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2015 Journal Article Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolutionBriggs, James A., Wolvetang, Ernst J., Mattick, John S., Rinn, John L. and Barry, Guy (2015). Mechanisms of long non-coding RNAs in mammalian nervous system development, plasticity, disease, and evolution. Neuron, 88 (5), 861-877. doi: 10.1016/j.neuron.2015.09.045 |
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2015 Journal Article Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesisTakasato, Minoru, Er, Pei X., Chiu, Han S., Maier, Barbara, Baillie, Gregory J., Ferguson, Charles, Parton, Robert G., Wolvetang, Ernst J., Roost, Matthias S., de Sousa Lopes, Susana M. Chuva and Little, Melissa H. (2015). Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis. Nature, 526 (7574), 564-568. doi: 10.1038/nature15695 |
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2015 Journal Article A protocol for the identification and validation of novel genetic causes of kidney diseaseMallett, Andrew, Patel, Chirag, Maier, Barbara, McGaughran, Julie, Gabbett, Michael, Takasato, Minoru, Cameron, Anne, Trnka, Peter, Alexander, Stephen I., Rangan, Gopala, Tchan, Michel C., Caruana, Georgina, John, George, Quinlan, Cathy, McCarthy, Hugh J., Hyland, Valentine, Hoy, Wedy E., Wolvetang, Ernst, Taft, Ryan, Simons, Cas, Healy H. and Little, Melissa (2015). A protocol for the identification and validation of novel genetic causes of kidney disease. BMC Nephrology, 16 (152) 148, 152. doi: 10.1186/s12882-015-0148-8 |
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2015 Journal Article Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic DevelopmentHasegawa, Yu., Taylor, Deanne., Ovchinnikov, Dmitry A., Wolvetang, Ernst J., de Torrente, Laurence. and Mar, Jessica C. (2015). Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development. PLoS Genetics, 11 (8) e1005428, e1005428. doi: 10.1371/journal.pgen.1005428 |
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2015 Journal Article A new model to study neurodegeneration in ataxia oculomotor apraxia type 2Becherel, Olivier J., Sun, Jane, Yeo, Abrey J., Nayler, Sam, Fogel, Brent L., Gao, Fuying, Coppola, Giovanni, Criscuolo, Chiara, De Michele, Giuseppe, Wolvetang, Ernst and Lavin, Martin F. (2015). A new model to study neurodegeneration in ataxia oculomotor apraxia type 2. Human Molecular Genetics, 24 (20), 5759-5774. doi: 10.1093/hmg/ddv296 |
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2015 Journal Article Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cellsArner, Erik, Daub, Carsten O., Vitting-Seerup, Kristoffer, Andersson, Robin, Lilje, Berit, Drabløs, Finn, Lennartsson, Andreas, Rönnerblad, Michelle, Hrydziuszko, Olga, Vitezic, Morana, Freeman, Tom C., Alhendi, Ahmad M. N., Arner, Peter, Axton, Richard, Baillie, J. Kenneth, Beckhouse, Anthony, Bodega, Beatrice, Briggs, James, Brombacher, Frank, Davis, Margaret, Detmar, Michael, Ehrlund, Anna, Endoh, Mitsuhiro, Eslami, Afsaneh, Fagiolini, Michela, Fairbairn, Lynsey, Faulkner, Geoffrey J., Ferrai, Carmelo, Fisher, Malcolm E. ... Hayashizaki, Yoshihide (2015). Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells. Science, 347 (6225), 1010-1014. doi: 10.1126/science.1259418 |
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2015 Journal Article High-throughput, deterministic single cell trapping and long-term clonal cell culture in microfluidic devicesChen, Huaying, Sun, Jane, Wolvetang, Ernst and Cooper-White, Justin (2015). High-throughput, deterministic single cell trapping and long-term clonal cell culture in microfluidic devices. Lab on a Chip, 15 (4), 1072-1083. doi: 10.1039/C4LC01176G |
