|
2021 Journal Article A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndromeCardoso, Fernanda C., Castro, Joel, Grundy, Luke, Schober, Gudrun, Garcia-Caraballo, Sonia, Zhao, Tianjiao, Herzig, Volker, King, Glenn F., Brierley, Stuart M. and Lewis, Richard J. (2021). A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome. Pain, 162 (2), 569-581. doi: 10.1097/j.pain.0000000000002041 |
|
2020 Journal Article Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otencyPeschel, Alicia, Cardoso, Fernanda C., Walker, Andrew A., Durek, Thomas, Stone, M Rhia L., Braga Emidio, Nayara, Dawson, Philip E., Muttenthaler, Markus and King, Glenn F. (2020). Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otency. Journal of Medicinal Chemistry, 63 (21), 12773-12785. doi: 10.1021/acs.jmedchem.0c01107 |
|
2020 Journal Article The neuronal calcium ion channel activity of constrained analogues of MONIRO-1Cardoso, Fernanda C., Marliac, Marie-Adeline, Geoffroy, Chloe, Schmit, Matthieu, Bispat, Anjie, Lewis, Richard J., Tuck, Kellie L. and Duggan, Peter J. (2020). The neuronal calcium ion channel activity of constrained analogues of MONIRO-1. Bioorganic and Medicinal Chemistry, 28 (18) 115655, 115655. doi: 10.1016/j.bmc.2020.115655 |
|
2020 Journal Article Characterisation of δ-Conotoxin TxVIA as a mammalian T-type calcium channel modulatorWang, Dan, Himaya, S.W.A., Giacomotto, Jean, Hasan, Md. Mahadhi, Cardoso, Fernanda C., Ragnarsson, Lotten and Lewis, Richard J. (2020). Characterisation of δ-Conotoxin TxVIA as a mammalian T-type calcium channel modulator. Marine Drugs, 18 (7) 343, 1-13. doi: 10.3390/md18070343 |
|
2020 Journal Article Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseasesCardoso, Fernanda C (2020). Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases. Biochemical Pharmacology, 181 114107, 114107. doi: 10.1016/j.bcp.2020.114107 |
|
2019 Journal Article Spider knottin pharmacology at voltage-gated sodium channels and their potential to modulate pain pathwaysDongol, Yashad, Cardoso, Fernanda C. and Lewis, Richard J. (2019). Spider knottin pharmacology at voltage-gated sodium channels and their potential to modulate pain pathways. Toxins, 11 (11) 10.3390/toxins11110626, 626. doi: 10.3390/toxins11110626 |
|
2019 Journal Article Venomic, transcriptomic, and bioactivity analyses of Pamphobeteus verdolaga venom reveal complex disulfide-rich peptides that modulate calcium channelsEstrada-Gomez, Sebastian, Cardoso,Fernanda Caldas, Vargas-Muñoz, Leidy Johana, Quintana-Castillo, Juan Carlos, Gómez, Claudia Marcela Arenas, Pineda, Sandy Steffany and Saldarriaga-Cordoba, Monica Maria (2019). Venomic, transcriptomic, and bioactivity analyses of Pamphobeteus verdolaga venom reveal complex disulfide-rich peptides that modulate calcium channels. Toxins, 11 (9) 496, 496. doi: 10.3390/toxins11090496 |
|
2019 Journal Article Multifunctional toxins in snake venoms and therapeutic implications: From pain to hemorrhage and necrosisFerraz, Camila R., Arrahman, Arif, Xie, Chunfang, Casewell, Nicholas R., Lewis, Richard J., Kool, Jeroen and Cardoso, Fernanda C. (2019). Multifunctional toxins in snake venoms and therapeutic implications: From pain to hemorrhage and necrosis. Frontiers in Ecology and Evolution, 7 (JUN) 218. doi: 10.3389/fevo.2019.00218 |
|
2019 Journal Article Structure–function and therapeutic potential of spider venom-derived cysteine knot peptides targeting sodium channelsCardoso, Fernanda C. and Lewis, Richard J. (2019). Structure–function and therapeutic potential of spider venom-derived cysteine knot peptides targeting sodium channels. Frontiers in Pharmacology, 10 (APR) 366, 366. doi: 10.3389/fphar.2019.00366 |
|
2019 Journal Article ‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET PotencyZiegman, Rebekah , Brust, Andreas , Jha, Prerna , Cardoso, Fernanda C. , Lewis, Richard J. and Alewood, Paul F. (2019). ‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency. Marine Drugs, 17 (3) 165, 165. doi: 10.3390/md17030165 |
