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2020 Journal Article Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venomLuna-Ramirez, Karen, Csoti, Agota, McArthur, Jeffrey R., Chin, Yanni K.Y., Anangi, Raveendra, Najera, Rosby del Carmen, Possani, Lourival D., King, Glenn F., Panyi, Gyorgy, Yu, Haibo, Adams, David J. and Finol-Urdaneta, Rocio K. (2020). Structural basis of the potency and selectivity of Urotoxin, a potent Kv1 blocker from scorpion venom. Biochemical Pharmacology, 174 113782, 113782. doi: 10.1016/j.bcp.2019.113782 |
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2020 Journal Article Weaponisation ‘on the fly’: convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin fliesJin, Jiayi, Agwa, Akello J., Szanto, Tibor G., Csóti, Agota, Panyi, Gyorgy, Schroeder, Christina I., Walker, Andrew A. and King, Glenn F. (2020). Weaponisation ‘on the fly’: convergent recruitment of knottin and defensin peptide scaffolds into the venom of predatory assassin flies. Insect Biochemistry and Molecular Biology, 118 103310, 1-12. doi: 10.1016/j.ibmb.2019.103310 |
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2020 Journal Article Addition of K22 converts spider venom peptide Pme2a from an activator to an inhibitor of NaV1.7Yin, Kathleen, Deuis, Jennifer R., Dekan, Zoltan, Jin, Ai-Hua, Alewood, Paul F., King, Glenn F., Herzig, Volker and Vetter, Irina (2020). Addition of K22 converts spider venom peptide Pme2a from an activator to an inhibitor of NaV1.7. Biomedicines, 8 (2) 37, 37. doi: 10.3390/biomedicines8020037 |
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2020 Journal Article Animal toxins — Nature's evolutionary-refined toolkit for basic research and drug discoveryHerzig, Volker, Cristofori-Armstrong, Ben, Israel, Mathilde R., Nixon, Samantha A., Vetter, Irina and King, Glenn F. (2020). Animal toxins — Nature's evolutionary-refined toolkit for basic research and drug discovery. Biochemical Pharmacology, 181 114096, 114096. doi: 10.1016/j.bcp.2020.114096 |
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2020 Conference Publication Discovery and characterisation of novel peptides from Amazonian stinging ant venoms with antiparasitic activityNixon, Samantha, Agwa, Akello, Robinson, Sam, Walker, Andrew, Touchard, Axel, Schroeder, Christina, Vetter, Irina, Kotze, Andrew C., Herzig, Volker and King, Glenn F. (2020). Discovery and characterisation of novel peptides from Amazonian stinging ant venoms with antiparasitic activity. 20th World Congress of the International-Society-on-Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier. |
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2020 Journal Article Fluorescence labeling of a NaV1.7-targeted peptide for near-infrared nerve visualizationGonzales, Junior, Pirovano, Giacomo, Chow, Chun Yuen, de Souza Franca, Paula Demetrio, Carter, Lukas M., Klint, Julie K., Guru, Navjot, Lewis, Jason S., King, Glenn F. and Reiner, Thomas (2020). Fluorescence labeling of a NaV1.7-targeted peptide for near-infrared nerve visualization. EJNMMI Research, 10 (1) 49, 49. doi: 10.1186/s13550-020-00630-4 |
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2020 Conference Publication The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutationFernandez-Rojo, Manuel A., Brust, Andreas, Potriquet, Jeremy, Daley, Joshua, Ragnarsson, Lotten, Andersson, Asa, Mukhopadhyay, Pamela, Wilhelm, Patrick, Chin, Yanni, Smallwood, Taylor, Clark, Richard, King, Glenn, Ramm, Grant, Waddell, Nic, Lewis, Richard, Boyle, Glen, Fry, Bryan, Alewood, Paul, Mulvenna, Jason, Miles, John and Ikonomopoulou, Maria P. (2020). The antiproliferative profile of a linear octopus-derived peptide in melanoma of BRAF-mutation. 20th World Congress of the International Society on Toxinology, Buenos Aires, Argentina, 8-13 September 2019. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.toxicon.2019.10.014 |
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2020 Journal Article Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7Rupasinghe, Darshani B., Herzig, Volker, Vetter, Irina, Dekan, Zoltan, Gilchrist, John, Bosmans, Frank, Alewood, Paul F., Lewis, Richard J. and King, Glenn F. (2020). Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target NaV1.7. Biochemical Pharmacology, 181 114080, 114080. doi: 10.1016/j.bcp.2020.114080 |
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2019 Journal Article Venom peptides with dual modulatory activity on the voltage-gated sodium channel NaV1.1 provide novel leads for development of antiepileptic drugsChow, Chun Yuen, Chin, Yanni K.-Y., Walker, Andrew A., Guo, Shaodong, Blomster, Linda V., Ward, Micaiah J., Herzig, Volker, Rokyta, Darin R. and King, Glenn F. (2019). Venom peptides with dual modulatory activity on the voltage-gated sodium channel NaV1.1 provide novel leads for development of antiepileptic drugs. ACS Pharmacology & Translational Science, 3 (1) acsptsci.9b00079, 119-134. doi: 10.1021/acsptsci.9b00079 |