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2015 Journal Article TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation.Thakar, Nilay Y., Ovchinnikov, Dmitry A., Hastie, Marcus L., Kobe, Bostjan, Gorman, Jeffrey J. and Wolvetang, Ernst J. (2015). TRAF2 recruitment via T61 in CD30 drives NFκB activation and enhances hESC survival and proliferation.. Molecular Biology of the Cell, 26 (5), 993-1006. doi: 10.1091/mbc.E14-08-1290 |
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2015 Journal Article The statistical geometry of transcriptome divergence in cell-type evolution and cancerLiang, Cong, The FANTOM Consortium, Forrest, Alistair R. R., Wagner, Guenter P., Kenna, Tony, Beckhouse, Anthony, Blumenthal, Antje, Briggs, James, Hitchens, Kelly, Ovchinnikov, Dmitry, Vijayan, Dipti, Wells, Christine and Wolvetang, Ernst (2015). The statistical geometry of transcriptome divergence in cell-type evolution and cancer. Nature Communications, 6 (1) 6066. doi: 10.1038/ncomms7066 |
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2015 Journal Article Expression of Histocompatibility 2 Blastocyst (H2-Bl) in embryonic stem cells inhibits CD8+ T-cell activation but is not sufficient to facilitate graft toleranceDingwall, Steven, Brooks, Andrew, Apte, Simon H., Waters, Mike, Lavin, Martin F. and Wolvetang, Ernst J. (2015). Expression of Histocompatibility 2 Blastocyst (H2-Bl) in embryonic stem cells inhibits CD8+ T-cell activation but is not sufficient to facilitate graft tolerance. Journal of Stem Cell Research and Therapy, 5 (12) 1000320, 1-8. doi: 10.4172/2157-7633.1000320 |
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2015 Journal Article RELB alters proliferation of human pluripotent stem cells via IMP3- and LIN28-mediated modulation of the expression of IGF2 and other cell-cycle regulatorsThakar, Nilay Yogeshkumar, Ovchinnikov, Dmitry Alexander, Hastie, Marcus Lachlan, Gorman, Jeffrey and Wolvetang, Ernst Jurgen (2015). RELB alters proliferation of human pluripotent stem cells via IMP3- and LIN28-mediated modulation of the expression of IGF2 and other cell-cycle regulators. Stem Cells and Development, 24 (16), 1888-1900. doi: 10.1089/scd.2014.0587 |
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2015 Journal Article Advances in reprogramming to pluripotencyAlateeq, Suad, Fortuna, Patrick R. J. and Wolvetang, Ernst (2015). Advances in reprogramming to pluripotency. Current Stem Cell Research and Therapy, 10 (3), 193-207. doi: 10.2174/1574888X10666150220154820 |
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2015 Journal Article ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1Kijas, Amanda W., Lim, Yi Chieh, Bolderson, Emma, Cerosaletti, Karen, Gatei, Magtouf, Jakob, Burkhard, Tobias, Frank, Taucher-Scholz, Gisela, Gueven, Nuri, Oakley, Greg, Concannon, Patrick, Wolvetang, Ernst, Khanna, Kum Kum, Wiesmuller, Lisa and Lavin, Martin F. (2015). ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1. Nucleic Acids Research, 43 (17), 8352-8367. doi: 10.1093/nar/gkv754 |
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2014 Journal Article Opportunities and limitations of modelling Alzheimer’s disease with induced pluripotent stem cellsOvchinnikov, Dmitry A. and Wolvetang, Ernst J. (2014). Opportunities and limitations of modelling Alzheimer’s disease with induced pluripotent stem cells. Journal of Clinical Medicine, 3 (4), 1357-1372. doi: 10.3390/jcm3041357 |
