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2025

Journal Article

Dual-Contrast Agent with Nanoparticle and Molecular Components in Photon-Counting Computed Tomography: Assessing Articular Cartilage Health

Paakkari, Petri, Inkinen, Satu I., Jäntti, Jiri, Tuppurainen, Juuso, Fugazzola, Maria C., Joenathan, Anisha, Ylisiurua, Sampo, Nieminen, Miika T., Kröger, Heikki, Mikkonen, Santtu, van Weeren, René, Snyder, Brian D., Töyräs, Juha, Honkanen, Miitu K. M., Matikka, Hanna, Grinstaff, Mark W., Honkanen, Juuso T. J. and Mäkelä, Janne T. A. (2025). Dual-Contrast Agent with Nanoparticle and Molecular Components in Photon-Counting Computed Tomography: Assessing Articular Cartilage Health. Annals of Biomedical Engineering, 1-16. doi: 10.1007/s10439-025-03715-0

Dual-Contrast Agent with Nanoparticle and Molecular Components in Photon-Counting Computed Tomography: Assessing Articular Cartilage Health

2025

Journal Article

Hybrid discrete and finite element analysis enables fast evaluation of hip joint cartilage mechanical response

Venäläinen, Mikko S., Li, Mao, Töyräs, Juha, Korhonen, Rami K., Fripp, Jurgen, Crozier, Stuart, Chandra, Shekhar S. and Engstrom, Craig (2025). Hybrid discrete and finite element analysis enables fast evaluation of hip joint cartilage mechanical response. Journal of Biomechanics, 182 112568, 1-6. doi: 10.1016/j.jbiomech.2025.112568

Hybrid discrete and finite element analysis enables fast evaluation of hip joint cartilage mechanical response

2025

Journal Article

Machine learning approaches for the fusion of near-infrared, mid-infrared, and Raman data to identify cartilage degradation in human osteochondral plugs

Tafintseva, Valeria, Nippolainen, Ervin, Virtanen, Vesa, Solheim, Johanne Heitmann, Zimmermann, Boris, Saarakkala, Simo, Kröger, Heikki, Kohler, Achim, Töyräs, Juha, Afara, Isaac O. and Shaikh, Rubina (2025). Machine learning approaches for the fusion of near-infrared, mid-infrared, and Raman data to identify cartilage degradation in human osteochondral plugs. Applied Spectroscopy, 79 (3), 385-395. doi: 10.1177/00037028241285583

Machine learning approaches for the fusion of near-infrared, mid-infrared, and Raman data to identify cartilage degradation in human osteochondral plugs

2025

Journal Article

Community prevalence of positional obstructive sleep apnea

Duce, Brett L., Kulkas, Antti E., Leppänen, Timo T., Oksenberg, Arie, Töyräs, Juha and Hukins, Craig A. (2025). Community prevalence of positional obstructive sleep apnea. Journal of Clinical Sleep Medicine. doi: 10.5664/jcsm.11584

Community prevalence of positional obstructive sleep apnea

2025

Journal Article

The Relationship Between the Optical Properties of Articular Cartilage and the Biomechanical Parameters of the Tissue

Kafian-Attari, Iman, Ebrahimi, Mohammad, Nippolainen, Ervin, Mirhashemi, Arash, Paakkari, Petri, Bergmann, Florian, Foschum, Florian, Kienle, Alwin, Toyras, Juha and Afara, Isaac (2025). The Relationship Between the Optical Properties of Articular Cartilage and the Biomechanical Parameters of the Tissue. Journal of Biophotonics, 18 (4) e202400460. doi: 10.1002/jbio.202400460

The Relationship Between the Optical Properties of Articular Cartilage and the Biomechanical Parameters of the Tissue

2024

Journal Article

Photon-counting in dual-contrast-enhanced computed tomography: a proof-of-concept quantitative biomechanical assessment of articular cartilage

Paakkari, Petri, Inkinen, Satu I., Mohammadi, Ali, Nieminen, Miika T., Joenathan, Anisha, Grinstaff, Mark W., Töyräs, Juha, Mäkelä, Janne T. A. and Honkanen, Juuso T. J. (2024). Photon-counting in dual-contrast-enhanced computed tomography: a proof-of-concept quantitative biomechanical assessment of articular cartilage. Scientific Reports, 14 (1) 29956, 1-14. doi: 10.1038/s41598-024-78237-1

Photon-counting in dual-contrast-enhanced computed tomography: a proof-of-concept quantitative biomechanical assessment of articular cartilage

2024

Journal Article

The human patellar tendon is mechanically homogenous at its mid-substance

Kositsky, Adam, Stenroth, Lauri, Nippolainen, Ervin, Torniainen, Jari, Mäkelä, Janne T.A., Paakkari, Petri, Paakkonen, Tommi, Kröger, Heikki, Töyräs, Juha, Afara, Isaac O. and Korhonen, Rami K. (2024). The human patellar tendon is mechanically homogenous at its mid-substance. Journal of the Mechanical Behavior of Biomedical Materials, 163 106875, 106875. doi: 10.1016/j.jmbbm.2024.106875

