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2020 Journal Article Olfactory bulb‐targeted quantum dot (QD) bioconjugate and Kv1.3 blocking peptide improve metabolic health in obese male miceSchwartz, Austin B., Kapur, Anshika, Huang, Zhenbo, Anangi, Raveendra, Spear, John M., Stagg, Scott, Fardone, Erminia, Dekan, Zolan, Rosenberg, Jens T., Grant, Samuel C., King, Glenn F., Mattoussi, Hedi and Fadool, Debra Ann (2020). Olfactory bulb‐targeted quantum dot (QD) bioconjugate and Kv1.3 blocking peptide improve metabolic health in obese male mice. Journal of Neurochemistry, 157 (6) jnc.15200, 1876-1896. doi: 10.1111/jnc.15200 |
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2020 Journal Article Heterodimeric insecticidal peptide provides new insights into the molecular and functional diversity of ant venomsTouchard, Axel, Mendel, Helen C., Boulogne, Isabelle, Herzig, Volker, Braga Emidio, Nayara, King, Glenn F., Triquigneaux, Mathilde, Jaquillard, Lucie, Beroud, Rémy, De Waard, Michel, Delalande, Olivier, Dejean, Alain, Muttenthaler, Markus and Duplais, Christophe (2020). Heterodimeric insecticidal peptide provides new insights into the molecular and functional diversity of ant venoms. ACS Pharmacology and Translational Science, 3 (6) acsptsci.0c00119, 1211-1224. doi: 10.1021/acsptsci.0c00119 |
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2020 Journal Article Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predatorsHerzig, Volker, Sunagar, Kartik, Wilson, David T. R., Pineda, Sandy S., Israel, Mathilde R., Dutertre, Sebastien, McFarland, Brianna Sollod, Undheim, Eivind A. B., Hodgson, Wayne C., Alewood, Paul F., Lewis, Richard J., Bosmans, Frank, Vetter, Irina, King, Glenn F. and Fry, Bryan G. (2020). Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators. Proceedings of the National Academy of Sciences, 117 (40), 24920-24928. doi: 10.1073/pnas.2004516117 |
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2020 Journal Article Deadly proteomes: a practical guide to proteotranscriptomics of animal venomsWalker, Andrew A., Robinson, Samuel D., Hamilton, Brett F., Undheim, Eivind A. B. and King, Glenn F. (2020). Deadly proteomes: a practical guide to proteotranscriptomics of animal venoms. Proteomics, 20 (17-18) 1900324, e1900324. doi: 10.1002/pmic.201900324 |
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2020 Journal Article It takes two: dimerization is essential for the broad-spectrum predatory and defensive activities of the venom peptide Mp1a from the jack jumper ant Myrmecia pilosulaNixon, Samantha A., Dekan, Zoltan, Robinson, Samuel D., Guo, Shaodong, Vetter, Irina, Kotze, Andrew C., Alewood, Paul F., King, Glenn F. and Herzig, Volker (2020). It takes two: dimerization is essential for the broad-spectrum predatory and defensive activities of the venom peptide Mp1a from the jack jumper ant Myrmecia pilosula. Biomedicines, 8 (7) 185, 1-13. doi: 10.3390/biomedicines8070185 |
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2020 Conference Publication A spider-venom peptide for preventing ischemic injuries of the heart: application to heart transplant and myocardial infarctionRedd, M. A., Scheuer, S. E., Saez, N. J., Macdonald, P. S., Palpant, N. J. and King, G. F. (2020). A spider-venom peptide for preventing ischemic injuries of the heart: application to heart transplant and myocardial infarction. Venom Week, Gainesville, FL, United States, 4-7 March, 2020. Oxford, United Kingdom : Elsevier. |
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2020 Conference Publication Discovery of a small-molecule toxin with inhibitory activity at human P2X4 ion channelsBibic, Lucka, Herzig, Volker, King, Glenn F., Searcey, Mark and Stokes, Leanne (2020). Discovery of a small-molecule toxin with inhibitory activity at human P2X4 ion channels. Meeting of the British-Pharmacological-Society, Edinburgh, Scotland, 15-17 December, 2019. Oxford, United Kingdom: John Wiley & Sons. doi: 10.1111/bph.15035 |
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2020 Journal Article Venom-derived modulators of epilepsy-related ion channelsChow, Chun Yuen, Absalom, Nathan, Biggs, Kimberley, King, Glenn F. and Ma, Linlin (2020). Venom-derived modulators of epilepsy-related ion channels. Biochemical Pharmacology, 181 114043, 114043. doi: 10.1016/j.bcp.2020.114043 |
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2020 Journal Article Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding genePineda, Sandy S., Chin, Yanni K.-Y., Undheim, Eivind A. B., Senff, Sebastian, Mobli, Mehdi, Dauly, Claire, Escoubas, Pierre, Nicholson, Graham M., Kaas, Quentin, Guo, Shaodong, Herzig, Volker, Mattick, John S. and King, Glenn F. (2020). Structural venomics reveals evolution of a complex venom by duplication and diversification of an ancient peptide-encoding gene. Proceedings of the National Academy of Sciences, 117 (21) A41, 201914536-11408. doi: 10.1073/pnas.1914536117 |
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2020 Journal Article A selective naV1.1 activator with potential for treatment of dravet syndrome epilepsyChow, Chun Yuen, Chin, Yanni K.Y., Ma, Linlin, Undheim, Eivind A.B., Herzig, Volker and King, Glenn F. (2020). A selective naV1.1 activator with potential for treatment of dravet syndrome epilepsy. Biochemical Pharmacology, 181 113991, 113991. doi: 10.1016/j.bcp.2020.113991 |
