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2017

Journal Article

Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish

Lagendijk, Anne Karine, Gomez, Guillermo A, Baek, Sungmin, Hesselson, Daniel, Hughes, William E, Paterson, Scott, Conway, Daniel E, Belting, Heinz-Georg, Affolter, Markus, Smith, Kelly A, Schwartz, Martin A, Yap, Alpha S and Hogan, Benjamin M (2017). Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish. Nature communications, 8 (1) 1402, 1-12. doi: 10.1038/s41467-017-01325-6

Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish

2017

Journal Article

Caveolae protect notochord cells against catastrophic mechanical failure during development

Lim, Ye-Wheen, Lo, Harriet P., Ferguson, Charles, Martel, Nick, Giacomotto, Jean, Gomez, Guillermo A., Yap, Alpha S., Hall, Thomas E. and Parton, Robert G. (2017). Caveolae protect notochord cells against catastrophic mechanical failure during development. Current Biology, 27 (13), 1968-1981.e7. doi: 10.1016/j.cub.2017.05.067

Caveolae protect notochord cells against catastrophic mechanical failure during development

2017

Journal Article

In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis

Duszyc, Kinga, Gomez, Guillermo A., Schroder, Kate, Sweet, Matthew J. and Yap, Alpha S. (2017). In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis. Tissue Barriers, 5 (4) e1345353, e1345353. doi: 10.1080/21688370.2017.1345353

In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis

2017

Journal Article

Mammalian diaphanous 1 mediates a pathway for E-cadherin to stabilize epithelial barriers through junctional contractility

Acharya, Bipul R., Wu, Selwin K., Lieu, Zi Zhao, Parton, Robert G., Grill, Stephan W., Bershadsky, Alexander D., Gomez, Guillermo A. and Yap, Alpha S. (2017). Mammalian diaphanous 1 mediates a pathway for E-cadherin to stabilize epithelial barriers through junctional contractility. Cell Reports, 18 (12), 2854-2867. doi: 10.1016/j.celrep.2017.02.078

Mammalian diaphanous 1 mediates a pathway for E-cadherin to stabilize epithelial barriers through junctional contractility

2017

Journal Article

Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis

Kerr, Markus C., Gomez, Guillermo A., Ferguson, Charles, Tanzer, Maria C., Murphy, James M., Yap, Alpha S., Parton, Robert G., Huston, Wilhelmina M. and Teasdale, Rohan D. (2017). Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis. Nature Communications, 8 (1) 14729, 14729. doi: 10.1038/ncomms14729

Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis

2017

Journal Article

Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions

Priya, Rashmi, Gomez, Guillermo A., Budnar, Srikanth, Acharya, Bipul R., Czirok, Andras, Yap, Alpha S. and Neufeld, Zoltan (2017). Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions. Plos Computational Biology, 13 (3) e1005411, e1005411. doi: 10.1371/journal.pcbi.1005411

Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions

2017

Journal Article

Correction to: Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover (Developmental Cell 40, 2017, 123-136)

De Angelis, Jessica E., Lagendijk, Anne K., Chen, Huijun, Tromp, Alisha, Bower, Neil I., Tunny, Kathryn A., Brooks, Andrew J., Bakkers, Jeroen, Francois, Mathias, Yap, Alpha S., Simons, Cas, Wicking, Carol, Hogan, Benjamin M. and Smith, Kelly A. (2017). Correction to: Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover (Developmental Cell 40, 2017, 123-136). Developmental Cell, 40 (4), 421-421. doi: 10.1016/j.devcel.2017.02.005

Correction to: Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover (Developmental Cell 40, 2017, 123-136)

2017

Journal Article

Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover

De Angelis, Jessica E., Lagendijk, Anne K., Chen, Huijun, Tromp, Alisha, Bower, Neil I., Tunny, Kathryn A., Brooks, Andrew J., Bakkers, Jeroen, Francois, Mathias, Yap, Alpha S., Simons, Cas, Wicking, Carol, Hogan, Benjamin M. and Smith, Kelly A. (2017). Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover. Developmental Cell, 40 (2), 123-136. doi: 10.1016/j.devcel.2016.12.017

Tmem2 regulates embryonic Vegf signaling by controlling hyaluronic acid turnover

2017

Journal Article

ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens

Priya, Rashmi, Liang, Xuan, Teo, Jessica L., Duszyc, Kinga, Yap, Alpha S. and Gomez, Guillermo A. (2017). ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens. Molecular Biology of the Cell, 28 (1), 12-20. doi: 10.1091/mbc.E16-04-0262

ROCK1 but not ROCK2 contributes to RhoA signaling and NMIIA-mediated contractility at the epithelial zonula adherens

2016

Journal Article

Editorial overview: membrane traffic and cell polarity

Bryant, David M. and Yap, Alpha S. (2016). Editorial overview: membrane traffic and cell polarity. Traffic, 17 (12), 1231-1232. doi: 10.1111/tra.12433

Editorial overview: membrane traffic and cell polarity

2016

Journal Article

Contact inhibition of locomotion and mechanical cross-talk between cell-cell and cell-substrate adhesion determine the pattern of junctional tension in epithelial cell aggregates