|
2018 Journal Article Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profilingSlagboom, Julien, Otvos, Reka A., Cardoso, Fernanda C., Iyer, Janaki, Visser, Jeroen C., van Doodewaerd, Bjorn R., McCleary, Ryan J.R., Niessen, Wilfried M.A., Somsen, Govert W., Lewis, Richard J., Kini, R. Manjunatha, Smit, August B., Casewell, Nicholas R. and Kool, Jeroen (2018). Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling. Toxicon, 148, 213-222. doi: 10.1016/j.toxicon.2018.04.022 |
|
2018 Journal Article Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channelsSairaman, Anjali, Cardoso, Fernanda Caldas, Bispat, Anjie, Lewis, Richard J., Duggan, Peter J. and Tuck, Kellie L. (2018). Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels. Bioorganic and Medicinal Chemistry, 26 (11), 3046-3059. doi: 10.1016/j.bmc.2018.03.031 |
|
2018 Journal Article Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptidesStefanucci, Azzurra, Novelino, Ettore, Macedonio, Giorgia, Dimmito, Marilia Pia, Mirzaie, Sako, Cardoso, Fernanda Caldas , Lewis, Richard, Zador, Ferenc, Erdei, Anna I., Dvoracsko, Szabolcs, Tomboly, Csaba, Benych, Sandor, Pieretti, Stefano, Minosi, Paola and Mollica, Adriano (2018). Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides. New Journal of Chemistry, 42 (8), 5656-5659. doi: 10.1039/c7nj04969b |
|
2018 Journal Article Toxins in painCardoso, Fernanda C., Hasan, Mahadhi, Zhao, Tianjiao and Lewis, Richard J. (2018). Toxins in pain. Current Opinion in Supportive and Palliative Care, 12 (2), 1-10. doi: 10.1097/SPC.0000000000000335 |
|
2017 Journal Article Sodium channels and pain: from toxins to therapiesCardoso, Fernanda Caldas and Lewis, Richard J. (2017). Sodium channels and pain: from toxins to therapies. British Journal of Pharmacology, 175 (12), 2138-2157. doi: 10.1111/bph.13962 |
|
2017 Journal Article Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatusCardoso, Fernanda Caldas, Dekan, Zoltan, Smith, Jennifer J., Deuis, Jennifer R., Vetter, Irina, Herzig, Volker, Alewood, Paul F., King, Glenn F and Lewis, Richard J. (2017). Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. British Journal of Pharmacology, 174 (15), 2528-2544. doi: 10.1111/bph.13865 |
|
2017 Journal Article The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variantRahnama, Sassan, Deuis, Jennifer R., Cardoso, Fernanda C., Ramanujam, Venkatraman, Lewis, Richard J., Rash, Lachlan D., King, Glenn F., Vetter, Irina and Mobli, Mehdi (2017). The structure, dynamics and selectivity profile of a NaV 1.7 potency-optimised huwentoxin-IV variant. PLoS One, 12 (3) e0173551, e0173551. doi: 10.1371/journal.pone.0173551 |
|
2016 Journal Article Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatusTouchard, Axel, Brust, Andreas, Cardoso, Fernanda C., Chin, K.-Y., Herzig, Volker, Jin, Ai-Hua, Dejean, Alain, Alewood, Paul F., King, Glenn F., Orivel, Jérôme and Escoubas, Pierre (2016). Isolation and characterization of a structurally unique β-hairpin venom peptide from the predatory ant Anochetus emarginatus. Biochimica et Biophysica Acta, 1860 (11 Part A), 2553-2562. doi: 10.1016/j.bbagen.2016.07.027 |
|
2015 Journal Article The role of defensive ecological interactions in the evolution of conotoxinsPrashanth, J. R., Dutertre, S., Jin, A. H., Lavergne, V., Hamilton, B., Cardoso, F. C., Griffin, J., Venter, D. J., Alewood, P. F. and Lewis, R. J. (2015). The role of defensive ecological interactions in the evolution of conotoxins. Molecular Ecology, 25 (2), 598-615. doi: 10.1111/mec.13504 |
|
2015 Journal Article Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriensCardoso, Fernanda C., Deka, Zoltan, Rosengren, K. Johan, Erickson, Andelain, Vetter, Irina, Deuis, Jennifer R., Herzig, Volker, Alewood, Paul F., King, Glenn F. and Lewis, Richard J. (2015). Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula Thrixopelma pruriens. Molecular Pharmacology, 88 (2), 291-303. doi: 10.1124/mol.115.098178 |
