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2013 Journal Article Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous familyBonnefond, A., Vaillant, E., Philippe, J., Skrobek, B., Lobbens, S., Yengo, L., Huyvaert, M., Cave, H., Busiah, K., Scharfmann, R., Polak, M., Abdul-Rasoul, M., Froguel, P. and Vaxillaire, M. (2013). Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family. Diabetes and Metabolism, 39 (3), 276-280. doi: 10.1016/j.diabet.2013.02.007 |
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2013 Journal Article Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetesBonnefond, A., Yengo, L., Philippe, J., Dechaume, A., Ezzidi, I., Vaillant, E., Gjesing, A. P., Andersson, E. A., Czernichow, S., Hercberg, S., Hadjadj, S., Charpentier, G., Lantieri, O., Balkau, B., Marre, M., Pedersen, O., Hansen, T., Froguel, P. and Vaxillaire, M. (2013). Reassessment of the putative role of BLK-p.A71T loss-of-function mutation in MODY and type 2 diabetes. Diabetologia, 56 (3), 492-496. doi: 10.1007/s00125-012-2794-8 |
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2013 Journal Article Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypesAlbrechtsen, A., Grarup, N., Li, Y., Sparso, T., Tian, G., Cao, H., Jiang, T., Kim, S. Y., Korneliussen, T., Li, Q., Nie, C., Wu, R., Skotte, L., Morris, A. P., Ladenvall, C., Cauchi, S., Stancakova, A., Andersen, G., Astrup, A., Banasik, K., Bennett, A. J., Bolund, L., Charpentier, G., Chen, Y., Dekker, J. M., Doney, A. S. F., Dorkhan, M., Forsen, T., Frayling, T. M. ... Pedersen, O. (2013). Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes. Diabetologia, 56 (2), 298-310. doi: 10.1007/s00125-012-2756-1 |
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2013 Journal Article Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican childrenMejia-Benitez, Aurora, Kluender-Kluender, Miguel, Yengo, Loic, Meyre, David, Aradillas, Celia, Cruz, Esperanza, Perez-Luque, Elva, Manuel Malacara, Juan, Eugenia Garay, Maria, Peralta-Romero, Jesus, Flores-Huerta, Samuel, Garcia-Mena, Jaime, Froguel, Philippe, Cruz, Miguel and Bonnefond, Amelie (2013). Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children. Bmc Medical Genetics, 14 (1) 21. doi: 10.1186/1471-2350-14-21 |
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2013 Journal Article Genome-wide association analyses identify 18 new loci associated with serum urate concentrationsKoettgen, Anna, Albrecht, Eva, Teumer, Alexander, Vitart, Veronique, Krumsiek, Jan, Hundertmark, Claudia, Pistis, Giorgio, Ruggiero, Daniela, O'Seaghdha, Conall M., Haller, Toomas, Yang, Qiong, Tanaka, Toshiko, Johnson, Andrew D., Kutalik, Zoltan, Smith, Albert V., Shi, Julia, Struchalin, Maksim, Middelberg, Rita P. S., Brown, Morris J., Gaffo, Angelo L., Pirastu, Nicola, Li, Guo, Hayward, Caroline, Zemunik, Tatijana, Huffman, Jennifer, Yengo, Loic, Zhao, Jing Hua, Demirkan, Ayse, Feitosa, Mary F. ... Gieger, Christian (2013). Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics, 45 (2), 145-154. doi: 10.1038/ng.2500 |
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2013 Journal Article GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search AlgorithmBottolo, Leonardo, Chadeau-Hyam, Marc, Hastie, David I., Zeller, Tanja, Liquet, Benoit, Newcombe, Paul, Yengo, Loic, Wild, Philipp S., Schillert, Arne, Ziegler, Andreas, Nielsen, Sune F., Butterworth, Adam S., Ho, Weang Kee, Castagne, Raphaele, Munzel, Thomas, Tregouet, David, Falchi, Mario, Cambien, Francois, Nordestgaard, Borge G., Fumeron, Frederic, Tybjaerg-Hansen, Anne, Froguel, Philippe, Danesh, John, Petretto, Enrico, Blankenberg, Stefan, Tiret, Laurence and Richardson, Sylvia (2013). GUESS-ing Polygenic Associations with Multiple Phenotypes Using a GPU-Based Evolutionary Stochastic Search Algorithm. PLoS Genetics, 9 (8) e1003657, e1003657. doi: 10.1371/journal.pgen.1003657 |
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2013 Journal Article Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French populationRobiou-du-Pont, S., Bonnefond, A., Yengo, L., Vaillant, E., Lobbens, S., Durand, E., Weill, J., Lantieri, O., Balkau, B., Charpentier, G., Marre, M., Froguel, P. and Meyre, D. (2013). Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population. International Journal of Obesity, 37 (7), 980-985. doi: 10.1038/ijo.2012.175 |
