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2016 Journal Article Review stapling peptides using cysteine crosslinkingFairlie, David P. and Dantas de Araujo, Aline (2016). Review stapling peptides using cysteine crosslinking. Biopolymers, 106 (6), 843-852. doi: 10.1002/bip.22877 |
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2016 Journal Article Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activationLoh, Liyen, Wang, Zhongfang, Sant, Sneha, Koutsakos, Marios, Jegaskanda, Sinthujan, Corbett, Alexandra J., Liu, Ligong, Fairlie, David P., Crowe, Jane, Rossjohn, Jamie, Xu, Jianqing, Doherty, Peter C., McCluskey, James and Kedzierska, Katherine (2016). Human mucosal-associated invariant T cells contribute to antiviral influenza immunity via IL-18-dependent activation. Proceedings of the National Academy of Sciences, 113 (36), 10133-10138. doi: 10.1073/pnas.1610750113 |
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2016 Journal Article Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2Lieu, T., Savage, E., Zhao, P., Edgington-Mitchell, L., Barlow, N., Bron, R., Poole, D. P., Mclean, P., Lohman, R. -J., Fairlie, D. P. and Bunnett, N. W. (2016). Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2. British Journal of Pharmacology, 173 (18), 2752-2765. doi: 10.1111/bph.13554 |
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2016 Journal Article Truncated glucagon-like peptide-1 and exendin-4 α-conotoxin pl14a peptide chimeras maintain potency and α-helicity and reveal interactions vital for cAMP signaling in vitroSwedberg, Joakim E., Schroeder, Christina I., Mitchell, Justin M., Fairlie, David P., Edmonds, David J., Griffith, David A., Ruggeri, Roger B., Derksen, David R., Loria, Paula M., Price, David A., Liras, Spiros and Craik, David J. (2016). Truncated glucagon-like peptide-1 and exendin-4 α-conotoxin pl14a peptide chimeras maintain potency and α-helicity and reveal interactions vital for cAMP signaling in vitro. Journal of Biological Chemistry, 291 (30), 15778-15787. doi: 10.1074/jbc.M116.724542 |
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2016 Journal Article Helix nucleation by the smallest known α-helix in waterHoang, Huy N., Driver, Russell W., Beyer, Renee L., Hill, Timothy A., de Araujo, Aline D., Plisson, Fabien, Harrison, Rosemary S., Goedecke, Lena, Shepherd, Nicholas E. and Fairlie, David P. (2016). Helix nucleation by the smallest known α-helix in water. Angewandte Chemie (International Edition), 55 (29), 8275-8279. doi: 10.1002/anie.201602079 |
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2016 Journal Article Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites (vol 5, pg 117, 2015)Engel, Jessica A., Jones, Amy J., Avery, Vicky M., Sumanadasa, Subathdrage D. M., Ng, Susanna S., Fairlie, David P., Skinner-Adams, Tina and Andrews, Katherine T. (2016). Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites (vol 5, pg 117, 2015). International Journal for Parasitology-Drugs and Drug Resistance, 6 (3), 287-287. doi: 10.1016/j.ijpddr.2016.05.001 |
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2016 Journal Article The intracellular pathway for the presentation of vitamin B–related antigens by the antigen-presenting molecule MR1McWilliam, Hamish E. G., Eckle, Sidonia B. G., Theodossis, Alex, Liu, Ligong, Chen, Zhenjun, Wubben, Jacinta M., Fairlie, David P., Strugnell, Richard A., Mintern, Justine D., McCluskey, James, Rossjohn, Jamie and Villadangos, Jose A. (2016). The intracellular pathway for the presentation of vitamin B–related antigens by the antigen-presenting molecule MR1. Nature Immunology, 17 (5), 531-537. doi: 10.1038/ni.3416 |
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2016 Journal Article Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonistsSeow, Vernon, Lim, Junxian, Cotterell, Adam J., Yau, Mei-Kwan, Xu, Weijun, Lohman, Rink-Jan, Kok, W. Mei, Stoermer, Martin J., Sweet, Matthew J., Reid, Robert C., Suen, Jacky Y. and Farilie, David P. (2016). Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists. Scientific Reports, 6 (1) 24575, 24575.1-24575.12. doi: 10.1038/srep24575 |
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2016 Journal Article Protease activated receptor 2 (PAR2) modulators: a patent review (2010–2015)Yau, Mei-Kwan, Lim, Junxian, Liu, Ligong and Fairlie, David P. (2016). Protease activated receptor 2 (PAR2) modulators: a patent review (2010–2015). Expert Opinion on Therapeutic Patents, 26 (4), 471-483. doi: 10.1517/13543776.2016.1154540 |
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2016 Journal Article Histone deacetylase inhibitors promote mitochondrial reactive oxygen species production and bacterial clearance by human macrophagesAriffin, Juliana K., das Gupta, Kaustav, Kapetanovic, Ronan, Iyer, Abishek, Reid, Robert C., Fairlie, David P. and Sweet, Matthew J. (2016). Histone deacetylase inhibitors promote mitochondrial reactive oxygen species production and bacterial clearance by human macrophages. Antimicrobial Agents and Chemotherapy, 60 (3), 1521-1529. doi: 10.1128/AAC.01876-15 |
