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2023 Journal Article Muscle and its neuromuscular synapse – players in the pathogenesis of motor neuron diseaseNoakes, Peter G., Phillips, William D., Jeffree, Rosalind L., Steyn, Frederik J., Wolvetang, Ernst J., Henderson, Rob D., McCombe, Pamela A. and Ngo, Shyuan T. (2023). Muscle and its neuromuscular synapse – players in the pathogenesis of motor neuron disease. Journal of Experimental Neurology, 4 (1), 1-5. doi: 10.33696/neurol.4.067 |
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2023 Journal Article Folium Hibisci Mutabilis extract, a potent autophagy enhancer, exhibits neuroprotective properties in multiple models of neurodegenerative diseasesHe, Chang-Long, Tang, Yong, Chen, Xue, Long, Tao, He, Yan-Ni, Wei, Jing, Wu, Jian-Ming, Lan, Cai, Yu, Lu, Huang, Fei-Hong, Gu, Cong-Wei, Liu, Jian, Yu, Chong-Lin, Wong, Vincent Kam-Wai, Law, Betty Yuen-Kwan, Qin, Da-Lian, Wu, An-Guo and Zhou, Xiao-Gang (2023). Folium Hibisci Mutabilis extract, a potent autophagy enhancer, exhibits neuroprotective properties in multiple models of neurodegenerative diseases. Phytomedicine, 109 154548, 1-18. doi: 10.1016/j.phymed.2022.154548 |
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2023 Journal Article SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike proteinAlbornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0 |
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2022 Journal Article Effectiveness of BNT162b2 and CoronaVac vaccinations against mortality and severe complications after SARS-CoV-2 Omicron BA.2 infection: a case-control studyYan, Vincent Ka Chun, Wan, Eric Yuk Fai, Ye, Xuxiao, Mok, Anna Hoi Ying, Lai, Francisco Tsz Tsun, Chui, Celine Sze Ling, Li, Xue, Wong, Carlos King Ho, Li, Philip Hei, Ma, Tiantian, Qin, Simon, Wong, Vincent Kai Chung, Tsang, Tat Chi, Tsui, Sik Hon, Chui, William Chun Ming, Cowling, Benjamin John, Leung, Gabriel Matthew, Lau, Chak Sing, Wong, Ian Chi Kei and Chan, Esther Wai Yin (2022). Effectiveness of BNT162b2 and CoronaVac vaccinations against mortality and severe complications after SARS-CoV-2 Omicron BA.2 infection: a case-control study. Emerging Microbes and Infections, 11 (1), 2304-2314. doi: 10.1080/22221751.2022.2114854 |
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2022 Journal Article Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesisSlonchak, Andrii, Wang, Xiaohui, Aguado, Julio, Sng, Julian D. J., Chaggar, Harman, Freney, Morgan E., Yan, Kexin, Torres, Francisco J., Amarilla, Alberto A., Balea, Rickyle, Setoh, Yin Xiang, Peng, Nias, Watterson, Daniel, Wolvetang, Ernst, Suhrbier, Andreas and Khromykh, Alexander A. (2022). Zika virus noncoding RNA cooperates with the viral protein NS5 to inhibit STAT1 phosphorylation and facilitate viral pathogenesis. Science Advances, 8 (48) eadd8095, eadd8095. doi: 10.1126/sciadv.add8095 |
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2022 Journal Article Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7)Grapotte, Mathys, Saraswat, Manu, Bessière, Chloé, Menichelli, Christophe, Ramilowski, Jordan A., Severin, Jessica, Hayashizaki, Yoshihide, Itoh, Masayoshi, Tagami, Michihira, Murata, Mitsuyoshi, Kojima-Ishiyama, Miki, Noma, Shohei, Noguchi, Shuhei, Kasukawa, Takeya, Hasegawa, Akira, Suzuki, Harukazu, Nishiyori-Sueki, Hiromi, Frith, Martin C., Abugessaisa, Imad, Aitken, Stuart, Aken, Bronwen L., Alam, Intikhab, Alam, Tanvir, Alasiri, Rami, Alhendi, Ahmad M. N., Alinejad-Rokny, Hamid, Alvarez, Mariano J., Andersson, Robin, Arakawa, Takahiro ... Lecellier, Charles-Henri (2022). Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network (Nature Communications, (2021), 12, 1, (3297), 10.1038/s41467-021-23143-7). Nature Communications, 13 (1) 1200. doi: 10.1038/s41467-022-28758-y |
