3), 492-496. doi: 10.1007/s00125-012-2794-8 |
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2013 Journal Article Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican childrenMejia-Benitez, Aurora, Kluender-Kluender, Miguel, Yengo, Loic, Meyre, David, Aradillas, Celia, Cruz, Esperanza, Perez-Luque, Elva, Manuel Malacara, Juan, Eugenia Garay, Maria, Peralta-Romero, Jesus, Flores-Huerta, Samuel, Garcia-Mena, Jaime, Froguel, Philippe, Cruz, Miguel and Bonnefond, Amelie (2013). Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children. Bmc Medical Genetics, 14 (1) 21. doi: 10.1186/1471-2350-14-21 |
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2013 Journal Article Genome-wide association analyses identify 18 new loci associated with serum urate concentrationsKoettgen, Anna, Albrecht, Eva, Teumer, Alexander, Vitart, Veronique, Krumsiek, Jan, Hundertmark, Claudia, Pistis, Giorgio, Ruggiero, Daniela, O'Seaghdha, Conall M., Haller, Toomas, Yang, Qiong, Tanaka, Toshiko, Johnson, Andrew D., Kutalik, Zoltan, Smith, Albert V., Shi, Julia, Struchalin, Maksim, Middelberg, Rita P. S., Brown, Morris J., Gaffo, Angelo L., Pirastu, Nicola, Li, Guo, Hayward, Caroline, Zemunik, Tatijana, Huffman, Jennifer, Yengo, Loic, Zhao, Jing Hua, Demirkan, Ayse, Feitosa, Mary F. ... Gieger, Christian (2013). Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics, 45 (2), 145-154. doi: 10.1038/ng.2500 |
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2013 Journal Article Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypesAlbrechtsen, A., Grarup, N., Li, Y., Sparso, T., Tian, G., Cao, H., Jiang, T., Kim, S. Y., Korneliussen, T., Li, Q., Nie, C., Wu, R., Skotte, L., Morris, A. P., Ladenvall, C., Cauchi, S., Stancakova, A., Andersen, G., Astrup, A., Banasik, K., Bennett, A. J., Bolund, L., Charpentier, G., Chen, Y., Dekker, J. M., Doney, A. S. F., Dorkhan, M., Forsen, T., Frayling, T. M. ... Pedersen, O. (2013). Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia, 56 (2), 298-310. doi: 10.1007/s00125-012-2756-1 |
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2013 Journal Article Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French populationRobiou-du-Pont, S., Bonnefond, A., Yengo, L., Vaillant, E., Lobbens, S., Durand, E., Weill, J., Lantieri, O., Balkau, B., Charpentier, G., Marre, M., Froguel, P. and Meyre, D. (2013). Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population. International Journal of Obesity, 37 (7), 980-985. doi: 10.1038/ijo.2012.175 |