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2020 Journal Article Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venomLuna-Ramirez, Karen, Csoti, Agota, McArthur, Jeffrey R., Chin, Yanni K.Y., Anangi, Raveendra, Najera, Rosby del Carmen, Possani, Lourival D., King, Glenn F., Panyi, Gyorgy, Yu, Haibo, Adams, David J. and Finol-Urdaneta, Rocio K. (2020). Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom. Biochemical Pharmacology, 174 113782, 113782. doi: 10.1016/j.bcp.2019.113782 |
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2020 Journal Article Weaponisation ‘on the fly’: convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin fliesJin, Jiayi, Agwa, Akello J., Szanto, Tibor G., Csóti, Agota, Panyi, Gyorgy, Schroeder, Christina I., Walker, Andrew A. and King, Glenn F. (2020). Weaponisation ‘on the fly’: convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies. Insect Biochemistry and Molecular Biology, 118 103310, 1-12. doi: 10.1016/j.ibmb.2019.103310 |
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2020 Journal Article Addition of K22 converts spider venom peptide Pme2a from an activator to an inhibitor of NaV1.7Yin, Kathleen, Deuis, Jennifer R., Dekan, Zoltan, Jin, Ai-Hua, Alewood, Paul F., King, Glenn F., Herzig, Volker and Vetter, Irina (2020). Addition of K22 converts spider venom peptide Pme2a from an activator to an inhibitor of NaV1.7. Biomedicines, 8 (2) 37, 37. doi: 10.3390/biomedicines8020037 |
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2020 Conference Publication Discovery and characterisation of novel peptides from Amazonian stinging ant venoms with antiparasitic activityNixon, Samantha, Agwa, Akello, Robinson, Sam, Walker, Andrew, Touchard, Axel, Schroeder, Christina, Vetter, Irina, Kotze, Andrew C., Herzig, Volker and King, Glenn F. (2020). Discovery and characterisation of novel peptides from Amazonian stinging ant venoms with antiparasitic activity. 20th World Congress of the International-Society-on-Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier. |
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2020 Journal Article Fluorescence labeling of a NaV1.7-targeted peptide for near-infrared nerve visualizationGonzales, Junior, Pirovano, Giacomo, Chow, Chun Yuen, de Souza Franca, Paula Demetrio, Carter, Lukas M., Klint, Julie K., Guru, Navjot, Lewis, Jason S., King, Glenn F. and Reiner, Thomas (2020). Fluorescence labeling of a NaV1.7-targeted peptide for near-infrared nerve visualization. EJNMMI Research, 10 (1) 49, 49. doi: 10.1186/s13550-020-00630-4 |
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2020 Conference Publication The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutationFernandez-Rojo, Manuel A., Brust, Andreas, Potriquet, Jeremy, Daley, Joshua, Ragnarsson, Lotten, Andersson, Asa, Mukhopadhyay, Pamela, Wilhelm, Patrick, Chin, Yanni, Smallwood, Taylor, Clark, Richard, King, Glenn, Ramm, Grant, Waddell, Nic, Lewis, Richard, Boyle, Glen, Fry, Bryan, Alewood, Paul, Mulvenna, Jason, Miles, John and Ikonomopoulou, Maria P. (2020). The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutation. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.toxicon.2019.10.014 |
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2020 Journal Article Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7Rupasinghe, Darshani B., Herzig, Volker, Vetter, Irina, Dekan, Zoltan, Gilchrist, John, Bosmans, Frank, Alewood, Paul F., Lewis, Richard J. and King, Glenn F. (2020). Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7. Biochemical Pharmacology, 181 114080, 114080. doi: 10.1016/j.bcp.2020.114080 |
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2020 Journal Article Animal toxins — Nature's evolutionary-refined toolkit for basic research and drug discoveryHerzig, Volker, Cristofori-Armstrong, Ben, Israel, Mathilde R., Nixon, Samantha A., Vetter, Irina and King, Glenn F. (2020). Animal toxins — Nature's evolutionary-refined toolkit for basic research and drug discovery. Biochemical Pharmacology, 181 114096, 114096. doi: 10.1016/j.bcp.2020.114096 |
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2019 Journal Article Venom peptides with dual modulatory activity on the voltage-gated sodium channel NaV1.1 provide novel leads for development of antiepileptic drugsChow, Chun Yuen, Chin, Yanni K.-Y., Walker, Andrew A., Guo, Shaodong, Blomster, Linda V., Ward, Micaiah J., Herzig, Volker, Rokyta, Darin R. and King, Glenn F. (2019). Venom peptides with dual modulatory activity on the voltage-gated sodium channel NaV1.1 provide novel leads for development of antiepileptic drugs. ACS Pharmacology & Translational Science, 3 (1) acsptsci.9b00079, 119-134. doi: 10.1021/acsptsci.9b00079 |
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2019 Journal Article A versatile and robust serine protease inhibitor scaffold from Actinia tenebrosaChen, Xingchen, Leahy, Darren, Van Haeften, Jessica, Hartfield, Perry, Prentis, Peter J., van der Burg, Chloé A., Surm, Joachim M., Pavasovic, Ana, Madio, Bruno, Hamilton, Brett R., King, Glenn F., Undheim, Eivind A. B., Brattsand, Maria and Harris, Jonathan M. (2019). A versatile and robust serine protease inhibitor scaffold from Actinia tenebrosa. Marine Drugs, 17 (12) 701, 701. doi: 10.3390/md17120701 |