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2012 Journal Article European genetic variants associated with type 2 diabetes in North African ArabsCauchi, S., Ezzidi, I., El Achhab, Y., Mtiraoui, N., Chaieb, L., Salah, D., Nejjari, C., Labrune, Y., Yengo, L., Beury, D., Vaxillaire, M., Mahjoub, T., Chikri, M. and Froguel, P. (2012). European genetic variants associated with type 2 diabetes in North African Arabs. Diabetes and Metabolism, 38 (4), 316-323. doi: 10.1016/j.diabet.2012.02.003 |
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2012 Journal Article Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetesMorris, Andrew P., Voight, Benjamin F., Teslovich, Tanya M., Ferreira, Teresa, Segre, Ayellet V., Steinthorsdottir, Valgerdur, Strawbridge, Rona J., Khan, Hassan, Grallert, Harald, Mahajan, Anubha, Prokopenko, Inga, Kang, Hyun Min, Dina, Christian, Esko, Tonu, Fraser, Ross M., Kanoni, Stavroula, Kumar, Ashish, Lagou, Vasiliki, Langenberg, Claudia, Luan, Jian'an, Lindgren, Cecilia M., Mueller-Nurasyid, Martina, Pechlivanis, Sonali, Rayner, N. William, Scott, Laura J., Wiltshire, Steven, Yengo, Loic, Kinnunen, Leena, Rossin, Elizabeth J. ... Shah, Sonia (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics, 44 (9), 981-990. doi: 10.1038/ng.2383 |
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2012 Journal Article Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populationsOkada, Y., Sim, X., Go, M. J., Wu, J. Y., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S. C., Wong, T. Y., Liu, J., Young, T. L., Aung, T., Seielstad, M., Teo, Y. Y., Kim, Y. J., Lee, J. Y., Han, B. g., Kang, D., Chen, C. h., Tsai, F. j., Chang, L. c., Fann, S. j., Mei, H., Rao, D. c., Hixson, J. e., Chen, S. ... Gieger, C. (2012). Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics, 44 (8), 904-909. doi: 10.1038/ng.2352 |
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2012 Journal Article Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese casesPerry, John R. B., Voight, Benjamin F., Yengo, Loic, Amin, Najaf, Dupuis, Josee, Ganser, Martha, Grallert, Harald, Navarro, Pau, Li, Man, Qi, Lu, Steinthorsdottir, Valgerdur, Scott, Robert A., Almgren, Peter, Arking, Dan E., Aulchenko, Yurii, Balkau, Beverley, Benediktsson, Rafn, Bergman, Richard N., Boerwinkle, Eric, Bonnycastle, Lori, Burtt, Noel P., Campbell, Harry, Charpentier, Guillaume, Collins, Francis S., Gieger, Christian, Green, Todd, Hadjadj, Samy, Hattersley, Andrew T., Herder, Christian ... Cauchi, Stephane (2012). Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. Plos Genetics, 8 (5) e1002741, e1002741. doi: 10.1371/journal.pgen.1002741 |
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2012 Journal Article Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and humanIchimura, Atsuhiko, Hirasawa, Akira, Poulain-Godefroy, Odile, Bonnefond, Amelie, Hara, Takafumi, Yengo, Loic, Kimura, Ikuo, Leloire, Audrey, Liu, Ning, Iida, Keiko, Choquet, Helene, Besnard, Philippe, Lecoeur, Cecile, Vivequin, Sidonie, Ayukawa, Kumiko, Takeuchi, Masato, Ozawa, Kentaro, Tauber, Maithe, Maffeis, Claudio, Morandi, Anita, Buzzetti, Raffaella, Elliott, Paul, Pouta, Anneli, Jarvelin, Marjo-Riitta, Koerner, Antje, Kiess, Wieland, Pigeyre, Marie, Caiazzo, Roberto, Van Hul, Wim ... Froguel, Philippe (2012). Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature, 483 (7389), 350-354. doi: 10.1038/nature10798 |
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2012 Journal Article O53 - Alteration of the omega-3 unsaturated fatty acid receptor GPR120 leads to obesity in humans and mice O53 L'altération du récepteur des acides gras insaturés de type omega-3 GPR120 entraîne une obésité chez l'Homme et la SourisBonnefond, A., Poulain-Godefroy, O., Ichimura, A., Hirasawa, A., Yengo, L., Leloire, A., Choquet, H., Meyre, D., Pattou, F., Wolowczuk, I., Tsujimoto, G. and Froguel, P. (2012). O53 - Alteration of the omega-3 unsaturated fatty acid receptor GPR120 leads to obesity in humans and mice O53 L'altération du récepteur des acides gras insaturés de type omega-3 GPR120 entraîne une obésité chez l'Homme et la Souris. Diabetes and Metabolism, 38. doi: 10.1016/S1262-3636(12)71031-5 |