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2019 Journal Article A versatile and robust serine protease inhibitor scaffold from Actinia tenebrosaChen, Xingchen, Leahy, Darren, Van Haeften, Jessica, Hartfield, Perry, Prentis, Peter J., van der Burg, Chloé A., Surm, Joachim M., Pavasovic, Ana, Madio, Bruno, Hamilton, Brett R., King, Glenn F., Undheim, Eivind A. B., Brattsand, Maria and Harris, Jonathan M. (2019). A versatile and robust serine protease inhibitor scaffold from Actinia tenebrosa. Marine Drugs, 17 (12) 701, 701. doi: 10.3390/md17120701 |
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2019 Journal Article Missiles of mass disruption: Composition and glandular origin of venom used as a projectile defensive weapon by the assassin bug Platymeris rhadamanthusWalker, Andrew A., Robinson, Samuel D., Undheim, Eivind A. B., Jin, Jiayi, Han, Xiao, Fry, Bryan G., Vetter, Irina and King, Glenn F. (2019). Missiles of mass disruption: Composition and glandular origin of venom used as a projectile defensive weapon by the assassin bug Platymeris rhadamanthus. Toxins, 11 (11) 673, 673. doi: 10.3390/toxins11110673 |
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2019 Journal Article Fluorescence imaging of peripheral nerves by a Nav1.7-targeted inhibitor cystine knot peptideGonzales, Junior, Demetrio de Souza Franca, Paula, Jiang, Yan, Pirovano, Giacomo, Kossatz, Susanne, Guru, Navjot, Yarilin, Dimitry, Agwa, Akello J., Schroeder, Christina I, Patel, Snehal, Ganly, Ian, King, Glenn F. and Reiner, Thomas (2019). Fluorescence imaging of peripheral nerves by a Nav1.7-targeted inhibitor cystine knot peptide. Bioconjugate Chemistry, 30 (11) acs.bioconjchem.9b00612, 2879-2888. doi: 10.1021/acs.bioconjchem.9b00612 |
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2019 Journal Article The unusual conformation of cross‐strand disulfide bonds is critical to the stability of β‐hairpin peptidesDeplazes, Evelyne, Chin, Yanni K.‐Y., King, Glenn F. and Mancera, Ricardo L. (2019). The unusual conformation of cross‐strand disulfide bonds is critical to the stability of β‐hairpin peptides. Proteins, 88 (3) prot.25828, 485-502. doi: 10.1002/prot.25828 |
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2019 Journal Article Development of high-throughput fluorescent-based screens to accelerate discovery of P2X inhibitors from animal venomsBibic, Lucka, Herzig, Volker, King, Glenn F. and Stokes, Leanne (2019). Development of high-throughput fluorescent-based screens to accelerate discovery of P2X inhibitors from animal venoms. Journal of Natural Products, 82 (9) acs.jnatprod.9b00410, 2559-2567. doi: 10.1021/acs.jnatprod.9b00410 |
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2019 Journal Article A cell-penetrating scorpion toxin enables mode-specific modulation of TRPA1 and painLin King, John V., Emrick, Joshua J., Kelly, Mark J. S., Herzig, Volker, King, Glenn F., Medzihradszky, Katalin F. and Julius, David (2019). A cell-penetrating scorpion toxin enables mode-specific modulation of TRPA1 and pain. Cell, 178 (6), 1362-1374.e16. doi: 10.1016/j.cell.2019.07.014 |
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2019 Journal Article Tying pest insects in knots: the deployment of spider‐venom‐derived knottins as bioinsecticidesKing, Glenn F. (2019). Tying pest insects in knots: the deployment of spider‐venom‐derived knottins as bioinsecticides. Pest Management Science, 75 (9) ps.5452, 2437-2445. doi: 10.1002/ps.5452 |
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2019 Journal Article Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureusMonk, Ian R., Shaikh, Nausad, Begg, Stephanie L., Gajdiss, Mike, Sharkey, Liam K. R., Lee, Jean Y. H., Pidot, Sacha J., Seemann, Torsten, Kuiper, Michael, Winnen, Brit, Hvorup, Rikki, Collins, Brett M., Bierbaum, Gabriele, Udagedara, Saumya R., Morey, Jacqueline R., Pulyani, Neha, Howden, Benjamin P., Maher, Megan J., McDevitt, Christopher A., King, Glenn F. and Stinear, Timothy P. (2019). Zinc-binding to the cytoplasmic PAS domain regulates the essential WalK histidine kinase of Staphylococcus aureus. Nature Communications, 10 (1) 3067, 3067. doi: 10.1038/s41467-019-10932-4 |
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2019 Journal Article The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitroNixon, Samantha A., Saez, Natalie J., Herzig, Volker, King, Glenn F. and Kotze, Andrew C. (2019). The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro. Veterinary Parasitology, 270, 40-46. doi: 10.1016/j.vetpar.2019.05.008 |
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2019 Journal Article Sea anemone toxins: a structural overviewMadio, Bruno, King, Glenn F. and Undheim, Eivind A. B. (2019). Sea anemone toxins: a structural overview. Marine Drugs, 17 (6) 325, 325. doi: 10.3390/md17060325 |
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2019 Journal Article Periplasmic expression of 4/7 alpha-conotoxin TxIA analogs in E. coli favors ribbon isomer formation suggestion of a binding mode at the α7 nAChREl Hamdaoui, Yamina, Wu, Xiaosa, Clark, Richard J., Giribaldi, Julien, Anangi, Raveendra, Craik, David J., King, Glenn F., Dutertre, Sebastien, Kaas, Quentin, Herzig, Volker and Nicke, Annette (2019). Periplasmic expression of 4/7 alpha-conotoxin TxIA analogs in E. coli favors ribbon isomer formation suggestion of a binding mode at the α7 nAChR. Frontiers in Pharmacology, 10 (MAY) 577, 577. doi: 10.3389/fphar.2019.00577 |