Coburn, Luke, Lopez, Hender, Caldwell, Benjamin J., Moussa, Elliott, Yap, Chloe, Priya, Rashmi, Noppe, Adrian, Roberts, Anthony P., Lobaskin, Vladimir, Yap, Alpha S., Neufeld, Zoltan and Gomez, Guillermo A. (2016). Contact inhibition of locomotion and mechanical cross-talk between cell-cell and cell-substrate adhesion determine the pattern of junctional tension in epithelial cell aggregates. Molecular Biology of the Cell, 27 (22), 3436-3448. doi: 10.1091/mbc.E16-04-0226

Contact inhibition of locomotion and mechanical cross-talk between cell-cell and cell-substrate adhesion determine the pattern of junctional tension in epithelial cell aggregates

2016

Journal Article

Coronin 1B supports RhoA signaling at cell-cell junctions through myosin II

Priya, Rashmi, Wee, Kenneth, Budnar, Srikanth, Gomez, Guillermo A., Yap, Alpha S. and Michael, Magdalene (2016). Coronin 1B supports RhoA signaling at cell-cell junctions through myosin II. Cell Cycle, 15 (22), 1-9. doi: 10.1080/15384101.2016.1234549

Coronin 1B supports RhoA signaling at cell-cell junctions through myosin II

2016

Journal Article

Cycling Rho for tissue contraction

Teo, Jessica L. and Yap, Alpha S. (2016). Cycling Rho for tissue contraction. Journal of Cell Biology, 214 (5), 495-498. doi: 10.1083/jcb.201608017

Cycling Rho for tissue contraction

2016

Journal Article

Resolution of novel pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling

Humphrey, Emily S., Su, Shih-Ping, Nagrial, Adnan M., Hochgraefe, Falko, Pajic, Marina, Lehrbach, Gillian M., Parton, Robert G., Yap, Alpha S., Horvath, Lisa G., Chang, David K., Biankin, Andrew V., Wu, Jianmin and Daly, Roger J. (2016). Resolution of novel pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling. Molecular and Cellular Proteomics, 15 (8), 2671-2685. doi: 10.1074/mcp.M116.058313

Resolution of novel pancreatic ductal adenocarcinoma subtypes by global phosphotyrosine profiling

2016

Journal Article

Remodeling the zonula adherens in response to tension and the role of afadin in this response

Choi, Wangsun, Acharya, Bipul R., Peyret, Grégoire, Fardin, Marc-Antoine, Mège, René-Marc, Ladoux, Benoit, Yap, Alpha S., Fanning, Alan S. and Peifer, Mark (2016). Remodeling the zonula adherens in response to tension and the role of afadin in this response. Journal of Cell Biology, 213 (2), 243-260. doi: 10.1083/jcb.201506115

Remodeling the zonula adherens in response to tension and the role of afadin in this response

2016

Journal Article

Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension

Lee, Natalie K., Fok, Ka Wai, White, Amanda, Wilson, Nicole H., O’Leary, Conor J., Cox, Hayley L., Michael, Magdalene, Yap, Alpha S. and Cooper, Helen M. (2016). Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension. Nature Communications, 7 (11082) 11082, 11082. doi: 10.1038/ncomms11082

Neogenin recruitment of the WAVE regulatory complex maintains adherens junction stability and tension

2016

Journal Article

Biomechanical guidance helps elongate a lumen

Wee, Kenneth and Yap, Alpha S. (2016). Biomechanical guidance helps elongate a lumen. Nature Cell Biology, 18 (3), 255-257. doi: 10.1038/ncb3319

Biomechanical guidance helps elongate a lumen

2016

Journal Article

The Nuclear Receptor, RORγ, Regulates Pathways Necessary for Breast Cancer Metastasis

Oh, Tae Gyu, Wang, Shu-Ching M., Acharya, Bipul R., Goode, Joel M., Graham, J. Dinny, Clarke, Christine L., Yap, Alpha S. and Muscat, George E. O. (2016). The Nuclear Receptor, RORγ, Regulates Pathways Necessary for Breast Cancer Metastasis. EBioMedicine, 6, 59-72. doi: 10.1016/j.ebiom.2016.02.028

The Nuclear Receptor, RORγ, Regulates Pathways Necessary for Breast Cancer Metastasis

2016

Journal Article

Coronin 1B reorganizes the architecture of f-actin networks for contractility at steady-state and apoptotic adherens junctions

Michael, Magdalene, Meiring, Joyce C. M., Acharya, Bipul R., Matthews, Daniel R., Verma, Suzie, Han, Siew Ping, Hill, Michelle M., Parton, Robert G., Gomez, Guillermo A. and Yap, Alpha S. (2016). Coronin 1B reorganizes the architecture of f-actin networks for contractility at steady-state and apoptotic adherens junctions. Developmental Cell, 37 (1), 58-71. doi: 10.1016/j.devcel.2016.03.008

Coronin 1B reorganizes the architecture of f-actin networks for contractility at steady-state and apoptotic adherens junctions

2016

Journal Article

Pli Selon Pli: mechanochemical feedback and the morphogenetic role of contractility at cadherin cell-cell junctions

Acharya, Bipul R. and Yap, Alpha S. (2016). Pli Selon Pli: mechanochemical feedback and the morphogenetic role of contractility at cadherin cell-cell junctions. Current Topics in Developmental Biology, 117, 631-646. doi: 10.1016/bs.ctdb.2015.10.021

Pli Selon Pli: mechanochemical feedback and the morphogenetic role of contractility at cadherin cell-cell junctions