The human patellar tendon is mechanically homogenous at its mid-substance

2024

Journal Article

Temporal and sleep stage‐dependent agreement in manual scoring of respiratory events

Pitkänen, Minna, Pitkänen, Henna, Nath, Rajdeep Kumar, Nikkonen, Sami, Kainulainen, Samu, Korkalainen, Henri, Ólafsdóttir, Kristín Anna, Arnardottir, Erna Sif, Sigurdardottir, Sigridur, Penzel, Thomas, Fanfulla, Francesco, Anttalainen, Ulla, Saaresranta, Tarja, Grote, Ludger, Hedner, Jan, Staats, Richard, Töyräs, Juha and Leppänen, Timo (2024). Temporal and sleep stage‐dependent agreement in manual scoring of respiratory events. Journal of Sleep Research, e14391. doi: 10.1111/jsr.14391

Temporal and sleep stage‐dependent agreement in manual scoring of respiratory events

2024

Journal Article

Retrospective validation of automatic sleep analysis with grey areas model for human‐in‐the‐loop scoring approach

Rusanen, Matias, Jouan, Gabriel, Huttunen, Riku, Nikkonen, Sami, Sigurðardóttir, Sigríður, Töyräs, Juha, Duce, Brett, Myllymaa, Sami, Arnardottir, Erna Sif, Leppänen, Timo, Islind, Anna Sigridur, Kainulainen, Samu and Korkalainen, Henri (2024). Retrospective validation of automatic sleep analysis with grey areas model for human‐in‐the‐loop scoring approach. Journal of Sleep Research, e14362. doi: 10.1111/jsr.14362

Retrospective validation of automatic sleep analysis with grey areas model for human‐in‐the‐loop scoring approach

2024

Journal Article

Arousal burden is highest in supine sleeping position and during light sleep

Pitkänen, Minna, Huovinen, Juho, Rissanen, Marika, Pitkänen, Henna, Kainulainen, Samu, Penzel, Thomas, Fanfulla, Francesco, Anttalainen, Ulla, Saaresranta, Tarja, Grote, Ludger, Hedner, Jan, Staats, Richard, Duce, Brett, Töyräs, Juha, Oksenberg, Arie and Leppänen, Timo (2024). Arousal burden is highest in supine sleeping position and during light sleep. Journal of Clinical Sleep Medicine, 21 (2), 337-344. doi: 10.5664/jcsm.11398

Arousal burden is highest in supine sleeping position and during light sleep

2024

Journal Article

An automated and robust tool for musculoskeletal and finite element modeling of the knee joint

Esrafilian, Amir, Chandra, Shekhar S., Gatti, Anthony A., Nissi, Mikko, Mustonen, Anne-Mari, Saisanen, Laura, Reijonen, Jusa, Nieminen, Petteri, Julkunen, Petro, Toyras, Juha, Saxby, David J., Lloyd, David G. and Korhonen, Rami K. (2024). An automated and robust tool for musculoskeletal and finite element modeling of the knee joint. IEEE Transactions on Biomedical Engineering, 72 (1), 1-13. doi: 10.1109/tbme.2024.3438272

An automated and robust tool for musculoskeletal and finite element modeling of the knee joint

2024

Journal Article

“An excellent servant but a terrible master”: understanding the value of wearables for self-management in people with cystic fibrosis and their healthcare providers – a qualitative study

Mattison, Graeme, Canfell, Oliver J., Smith, Daniel, Forrester, Doug, Reid, David, Töyräs, Juha and Dobbins, Chelsea (2024). “An excellent servant but a terrible master”: understanding the value of wearables for self-management in people with cystic fibrosis and their healthcare providers – a qualitative study. International Journal of Medical Informatics, 189 105532, 105532. doi: 10.1016/j.ijmedinf.2024.105532

“An excellent servant but a terrible master”: understanding the value of wearables for self-management in people with cystic fibrosis and their healthcare providers – a qualitative study

2024

Journal Article

Relationship between depth-wise refractive index and biomechanical properties of human articular cartilage

Khan, Bilour, Nippolainen, Ervin, Shahini, Fatemeh, Nonappa, , Popov, Alexey, Töyräs, Juha and Afara, Isaac O. (2024). Relationship between depth-wise refractive index and biomechanical properties of human articular cartilage. Journal of biomedical optics, 29 (9) 095003, 095003-095003. doi: 10.1117/1.JBO.29.9.095003

Relationship between depth-wise refractive index and biomechanical properties of human articular cartilage

2024

Journal Article

Estimation of photon path length and penetration depth in articular cartilage zonal architecture over the therapeutic window