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2016 Journal Article Differential anti-inflammatory activity of HDAC inhibitors in human macrophages and rat arthritisLohman, Rink-Jan, Iyer, Abishek, Fairlie, Thomas J., Cotterell, Adam, Gupta, Praveer, Reid, Robert C., Vesey, David A., Sweet, Matthew J. and Fairlie, David P. (2016). Differential anti-inflammatory activity of HDAC inhibitors in human macrophages and rat arthritis. Journal of Pharmacology and Experimental Therapeutics, 356 (2), 387-396. doi: 10.1124/jpet.115.229328 |
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2016 Journal Article Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activityYau, Mei-Kwan, Liu, Ligong, Lim, Junxian, Lohman, Rink-Jan, Cotterell, Adam J., Suen, Jacky Y., Vesey, David A., Reid, Robert C. and Fairlie, David P. (2016). Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity. Bioorganic and Medicinal Chemistry Letters, 26 (3), 986-991. doi: 10.1016/j.bmcl.2015.12.048 |
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2016 Journal Article Histone deacetylases in monocyte/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseasesDas Gupta, Kaustav, Melanie Shakespear R., Iyer, Abishek, Fairlie, David P. and Sweet, Matthew J. (2016). Histone deacetylases in monocyte/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseases. Clinical and Translational Immunology, 5 (1) e62, e62. doi: 10.1038/cti.2015.46 |
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2016 Journal Article Diversity of T cells restricted by the MHC class I-related molecule MR1 facilitates differential antigen recognitionGherardin, Nicholas A., Keller, Andrew N., Woolley, Rachel E., Le Nours, Jerome, Ritchie, David S., Neeson, Paul J., Birkinshaw, Richard W., Eckle, Sidonia B. G., Waddington, John N., Liu, Ligong, Fairlie, David P., Uldrich, Adam P., Pellicci, Daniel G., McCluskey, James, Godfrey, Dale I and Rossjohn, Jamie (2016). Diversity of T cells restricted by the MHC class I-related molecule MR1 facilitates differential antigen recognition. Immunity, 44 (1), 32-45. doi: 10.1016/j.immuni.2015.12.005 |
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2016 Journal Article Potent small agonists of protease activated receptor 2Yau, Mei-Kwan, Suen, Jacky Y., Xu, Weijun, Lim, Junxian, Liu, Ligong, Adams, Mark N., He, Yaowu, Hooper, John D., Reid, Robert C. and Fairlie, David P. (2016). Potent small agonists of protease activated receptor 2. ACS Medicinal Chemistry Letters, 7 (1), 105-110. doi: 10.1021/acsmedchemlett.5b00429 |
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2016 Journal Article Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactionsPhilippe, Gregoire, Huang, Yen-Hua, Cheneval, Olivier, Lawrence, Nicole, Zhang, Zhen, Fairlie, David P., Craik, David J., Dantas De Araujo, Aline and Troeira Henriques, Sonia (2016). Development of cell-penetrating peptide-based drug leads to inhibit MDMX:p53 and MDM2:p53 interactions. Biopolymers - Peptide Science, 106 (6), 853-863. doi: 10.1002/bip.22893 |
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2016 Journal Article PAR2 modulators derived from GB88Yau, Mei-Kwan, Liu, Ligong, Suen, Jacky Y., Lim, Junxian, Lohman, Rink-Jan, Jiang, Yuhong, Cotterell, Adam J., Barry, Grant D., Mak, Jeffrey Y. W., Vesey, David A., Reid, Robert C. and Fairlie, David P. (2016). PAR2 modulators derived from GB88. ACS Medicinal Chemistry Letters, 7 (12), 1179-1184. doi: 10.1021/acsmedchemlett.6b00306 |
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2015 Journal Article Recognition of Vitamin B precursors and byproducts by Mucosal Associated Invariant T cellsEckle, Sidonia B.G., Corbett, Alexandra J., Keller, Andrew, Chen, Zhenjun, Godfrey, Dale I., Liu, Ligong, Mak, Jeffrey Y. W., Fairlie, David P., Rossjohn, Jamie and McCluskey, James (2015). Recognition of Vitamin B precursors and byproducts by Mucosal Associated Invariant T cells. The Journal of Biological Chemistry, 290 (51), 30204-30211. doi: 10.1074/jbc.R115.685990 |
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2015 Journal Article Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasitesEngel, Jessica A., Jones, Amy J., Avery, Vicky M., Sumanadasa, Subathdrage D. M., Ng, Susanna S., Fairlie, David P., Adams, Tina S. and Andrews, Katherine T. (2015). Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites. International Journal for Parasitology: Drugs and Drug Resistance, 5 (3), 117-126. doi: 10.1016/j.ijpddr.2015.05.004 |
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2015 Journal Article Potent complement C3a receptor agonists derived from oxazole amino acids: structure-activity relationshipsSingh, Ranee, Reed, Anthony N., Chu, Peifei, Scully, Conor C. G., Yau, Mei-Kwan, Suen, Jacky Y., Durek, Thomas, Reid, Robert C. and Fairlie, David P. (2015). Potent complement C3a receptor agonists derived from oxazole amino acids: structure-activity relationships. Bioorganic and Medicinal Chemistry Letters, 25 (23), 5604-5608. doi: 10.1016/j.bmcl.2015.10.038 |
