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2015 Journal Article Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide libraryde Veer, Simon J., Wang, Conan, Harris, Jonathan M., Craik, David J. and Swedberg, Joakim E. (2015). Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library. Journal of Medicinal Chemistry, 58 (20), 8257-8268. doi: 10.1021/acs.jmedchem.5b01148 |
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2015 Journal Article Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffoldHuang, Yen-Hua, Henriques, Sonia T., Wang, Conan K., Thorstholm, Louise, Daly, Norelle L., Kaas, Quentin and Craik, David J. (2015). Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold. Scientific Reports, 5 (1) 12974, 1-15. doi: 10.1038/srep12974 |
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2015 Journal Article Exploring experimental and computational markers of cyclic peptides: charting islands of permeabilityWang, Conan K., Northfield, Susan Ellen, Swedberg, Joakim E., Colless, Barbara, Chaousis, Stephanie, Price, David A., Liras, Spiros and Craik, David J. (2015). Exploring experimental and computational markers of cyclic peptides: charting islands of permeability. European Journal of Medicinal Chemistry, 97, 202-213. doi: 10.1016/j.ejmech.2015.04.049 |
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2015 Journal Article An integrated Java tool for generating amino acid sequence alignments with mapped secondary structure elementsWang, Conan K. and Hofmann, Andreas (2015). An integrated Java tool for generating amino acid sequence alignments with mapped secondary structure elements. 3 Biotech, 5 (1), 87-92. doi: 10.1007/s13205-014-0222-0 |
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2014 Journal Article Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficientsWang, Conan K., Northfield, Susan E., Colless, Barbara, Chaousis, Stephanie, Hamernig, Ingrid, Lohman, Rink-Jan, Nielsen, Daniel S., Schroeder, Christina I., Liras, Spiros, Price, David, A., Fairlie, David and Craik, David J. (2014). Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 111 (49), 17504-17509. doi: 10.1073/pnas.1417611111 |
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2014 Journal Article Insights into the molecular flexibility of theta-defensins by NMR relaxation analysisConibear, Anne C., Wang, Conan K., Bi, Tao, Rosengren, K. Johan, Camarero, Julio A. and Craik, David J. (2014). Insights into the molecular flexibility of theta-defensins by NMR relaxation analysis. Journal of Physical Chemistry B, 118 (49), 14257-14266. doi: 10.1021/jp507754c |
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2014 Journal Article Native peptide folding dominates over stereoelectronic effects of prolyl hydroxylation in loop 5 of the macrocyclic peptide kalata B1Taylor, Carol M., Northfield, Susan E., Wang, Conan K. and Craik, David J. (2014). Native peptide folding dominates over stereoelectronic effects of prolyl hydroxylation in loop 5 of the macrocyclic peptide kalata B1. Tetrahedron, 70 (42), 7669-7674. doi: 10.1016/j.tet.2014.06.058 |
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2014 Journal Article Racemic and quasi-racemic x-ray structures of cyclic disulfide-rich peptide drug scaffoldsWang, Conan K., King, Gordon J., Northfield, Susan E., Ojeda, Paola G. and Craik, David J. (2014). Racemic and quasi-racemic x-ray structures of cyclic disulfide-rich peptide drug scaffolds. Angewandte Chemie - International Edition, 53 (42), 11236-11241. doi: 10.1002/anie.201406563 |
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2014 Journal Article The role of disulfide bonds in structure and activity of chlorotoxinOjeda, Paola G., Chan, Lai Y., Poth, Aaron G., Wang, Conan K. and Craik, David J. (2014). The role of disulfide bonds in structure and activity of chlorotoxin. Future Medicinal Chemistry, 6 (15), 1617-1628. doi: 10.4155/FMC.14.93 |
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2014 Journal Article Specific interaction to PIP2 increases the kinetic rate of membrane binding of VILIPs, a subfamily of Neuronal Calcium Sensors (NCS) proteinsRebaud, Samuel, Wang, Conan K., Sarkis, Joe, Mason, Lyndel, Simon, Anne, Blum, Loic J., Hofmann, Andreas and Girard-Egrot, Agnes P. (2014). Specific interaction to PIP2 increases the kinetic rate of membrane binding of VILIPs, a subfamily of Neuronal Calcium Sensors (NCS) proteins. Biochimica et Biophysica Acta - Biomembranes, 1838 (10), 2698-2707. doi: 10.1016/j.bbamem.2014.06.021 |