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2022 Journal Article Poria cocos polysaccharides exert prebiotic function to attenuate the adverse effects and improve the therapeutic outcome of 5-FU in ApcMin/+ miceYin, Lin, Huang, Guoxin, Khan, Imran, Su, Lu, Xia, Wenrui, Law, Betty Yuen Kwan, Wong, Vincent Kam Wai, Wu, Qiang, Wang, Jingyi, Leong, Wai Kit and Hsiao, W. L. Wendy (2022). Poria cocos polysaccharides exert prebiotic function to attenuate the adverse effects and improve the therapeutic outcome of 5-FU in ApcMin/+ mice. Chinese Medicine, 17 (1) 116, 1-14. doi: 10.1186/s13020-022-00667-8 |
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2022 Journal Article Generation of iPSC lines from hereditary spastic paraplegia 56 (SPG56) patients and family members carrying CYP2U1 mutationsLeeson, Hannah C., Goh, Denise, Coman, David and Wolvetang, Ernst J. (2022). Generation of iPSC lines from hereditary spastic paraplegia 56 (SPG56) patients and family members carrying CYP2U1 mutations. Stem Cell Research, 64 102917, 1-5. doi: 10.1016/j.scr.2022.102917 |
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2022 Journal Article Generation of human induced pluripotential stem cells from individuals with complex heterozygous, isogenic corrected, and homozygous Bloc1s1 mutationsWu, Kaiyuan, Takanohashi, Asako, Woidill, Sarah, Seylani, Allen, Helman, Guy, Dias, Patricia, Beers, Jeanette, Lin, Yongshun, Simons, Cas, Wolvetang, Ernst, Zou, Jizhong, Vanderver, Adeline and Sack, Michael N. (2022). Generation of human induced pluripotential stem cells from individuals with complex heterozygous, isogenic corrected, and homozygous Bloc1s1 mutations. Stem Cell Research, 64 102905, 1-6. doi: 10.1016/j.scr.2022.102905 |
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2022 Journal Article Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3η proteinGao, Zhenxiong, Fan, Tingting, Chen, Linbo, Yang, Mengchu, Wong, Vincent Kam Wai, Chen, Dawei, Liu, Zijian, Zhou, Yaoyao, Wu, Weibin, Qiu, Zixuan, Zhang, Cunlong, Li, Yuan and Jiang, Yuyang (2022). Design, synthesis and antitumor evaluation of novel 1H-indole-2-carboxylic acid derivatives targeting 14-3-3η protein. European Journal of Medicinal Chemistry, 238 114402, 1-15. doi: 10.1016/j.ejmech.2022.114402 |
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2022 Journal Article The hallmarks of aging in ataxia-telangiectasiaAguado, Julio, Gómez-Inclán, Cecilia, Leeson, Hannah C., Lavin, Martin F., Shiloh, Yosef and Wolvetang, Ernst J. (2022). The hallmarks of aging in ataxia-telangiectasia. Ageing Research Reviews, 79 101653, 1-15. doi: 10.1016/j.arr.2022.101653 |
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2022 Journal Article Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variantsIsaacs, Ariel, Amarilla, Alberto A., Aguado, Julio, Modhiran, Naphak, Albornoz, Eduardo A., Baradar, Alireza A., McMillan, Christopher L. D., Choo, Jovin J. Y., Idris, Adi, Supramaniam, Aroon, McMillan, Nigel A. J., Muller, David A., Young, Paul R., Woodruff, Trent M., Wolvetang, Ernst J., Chappell, Keith J. and Watterson, Daniel (2022). Nucleocapsid specific diagnostics for the detection of divergent SARS-CoV-2 variants. Frontiers in Immunology, 13 926262, 926262. doi: 10.3389/fimmu.2022.926262 |
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2022 Journal Article Robust and highly reproducible generation of cortical brain organoids for modelling brain neuronal senescence in vitroShaker, Mohammed R., Hunter, Zoe L. and Wolvetang, Ernst J. (2022). Robust and highly reproducible generation of cortical brain organoids for modelling brain neuronal senescence in vitro. Journal of Visualized Experiments, 2022 (183) e63714. doi: 10.3791/63714 |