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2012 Journal Article Low-frequency variants in HMGA1 are not associated with type 2 diabetes riskMarquez, Marcel, Huyvaert, Marlene, Perry, John R. B., Pearson, Richard D., Falchi, Mario, Morris, Andrew P., Vivequin, Sidonie, Lobbens, Stephane, Yengo, Loic, Gaget, Stefan, Pattou, Francois, Poulain-Godefroy, Odile, Charpentier, Guillaume, Carlsson, Lena M. S., Jacobson, Peter, Sjostrom, Lars, Lantieri, Olivier, Heude, Barbara, Walley, Andrew, Balkau, Beverley, Marre, Michel, Froguel, Philippe and Cauchi, Stephane (2012). Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes, 61 (2), 524-530. doi: 10.2337/db11-0728 |
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2012 Journal Article Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesityCreemers, John W. M., Choquet, Helene, Stijnen, Pieter, Vatin, Vincent, Pigeyre, Marie, Beckers, Sigri, Meulemans, Sandra, Than, Manuel E., Yengo, Loic, Tauber, Maithe, Balkan, Beverley, Elliott, Paul, Jarvelin, Marjo-Riitta, Van Hul, Wim, Van Gaal, Luc, Horber, Fritz, Pattou, Francois, Froguel, Philippe and Meyre, David (2012). Heterozygous mutations causing partial prohormone convertase 1 deficiency contribute to human obesity. Diabetes, 61 (2), 383-390. doi: 10.2337/db11-0305 |
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2012 Journal Article Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetesBonnefond, Amelie, Clement, Nathalie, Fawcett, Katherine, Yengo, Loic, Vaillant, Emmanuel, Guillaume, Jean-Luc, Dechaume, Aurelie, Payne, Felicity, Roussel, Ronan, Czernichow, Sebastien, Hercberg, Serge, Hadjadj, Samy, Balkau, Beverley, Marre, Michel, Lantieri, Olivier, Langenberg, Claudia, Bouatia-Naji, Nabila, Charpentier, Guillaume, Vaxillaire, Martine, Rocheleau, Ghislain, Wareham, Nicholas J., Sladek, Robert, McCarthy, Mark I., Dina, Christian, Barroso, Ines, Jockers, Ralf and Froguel, Philippe (2012). Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nature Genetics, 44 (3), 297-301. doi: 10.1038/ng.1053 |
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2012 Journal Article Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathwaysScott, Robert A., Lagou, Vasiliki, Welch, Ryan P., Wheeler, Eleanor, Montasser, May E., Luan, Jian’an, Mägi, Reedik, Strawbridge, Rona J., Rehnberg, Emil, Gustafsson, Stefan, Kanoni, Stavroula, Rasmussen-Torvik, Laura J., Yengo, Loïc, Lecoeur, Cecile, Shungin, Dmitry, Sanna, Serena, Sidore, Carlo, Johnson, Paul C. D., Jukema, J. Wouter, Johnson, Toby, Mahajan, Anubha, Verweij, Niek, Thorleifsson, Gudmar, Hottenga, Jouke-Jan, Shah, Sonia, Smith, Albert V., Sennblad, Bengt, Gieger, Christian, Salo, Perttu ... Barroso, Inês (2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics, 44 (9), 991-1005. doi: 10.1038/ng.2385 |
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2011 Journal Article Disruption of a novel Krüppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitusBonnefond, Amelie, Lomberk, Gwen, Buttar, Navtej, Busiah, Kanetee, Vaillant, Emmanuel, Lobbens, Stephane, Yengo, Loic, Dechaume, Aurelie, Mignot, Brigitte, Simon, Albane, Scharfmann, Raphael, Neve, Bernadette, Tanyolac, Sinan, Hodoglugil, Ugur, Pattou, Francois, Cave, Helene, Iovanna, Juan, Stein, Roland, Polak, Michel, Vaxillaire, Martine, Froguel, Philippe and Urrutia, Raul (2011). Disruption of a novel Krüppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus. Journal of Biological Chemistry, 286 (32), 28414-28424. doi: 10.1074/jbc.M110.215822 |
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2010 Conference Publication Combined global sensitivity analysis and population PBPK modeling for assessing consistency of TCDD toxicokinetics data in miceYengo, Loïc, Brochot, Céline and Péry, Alexandre (2010). Combined global sensitivity analysis and population PBPK modeling for assessing consistency of TCDD toxicokinetics data in mice. doi: 10.1016/j.sbspro.2010.05.220 |