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2014 Journal Article Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2Hawksworth, Owen A., Coulthard, Liam G., Taylor, Stephen M., Wolvetang, Ernst J. and Woodruff, Trent M. (2014). Brief report: Complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2. Stem Cells, 32 (12), 3278-3284. doi: 10.1002/stem.1801 |
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2014 Journal Article Polymeric nanofibrous substrates stimulate pluripotent stem cells to form three-dimensional multilayered patty-like spheroids in feeder-free culture and maintain their pluripotency.Alamein, Mohammad A., Wolvetang, Ernst J., Ovchinnikov, Dmitry A., Stephens, Sebastien, Sanders, Katherine and Warnke, Patrick H. (2014). Polymeric nanofibrous substrates stimulate pluripotent stem cells to form three-dimensional multilayered patty-like spheroids in feeder-free culture and maintain their pluripotency.. Journal of Tissue Engineering and Regenerative Medicine, 9 (9), 1078-1083. doi: 10.1002/term.1960 |
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2014 Journal Article Metabolic profiling and flux analysis of MEL-2 human embryonic stem cells during exponential growth at physiological and atmospheric oxygen concentrationsTurner, Jennifer, Quek,Lake-Ee, Titmarsh, Drew, Kromer, Jens O., Kao, Li-Pin, Nielsen, Lars, Wolvetang, Ernst and Cooper-White, Justin (2014). Metabolic profiling and flux analysis of MEL-2 human embryonic stem cells during exponential growth at physiological and atmospheric oxygen concentrations. PLoS One, 9 (11) e112757, e112757.1-e112757.13. doi: 10.1371/journal.pone.0112757 |
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2014 Journal Article Specific mesothelial signature marks the heterogeneity of mesenchymal stem cells from high-grade serous ovarian cancerVerardo, Roberto, Piazza, Silvano, Klaric, Enio, Ciani, Yari, Bussadori, Giulio, Marzinotto, Stefania, Mariuzzi, Laura, Cesselli, Daniela, Beltrami, Antonio P., Mano, Miguel, Itoh, Masayoshi, Kawaji, Hideya, Lassmann, Timo, Carninci, Piero, Hayashizaki, Yoshihide, Forrest, Alistair R. R., Beltrami, Carlo A., The Fantom Consortium, Schneider, Claudio, Beckhouse, Anthony, Wells, Christine, Vijayan, Dipti, Wolvetang, Ernst, Hitchens, Kelly, Kenna, Tony, Blumenthal, Antje, Briggs, James, Ovchinnikov, Dmitry, Fearnley, Liam ... Nielsen, Lars (2014). Specific mesothelial signature marks the heterogeneity of mesenchymal stem cells from high-grade serous ovarian cancer. Stem Cells (Durham), 32 (11), 2998-3011. doi: 10.1002/stem.1791 |
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2014 Journal Article Isolation of contractile cardiomyocytes from human pluripotent stem-cell-derived cardiomyogenic cultures using a human NCX1-EGFP reporterOvchinnikov, Dmitry A.,, Hidalgo, Alejandro, Yang, Seung-Kwon, Zhang, Xinli, Hudson, James, Mazzone, Stuart B., Chen, Chen, Cooper-White, Justin J. and Wolvetang, Ernst J. (2014). Isolation of contractile cardiomyocytes from human pluripotent stem-cell-derived cardiomyogenic cultures using a human NCX1-EGFP reporter. Stem Cells and Development, 24 (1), 11-20. doi: 10.1089/scd.2014.0195 |
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2014 Journal Article Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitroOvchinnikov, Dmitry A., Titmarsh, Drew M., Fortuna, Patrick R. J., Hidalgo, Alejandro, Alharbi, Samah, Whitworth, Deanne J., Cooper-White, Justin J. and Wolvetang, Ernst J. (2014). Transgenic human ES and iPS reporter cell lines for identification and selection of pluripotent stem cells in vitro. Stem Cell Research, 13 (2), 251-261. doi: 10.1016/j.scr.2014.05.006 |