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2022 Journal Article Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron DiseaseDing, Qiao, Kesavan, Kaamini, Lee, Kah Meng, Wimberger, Elyse, Robertson, Thomas, Gill, Melinder, Power, Dominique, Chang, Jeryn, Fard, Atefeh T., Mar, Jessica C., Henderson, Robert D., Heggie, Susan, McCombe, Pamela A., Jeffree, Rosalind L., Colditz, Michael J., Hilliard, Massimo A., Ng, Dominic C. H., Steyn, Frederik J., Phillips, William D., Wolvetang, Ernst J., Ngo, Shyuan T. and Noakes, Peter G. (2022). Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease. Acta Neuropathologica Communications, 10 (1) 61, 61. doi: 10.1186/s40478-022-01360-5 |
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2022 Journal Article Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screeningHunter, Zoe L., Leeson, Hannah C., Shaker, Mohammed R., Wolvetang, Ernst J. and Vadlamudi, Lata (2022). Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening. Stem Cell Research, 60 102673, 102673. doi: 10.1016/j.scr.2022.102673 |
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2022 Journal Article Inhibition of the CDK9-cyclin T1 protein-protein interaction as a new approach against triple-negative breast cancerCheng, Sha-Sha, Qu, Yuan-Qing, Wu, Jia, Yang, Guan-Jun, Liu, Hao, Wang, Wanhe, Huang, Qi, Chen, Feng, Li, Guodong, Wong, Chun-Yuen, Wong, Vincent Kam Wai, Ma, Dik-Lung and Leung, Chung-Hang (2022). Inhibition of the CDK9-cyclin T1 protein-protein interaction as a new approach against triple-negative breast cancer. Acta Pharmaceutica Sinica B, 12 (3), 1390-1405. doi: 10.1016/j.apsb.2021.10.024 |
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2022 Journal Article 2-Bromo-3-((1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)-methoxy)-benzaldehydeYun, Xiaoyun, Xie, Yuhan, Ng, Jerome P. L., Law, Betty Yuen Kwan, Wong, Vincent Kam Wai and Coghi, Paolo (2022). 2-Bromo-3-((1-(7-chloroquinolin-4-yl)-1H-1,2,3-triazol-4-yl)-methoxy)-benzaldehyde. Molbank, 2022 (1) M1351, 1-7. doi: 10.3390/M1351 |
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2022 Journal Article Exploring aging interventions in human brain organoidsAguado, Julio and Wolvetang, Ernst J (2022). Exploring aging interventions in human brain organoids. Aging, 14 (4), 1592-1593. doi: 10.18632/aging.203925 |
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2022 Journal Article Neural epidermal growth factor-like like protein 2 is expressed in human oligodendroglial cell typesShaker, Mohammed R., Kahtan, Amna, Prasad, Renuka, Lee, Ju-Hyun, Pietrogrande, Giovanni, Leeson, Hannah C., Sun, Woong, Wolvetang, Ernst J. and Slonchak, Andrii (2022). Neural epidermal growth factor-like like protein 2 is expressed in human oligodendroglial cell types. Frontiers in Cell and Developmental Biology, 10 803061, 803061. doi: 10.3389/fcell.2022.803061 |
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2022 Journal Article Nimbolide inhibits 2D and 3D prostate cancer cells migration, affects microtubules and angiogenesis and suppresses B-RAF/p.ERK-mediated in vivo tumor growthMahmoud, Nuha, Dawood, Mona, Huang, Qi, Ng, Jerome P. L., Ren, Fang, Wong, Vincent K. W. and Efferth, Thomas (2022). Nimbolide inhibits 2D and 3D prostate cancer cells migration, affects microtubules and angiogenesis and suppresses B-RAF/p.ERK-mediated in vivo tumor growth. Phytomedicine, 94 153826, 1-13. doi: 10.1016/j.phymed.2021.153826 |