Kafian-Attari, I., Nippolainen, E., Bergmann, F., George, A., Paakkari, P., Mirhashemi, A., Foschum, F., Kienle, A., Toyras, J. and Afara, I. O. (2024). Estimation of photon path length and penetration depth in articular cartilage zonal architecture over the therapeutic window. IEEE Transactions on Biomedical Engineering, 71 (8), 2300-2310. doi: 10.1109/TBME.2024.3368012

Estimation of photon path length and penetration depth in articular cartilage zonal architecture over the therapeutic window

2024

Journal Article

Infrared spectroscopy can differentiate between cartilage injury models: implication for assessment of cartilage integrity

Shahini, Fatemeh, Oskouei, Soroush, Nippolainen, Ervin, Mohammadi, Ali, Sarin, Jaakko K., Moller, Nikae C. R. te, Brommer, Harold, Shaikh, Rubina, Korhonen, Rami K., van Weeren, P. René, Töyräs, Juha and Afara, Isaac O. (2024). Infrared spectroscopy can differentiate between cartilage injury models: implication for assessment of cartilage integrity. Annals of Biomedical Engineering, 52 (9), 2521-2533. doi: 10.1007/s10439-024-03540-x

Infrared spectroscopy can differentiate between cartilage injury models: implication for assessment of cartilage integrity

2024

Journal Article

Laser-irradiating infrared attenuated total reflection spectroscopy of articular cartilage: potential and challenges for diagnosing osteoarthritis

Krebs, P., Nägele, M., Fomina, P., Virtanen, V., Nippolainen, E., Shaikh, R., Afara, I. O., Töyräs, J., Usenov, I., Sakharova, T., Artyushenko, V., Tafintseva, V., Solheim, J.H., Zimmermann, B., Kohler, A., König, O., Saarakkala, S. and Mizaikoff, B. (2024). Laser-irradiating infrared attenuated total reflection spectroscopy of articular cartilage: potential and challenges for diagnosing osteoarthritis. Osteoarthritis and Cartilage Open, 6 (2) 100466. doi: 10.1016/j.ocarto.2024.100466

Laser-irradiating infrared attenuated total reflection spectroscopy of articular cartilage: potential and challenges for diagnosing osteoarthritis

2024

Journal Article

Sleep stage continuity is associated with objective daytime sleepiness in patients with suspected obstructive sleep apnea

Chen, Xin, Leppänen, Timo, Kainulainen, Samu, Howarth, Timothy P., Oksenberg, Arie, Töyräs, Juha, Terrill, Philip I. and Korkalainen, Henri (2024). Sleep stage continuity is associated with objective daytime sleepiness in patients with suspected obstructive sleep apnea. Journal of Clinical Sleep Medicine, 20 (10), 1595-1606. doi: 10.5664/jcsm.11198

Sleep stage continuity is associated with objective daytime sleepiness in patients with suspected obstructive sleep apnea

2024

Journal Article

Site-specific elastic and viscoelastic biomechanical properties of healthy and osteoarthritic human knee joint articular cartilage

Linus, Awuniji, Tanska, Petri, Nippolainen, Ervin, Tiitu, Virpi, Töyras, Juha, Korhonen, Rami K., Afara, Isaac O. and Mononen, Mika E. (2024). Site-specific elastic and viscoelastic biomechanical properties of healthy and osteoarthritic human knee joint articular cartilage. Journal of Biomechanics, 169 112135. doi: 10.1016/j.jbiomech.2024.112135

Site-specific elastic and viscoelastic biomechanical properties of healthy and osteoarthritic human knee joint articular cartilage

2024

Journal Article

Increased flow limitation during sleep is associated with increased psychomotor vigilance task lapses in individuals with suspected obstructive sleep apnea

Staykov, Eric, Mann, Dwayne L., Duce, Brett, Kainulainen, Samu, Leppänen, Timo, Töyräs, Juha, Azarbarzin, Ali, Georgeson, Thomas, Sands, Scott A. and Terrill, Philip I. (2024). Increased flow limitation during sleep is associated with increased psychomotor vigilance task lapses in individuals with suspected obstructive sleep apnea. CHEST, 165 (4), 990-1003. doi: 10.1016/j.chest.2023.11.031

Increased flow limitation during sleep is associated with increased psychomotor vigilance task lapses in individuals with suspected obstructive sleep apnea

2024

Journal Article

Reaction time in psychomotor vigilance task is related to hypoxic load in males with sleep apnea

Pahari, Purbanka, Korkalainen, Henri, Karhu, Tuomas, Arnardottir, Erna Sif, Töyräs, Juha, Leppänen, Timo and Nikkonen, Sami (2024). Reaction time in psychomotor vigilance task is related to hypoxic load in males with sleep apnea. Journal of Sleep Research, 33 (2) e13988, e13988. doi: 10.1111/jsr.13988

Reaction time in psychomotor vigilance task is related to hypoxic load in males with sleep apnea