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2014 Journal Article Translational diffusion of cyclic peptides measured using pulsed-field gradient NMRWang, Conan K., Northfield, Susan E., Swedberg, Joakim E., Harvey, Peta J., Mathiowetz, Alan M., Price, David A, Liras, Spiros and Craik, David J. (2014). Translational diffusion of cyclic peptides measured using pulsed-field gradient NMR. Journal of Physical Chemistry B, 118 (38), 11129-11136. doi: 10.1021/jp506678f |
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2014 Journal Article Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targetingHenriques, Sonia Troeira, Huang, Yen-Hua, Chaousis, Steph, Wang, Conan and Craik, David J. (2014). Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting. Chembiochem, 15 (13), 1956-1965. doi: 10.1002/cbic.201402144 |
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2014 Journal Article Structural parameters modulating the cellular uptake of disulfide-rich cyclic cell-penetrating peptides: MCoTI-II and SFTI-1D'Souza, Charlotte, Troeira Henriques, Sonia, Wang, Conan K. and Craik, David J. (2014). Structural parameters modulating the cellular uptake of disulfide-rich cyclic cell-penetrating peptides: MCoTI-II and SFTI-1. European Journal of Medicinal Chemistry, 88, 10-18. doi: 10.1016/j.ejmech.2014.06.047 |
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2014 Journal Article Comparison of VILIP-1 and VILIP-3 binding to phospholipid monolayersRebaud S., Simon A., Wang C.K., Mason L., Blum L., Hofmann A. and Girard-Egrot A. (2014). Comparison of VILIP-1 and VILIP-3 binding to phospholipid monolayers. PLoS ONE, 9 (4) e93948, e93948.1-e93948.8. doi: 10.1371/journal.pone.0093948 |
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2014 Journal Article Disulfide-rich macrocyclic peptides as templates in drug designNorthfield, Susan E., Wang, Conan K., Schroeder, Christina I., Durek, Thomas, Kan, Meng-Wei, Swedberg, Joakim E. and Craik, David J. (2014). Disulfide-rich macrocyclic peptides as templates in drug design. European Journal of Medicinal Chemistry, 77 (2), 248-257. doi: 10.1016/j.ejmech.2014.03.011 |
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2014 Journal Article The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motifConibear, Anne C., Bochen, Alexander, Rosengren, K. Johan, Stupar, Petar, Wang, Conan, Kessler, Horst and Craik, David J. (2014). The cyclic cystine ladder of theta-defensins as a stable, bifunctional scaffold: a proof-of-concept study using the integrin-binding RGD motif. ChemBioChem, 15 (3), 451-459. doi: 10.1002/cbic.201300568 |
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2014 Journal Article Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosisWang, Conan K., Gruber, Christian W., Cemazar, Masa, Siatskas, Christopher, Tagore, Prascilla, Payne, Natalie, Sun, Guizhi, Wang, Shunhe, Bernard, Claude C. and Craik, David J. (2014). Molecular grafting onto a stable framework yields novel cyclic peptides for the treatment of multiple sclerosis. ACS Chemical Biology, 9 (1), 156-163. doi: 10.1021/cb400548s |
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2012 Journal Article Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactionsWang, Conan K., Wacklin, Hanna P. and Craik, David J. (2012). Cyclotides insert into lipid bilayers to form membrane pores and destabilize the membrane through hydrophobic and phosphoethanolamine-specific interactions. Journal of Biological Chemistry, 287 (52), 43884-43898. doi: 10.1074/jbc.M112.421198 |
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2012 Journal Article Alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanismsWeeratunga, Saroja K., Osman, Asiah, Hu, Nien-Jen, Wang, Conan K., Mason, Lyndel, Svard, Staffan, Hope, Greg, Jones, Malcolm K. and Hofmann, Andreas (2012). Alpha-1 giardin is an annexin with highly unusual calcium-regulated mechanisms. Journal of Molecular Biology, 423 (2), 169-181. doi: 10.1016/j.jmb.2012.06.041 |
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2012 Journal Article Hookworm SCP/TAPS protein structure - A key to understanding host-parasite interactions and developing new interventionsOsman, Asiah, Wang, Conan K., Winter, Anja, Loukas, Alex, Tribolet, Leon, Gasser, Robin B. and Hofmann, Andreas (2012). Hookworm SCP/TAPS protein structure - A key to understanding host-parasite interactions and developing new interventions. Biotechnology Advances, 30 (3), 652-657. doi: 10.1016/j.biotechadv.2011.11.002 |
